公开(公告)号：US06613903B2

公开(公告)日：2003-09-02

申请号：US09901367

申请日：2001-07-09

申请人： Henrik Sune Andersen ,  Thomas Kruse Hansen ,  Jesper Lau ,  Niels Peter Hundahl Moller ,  Ole Hvilsted Olsen ,  Frank Urban Axe ,  Farid Bakir ,  Yu Ge ,  Daniel Dale Holsworth ,  Luke Milburn Judge ,  Michael James Newman ,  Roy Teruyuki Uyeda ,  Barry Zvi Shapira

发明人： Henrik Sune Andersen ,  Thomas Kruse Hansen ,  Jesper Lau ,  Niels Peter Hundahl Moller ,  Ole Hvilsted Olsen ,  Frank Urban Axe ,  Farid Bakir ,  Yu Ge ,  Daniel Dale Holsworth ,  Luke Milburn Judge ,  Michael James Newman ,  Roy Teruyuki Uyeda ,  Barry Zvi Shapira

IPC分类号： C07D47102

CPC分类号： C07D495/04 ,  A61K31/4365

摘要： The present invention provides novel thienopyridines, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP, wherein X, R1, R2, R3, and R4 are defined more fully in the description. The compounds are useful in the treatment of type 1 diabetes, type 2 diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.

摘要翻译： 本发明提供新颖的噻吩并吡啶类，其新颖的组合物，使用方法及其制备方法，其中式1化合物是包括PTP1B，T细胞PTP在内的蛋白酪氨酸磷酸酶（PTPase）的药理学有用的抑制剂，其中X， R2，R3和R4在说明书中更全面地定义。 该化合物可用于治疗1型糖尿病，2型糖尿病，葡萄糖耐量降低，胰岛素抵抗，肥胖症等疾病。

公开(公告)号：US07115624B1

公开(公告)日：2006-10-03

申请号：US09659622

申请日：2000-09-11

申请人： Henrik Sune Andersen ,  Thomas Kruse Hansen ,  Lars Fogh Iversen ,  Jesper Lau ,  Niels Peter Hundahl Møller ,  Ole Hvilsted Olsen ,  Frank Urban Axe ,  Yu Ge ,  Daniel Dale Holsworth ,  Todd Kevin Jones ,  Luke Milburn Judge ,  Wiliam Charles Ripka ,  Barry Zvi Shapira ,  Roy Teruyuki Uyeda

发明人： Henrik Sune Andersen ,  Thomas Kruse Hansen ,  Lars Fogh Iversen ,  Jesper Lau ,  Niels Peter Hundahl Møller ,  Ole Hvilsted Olsen ,  Frank Urban Axe ,  Yu Ge ,  Daniel Dale Holsworth ,  Todd Kevin Jones ,  Luke Milburn Judge ,  Wiliam Charles Ripka ,  Barry Zvi Shapira ,  Roy Teruyuki Uyeda

IPC分类号： A01N43/42 ,  A61K31/44

CPC分类号： A61K31/44

摘要： The present invention provides a method of inhibiting a member of a family of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTPα, PTPε, PTPμ, PTPδ, PTPσ, PTPζ, PTPβ, PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR, and HePTP by exposing said Ptpase member by administration to a host or otherwise to at least one compound with certain structural, physical and spatial characteristics that allow for the interaction of said compound with specific residues of the active site of PTP1B and/or TC-PTP. These compounds are indicated in the management or treatment of a broad range of diseases such as autoimmune diseases, acute and chronic inflammation, osteoporosis, various forms of cancer and malignant diseases, and type I diabetes and type II diabetes, as well as in the isolation of PTPases and in elucidation or further elucidation of their biological function.

摘要翻译： 本发明提供了抑制蛋白酪氨酸磷酸酶（PTPase，PTP）家族成员如PTP1B，TC-PTP，CD45，SHP-1，SHP-2，PTPalpha，PTPepsilon，PTPmu，PTPdelta，PTPsigma， PTPzeta，PTPbeta，PTPD1，PTPD2，PTPH1，PTP-MEG1，PTP-LAR和HePTP，通过将所述Ptpase成员通过给予宿主或以其他方式暴露于至少一种具有允许相互作用的结构，物理和空间特征的化合物 的所述化合物与PTP1B和/或TC-PTP的活性位点的特异性残基。 这些化合物在管理或治疗广泛的疾病如自身免疫性疾病，急性和慢性炎症，骨质疏松症，各种形式的癌症和恶性疾病以及I型糖尿病和II型糖尿病以及在隔离中被指示 的PTPases，并阐明或进一步阐明其生物学功能。

