公开(公告)号：US4034096A

公开(公告)日：1977-07-05

申请号：US595953

申请日：1975-07-14

申请人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D221/16 ,  C07D215/56

CPC分类号： C07D221/16

摘要： New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.

摘要翻译： 其中R是饱和或不饱和脂族烃基，例如烷基和链烯基，X是氢或烷基，Y是卤素，叠氮基，烷硫基，烷基磺酰基或腈或未取代的新的环戊烯 - 喹诺酮衍生物 或取代的（例如烷基单或二取代的）氨基; 及其药理学兼容性; 作为母体中的细菌具有非常有效的作用。

公开(公告)号：US4033967A

公开(公告)日：1977-07-05

申请号：US515790

申请日：1974-10-17

申请人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  Werner Plattner, administrator ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  Werner Plattner, administrator ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D215/20 ,  A61K31/473 ,  C07D215/06 ,  C07D215/233 ,  C07D221/16 ,  C07D215/56

CPC分类号： C07D221/16

摘要： New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.

摘要翻译： 其中R是饱和或不饱和脂族烃基，例如烷基和链烯基，X是氢或烷基，Y是卤素，叠氮基，烷硫基，烷基磺酰基或腈或未取代的新的环戊烯 - 喹诺酮衍生物 或取代的（例如烷基单或二取代的）氨基; 及其药理学兼容性; 作为母体中的细菌具有非常有效的作用。

公开(公告)号：US3988460A

公开(公告)日：1976-10-26

申请号：US558101

申请日：1975-03-13

申请人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  by Werner Plattner, executor ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  by Werner Plattner, executor ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： A61K31/47

CPC分类号： A61K31/47

摘要： Certain novel cyclopentenoquinolone derivatives of the formula: ##SPC1##WhereinR and X, which may be the same or different, are hydrogen or lower saturated or unsaturated aliphatic hydrocarbyl;Y is hydroxyl or lower alkoxy or lower acyloxy (i.e., alkanoyloxy); andZ is hydrogen or lower alkoxy, or, together with Y, represents an oxo or lower alkenyldioxy radical; and the pharmacologically compatibile salts thereofAre outstandingly effective as anti-microbials, particularly for applications against infections of the urinary tract.

摘要翻译： 某些新的环戊烯喹诺酮衍生物，其结构如下：

公开(公告)号：US4105772A

公开(公告)日：1978-08-08

申请号：US744215

申请日：1976-11-22

申请人： Herbert Berger ,  Rudi Gall ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Max Thiel ,  Wolfgang Vomel

发明人： Herbert Berger ,  Rudi Gall ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Max Thiel ,  Wolfgang Vomel

IPC分类号： C07D231/16 ,  A61K31/41 ,  C07D231/10

CPC分类号： C07D231/16

摘要： New 3-nitropyrazole compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is cyano, carboxyl or lower alkoxycarbonyl or the radical --CO--NR.sub.4 R.sub.5, in whichR.sub.4 is hydrogen or hydroxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, thiocarbamoyl, ureido, thioureido, hydroxyphenyl, picolyl or is a lower alkyl, alkenyl or cycloalkyl radical substituted, if desired, by a cyano, hydroxyl, pyrrolidino, piperidino, amino, lower alkylamino, lower dialkylamino or lower acylamino substituent andR.sub.5 is a hydrogen atom or a lower alkyl radical orR.sub.4 and R.sub.5 together represent a lower alkylene bridge;And the pharmacologically compatible salts thereof, are outstandingly effective as anti-microbial agents, particularly systemically and in the urinary tract.

摘要翻译： 新的具有下式的3-硝基吡唑化合物：其中R 1是低级烷基; R2是氢或低级烷基; R3是氰基，羧基或低级烷氧基羰基或基团-CO-NR4R5，其中R4是氢或羟基，氨基甲酰基，烷基氨基甲酰基，二烷基氨基甲酰基，硫代氨基甲酰基，脲基，硫脲基，羟基苯基，吡啶甲基或是低级烷基，烯基或环烷基取代 如果需要，通过氰基，羟基，吡咯烷子基，哌啶子基，氨基，低级烷基氨基，低级二烷基氨基或低级酰基氨基取代基，R 5是氢原子或低级烷基，或者R 4和R 5一起代表低级亚烷基桥; 并且其药理学兼容的药物作为抗微生物剂，特别是在系统性和全球性的治疗中是非常有效的。

公开(公告)号：US4172136A

公开(公告)日：1979-10-23

申请号：US889594

申请日：1978-03-23

申请人： Herbert Berger ,  Rudi Gall ,  Kurt Stach, deceased ,  Max Thiel ,  Wolfgang Vomel

发明人： Herbert Berger ,  Rudi Gall ,  Kurt Stach, deceased ,  Max Thiel ,  Wolfgang Vomel

IPC分类号： C07D231/16 ,  C07D401/02 ,  C07D403/02

CPC分类号： C07D231/16

摘要： New 3-nitropyrazole compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is cyano, carboxyl or lower alkoxycarbonyl or the radical --CO-NR.sub.4 R.sub.5, in whichR.sub.4 is hydrogen or hydroxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, thiocarbamoyl, ureido, thioureido, hydroxyphenyl, picolyl or is a lower alkyl, alkenyl or cycloalkyl radical substituted, if desired, by a cyano, hydroxyl, pyrrolidino, piperidino, amino, lower alkylamino, lower dialkylamino or lower acylamino substituent andR.sub.5 is a hydrogen atom or a lower alkyl radical orR.sub.4 and R.sub.5 together represent a lower alkylene bridge;And the pharmacologically compatible salts thereof are outstandingly effective as anti-microbial agents, particularly systemically and in the urinary tract.

