摘要:
11-Methylene-.DELTA..sup.15 -steroids of Formula I ##STR1## wherein R.sup.1 is hydrogen or acyl andR.sup.2 is ethynyl, chloroethynyl or propynyl,are distinguished by a strong progestational activity and exhibit only a very low androgenic side effect.
摘要:
11-Methylene steroids of Formula I ##STR1## wherein R is hydrogen or acyl, andX is oxygen or two hydrogen atomshave valuable pharmacological properties.
摘要:
.DELTA..sup.15 -Steroids of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, trialkylsilyl or acyl; R.sub.2 is ethynyl, chloroethynyl or propinyl; and X is an oxygen atom, ##STR2## or NOR.sub.4 wherein R.sub.3 is a hydrogen atom or acyl and R.sub.4 is a hydrogen atom, acyl, alkyl or tetrahydropyranyl, possess progestational and ovulation and nidation inhibiting activities.
摘要:
11.beta.-Fluoropregnenes of the formula ##STR1## wherein 6 7 IS A SINGLE OR DOUBLE BOND,R.sub.1 and R.sub.2 each are H or collectively CH.sub.2 or a single bond;R.sub.3 is H or, when 6 7 is a double bond, H, F or Cl,X or O or HOR.sub.4 andR.sub.4 is H or acyl, strong progestational activity and only weak antiandrogenic activity.
摘要:
11.beta.-Fluoroandrostenes of the formula ##SPC1##Wherein R.sub.1 and R.sub.2 are hydrogen atoms, methylene or another C--C bond; R.sub.3 is H or Cl, R.sub.4 is H, F or Cl; and X is carbonyl, .beta.-hydroxymethylene, or an ester or ether thereof or .alpha.-alkyl-.beta.-hydroxymethylene or an ester thereof, possess androgenic activity and can be prepared by the dehalogenation of a corresponding 9.alpha.-halo-11.beta.-F steroid.
摘要:
6.alpha.-methylhydrocortisones of Formula I ##STR1## wherein R.sub.1 is alkanoyl of 2-6 carbon atoms or benzoyl andR.sub.2 is hydrogen or alkanoyl of 2-6 carbon atomshave valuable antiinflammatory properties.
摘要:
6.alpha.-Methylprednisolone derivatives of Formula I ##STR1## wherein R.sub.1 is 1-oxoalkyl of 2-6 carbon atoms or benzoyl andR.sub.2 is 1-oxoalkyl of 2-6 carbon atoms, are pharmacologically efficacious compounds, e.g., as antiinflammatories.
摘要:
11.beta.-Chloro-.DELTA..sup.15 -steroids of Formula I ##STR1## wherein R.sup.1 is hydrogen or acyl andR.sup.2 is ethynyl, chloroethynyl, or propynyl have strong progestational activity.
摘要:
Novel corticoid 17-thioacetals of the formula: ##STR1## wherein X is hydrogen, fluorine or methyl,R.sub.1 is hydrogen or C.sub.1 -C.sub.6 alkyl, andR.sub.2 is hydrogen or the acyl group of a C.sub.1-16 - hydrocarbon carboxylic acid,have valuable medicinal properties, e.g., as antiinflammatories.
摘要:
1.alpha.,2.alpha.-methylene-6-methylene- and 6.alpha.-methylpregnenes of Formula I ##STR1## wherein A is ##STR2## and R is a hydrogen atom, an acyl group, or an alkoxymethyl groupare strong antiandrogens, and suitable for the topical treatment of seborrhea, acne, alopecia, and hirsutism.