Anti-Aβ globulomer 5F7 antibodies
    2.
    发明授权
    Anti-Aβ globulomer 5F7 antibodies 有权
    反A&BGR 球聚体5F7抗体

    公开(公告)号:US08691224B2

    公开(公告)日:2014-04-08

    申请号:US11574876

    申请日:2006-11-30

    IPC分类号: A61K39/00 A61K39/395

    摘要: Anti-Aβ globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies.The present invention relates to anti-Aβ globulomer antibodies having a binding affinity to Aβ(20-42) globulomer that is greater than the binding affinity of the antibody to Aβ(1-42) globulomer, antigen-binding moieties thereof, hybridomas producing said antibodies, nucleic acids encoding said antibodies, vectors comprising said nucleic acids, host cells comprising said vectors, methods of producing said antibodies, compositions comprising said antibodies, therapeutic and diagnostic uses of said antibodies and corresponding methods relating to Alzheimer's disease and other amyloidoses.

    摘要翻译: 反A&BGR 球聚体抗体,其抗原结合部分,相应的杂交瘤,核酸,载体,宿主细胞,产生所述抗体的方法,包含所述抗体的组合物,所述抗体的用途和使用所述抗体的方法。 本发明涉及抗A&Bgr; 具有与A&Bgr(20-42)球聚体的结合亲和力的球聚体抗体,其大于抗体对Aβ和(1-42)球聚体,其抗原结合部分的结合亲和力,产生所述抗体的杂交瘤,编码所述抗体的核酸 包含所述核酸的载体,包含所述载体的宿主细胞,产生所述抗体的方法,包含所述抗体的组合物,所述抗体的治疗和诊断用途以及与阿尔茨海默病和其它淀粉样变性有关的相应方法。