-
1.发明授权Derivatives of 3-guanidinocarbonyl-1-heteroaryl-pyrrole, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them 失效3-胍基羰基-1-杂芳基吡咯的衍生物，该方法的制备方法和中间体，它们作为药物的用途，以及包含它们的药物组合物公开(公告)号：US07078414B2
公开(公告)日：2006-07-18
申请号：US10745909
申请日：2003-12-23
申请人： Heinz-Werner Kleemann , Pascal Desmazeau , Jean-Christophe Carry , Baptiste Ronan , Serge Mignani , Jean Bououerel , Arielle Genevois-Borella
发明人： Heinz-Werner Kleemann , Pascal Desmazeau , Jean-Christophe Carry , Baptiste Ronan , Serge Mignani , Jean Bououerel , Arielle Genevois-Borella
IPC分类号： A61K31/47 , A61K31/40 , C07D215/02 , C07D301/27
CPC分类号： C07D401/04 , C07D403/04
摘要： The present invention relates to 3-guanidinocarbonyl-1-heteroaryl-pyrrole derivatives of formula (I) wherein R1 to R3 and Ar are as defined herein, pharmaceutical compositions comprising such derivatives, methods of treatment comprising administering such derivatives, and processes for their preparation
摘要翻译： 本发明涉及式（I）的3-胍基羰基-1-杂芳基吡咯衍生物，其中R 1至R 3和Ar如本文所定义，药物组合物包含 这样的衍生物，治疗方法，包括施用此类衍生物，及其制备方法
-
公开(公告)号：US07531663B2
公开(公告)日：2009-05-12
申请号：US10749630
申请日：2003-12-31
申请人： Heinz-Werner Kleemann , Jean-Christophe Carry , Pascal Desmazeau , Serge Mignani , Jean Bouquerel , Arielle Genevois-Borella , Baptiste Ronan
发明人： Heinz-Werner Kleemann , Jean-Christophe Carry , Pascal Desmazeau , Serge Mignani , Jean Bouquerel , Arielle Genevois-Borella , Baptiste Ronan
IPC分类号： C07D215/38
CPC分类号： C07D401/04 , C07D403/04
摘要： The present invention relates to 3-guanidinocarbonyl-1-heteroaryl-indole derivatives, pharmaceutical compositions comprising such derivatives, methods of treatment comprising administering such derivatives, and processes for their preparation.
-
3.发明申请3-Guanidinocarbonyl-1-heteroaryl-indole derivatives, preparation process, their use as medicaments, and pharmaceutical compositions comprising them 失效3-胍基羰基-1-杂芳基 - 吲哚衍生物，制备方法，它们作为药物的用途以及包含它们的药物组合物公开(公告)号：US20050026989A1
公开(公告)日：2005-02-03
申请号：US10749630
申请日：2003-12-31
申请人： Heinz-Werner Kleemann , Jean-Christophe Carry , Pascal Desmazeau , Serge Mignani , Jean Bouquerel , Arielle Genevois-Borella , Baptiste Ronan
发明人： Heinz-Werner Kleemann , Jean-Christophe Carry , Pascal Desmazeau , Serge Mignani , Jean Bouquerel , Arielle Genevois-Borella , Baptiste Ronan
IPC分类号： A61P3/00 , A61P9/00 , A61P35/00 , A61P37/06 , C07D401/04 , C07D403/04 , A61K31/405 , C07D209/42 , C07
CPC分类号： C07D401/04 , C07D403/04
摘要： The present invention relates to 3-guanidinocarbonyl-1-heteroaryl-indole derivatives, pharmaceutical compositions comprising such derivatives, methods of treatment comprising administering such derivatives, and processes for their preparation.
摘要翻译： 本发明涉及3-胍基羰基-1-杂芳基 - 吲哚衍生物，包含这些衍生物的药物组合物，包括施用此类衍生物的治疗方法及其制备方法。
-
4.发明授权3-guanidinocarbonyl-1-heteroaryl-indole derivatives, preparation process, their use as medicaments, and pharmaceutical compositions comprising them 失效3-胍基羰基-1-杂芳基 - 吲哚衍生物，制备方法，它们作为药物的用途，以及包含它们的药物组合物公开(公告)号：US07638521B2
公开(公告)日：2009-12-29
申请号：US10749631
申请日：2003-12-31
申请人： Heinz-Werner Kleemann , Jean-Christophe Carry , Pascal Desmazeau , Serge Mignani , Jean Bouquerel , Arielle Genevois-Borella , Baptiste Ronan
发明人： Heinz-Werner Kleemann , Jean-Christophe Carry , Pascal Desmazeau , Serge Mignani , Jean Bouquerel , Arielle Genevois-Borella , Baptiste Ronan
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D401/04 , C07D403/04 , C07D487/04
摘要： The present invention relates to 3-guanidinocarbonyl-1-heteroaryl-indole derivatives, pharmaceutical compositions comprising such derivatives, methods of treatment comprising administering such derivatives, and processes for their preparation.
