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公开(公告)号：US09034608B2
公开(公告)日：2015-05-19
申请号：US13822288
申请日：2011-10-11
申请人： Hendrik Wouter Wisselink , Antonius Jeroen Adriaan Van Maris , Jacobus Thomas Pronk , Paul Klaassen , Rene Marcel De Jong
发明人： Hendrik Wouter Wisselink , Antonius Jeroen Adriaan Van Maris , Jacobus Thomas Pronk , Paul Klaassen , Rene Marcel De Jong
IPC分类号： C12P19/18 , C12P7/56 , C12P7/16 , C12P7/06 , C12P7/14 , C12N9/12 , C12N1/00 , C12P21/06 , C12P19/34 , C12N15/00 , C07H21/04 , C07K1/00 , C12N15/81 , C07K14/395 , C12P7/10
CPC分类号： C12N15/81 , C07K14/395 , C12N9/1205 , C12P7/06 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要： The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO: 55, and wherein the polypeptide has permease activity.
摘要翻译： 本发明涉及在一个或多个对应于SEQ ID NO：55的T219的位置具有突变的多肽，其中多肽与SEQ ID NO：55具有至少50％的序列同一性，并且其中多肽具有通透酶活性。
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公开(公告)号：US20130236932A1
公开(公告)日：2013-09-12
申请号：US13822288
申请日：2011-10-11
申请人： Hendrik Wouter Wisselink , Antonius Jeroen Adriaan Van Maris , Jacobus Thomas Pronk , Paul Klaassen , Rene Marcel De Jong
发明人： Hendrik Wouter Wisselink , Antonius Jeroen Adriaan Van Maris , Jacobus Thomas Pronk , Paul Klaassen , Rene Marcel De Jong
IPC分类号： C12N9/12
CPC分类号： C12N15/81 , C07K14/395 , C12N9/1205 , C12P7/06 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要： The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO: 55, and wherein the polypeptide has permease activity.
摘要翻译： 本发明涉及在一个或多个对应于SEQ ID NO：55的T219的位置具有突变的多肽，其中多肽与SEQ ID NO：55具有至少50％的序列同一性，并且其中多肽具有通透酶活性。
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公开(公告)号：US09353376B2
公开(公告)日：2016-05-31
申请号：US13822285
申请日：2011-10-11
CPC分类号： C12N15/81 , C07K14/395 , C12N9/1205 , C12P7/06 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to a yeast cell comprising one or more exogenous genes of a pentose metabolic pathway non-native to the yeast cell wherein the yeast cell has a disruption of the hxk1, hxk2 glk1 and gal1 native in the yeast cell. The invention further relates to pentose and glucose fermenting yeast cell that is capable of simultaneous pentose and glucose consumption.
摘要翻译： 本发明涉及酵母细胞，其包含一个或多个酵母细胞非天然戊糖代谢途径的外源基因，其中酵母细胞在酵母细胞中具有hxk1，hxk2 glk1和gal1天然的破坏。 本发明还涉及能够同时戊糖和葡萄糖消耗的戊糖和葡萄糖发酵酵母细胞。
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公开(公告)号：US20100086965A1
公开(公告)日：2010-04-08
申请号：US12442013
申请日：2007-10-01
申请人： Antonius Jeroen Adriaan Van Maris , Jacobus Thomas Pronk , Hendrik Wouter Wisselink , Johannes Pieter Van Dijken , Aaron Adriaan Winkler , Johannes Hendrik De Winde
发明人： Antonius Jeroen Adriaan Van Maris , Jacobus Thomas Pronk , Hendrik Wouter Wisselink , Johannes Pieter Van Dijken , Aaron Adriaan Winkler , Johannes Hendrik De Winde
IPC分类号： C12P35/00 , C12N1/19 , C12N15/74 , C12P7/40 , C12P7/54 , C12P7/52 , C12P7/48 , C12P7/46 , C12P7/06 , C12P7/04 , C12P7/16 , C12P13/04 , C12P5/02 , C12P19/44
CPC分类号： C12N9/90 , C12N9/1205 , C12P7/08 , Y02E50/17 , Y02E50/343
摘要： The invention relates to an eukaryotic cell expressing nucleotide sequences encoding the ara A, ara B and ara D enzymes whereby the expression of these nucleotide sequences confers on the cell the ability to use L-arabinose and/or convert L-arabinose into L-ribulose, and/or xylulose 5-phosphate and/or into a desired fermentation product such as ethanol. Optionally, the eukaryotic cell is also able to convert xylose into ethanol.
