-
1.发明授权
公开(公告)号：US5607976A
公开(公告)日：1997-03-04
申请号：US598319
申请日：1996-02-08
申请人： Heinrich Englert , Uwe Gerlach , Peter Crause , Dieter Mania , Heinz G ogelein , Joachim Kaiser
发明人： Heinrich Englert , Uwe Gerlach , Peter Crause , Dieter Mania , Heinz G ogelein , Joachim Kaiser
IPC分类号： C07D333/20 , A61K31/18 , A61K31/34 , A61K31/35 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/40 , A61K31/425 , A61K31/426 , A61K31/64 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , C07C233/00 , C07C303/40 , C07C311/58 , C07C327/40 , C07C335/42 , C07D207/32 , C07D207/335 , C07D213/40 , C07D277/28 , C07D307/52
CPC分类号： C07C335/42 , C07C311/58
摘要： Substituted benzenesulfonylureas and -thioureas, processes for their preparation, their use for the production of pharmaceutical preparations, and pharmaceutical preparations containing them.Substituted benzenesulfonylureas and -thioureas of the formula I ##STR1## exhibit effects on the cardiovascular system.
摘要翻译： 取代的苯磺酰脲和硫脲，其制备方法，其用于制备药物制剂的用途，以及含有它们的药物制剂。 式I的取代苯磺酰脲和硫脲显示出对心血管系统的作用。
-
2.发明授权
公开(公告)号：US5633239A
公开(公告)日：1997-05-27
申请号：US601109
申请日：1996-02-16
申请人： Heinrich Englert , Uwe Gerlach , Dieter Mania , Heinz G ogelein , Joachim Kaiser
发明人： Heinrich Englert , Uwe Gerlach , Dieter Mania , Heinz G ogelein , Joachim Kaiser
IPC分类号： C07D331/02 , A61K31/18 , A61K31/38 , A61K31/64 , A61P9/00 , A61P9/02 , A61P9/06 , A61P9/10 , C07C233/00 , C07C303/40 , C07C311/58 , C07C327/46 , C07C335/42 , C07D295/00 , C07D303/48 , A61K31/395 , C07D203/12
CPC分类号： C07D303/48 , C07C335/42 , C07C2101/02
摘要： Substituted benzenesulfonylureas and -thioureas of the formula I ##STR1## exhibit outstanding effects on the cardiovascular system.
摘要翻译： 式I的取代苯磺酰脲和硫脲对心血管系统表现出突出的作用。
-
3.发明授权Substituted benzenesulfonylureas and -thioureas, preparation processes and possible uses of pharmaceutical preparations based on these compounds 失效取代的苯磺酰脲和硫脲，基于这些化合物的药物制剂的制备方法和可能的用途
公开(公告)号：US5631275A
公开(公告)日：1997-05-20
申请号：US462033
申请日：1995-06-05
申请人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz G ogelein , Joachim Kaiser , Uwe Gerlach
发明人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz G ogelein , Joachim Kaiser , Uwe Gerlach
IPC分类号： C07D207/38 , C07D521/00 , C07D209/46 , A61K31/40 , A61K31/47 , C07D207/18
CPC分类号： C07D521/00 , C07D207/38
摘要： This invention relates to substituted benzenesulfonylureas and -thioureas, processes for their preparation, and uses of the pharmaceutical products based on these compounds. The substituted benzenesulfonylureas and -thioureas are of the formula I ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 E, and y are as defined in the specification. The compounds of formula I have antiarrhythmic activity.
摘要翻译： 本发明涉及取代的苯磺酰脲和硫脲，其制备方法以及基于这些化合物的药物产品的用途。 取代的苯磺酰脲和硫脲具有式I（I）其中R1，R2，R3E和y如说明书中所定义。 式I化合物具有抗心律不齐活性。
-
4.发明授权Substituted thiophenesulfonylureas and -thioureas, processes for their preparation, their use as a medicament or diagnostic, and medicament containing them 失效取代的噻吩磺酰脲和硫脲，其制备方法，它们作为药物或诊断剂的用途，以及含有它们的药物
公开(公告)号：US5792788A
公开(公告)日：1998-08-11
申请号：US593621
申请日：1996-01-30
申请人： Heinrich Englert , Jens Hartung , Peter Crause , Dieter Mania , Heinz Gogelein , Joachim Kaiser
发明人： Heinrich Englert , Jens Hartung , Peter Crause , Dieter Mania , Heinz Gogelein , Joachim Kaiser
IPC分类号： A61K31/38 , A61K31/381 , A61K31/64 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P43/00 , C07C335/00 , C07D333/34 , C07D333/32
CPC分类号： C07D333/34
摘要： Substituted thiophenesulfonylureas and -thioureas I ##STR1## wherein R(1) is selected from the group consisting of hydrogen, halogen, alkyl having 1 or 2 carbon atoms, alkoxy having 1 or 2 carbon atoms, mercaptoalkyl having 1 or 2 carbon atoms, fluoroalkoxy having 1 or 2 carbon atoms, and fluoroalkyl having 1 or 2 carbon atoms; R(2) is selected from the group consisting of hydrogen, alkyl having 1 or 2 carbon atoms such as methyl, alkoxy having 1 or 2 carbon atoms, and trifluoromethyl; X is selected from the group consisting of oxygen (compounds Ia) or sulfur (compounds Ib); Y and Z are identical or different and are selected from the group consisting of hydrogen, F, Cl, Br, I, alkyl having 1 or 2 carbon atoms and alkoxy having 1 or 2 carbon atoms.