摘要翻译： 本发明涉及3-胍基羰基-1-杂芳基 - 吲哚衍生物，包含这些衍生物的药物组合物，包括施用此类衍生物的治疗方法及其制备方法。
-
5.发明授权Derivatives of 3-(Guanidinocarbonyl) heterocycle, methods of preparation and intermediates thereof, their use as medicaments, and pharmaceutical compositions therefrom 失效3-（胍基羰基）杂环的衍生物，其制备方法及其中间体，其作为药物的用途及其药物组合物公开(公告)号：US07230007B2
公开(公告)日：2007-06-12
申请号：US10865454
申请日：2004-06-10
申请人： Jean-Christophe Carry , Gilles Doerflinger , Arielle Genevois-Borella , Michel Evers , Alain Le Brun , Jean-Paul Martin , Pascal Desmazeau , Serge Mignani , Heinz-Werner Kleemann
发明人： Jean-Christophe Carry , Gilles Doerflinger , Arielle Genevois-Borella , Michel Evers , Alain Le Brun , Jean-Paul Martin , Pascal Desmazeau , Serge Mignani , Heinz-Werner Kleemann
IPC分类号： A61K31/44 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention discloses and claims compounds of formula I and their pharmaceutically acceptable salts, and methods of using said compounds of formula I, either alone or in combination with other medicaments, as antiarrhythmic medicaments with a cardioprotective component for prophylaxis or treatment of infarction, for the treatment of angina pectoris, and as inhibitors of pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure. Pharmaceutical compositions comprising compounds of formula I or compounds of formula I in combination with one or more other medicaments and processes for the preparation of compounds of formula I are also disclosed and claimed.
摘要翻译： 本发明公开并要求式I化合物及其药学上可接受的盐，以及使用所述式I化合物单独或与其它药物组合的抗心律失常药物与预防或治疗梗死的心脏保护组分的方法，用于 心绞痛的治疗以及与局部缺血诱导的损伤发展相关的病理生理过程的抑制剂，特别是引发缺血诱导的心律失常和心力衰竭。 包含式I化合物或式I化合物与一种或多种其它药物组合的药物组合物和式I化合物的制备方法也被公开并要求保护。
-
6.发明申请Derivatives of 3-(guanidinocarbonyl) heterocycle, methods of preparation and intermediates thereof, their use as medicaments, and pharmaceutical compositions therefrom 失效3-（胍基羰基）杂环的衍生物，其制备方法及其中间体，它们作为药物的用途及其药物组合物公开(公告)号：US20050014758A1
公开(公告)日：2005-01-20
申请号：US10865454
申请日：2004-06-10
申请人： Jean-Christophe Carry , Gilles Doerflinger , Arielle Genevois-Borella , Michel Evers , Alain Le Brun , Jean-Paul Martin , Pascal Desmazeau , Serge Mignani , Heinz-Werner Kleemann
发明人： Jean-Christophe Carry , Gilles Doerflinger , Arielle Genevois-Borella , Michel Evers , Alain Le Brun , Jean-Paul Martin , Pascal Desmazeau , Serge Mignani , Heinz-Werner Kleemann
IPC分类号： C07D471/04 , C07D471/02 , A61K31/4745 , A61K31/503 , A61K31/519 , C07D487/02
CPC分类号： C07D471/04
摘要： The present invention discloses and claims compounds of formula I and their pharmaceutically acceptable salts, and methods of using said compounds of formula I, either alone or in combination with other medicaments, as antiarrhythmic medicaments with a cardioprotective component for prophylaxis or treatment of infarction, for the treatment of angina pectoris, and as inhibitors of pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure. Pharmaceutical compositions comprising compounds of formula I or compounds of formula I in combination with one or more other medicaments and processes for the preparation of compounds of formula I are also disclosed and claimed.
摘要翻译： 本发明公开并要求式I化合物及其药学上可接受的盐，以及使用所述式I化合物单独或与其它药物组合的抗心律失常药物与预防或治疗梗死的心脏保护组分的方法，用于 心绞痛的治疗以及与局部缺血诱导的损伤发展相关的病理生理过程的抑制剂，特别是引发缺血诱导的心律失常和心力衰竭。 包含式I化合物或式I化合物与一种或多种其它药物组合的药物组合物和式I化合物的制备方法也被公开并要求保护。
-
公开(公告)号：US07078428B2
公开(公告)日：2006-07-18
申请号：US10445618
申请日：2003-05-27
申请人： Heinz-Werner Kleemann , Armin Hofmeister , Jean-Christophe Carry , Baptiste Ronan , Serge Mignani , Antony Bigot
发明人： Heinz-Werner Kleemann , Armin Hofmeister , Jean-Christophe Carry , Baptiste Ronan , Serge Mignani , Antony Bigot
IPC分类号： A61K31/4035 , C07D209/44
CPC分类号： C07D209/46
摘要： The present invention relates to the novel isoindolone derivatives of the formula I in which R1 to R6 have the meanings stated in the claims. The inventive compounds are suitable as antiarrhythmic medicaments with a cardioprotective component for infarction prophylaxis and infarction treatment and for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure.