摘要翻译： 本发明涉及表达编码ara A，ara B和ara D酶的核苷酸序列的真核细胞，由此这些核苷酸序列的表达赋予细胞使用L-阿拉伯糖和/或将L-阿拉伯糖转化成L-核酮糖的能力 ，和/或木酮糖5-磷酸酯和/或转化成所需的发酵产物如乙醇。 任选地，真核细胞还能够将木糖转化为乙醇。
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公开(公告)号：US09303253B2
公开(公告)日：2016-04-05
申请号：US13345146
申请日：2012-01-06
申请人： Antonius Jeroen Adriaan Van Maris , Jacobus Thomas Pronk , Hendrik Wouter Wisselink , Johannes Pieter Van Dijken , Aaron Adriaan Winkler , Johannes Hendrik Winde
发明人： Antonius Jeroen Adriaan Van Maris , Jacobus Thomas Pronk , Hendrik Wouter Wisselink , Johannes Pieter Van Dijken , Aaron Adriaan Winkler , Johannes Hendrik Winde
IPC分类号： C12P35/00 , C12P7/40 , C12P7/06 , C12N9/00 , C12N1/20 , C12N15/00 , C07H21/04 , C12N9/90 , C12N9/12 , C12P7/08
CPC分类号： C12N9/90 , C12N9/1205 , C12P7/08 , Y02E50/17 , Y02E50/343
摘要： The invention relates to an eukaryotic cell expressing nucleotide sequences encoding the ara A, ara B and ara D enzymes whereby the expression of these nucleotide sequences confers on the cell the ability to use L-arabinose and/or convert L-arabinose into L-ribulose, and/or xylulose 5-phosphate and/or into a desired fermentation product such as ethanol. Optionally, the eukaryotic cell is also able to convert xylose into ethanol.
摘要翻译： 本发明涉及表达编码ara A，ara B和ara D酶的核苷酸序列的真核细胞，由此这些核苷酸序列的表达赋予细胞使用L-阿拉伯糖和/或将L-阿拉伯糖转化成L-核酮糖的能力 ，和/或木酮糖5-磷酸酯和/或转化成所需的发酵产物如乙醇。 任选地，真核细胞还能够将木糖转化为乙醇。
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公开(公告)号：US20130273601A1
公开(公告)日：2013-10-17
申请号：US13822285
申请日：2011-10-11
CPC分类号： C12N15/81 , C07K14/395 , C12N9/1205 , C12P7/06 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to a yeast cell comprising one or more exogenous genes of a pentose metabolic pathway non-native to the yeast cell wherein the yeast cell has a disruption of the hxk1, hxk2 glk1 and gal1 native in the yeast cell. The invention further relates to pentose and glucose fermenting yeast cell that is capable of simultaneous pentose and glucose consumption.
摘要翻译： 本发明涉及酵母细胞，其包含一个或多个酵母细胞非天然戊糖代谢途径的外源基因，其中酵母细胞在酵母细胞中具有hxk1，hxk2 glk1和gal1天然的破坏。 本发明还涉及能够同时戊糖和葡萄糖消耗的戊糖和葡萄糖发酵酵母细胞。
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公开(公告)号：US20110104736A1
公开(公告)日：2011-05-05
申请号：US12921937
申请日：2009-03-10
IPC分类号： C12Q1/02 , C12N1/14 , C12N1/16 , C12P1/02 , C12P7/06 , C12P7/16 , C12P7/56 , C12P7/42 , C12P7/40 , C12P7/54 , C12P7/46 , C12P7/48 , C12P13/00 , C12P7/18 , C12P5/02 , C12P7/20 , C12P35/00 , C12P37/00
摘要： The present invention relates to a method for selecting a strain of an organism capable of improved consumption of a mixed substrate comprising two or more carbon sources as compared to a reference strain of the organism, which method comprises: growing a population of the reference strain of the organism in the presence of the two or more carbon sources, wherein the number of generations of growth of the said population on each of the said carbon sources is at least about 50% of the number of generations of growth on the carbon source most preferred by the organism; and selecting the resulting strain of the organism, thereby to select a strain of the organism capable of improved consumption of a mixed substrate comprising the two or more carbon sources as compared to the reference strain of the organism. The invention also relates to strains of organisms selected using such a method. Strains of organisms identified using the selection method may be used in fermentation processes in which a mixed substrate is used.