摘要翻译： 取代的噻吩磺酰脲和硫脲I其中R（1）选自氢，卤素，具有1或2个碳原子的烷基，具有1或2个碳原子的烷氧基，具有1或2个碳原子的巯基烷基， 具有1或2个碳原子的氟烷氧基和具有1或2个碳原子的氟代烷基; R（2）选自氢，具有1或2个碳原子的烷基，例如甲基，具有1或2个碳原子的烷氧基和三氟甲基; X选自氧（化合物Ia）或硫（化合物Ib）; Y和Z相同或不同，并且选自氢，F，Cl，Br，I，具有1或2个碳原子的烷基和具有1或2个碳原子的烷氧基。
-
5.发明授权
公开(公告)号：US5977177A
公开(公告)日：1999-11-02
申请号：US90403
申请日：1998-06-04
申请人： Heinrich Englert , Uwe Gerlach , Dieter Mania , Heinz Gogelein , Joachim Kaiser
发明人： Heinrich Englert , Uwe Gerlach , Dieter Mania , Heinz Gogelein , Joachim Kaiser
IPC分类号： A61K31/18 , A61K31/64 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , C07C233/00 , C07C303/36 , C07C303/40 , C07C311/57 , C07C311/58 , C07C311/59 , C07C327/40 , C07C335/00 , C07C335/42 , A61K31/175 , C07C311/16
CPC分类号： C07C335/42 , C07C311/58 , C07C2101/02 , C07C2101/14 , Y10S514/821
摘要： This invention relates to substituted benzenesulfonylureas and -thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them.Substituted benzenesulfonylureas and -thioureas of the formula I ##STR1## exhibit effects on the cardiovascular system.
摘要翻译： 本发明涉及取代的苯磺酰脲和硫脲，其制备和使用基于这些化合物的药物制剂及其含有药物的方法。 式I的取代苯磺酰脲和硫脲显示出对心血管系统的作用。
-
6.发明授权Substituted benzenesulfonylureas and -thioureas, preparation processes and possible uses of pharmaceutical preparations based on these compounds 失效取代的苯磺酰脲和硫脲，基于这些化合物的药物制剂的制备方法和可能的用途
公开(公告)号：US5731341A
公开(公告)日：1998-03-24
申请号：US705697
申请日：1996-08-30
申请人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gogelein , Joachim Kaiser , Uwe Gerlach
发明人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gogelein , Joachim Kaiser , Uwe Gerlach
IPC分类号： C07D207/38 , C07D521/00 , A61K31/40 , C07D209/46
CPC分类号： C07D521/00 , C07D207/38
摘要： Described herein are substituted benzenesulfonylureas and -thioureas of the formula (I): ##STR1## useful in treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrythmia. The compounds of formula (I) can be used as antiarrythmics and are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.
摘要翻译： 本文描述了可用于治疗心律紊乱和预防由心律失常引起的心脏猝死的突发性的式（I）的取代苯磺酰脲和硫脲。 式（I）化合物可用作抗焦虑症，并且特别适用于心律失常是冠状血管狭窄（如心绞痛或急性心肌梗塞）的结果的那些情况。
-
7.发明授权Substituted benzenesulfonylureas and-thioureas, processes for their preparation, their use as a medicament or diagnostic, and medicament containing them 失效取代的苯磺酰脲和硫脲，其制备方法，它们作为药物或诊断剂的用途，以及含有它们的药物
公开(公告)号：US5652268A
公开(公告)日：1997-07-29
申请号：US602053
申请日：1996-02-15
申请人： Heinrich Englert , Uwe Gerlach , Dieter Mania , Heinz Gogelein , Joachim Kaiser
发明人： Heinrich Englert , Uwe Gerlach , Dieter Mania , Heinz Gogelein , Joachim Kaiser
IPC分类号： A61K31/18 , A61K31/64 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , C07C233/00 , C07C303/40 , C07C311/58 , C07C311/59 , C07C327/40 , C07C335/42 , A61K31/17 , C07C273/00 , C07C275/00
CPC分类号： C07C311/58 , C07C335/42 , Y10S514/821
摘要： This invention relates to substituted benzenesulfonylureas and -thioureas, processes for their preparation, their use as a medicament or diagnostic, and medicament containing them.Substituted benzenesulfonylureas and -thioureas 1 ##STR1## exhibit effects on the cardiovascular system.