公开(公告)号：US07019026B1

公开(公告)日：2006-03-28

申请号：US09662457

申请日：2000-09-11

申请人： Henrik Sune Andersen ,  Thomas Kruse Hansen ,  Jesper Lau ,  Niels Peter Hundahl Møller ,  Ole Hvilsted Olsen ,  Frank Urban Axe ,  Yu Ge ,  Daniel Dale Holsworth ,  Todd Kevin Jones ,  Luke Milburn Judge ,  Wiliam Charles Ripka ,  Barry Zvi Shapira ,  Roy Teruyuki Uyeda

发明人： Henrik Sune Andersen ,  Thomas Kruse Hansen ,  Jesper Lau ,  Niels Peter Hundahl Møller ,  Ole Hvilsted Olsen ,  Frank Urban Axe ,  Yu Ge ,  Daniel Dale Holsworth ,  Todd Kevin Jones ,  Luke Milburn Judge ,  Wiliam Charles Ripka ,  Barry Zvi Shapira ,  Roy Teruyuki Uyeda

IPC分类号： A61K31/381 ,  C07D409/04

CPC分类号： C07D495/04

摘要： Disclosed are novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like, wherein n, m, X, Y, R1, R2, R3, R4, R5 and R6 are defined more fully in the description. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.

摘要翻译： 公开了新的化合物，新组合物，其使用方法及其制备方法，其中式1的这种化合物是蛋白质酪氨酸磷酸酶（PTPase）如PTP1B，CD45，SHP-1，SHP-2， PTPalpha，LAR和HePTP等，其中n，m，X，Y，R 1，R 2，R 3，R 3， 在说明书中更完整地定义了SUB 4，R 5和R 6。 该化合物可用于治疗I型糖尿病，II型糖尿病，葡萄糖耐量降低，胰岛素抵抗，肥胖症等疾病。

公开(公告)号：US06410556B1

公开(公告)日：2002-06-25

申请号：US09659547

申请日：2000-09-11

申请人： Henrik Sune Andersen ,  Thomas Kruse Hansen ,  Jesper Lau ,  Niels Peter Hundahl Møller ,  Ole Hvilsted Olsen ,  Frank Urban Axe ,  Yu Ge ,  Daniel Dale Holsworth ,  Todd Kevin Jones ,  Luke Milburn Judge ,  Wiliam Charles Ripka ,  Barry Zvi Shapira ,  Roy Teruyuki Uyeda

发明人： Henrik Sune Andersen ,  Thomas Kruse Hansen ,  Jesper Lau ,  Niels Peter Hundahl Møller ,  Ole Hvilsted Olsen ,  Frank Urban Axe ,  Yu Ge ,  Daniel Dale Holsworth ,  Todd Kevin Jones ,  Luke Milburn Judge ,  Wiliam Charles Ripka ,  Barry Zvi Shapira ,  Roy Teruyuki Uyeda

IPC分类号： A61K31435

CPC分类号： C07D495/04 ,  A61K31/4365 ,  A61K45/06 ,  A61K2300/00

摘要： Disclosed are novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP, wherein n, m, X, R1, R2, R3, R4, R5, R6, and R7 are defined more fully in the description. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.

摘要翻译： 公开了新型化合物，新组合物，其使用方法及其制备方法，其中式1的这种化合物是包括PTP1B，T细胞PTP的蛋白质酪氨酸磷酸酶（PTPase）的药理学上有用的抑制剂，其中n，m，X， R1，R2，R3，R4，R5，R6和R7在说明书中更充分地定义。 该化合物可用于治疗I型糖尿病，II型糖尿病，葡萄糖耐量降低，胰岛素抵抗，肥胖症等疾病。

公开(公告)号：US06951878B2

公开(公告)日：2005-10-04

申请号：US10158464

申请日：2002-05-28

申请人： Niels Peter Hundahl Møller ,  Henrik Sune Andersen ,  Lars Fogh Iversen ,  Ole Hvilsted Olsen ,  Sven Branner ,  Daniel Dale Holsworth ,  Farid Bakir ,  Luke Milburn Judge ,  Frank Urban Axe ,  Todd Kevin Jones ,  William Charles Ripka ,  Yu Ge ,  Roy Teruyuki Uyeda

