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8 条记录 (耗时 0.03 秒)

    Cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives, processes for their preparation, their use, and pharmaceutical preparations comprising them
    3.
    发明授权
    Cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives, processes for their preparation, their use, and pharmaceutical preparations comprising them 有权
    肉桂酰氨基烷基取代的苯磺酰胺衍生物，其制备方法，用途及包含它们的药物制剂

    公开(公告)号：US06350778B1

    公开(公告)日：2002-02-26

    申请号：US09573166

    申请日：2000-05-19

    申请人： Holger Heitsch ,  Heinrich Christian Englert ,  Klaus Wirth ,  Heinz Gögelein

    发明人： Holger Heitsch ,  Heinrich Christian Englert ,  Klaus Wirth ,  Heinz Gögelein

    IPC分类号： A61K3134

    CPC分类号： A61K31/18 ,  C07C311/53 ,  C07C311/58 ,  C07C335/42 ,  C07D307/52

    摘要： The present invention relates to cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives of formula I in which A(1), A(2), A(3), R(1), R(2), R(3), R(4), X, Y, and Z have the meanings indicated in the claims. Compounds of formula I are valuable pharmaceutical active compounds which exhibit, for example, an inhibitory action on ATP-sensitive potassium channels in the cardiac muscle and/or in the cardiac nerve and are suitable, for example, for the treatment of disorders of the cardiovascular system such as coronary heart disease, arrhythmias, cardiac insufficiency or cardiomyopathies, or for the prevention of sudden cardiac death, or for improving decreased contractility of the heart. The invention furthermore relates to processes for the preparation of compounds of formula I, their use, and pharmaceutical preparations comprising them.

    摘要翻译： 本发明涉及式Iin的肉桂酰氨基烷基取代的苯磺酰胺衍生物，其中A（1），A（2），A（3），R（1），R（2），R（3），R（4） ，Y和Z具有权利要求中所示的含义。 式I化合物是有价值的药物活性化合物，其表现出例如对心肌和/或心脏神经中对ATP敏感的钾通道的抑制作用，并且适用于例如治疗心血管疾病 冠状动脉心脏病，心律失常，心功能不全或心肌病等系统，或用于预防心源性猝死或改善心脏收缩力的减轻。 本发明还涉及制备式I化合物，其用途和包含它们的药物制剂的方法。

    Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them
    8.
    发明授权
    Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them 有权
    磺酰胺取代的苯并二氢吡喃染料，其制备方法，它们作为药物或诊断剂的用途，以及包含它们的药物

    公开(公告)号：US06191164B1

    公开(公告)日：2001-02-20

    申请号：US09258289

    申请日：1999-02-26

    申请人： Hans Jochen Lang ,  Uwe Gerlach ,  Joachim Brendel ,  Henrich Christian Englert ,  Heinz Gögelein ,  Max Hropot ,  Helmut Bohn ,  Andreas Herling ,  Andreas Busch ,  Rainer Greger

    发明人： Hans Jochen Lang ,  Uwe Gerlach ,  Joachim Brendel ,  Henrich Christian Englert ,  Heinz Gögelein ,  Max Hropot ,  Helmut Bohn ,  Andreas Herling ,  Andreas Busch ,  Rainer Greger

    IPC分类号： A01N4316

    CPC分类号： A61K31/353

    摘要： Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or a diagnostic, and medicament comprising them Chromans of the formula I and of the formula 1a having the meanings R(A), R(B), R(C) and R(1) to R(8) indicated in the claims are outstandingly suitable for preparing a medicament for blocking the K+ channel which is opened by cyclic adenosine monophosphate (cAMP); and further for preparing a medicament for inhibiting gastric acid secretion; for the treatment of ulcers of the stomach and of the intestinal region, in particular of the duodenum, for the treatment of reflux esophagitis, for the treatment of diarrheal illnesses, for the treatment and prevention of all types of arrhythmias including ventricular and supraventricular arrhythmias, and for the control of reentry arrhythmias and for the prevention of sudden heart death as a result of ventricular fibrillation.

    摘要翻译： 磺酰胺取代的苯并二氢吡喃染色剂，其制备方法，它们作为药物或诊断剂的用途，以及包含它们的药物式I和式1的色素具有R（A），R（B），R（C）和R 1）至权利要求所述的R（8）非常适用于制备用于封闭由环磷酸腺苷（cAMP）打开的K +通道的药物; 并进一步制备用于抑制胃酸分泌的药物; 用于治疗胃和肠道区域，特别是十二指肠的溃疡，用于治疗反流性食管炎，用于治疗腹泻疾病，用于治疗和预防所有类型的心律失常，包括室性和室上性心律失常， 并且用于控制再入心律失常和由于心室颤动而预防心脏死亡。