摘要:
The present invention relates to compounds and methods useful as inhibitors of protein kinases, including B-Raf and several receptor tyrosine and cytoplasmic tyrosine kinases. The present invention is directed to new substituted pyrimidinyloxy urea compounds of Formulas II, III and IV and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulating of protein kinase activity in a human or animal subject are also provided for the treatment diseases such as cancers.
摘要:
The present invention relates to compounds and methods useful as inhibitors of protein kinases, including B-Raf and several receptor tyrosine and cytoplasmic tyrosine kinases. The present invention is directed to new substituted pyrimidinyloxy urea compounds of Formulas II, III and IV and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulating of protein kinase activity in a human or animal subject are also provided for the treatment diseases such as cancers.
摘要:
The present invention relates to compounds useful as inhibitors of MEK kinase and methods for the treatment or prevention of cellular proliferative disease states, such as conditions related to the hyperactivity of MEK, as well as diseases modulated by the MEK cascade.
摘要:
A real-time system and method that monitors and maintains greatly enhanced safety and security for travelers and corporations by creating a multi layered and integrated system of multi faceted intelligence collection and dissemination, global electronic monitoring, locating and tracking technology, telecommunications, multi channel electronic distribution of relevance-parameterized advice and information to travelers with full acknowledgements and audit trail of critical alert messages both pushed to the traveler or traveler-requested, individual and corporate global security services, emergency response, search and rescue operations initiated either/both by monitor processes or by the traveler and a wide range of travel safety and security related ancillary services, all coordinated under the management of a central international command and control center with regional sub control centers throughout the world. All these component parts are brought together by the method and process to work synergistically in a way not previously described or existing.
摘要:
A water containment apparatus includes a straight strut arrangement comprising a plurality of straight strut assemblies forming an alternating v-shape and inverted v-shape pattern; and a curved strut arrangement comprising a plurality of corner strut assemblies forming a desired curvature and connecting two straight strut arrangements to form a closed loop water containment system.
摘要:
The present invention relates to substituted tetrazolo[1,5-a]pyrazine compounds for Formula IX: as well as pharmaceutical compositions thereof, which may be useful as inhibitors of H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
摘要:
Methods are described for removing contaminates from aqueous industrial wastewater process streams, specifically industrial laundries to yield a less contaminated aqueous effluent for discharge to a sewer and reduce the sludge generated therefrom. A premixed medium/high molecular weight and medium/high charged cationic coagulant solution polymer and an inorganic aluminum species is added to the wastewater, and after at least a two second delay, a high molecular weight highly charged anionic flocculent is injected into the wastewater which reduces sludge generation, while maintaining or exceeding effluent quality. Also, no coagulant, flocculent or sludge aids are needed to attain the results and the sludge can be dewatered in a plate and frame press.
摘要:
The present invention provides an apparatus for instilling fluid into a patient having an intestinal stoma so as to administer an antegrade colonic enema. The portable instillation apparatus comprising in combination: a fluid reservoir, a pump assembly, a control module, a fluid delivery tube and an intestinal stoma catheter wherein the control module is operable to automatically deliver a predetermined volume of instillation fluid at a specific flow rate and pressure range suitable for a particular patient. The portable instillation apparatus utilities a gear pump manifold and a robust empty reservoir detection mechanism, facilitating the portability, durability and reliability of the apparatus over-coming the disadvantages of traditional peristaltic pump mechanisms. The portable instillation apparatus maximizes the ease of transport and use of the device while also enabling a method for a patient to self-administer an antegrade colonic enema within a short time period and without intervention.
摘要:
Methods of allocating dividends to a set of long positions. The methods may comprise the steps of identifying a set of short positions and matching the set of short positions with selected long positions from the set of long positions. The methods may also comprise the step of allocating a manufactured dividend to each of the selected long positions. Each manufactured dividend may originate from one of the set of short positions. The methods may additionally comprise the step of allocating a real dividend to any long positions remaining in the set of long positions.
摘要:
Inverse agonists and antagonists of serotonin receptors are disclosed for use in treating sleep disorders such as insomnia, and specifically sleep maintenance insomnia. The compound increase slow wave sleep, decrease the number of awakenings after sleep onset, and decrease the time awake after sleep onset.