-
8.发明授权Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them 有权异吲哚酮衍生物，该方法的制备方法和中间体，它们作为药物的用途，以及包含它们的药物组合物公开(公告)号：US07589117B2
公开(公告)日：2009-09-15
申请号：US11365319
申请日：2006-03-01
申请人： Heinz-Werner Kleemann , Armin Hofmeister , Jean-Christophe Carry , Baptiste Ronan , Serge Mignani , Antony Bigot
发明人： Heinz-Werner Kleemann , Armin Hofmeister , Jean-Christophe Carry , Baptiste Ronan , Serge Mignani , Antony Bigot
IPC分类号： A61K31/40
CPC分类号： C07D209/46
摘要： The present invention relates to the novel isoindolone derivatives of the formula I in which R1 to R6 have the meanings stated in the claims. The inventive compounds are suitable as antiarrhythmic medicaments with a cardioprotective component for infarction prophylaxis and infarction treatment and for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure.
摘要翻译： 本发明涉及式I的新型异吲哚酮衍生物，其中R 1至R 6具有权利要求中所述的含义。 本发明化合物适合作为具有用于梗塞预防和梗塞治疗的心脏保护组分和用于治疗心绞痛的抗心律失常药物。 它们还以预防的方式抑制与缺血诱导的损伤的发展相关的病理生理过程，特别是在引发缺血诱导的心律失常和心力衰竭中。
-
公开(公告)号：US20060148880A1
公开(公告)日：2006-07-06
申请号：US11365319
申请日：2006-03-01
申请人： Heinz-Werner Kleemann , Armin Hofmeister , Jean-Christophe Carry , Baptiste Ronan , Serge Mignani , Antony Bigot
发明人： Heinz-Werner Kleemann , Armin Hofmeister , Jean-Christophe Carry , Baptiste Ronan , Serge Mignani , Antony Bigot
IPC分类号： A61K31/4035 , C07D403/02 , C07D209/46
CPC分类号： C07D209/46
摘要： The present invention relates to the novel isoindolone derivatives of the formula I in which R1 to R6 have the meanings stated in the claims. The inventive compounds are suitable as antiarrhythmic medicaments with a cardioprotective component for infarction prophylaxis and infarction treatment and for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure.
-
10.发明授权Use of 2-amino-4-pyridylmethyl-thiazoline derivatives as inhibitors of inducible no-synthase 失效使用2-氨基-4-吡啶基甲基 - 噻唑啉衍生物作为诱导型无合成酶的抑制剂公开(公告)号：US06762196B2
公开(公告)日：2004-07-13
申请号：US10290624
申请日：2002-11-08
申请人： Eric Bacque , Antony Bigot , Jean-Christophe Carry , Serge Mignani , Baptiste Ronan , Michel Tabart
发明人： Eric Bacque , Antony Bigot , Jean-Christophe Carry , Serge Mignani , Baptiste Ronan , Michel Tabart
IPC分类号： A61K314436
CPC分类号： C07D213/40 , C07D213/55 , C07D213/64 , C07D213/89 , C07D417/06 , C07F7/1804
摘要： The present invention relates to the use of 2-amino-4-pyridylmethyl thiazoline derivatives of formula (I) wherein either R1═R2═Cl or (C1-C4)alkyl, or hydroxy; or (C1-C4)alkoxy or at least one of R1 or R2 is a hydrogen and the other is a (C1-C4)alkyl, hydroxy, (C1-C4)alkoxy or chlorine or pharmaceutically acceptable salts thereof as inhibitors of inducible NO-synthase.
摘要翻译： 本发明涉及式（I）的2-氨基-4-吡啶基甲基噻唑啉衍生物，其中R 1 = R 2 = Cl或（C 1 -C 4）烷基或羟基; 或（C1-C4）烷氧基，或R1或R2中的至少一个为氢，另一个为（C 1 -C 4）烷基，羟基，（C 1 -C 4）烷氧基或氯或其药学上可接受的盐作为诱导型NO -Synthase。
-
-
-
-
-
-
-
-
-
搜索结果
82 条记录 (耗时 0.041 秒)