发明人： Niels Peter Hundahl Møller ,  Henrik Sune Andersen ,  Lars Fogh Iversen ,  Ole Hvilsted Olsen ,  Sven Branner ,  Daniel Dale Holsworth ,  Farid Bakir ,  Luke Milburn Judge ,  Frank Urban Axe ,  Todd Kevin Jones ,  William Charles Ripka ,  Yu Ge ,  Roy Teruyuki Uyeda

IPC分类号： C07C233/56 ,  C07C237/22 ,  C07D207/34 ,  C07D209/08 ,  C07D209/14 ,  C07D213/79 ,  C07D213/80 ,  C07D231/40 ,  C07D239/42 ,  C07D239/54 ,  C07D239/557 ,  C07D261/08 ,  C07D271/10 ,  C07D333/38 ,  C07D333/66 ,  C07D333/68 ,  C07D409/04 ,  C07D409/06 ,  C07D413/04 ,  C07D495/04 ,  C07D495/10 ,  C07D495/14 ,  A61K31/41 ,  A61K31/381

CPC分类号： C07D213/79 ,  C07C233/56 ,  C07C237/22 ,  C07D207/34 ,  C07D209/08 ,  C07D209/14 ,  C07D213/80 ,  C07D231/40 ,  C07D239/42 ,  C07D239/557 ,  C07D261/08 ,  C07D271/10 ,  C07D333/38 ,  C07D333/66 ,  C07D333/68 ,  C07D409/04 ,  C07D409/06 ,  C07D413/04 ,  C07D495/04 ,  C07D495/10 ,  C07D495/14

摘要： The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like.The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

摘要翻译： 本发明提供新型化合物，新型组合物，其使用方法及其制备方法，其中这些化合物是蛋白酪氨酸磷酸酶（PTPase）如PTP1B，CD45，SHP-1，SHP-2，PTPα的药理学有用的抑制剂 ，LAR和HePTP等。 该化合物可用于治疗I型糖尿病，II型糖尿病，葡萄糖耐量降低，胰岛素抵抗，肥胖症，免疫功能障碍，包括凝血系统功能障碍的自身免疫性疾病，包括哮喘，过度性疾病，骨质疏松症，包括癌症和牛皮癣在内的增殖性疾病 ，具有减少或增加的生长激素合成或作用的疾病，调节生长激素释放/或对生长激素的反应，包括阿尔茨海默氏病和精神分裂症的疾病以及传染病的激素或细胞因子合成减少或增加的疾病。

公开(公告)号：US06410586B1

公开(公告)日：2002-06-25

申请号：US09810266

申请日：2001-03-16

申请人： Niels Peter Hundahl Møller ,  Henrik Sune Andersen ,  Lars Fogh Iversen ,  Ole Hvilsted Olsen ,  Sven Branner ,  Daniel Dale Holsworth ,  Farid Bakir ,  Luke Milburn Judge ,  Frank Urban Axe ,  Todd Kevin Jones ,  William Charles Ripka ,  Yu Ge ,  Roy Teruyuki Uyeda

发明人： Niels Peter Hundahl Møller ,  Henrik Sune Andersen ,  Lars Fogh Iversen ,  Ole Hvilsted Olsen ,  Sven Branner ,  Daniel Dale Holsworth ,  Farid Bakir ,  Luke Milburn Judge ,  Frank Urban Axe ,  Todd Kevin Jones ,  William Charles Ripka ,  Yu Ge ,  Roy Teruyuki Uyeda

IPC分类号： A61K31381

CPC分类号： C07D213/79 ,  C07C233/56 ,  C07C237/22 ,  C07D207/34 ,  C07D209/08 ,  C07D209/14 ,  C07D213/80 ,  C07D231/40 ,  C07D239/42 ,  C07D239/557 ,  C07D261/08 ,  C07D271/10 ,  C07D333/38 ,  C07D333/66 ,  C07D333/68 ,  C07D409/04 ,  C07D409/06 ,  C07D413/04 ,  C07D495/04 ,  C07D495/10 ,  C07D495/14

摘要： The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B. CD45, SHP-1, SHP-2, PTP&agr;, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