摘要翻译： 本发明涉及一种与生物体的参考菌株相比，选择能够提高包含两种或多种碳源的混合底物消耗的生物体的菌株的方法，所述方法包括：将所述参考菌株 在两种或多种碳源的存在下的生物体，其中所述碳源的每一个上的所述群体的生长代数为碳源上生长代数的至少约50％ 由有机体; 并选择生物体的所得菌株，从而与生物体的参考菌株相比，选择能够改善包含两个或更多个碳源的混合基质的消耗的生物体的菌株。 本发明还涉及使用这种方法选择的生物菌株。 使用选择方法鉴定的生物菌株可用于其中使用混合基质的发酵过程中。
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8.发明授权公开(公告)号：US07229631B2
公开(公告)日：2007-06-12
申请号：US10672040
申请日：2003-09-26
申请人： Joseph Hubertus Olijve , Jan Bastiaan Bouwstra , Frederik Anton Wolf De , Marc Willem Theodoor Werten , Hendrik Wouter Wisselink , Richéle Deodata Wind , Tanja Jacoba Bosch Van Den , Yuzo Toda
发明人： Joseph Hubertus Olijve , Jan Bastiaan Bouwstra , Frederik Anton Wolf De , Marc Willem Theodoor Werten , Hendrik Wouter Wisselink , Richéle Deodata Wind , Tanja Jacoba Bosch Van Den , Yuzo Toda
IPC分类号： A61K9/00
CPC分类号： G03C1/005
摘要： The invention provides oil-in-water emulsions comprising recombinant collagen-like polymer in an amount sufficient to act as stabiliser of the emulsion. The polymer is especially a polypeptide which is free of helix structure, has an isoelectric point at least 0.5 pH units removed from the pH of the oil-in-water emulsion. Furthermore, amphiphilic recombinant collagen-like polymers are provided for use in oil-in-water emulsions. The amphiphilic polymers are polar at one end as a result of a relative abundance of polar amino acids, and apolar at the other end as a result of a relative abundance of apolar amino acids.
摘要翻译： 本发明提供了包含足以作为乳液稳定剂的量的重组胶原样聚合物的水包油乳液。 聚合物特别是不含螺旋结构的多肽，具有从水包油乳液的pH去除至少0.5个pH单位的等电点。 此外，提供两亲重组胶原样聚合物用于水包油乳剂中。 由于极性氨基酸的相对丰度，两亲聚合物在一端是极性的，另一端由于非极性氨基酸的相对丰度而非极性。
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9.发明授权公开(公告)号：US06645712B1
公开(公告)日：2003-11-11
申请号：US09602459
申请日：2000-06-23
申请人： Joseph Hubertus Olijve , Jan Bastiaan Bouwstra , Frederik Anton De Wolf , Marc Willem Theodoor Werten , Hendrik Wouter Wisselink , Richéle Deodata Wind , Tanja Jacoba Van Den Bosch , Yuzo Toda
发明人： Joseph Hubertus Olijve , Jan Bastiaan Bouwstra , Frederik Anton De Wolf , Marc Willem Theodoor Werten , Hendrik Wouter Wisselink , Richéle Deodata Wind , Tanja Jacoba Van Den Bosch , Yuzo Toda
IPC分类号： G03C108
CPC分类号： G03C1/005
摘要： The invention provides oil-in-water emulsions comprising recombinant collagen-like polymer in an amount sufficient to act as stabiliser of the emulsion. The polymer is especially a polypeptide which is free of helix structure, has an isoelectric point at least 0.5 pH units removed from the pH of the oil-in-water emulsion. Furthermore, amphiphilic recombinant collagen-like polymers are provided for use in oil-in-water emulsions. The amphiphilic polymers are polar at one end as a result of a relative abundance of polar amino acids, and apolar at the other end as a result of a relative abundance of apolar amino acids,
摘要翻译： 本发明提供了包含足以作为乳液稳定剂的量的重组胶原样聚合物的水包油乳液。 聚合物特别是不含螺旋结构的多肽，具有从水包油乳液的pH去除至少0.5个pH单位的等电点。 此外，提供两亲重组胶原样聚合物用于水包油乳剂中。 由于极性氨基酸的相对丰度，两亲聚合物在一端是极性的，另一端由于非极性氨基酸的相对丰度而非极性，
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