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公开(公告)号:US20130236932A1
公开(公告)日:2013-09-12
申请号:US13822288
申请日:2011-10-11
申请人: Hendrik Wouter Wisselink , Antonius Jeroen Adriaan Van Maris , Jacobus Thomas Pronk , Paul Klaassen , Rene Marcel De Jong
发明人: Hendrik Wouter Wisselink , Antonius Jeroen Adriaan Van Maris , Jacobus Thomas Pronk , Paul Klaassen , Rene Marcel De Jong
IPC分类号: C12N9/12
CPC分类号: C12N15/81 , C07K14/395 , C12N9/1205 , C12P7/06 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要: The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO: 55, and wherein the polypeptide has permease activity.
摘要翻译: 本发明涉及在一个或多个对应于SEQ ID NO:55的T219的位置具有突变的多肽,其中多肽与SEQ ID NO:55具有至少50%的序列同一性,并且其中多肽具有通透酶活性。
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公开(公告)号:US09034608B2
公开(公告)日:2015-05-19
申请号:US13822288
申请日:2011-10-11
申请人: Hendrik Wouter Wisselink , Antonius Jeroen Adriaan Van Maris , Jacobus Thomas Pronk , Paul Klaassen , Rene Marcel De Jong
发明人: Hendrik Wouter Wisselink , Antonius Jeroen Adriaan Van Maris , Jacobus Thomas Pronk , Paul Klaassen , Rene Marcel De Jong
IPC分类号: C12P19/18 , C12P7/56 , C12P7/16 , C12P7/06 , C12P7/14 , C12N9/12 , C12N1/00 , C12P21/06 , C12P19/34 , C12N15/00 , C07H21/04 , C07K1/00 , C12N15/81 , C07K14/395 , C12P7/10
CPC分类号: C12N15/81 , C07K14/395 , C12N9/1205 , C12P7/06 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要: The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO: 55, and wherein the polypeptide has permease activity.
摘要翻译: 本发明涉及在一个或多个对应于SEQ ID NO:55的T219的位置具有突变的多肽,其中多肽与SEQ ID NO:55具有至少50%的序列同一性,并且其中多肽具有通透酶活性。
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公开(公告)号:US20140162312A1
公开(公告)日:2014-06-12
申请号:US14236191
申请日:2012-08-02
IPC分类号: C12N15/81 , C12P7/16 , C12P7/56 , C12P7/42 , C12P7/40 , C12P35/00 , C12P7/46 , C12P7/48 , C12P7/18 , C12P5/02 , C12P7/20 , C12P7/06 , C12P7/54
CPC分类号: C12N15/81 , C12N9/92 , C12N15/815 , C12P5/026 , C12P7/06 , C12P7/10 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/40 , C12P7/42 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P35/00 , C12Y503/01005 , Y02E50/16 , Y02E50/17
摘要: The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least 75% sequence identity to the amino acid sequence set out in SEQ ID NO: 2 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.
摘要翻译: 本发明涉及包含编码木糖异构酶的核苷酸序列的细胞,其中所述木糖异构酶的氨基酸序列与SEQ ID NO:2所示的氨基酸序列具有至少75%的序列同一性,并且其中所述核苷酸序列 与宿主异源。 本发明的细胞可用于生产发酵产物如乙醇的方法中。 这样的方法可以包括用本发明的细胞发酵含有木糖来源的培养基,使得细胞向发酵产物发酵木糖。
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公开(公告)号:US09701972B2
公开(公告)日:2017-07-11
申请号:US14236191
申请日:2012-08-02
IPC分类号: C12N15/81 , C12N9/92 , C12P7/10 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/40 , C12P7/42 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P5/02 , C12P7/06 , C12P35/00
CPC分类号: C12N15/81 , C12N9/92 , C12N15/815 , C12P5/026 , C12P7/06 , C12P7/10 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/40 , C12P7/42 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P35/00 , C12Y503/01005 , Y02E50/16 , Y02E50/17
摘要: The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least 75% sequence identity to the amino acid sequence set out in SEQ ID NO: 2 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.
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公开(公告)号:US09121013B2
公开(公告)日:2015-09-01
申请号:US13806124
申请日:2011-06-23
申请人: Margot Elisabeth Francoise Schooneveld-Bergmans , Wilbert Herman Marie Heijne , Rene Marcel De Jong , Robbertus Antonius Damveld
发明人: Margot Elisabeth Francoise Schooneveld-Bergmans , Wilbert Herman Marie Heijne , Rene Marcel De Jong , Robbertus Antonius Damveld
CPC分类号: C12N9/2445 , C12Y302/01021 , Y02E50/16
摘要: The invention relates to a polypeptide comprising the amino acid sequence set out in SEQ ID NO: 2 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 70% sequence identity with the sequence set out in SEQ ID NO: 2 or the variant polynucleotide encodes a polypeptide that has at least 70% sequence identity with the sequence set out in SEQ ID NO: 2. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional polypeptide and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.