摘要翻译： 本发明提供新型化合物，新组合物，其用途及其制备方法，其中这些化合物是蛋白酪氨酸磷酸酶（PTPase）如PTP1B的药理学有用的抑制剂。 CD45，SHP-1，SHP-2，PTPalpha，LAR和HePTP等。 该化合物可用于治疗I型糖尿病，II型糖尿病，葡萄糖耐量降低，胰岛素抵抗，肥胖症，免疫功能障碍，包括凝血系统功能障碍的自身免疫性疾病，包括哮喘，过度性疾病，骨质疏松症，包括癌症和牛皮癣在内的增殖性疾病 ，具有减少或增加的生长激素合成或作用的疾病，调节生长激素释放/或对生长激素的反应，包括阿尔茨海默氏病和精神分裂症的疾病以及传染病的激素或细胞因子合成减少或增加的疾病。

公开(公告)号：US06262044B1

公开(公告)日：2001-07-17

申请号：US09268490

申请日：1999-03-11

申请人： Niels Peter Hundahl Møller ,  Henrik Sune Andersen ,  Lars Fogh Iversen ,  Ole Hvilsted Olsen ,  Sven Branner ,  Daniel Dale Holsworth ,  Farid Bakir ,  Luke Milburn Judge ,  Frank Urban Axe ,  Todd Kevin Jones ,  William Charles Ripka ,  Yu Ge ,  Roy Teruyuki Uyeda

发明人： Niels Peter Hundahl Møller ,  Henrik Sune Andersen ,  Lars Fogh Iversen ,  Ole Hvilsted Olsen ,  Sven Branner ,  Daniel Dale Holsworth ,  Farid Bakir ,  Luke Milburn Judge ,  Frank Urban Axe ,  Todd Kevin Jones ,  William Charles Ripka ,  Yu Ge ,  Roy Teruyuki Uyeda

IPC分类号： A61K31546

CPC分类号： C07D213/79 ,  C07C233/56 ,  C07C237/22 ,  C07D207/34 ,  C07D209/08 ,  C07D209/14 ,  C07D213/80 ,  C07D231/40 ,  C07D239/42 ,  C07D239/557 ,  C07D261/08 ,  C07D271/10 ,  C07D333/38 ,  C07D333/66 ,  C07D333/68 ,  C07D409/04 ,  C07D409/06 ,  C07D413/04 ,  C07D495/04 ,  C07D495/10 ,  C07D495/14

摘要： The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTP&agr;, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

摘要翻译： 本发明提供新型化合物，新型组合物，其使用方法及其制备方法，其中这些化合物是蛋白酪氨酸磷酸酶（PTPase）如PTP1B，CD45，SHP-1，SHP-2，PTPα的药理学有用的抑制剂 ，LAR和HePTP等。 该化合物可用于治疗I型糖尿病，II型糖尿病，葡萄糖耐量降低，胰岛素抵抗，肥胖症，免疫功能障碍，包括凝血系统功能障碍的自身免疫性疾病，包括哮喘，过度性疾病，骨质疏松症，包括癌症和牛皮癣在内的增殖性疾病 ，具有减少或增加的生长激素合成或作用的疾病，调节生长激素释放/或对生长激素的反应，包括阿尔茨海默氏病和精神分裂症的疾病以及传染病的激素或细胞因子合成减少或增加的疾病。

公开(公告)号：US06225329B1

公开(公告)日：2001-05-01

申请号：US09265069

申请日：1999-03-09

申请人： Lutz Stefan Richter ,  Henrik Sune Andersen ,  Josef Vagner ,  Claus Bekker Jeppesen ,  Niels Peter Hundahl Møller ,  Sven Branner ,  Jing Su ,  Farid Bakir ,  Luke Milburn Judge

发明人： Lutz Stefan Richter ,  Henrik Sune Andersen ,  Josef Vagner ,  Claus Bekker Jeppesen ,  Niels Peter Hundahl Møller ,  Sven Branner ,  Jing Su ,  Farid Bakir ,  Luke Milburn Judge

IPC分类号： A61K3141

CPC分类号： C07D213/79 ,  C07D213/80 ,  C07D239/557 ,  C07D241/26 ,  C07D261/08 ,  C07D271/07

摘要： The present invention provides novel compounds of Formula 1, compositions containing these compounds, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTP&agr;, LAR and HePTP or the like, wherein A, R1, R2, R3, R4, R16 and R17 are as defined in the specification. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

