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16 条记录 (耗时 0.024 秒)

    3-Nitropyrazole compounds and anti-microbial compositions
    6.
    发明授权
    3-Nitropyrazole compounds and anti-microbial compositions 失效
    3-硝基吡唑化合物和抗微生物组合物

    公开(公告)号：US4172136A

    公开(公告)日：1979-10-23

    申请号：US889594

    申请日：1978-03-23

    申请人： Herbert Berger ,  Rudi Gall ,  Kurt Stach, deceased ,  Max Thiel ,  Wolfgang Vomel

    发明人： Herbert Berger ,  Rudi Gall ,  Kurt Stach, deceased ,  Max Thiel ,  Wolfgang Vomel

    IPC分类号： C07D231/16 ,  C07D401/02 ,  C07D403/02

    CPC分类号： C07D231/16

    摘要： New 3-nitropyrazole compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is cyano, carboxyl or lower alkoxycarbonyl or the radical --CO-NR.sub.4 R.sub.5, in whichR.sub.4 is hydrogen or hydroxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, thiocarbamoyl, ureido, thioureido, hydroxyphenyl, picolyl or is a lower alkyl, alkenyl or cycloalkyl radical substituted, if desired, by a cyano, hydroxyl, pyrrolidino, piperidino, amino, lower alkylamino, lower dialkylamino or lower acylamino substituent andR.sub.5 is a hydrogen atom or a lower alkyl radical orR.sub.4 and R.sub.5 together represent a lower alkylene bridge;And the pharmacologically compatible salts thereof are outstandingly effective as anti-microbial agents, particularly systemically and in the urinary tract.

    摘要翻译： 新的具有下式的3-硝基吡唑化合物：其中R 1是低级烷基; R2是氢或低级烷基; R3是氰基，羧基或低级烷氧基羰基或基团-CO-NR4R5，其中R4是氢或羟基，氨基甲酰基，烷基氨基甲酰基，二烷基氨基甲酰基，硫代氨基甲酰基，脲基，硫脲基，羟基苯基，吡啶甲基或是低级烷基，烯基或环烷基取代 如果需要，通过氰基，羟基，吡咯烷子基，哌啶子基，氨基，低级烷基氨基，低级二烷基氨基或低级酰基氨基取代基，R 5是氢原子或低级烷基，或者R 4和R 5一起代表低级亚烷基桥; 并且其药理学兼容的药物作为抗微生物药剂，特别是在系统性和在尿道感染中是非常有效的。

    3-Nitropyrazole compounds and anti-microbial compositions
    7.
    发明授权
    3-Nitropyrazole compounds and anti-microbial compositions 失效
    3-硝基吡唑化合物和抗微生物组合物

    公开(公告)号：US4105772A

    公开(公告)日：1978-08-08

    申请号：US744215

    申请日：1976-11-22

    申请人： Herbert Berger ,  Rudi Gall ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Max Thiel ,  Wolfgang Vomel

    发明人： Herbert Berger ,  Rudi Gall ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Max Thiel ,  Wolfgang Vomel

    IPC分类号： C07D231/16 ,  A61K31/41 ,  C07D231/10

    CPC分类号： C07D231/16

    摘要： New 3-nitropyrazole compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is cyano, carboxyl or lower alkoxycarbonyl or the radical --CO--NR.sub.4 R.sub.5, in whichR.sub.4 is hydrogen or hydroxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, thiocarbamoyl, ureido, thioureido, hydroxyphenyl, picolyl or is a lower alkyl, alkenyl or cycloalkyl radical substituted, if desired, by a cyano, hydroxyl, pyrrolidino, piperidino, amino, lower alkylamino, lower dialkylamino or lower acylamino substituent andR.sub.5 is a hydrogen atom or a lower alkyl radical orR.sub.4 and R.sub.5 together represent a lower alkylene bridge;And the pharmacologically compatible salts thereof, are outstandingly effective as anti-microbial agents, particularly systemically and in the urinary tract.

    摘要翻译： 新的具有下式的3-硝基吡唑化合物：其中R 1是低级烷基; R2是氢或低级烷基; R3是氰基，羧基或低级烷氧基羰基或基团-CO-NR4R5，其中R4是氢或羟基，氨基甲酰基，烷基氨基甲酰基，二烷基氨基甲酰基，硫代氨基甲酰基，脲基，硫脲基，羟基苯基，吡啶甲基或是低级烷基，烯基或环烷基取代 如果需要，通过氰基，羟基，吡咯烷子基，哌啶子基，氨基，低级烷基氨基，低级二烷基氨基或低级酰基氨基取代基，R 5是氢原子或低级烷基，或者R 4和R 5一起代表低级亚烷基桥; 并且其药理学兼容的药物作为抗微生物剂，特别是在系统性和全球性的治疗中是非常有效的。

    Hypoglycaemically and hypolipidaemically active derivatives of phenyl-alkane-carboxylic acids
    8.
    发明授权
    Hypoglycaemically and hypolipidaemically active derivatives of phenyl-alkane-carboxylic acids 失效
    苯基 - 烷烃 - 羧酸的低血糖和降血糖活性衍生物

    公开(公告)号：US4238506A

    公开(公告)日：1980-12-09

    申请号：US920508

    申请日：1978-06-29

    申请人： Kurt Stach, deceased ,  Elmar Bosies ,  Ruth Heerdt ,  Hans-Frieder Kuhnle ,  Felix H. Schmidt

    发明人： Kurt Stach, deceased ,  Elmar Bosies ,  Ruth Heerdt ,  Hans-Frieder Kuhnle ,  Felix H. Schmidt

    IPC分类号： C07D213/82 ,  C07D241/24 ,  C07D307/79 ,  C07D311/66 ,  C07D333/38 ,  C07C101/42

    CPC分类号： C07D213/82 ,  C07D241/24 ,  C07D307/79 ,  C07D311/66 ,  C07D333/38 ,  C07C2103/18

    摘要： Phenyl-alkane-carboxylic acids of the formula ##STR1## wherein A is an aryl, aralkyl or arylvinyl radical optionally substituted by hydroxy, halogen, trifluoromethyl, alkyl, alkylthio, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino, aryloxy or alkoxy-substituted aryloxy, or is an aryloxyalkyl or arylthioalkyl radical, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy,Y is a valency bond or an unbranched or branched lower alkylene radical containing up to 3 carbon atoms,X is a straight or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing 2 to 8 carbon atoms, there being at least 2 carbon atoms between the benzene ring and the carboxyl group, andR is a hydrogen atom or a lower alkyl radical, as well as physiologically compatible salts, esters and amides thereof, exhibit hypoglycaemic and hypolipidaemic activity.

    摘要翻译： 式（I）的苯基 - 烷烃 - 羧酸其中A是任选被羟基，卤素，三氟甲基，烷基，烷硫基，烷氧基，烯氧基，烷氧基烷氧基，烷基取代的氨基，芳氧基 或烷氧基取代的芳氧基，或是芳氧基烷基或芳硫基烷基，或任选被卤素，烷基或烷氧基取代的杂环体系，Y是价态键或含有至多3个碳原子的无支链或支链低级亚烷基，X是 含有2至8个碳原子的直链或支链，饱和或不饱和的二价脂族烃基，苯环和羧基之间至少有2个碳原子，R是氢原子或低级烷基，以及 其生理上相容的盐，酯和酰胺显示出低血糖和降血脂活性。