摘要翻译: 本发明涉及包含SEQ ID NO:2所示的氨基酸序列或由SEQ ID NO:1的核苷酸序列编码的氨基酸序列或其变体多肽或其变体多核苷酸的多肽,其中所述变体多肽具有 与SEQ ID NO:2所示的序列至少70%的序列同一性或变体多核苷酸编码与SEQ ID NO:2所示的序列具有至少70%的序列同一性的多肽。本发明的特征在于全长 新基因的编码序列以及全长功能多肽的氨基酸序列和基因或氨基酸序列的功能等同物。 本发明还涉及在工业过程中使用该多肽的方法。 本发明还包括用适合于生产这些蛋白质的根据本发明的多核苷酸转化的细胞。
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公开(公告)号:US20130095531A1
公开(公告)日:2013-04-18
申请号:US13806124
申请日:2011-06-23
申请人: Margot Elisabeth Francoise Schooneveld-Bergmans , Wilbert Herman Marie Heijne , Rene Marcel De Jong , Robbertus Antonius Damveld
发明人: Margot Elisabeth Francoise Schooneveld-Bergmans , Wilbert Herman Marie Heijne , Rene Marcel De Jong , Robbertus Antonius Damveld
IPC分类号: C12N9/42
CPC分类号: C12N9/2445 , C12Y302/01021 , Y02E50/16
摘要: The invention relates to a polypeptide comprising the amino acid sequence set out in SEQ ID NO: 2 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 70% sequence identity with the sequence set out in SEQ ID NO: 2 or the variant polynucleotide encodes a polypeptide that has at least 70% sequence identity with the sequence set out in SEQ ID NO: 2. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional polypeptide and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.
摘要翻译: 本发明涉及包含SEQ ID NO:2所示的氨基酸序列或由SEQ ID NO:1的核苷酸序列编码的氨基酸序列或其变体多肽或其变体多核苷酸的多肽,其中所述变体多肽具有 与SEQ ID NO:2所示的序列至少70%的序列同一性或变体多核苷酸编码与SEQ ID NO:2所示的序列具有至少70%的序列同一性的多肽。本发明的特征在于全长 新基因的编码序列以及全长功能多肽的氨基酸序列和基因或氨基酸序列的功能等同物。 本发明还涉及在工业过程中使用该多肽的方法。 本发明还包括用适合于生产这些蛋白质的根据本发明的多核苷酸转化的细胞。
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公开(公告)号:US09441214B2
公开(公告)日:2016-09-13
申请号:US13805148
申请日:2011-06-23
申请人: Margot Elisabeth Francoise Schoonneveld-Bergmans , Wilbert Herman Marie Heijne , Rene Marcel De Jong , Robbertus Antonius Damveld
发明人: Margot Elisabeth Francoise Schoonneveld-Bergmans , Wilbert Herman Marie Heijne , Rene Marcel De Jong , Robbertus Antonius Damveld
CPC分类号: C12N9/2445 , C12N9/2434 , C12N9/2437 , C12N15/8257 , C12P19/02 , C12P19/14 , C12P2203/00 , C12Y302/01021
摘要: The invention relates to a polypeptide comprising the amino acid sequence set out in SEQ ID NO: 2 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 96% sequence identity with the sequence set out in SEQ ID NO: 2 or the variant polynucleotide encodes a polypeptide that has at least 96% sequence identity with the sequence set out in SEQ ID NO: 2. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional polypeptide and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.
摘要翻译: 本发明涉及包含SEQ ID NO:2所示的氨基酸序列或由SEQ ID NO:1的核苷酸序列编码的氨基酸序列或其变体多肽或其变体多核苷酸的多肽,其中所述变体多肽具有 与SEQ ID NO:2中所示的序列具有至少96%的序列同一性或变体多核苷酸编码与SEQ ID NO:2所示的序列具有至少96%的序列同一性的多肽。本发明特征在于全长 新基因的编码序列以及全长功能多肽的氨基酸序列和基因或氨基酸序列的功能等同物。 本发明还涉及在工业过程中使用该多肽的方法。 本发明还包括用适合于生产这些蛋白质的根据本发明的多核苷酸转化的细胞。
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公开(公告)号:US20130104264A1
公开(公告)日:2013-04-25
申请号:US13805148
申请日:2011-06-23
申请人: Margot Elisabeth Francoise Schoonneveld-Bergmans , Wilbert Herman Marie Heijne , Rene Marcel De Jong , Robbertus Antonius Damveld
发明人: Margot Elisabeth Francoise Schoonneveld-Bergmans , Wilbert Herman Marie Heijne , Rene Marcel De Jong , Robbertus Antonius Damveld
IPC分类号: C12N9/42
CPC分类号: C12N9/2445 , C12N9/2434 , C12N9/2437 , C12N15/8257 , C12P19/02 , C12P19/14 , C12P2203/00 , C12Y302/01021
摘要: The invention relates to a polypeptide comprising the amino acid sequence set out in SEQ ID NO: 2 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 96% sequence identity with the sequence set out in SEQ ID NO: 2 or the variant polynucleotide encodes a polypeptide that has at least 96% sequence identity with the sequence set out in SEQ ID NO: 2. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional polypeptide and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.
摘要翻译: 本发明涉及包含SEQ ID NO:2所示的氨基酸序列或由SEQ ID NO:1的核苷酸序列编码的氨基酸序列或其变体多肽或其变体多核苷酸的多肽,其中所述变体多肽具有 与SEQ ID NO:2中所示的序列具有至少96%的序列同一性或变体多核苷酸编码与SEQ ID NO:2所示的序列具有至少96%的序列同一性的多肽。本发明特征在于全长 新基因的编码序列以及全长功能多肽的氨基酸序列和基因或氨基酸序列的功能等同物。 本发明还涉及在工业过程中使用该多肽的方法。 本发明还包括用适合于生产这些蛋白质的根据本发明的多核苷酸转化的细胞。
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