摘要翻译： 本发明提供新的式1化合物，含有这些化合物的组合物，其使用方法及其制备方法，其中这些化合物是蛋白酪氨酸磷酸酶（PTPase）如PTP1B，CD45，SHP-1， SHP-2，PTPalpha，LAR和HePTP等，其中A，R1，R2，R3，R4，R16和R17如说明书中所定义。 该化合物可用于治疗I型糖尿病，II型糖尿病，葡萄糖耐量降低，胰岛素抵抗，肥胖症，免疫功能障碍，包括凝血系统功能障碍的自身免疫性疾病，包括哮喘，过度性疾病，骨质疏松症，包括癌症和牛皮癣在内的增殖性疾病 ，具有减少或增加的生长激素合成或作用的疾病，调节生长激素释放/或对生长激素的反应，包括阿尔茨海默氏病和精神分裂症的疾病以及传染病的激素或细胞因子合成减少或增加的疾病。

公开(公告)号：US5958957A

公开(公告)日：1999-09-28

申请号：US842801

申请日：1997-04-16

申请人： Henrik Sune Andersen ,  Niels Peter Hundahl Moller ,  Peter Madsen

发明人： Henrik Sune Andersen ,  Niels Peter Hundahl Moller ,  Peter Madsen

IPC分类号： C07D231/20 ,  C07D249/14 ,  C07D257/04 ,  C07D271/10 ,  C07D271/113 ,  C07D277/34 ,  C07D285/08 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D417/06 ,  C07F9/38 ,  A61K31/14 ,  C07D271/07

CPC分类号： C07D271/113 ,  C07D231/20 ,  C07D249/14 ,  C07D257/04 ,  C07D277/34 ,  C07D285/08 ,  C07D285/125 ,  C07D285/135 ,  C07D417/06 ,  C07F9/3834 ,  C07F9/3882

摘要： The present invention relates to novel organic compounds, to methods for their preparation, to compositions containing them, to their use for treatment of human and animal disorders, to their use for purification of proteins or glycoproteins, and to their use in diagnosis. The invention relates to modulation of the activity of molecules with phospho-tyrosine recognition units, including protein tyrosine phosphatases (PTPases) and proteins with Src-homology-2 domains, in in vitro systems, microorganisms, eukaryotic cells, whole animals and human beings. The novel organic compounds are compounds of formula (I)(L).sub.n --Ar.sub.1 --R.sub.1 --A (I)wherein(L).sub.n, n, Ar.sub.1, R.sub.1 and A are as defined in the application.

公开(公告)号：US6080770A

公开(公告)日：2000-06-27

申请号：US253419

申请日：1999-02-19

申请人： Henrik Sune Andersen ,  Niels Peter Hundahl Moller ,  Peter Madsen

发明人： Henrik Sune Andersen ,  Niels Peter Hundahl Moller ,  Peter Madsen

IPC分类号： C07D231/20 ,  C07D249/14 ,  C07D257/04 ,  C07D271/10 ,  C07D271/113 ,  C07D277/34 ,  C07D285/08 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D417/06 ,  C07F9/38 ,  A61K31/41 ,  C07D249/04 ,  C07D403/06

CPC分类号： C07D271/113 ,  C07D231/20 ,  C07D249/14 ,  C07D257/04 ,  C07D277/34 ,  C07D285/08 ,  C07D285/125 ,  C07D285/135 ,  C07D417/06 ,  C07F9/3834 ,  C07F9/3882

摘要： The present invention relates to novel organic compounds, to methods for their preparation, to compositions containing them, to their use for treatment of human and animal disorders, to their use for purification of proteins or glycoproteins, and to their use in diagnosis. The invention relates to modulation of the activity of molecules with phospho-tyrosine recognition units, including protein tyrosine phosphatases (PTPases) and proteins with Src-homology-2 domains, in in vitro systems, microorganisms, eukaryotic cells, whole animals and human beings. The novel organic compounds are compounds of formula (I) ##STR1## wherein (L).sub.n, Ar.sub.1, R.sub.1 and A are as defined in the application.

摘要翻译： 本发明涉及新型有机化合物，其制备方法，含有它们的组合物，其用于治疗人和动物疾病的用途，其用于蛋白质或糖蛋白的纯化及其在诊断中的用途。 本发明涉及在体外系统，微生物，真核细胞，整个动物和人类中调节具有磷酸 - 酪氨酸识别单元的分子的活性，包括蛋白酪氨酸磷酸酶（PTPases）和具有Src-同源性-2结构域的蛋白质。 新型有机化合物是式（I）的化合物，其中（L）n，Ar 1，R 1和A如本申请中所定义。