摘要翻译： 本发明涉及取代的苯磺酰脲和硫脲，其制备方法，它们作为药物或诊断剂的用途，以及含有它们的药物。 取代的苯磺酰脲和硫脲1表现出对心血管系统的作用。
-
8.发明授权
公开(公告)号：US5880155A
公开(公告)日：1999-03-09
申请号：US602018
申请日：1996-02-15
申请人： Heinrich Englert , Uwe Gerlach , Dieter Mania , Heinz Gogelein , Joachim Kaiser
发明人： Heinrich Englert , Uwe Gerlach , Dieter Mania , Heinz Gogelein , Joachim Kaiser
IPC分类号： A61K31/18 , A61K31/64 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , C07C233/00 , C07C303/36 , C07C303/40 , C07C311/57 , C07C311/58 , C07C311/59 , C07C327/40 , C07C335/00 , C07C335/42 , A61K31/17 , C07C311/16
CPC分类号： C07C335/42 , C07C311/58 , C07C2101/02 , C07C2101/14 , Y10S514/821
摘要： This invention relates to substituted benzenesulfonylureas and -thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them.Substituted benzenesulfonylureas and -thioureas of the formula I ##STR1## exhibit effects on the cardiovascular system.
摘要翻译： 本发明涉及取代的苯磺酰脲和硫脲，其制备和使用基于这些化合物的药物制剂及其含有药物的方法。 式I的取代苯磺酰脲和硫脲显示出对心血管系统的作用。
-
9.发明授权公开(公告)号：US06335467B1
公开(公告)日：2002-01-01
申请号：US09490078
申请日：2000-01-24
申请人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gögelein , Joachim Kaiser , Wolfgang Linz , David Wettlauper
发明人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gögelein , Joachim Kaiser , Wolfgang Linz , David Wettlauper
IPC分类号： C07C31116
CPC分类号： C07C311/46 , C07C311/58 , C07C335/42 , Y10S514/821
摘要： Benzenesulfonylureas and -thioureas of the formula I where R(1) in N or (fluoro)methyl, R(2) is H, Hal or (fluoro)(mercapto)alk(oxy)yl, E is O or S, Y is —[CR(3)2]n—, where R(3)=H or alkyl and n=1-4, X is H, Hal or alkyl and Z is Hal, NO2 or alk(yl)oxy, are described. The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used as antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.
摘要翻译： 苯基磺酰脲和硫脲，其中R（1）在N或（氟）甲基中，R（2）是H，Hal或（氟）（巯基）烷（氧）），E是O或S，Y是 - [CR（3）2] n-，其中R（3）= H或烷基，n = 1-4，X为H，Hal或烷基，Z为Hal，NO 2或烷基（yl） 化合物I用于治疗心律紊乱和预防心律失常引起的心源性猝死，因此可用作抗心律失常药物。 它们特别适用于心律失常是冠状血管狭窄（如心绞痛或急性心肌梗死）的结果的情况。
-
10.发明授权
公开(公告)号：US5698596A
公开(公告)日：1997-12-16
申请号：US707103
申请日：1996-09-03
申请人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gogelein , Joachim Kaiser , Wolfgang Linz , David Wettlaufer
发明人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gogelein , Joachim Kaiser , Wolfgang Linz , David Wettlaufer
IPC分类号： A61K31/18 , A61K31/64 , A61P9/00 , A61P9/04 , A61P9/10 , C07C303/40 , C07C311/46 , C07C311/58 , C07C323/67 , C07C335/42 , A61K31/17
CPC分类号： C07C311/46 , C07C311/58 , C07C335/42 , Y10S514/821
摘要： Substituted benzenesulfonylureas and -thioureas--processes for their preparation and their use as pharmaceuticals Benzenesulfonylureas and -thioureas of the formula I ##STR1## where R(1) is H or (fluoro)methyl, R(2) is H, Hal or (fluoro)(mercapto)alk(oxy)yl, E is O or S; Y is --�CR(3).sub.2 !.sub.n --, where R(3)=H or alkyl and n=1-4, X is H, Hal or alkyl and Z is Hal, NO.sub.2 or alk(yl)oxy, are described. The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used as antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.
摘要翻译： 取代的苯磺酰脲和硫脲 - 其制备方法及其作为药物的用途式I的苯磺酰脲和硫脲其中R（1）为H或（氟）甲基，R（2）为H，Hal或（ 氟）（巯基）烷（氧）基，E是O或S; Y是 - [CR（3）2] n - ，其中R（3）= H或烷基，n = 1-4，X是H，Hal或烷基，Z是Hal，NO 2或烷基（yl） 描述。 化合物I用于治疗心律紊乱和预防心律失常引起的心源性猝死，因此可用作抗心律失常药物。 它们特别适用于心律失常是冠状血管狭窄（如心绞痛或急性心肌梗死）的结果的情况。
-
-
-
-
-
-
-
-
-
搜索结果
36 条记录 (耗时 0.028 秒)