摘要翻译： 新的具有下式的3-硝基吡唑化合物：其中R 1是低级烷基; R2是氢或低级烷基; R3是氰基，羧基或低级烷氧基羰基或基团-CO-NR4R5，其中R4是氢或羟基，氨基甲酰基，烷基氨基甲酰基，二烷基氨基甲酰基，硫代氨基甲酰基，脲基，硫脲基，羟基苯基，吡啶甲基或是低级烷基，烯基或环烷基取代 如果需要，通过氰基，羟基，吡咯烷子基，哌啶子基，氨基，低级烷基氨基，低级二烷基氨基或低级酰基氨基取代基，R 5是氢原子或低级烷基，或者R 4和R 5一起代表低级亚烷基桥; 并且其药理学兼容的药物作为抗微生物药剂，特别是在系统性和在尿道感染中是非常有效的。

公开(公告)号：US4243807A

公开(公告)日：1981-01-06

申请号：US737518

申请日：1976-11-01

申请人： Walter-Gunar Friebe ,  Max Thiel ,  Kurt Stach, deceased ,  by Werner Plattner, administrator

发明人： Walter-Gunar Friebe ,  Max Thiel ,  Kurt Stach, deceased ,  by Werner Plattner, administrator

IPC分类号： C07D211/18 ,  C07D211/22 ,  C07D213/26 ,  C07D213/30

CPC分类号： C07D211/22 ,  C07D211/18

摘要： 4-Phenoxymethyl-piperidines of the formula ##STR1## wherein R is hydrogen, halogen, nitro, lower alkyl or lower alkoxy, in the form of the free base or an acid addition salt, are provided and they are useful as intermediates in the production of anti-hypertensive agents through condensation with (a) propyl chloride and then with an adenine, or (b) a propyl indole.

摘要翻译： 其中R为氢，卤素，硝基，低级烷基或低级烷氧基的式为“IMAGE”的4-苯氧基甲基 - 哌啶，以游离碱或酸加成盐的形式提供，它们可用作生产中的中间体 的抗高血压药通过与（a）丙基氯然后与腺嘌呤缩合，或（b）丙基吲哚。

公开(公告)号：US4229464A

公开(公告)日：1980-10-21

申请号：US943512

申请日：1978-09-18

申请人： Wolfgang Kampe ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Max Thiel ,  Wolfgang Bartsch ,  Karl Dietmann ,  Egon Roesch ,  Wolfgang Schaumann

发明人： Wolfgang Kampe ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Max Thiel ,  Wolfgang Bartsch ,  Karl Dietmann ,  Egon Roesch ,  Wolfgang Schaumann

IPC分类号： C07D209/43 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61P25/02 ,  C07D209/08 ,  C07D209/12 ,  C07D209/32 ,  C07D209/42 ,  C07D209/18 ,  C07D209/20

CPC分类号： C07D209/42 ,  C07D209/08 ,  C07D209/12 ,  Y10S514/927

摘要： New aminopropanol compounds of the formula ##STR1## wherein R is lower alkyl, cycloalkyl or alkylthioalkyl,R.sub.1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or --CONR.sub.3 R.sub.4, in which R.sub.3 and R.sub.4 which can be the same or different, represent hydrogen or lower alkyl, andR.sub.2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R.sub.1 is pivaloyloxyalkyl, R.sub.2 can also be hydrogen and the pharmacologically acceptable salts thereof; are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.

摘要翻译： 新的式（I）的氨基丙醇化合物其中R是低级烷基，环烷基或烷硫基烷基，R1是氢或低级烷基，羟烷基，新戊酰氧基烷基，烷氧基烷基，烷氧基羰基，羧基或-CONR3R4，其中R3和R4可以是 R 2为低级烷基，羟基烷基，烷氧基烷基或新戊酰氧基烷基，或当R为烷硫基烷基或R 1为新戊酰氧基烷基时，R 2也可为氢及其药理学上可接受的盐; 在治疗或预防心脏和循环系统疾病方面非常有效。

公开(公告)号：US4107299A

公开(公告)日：1978-08-15

申请号：US738808

申请日：1976-11-04

申请人： Fritz Kaiser ,  Wolfgang Schaumann ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Wolfgang Voightlander

发明人： Fritz Kaiser ,  Wolfgang Schaumann ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Wolfgang Voightlander

IPC分类号： A61K31/704 ,  A61P9/04 ,  C07J19/00 ,  A61K31/705

CPC分类号： C07J19/005

摘要： 12-Epi-digoxins of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently is hydrogen or a lower alkanoyl or alkyl radical,R.sub.3 is hydrogen or a lower alkanoyl radical, andR.sub.4 is hydrogen or a lower alkyl, alkenyl or alkynyl radical,Are characterized by marked cardioactivity and therapeutic spectrum. They are produced by reduction of the corresponding 12-dehydrodigoxin.

摘要翻译： 其中R 1和R 2各自独立地为氢或低级烷酰基或烷基，R 3为氢或低级烷酰基，R 4为氢或低级烷基， 烯基或炔基，由标记的亲和力和治疗谱表征。 它们通过还原相应的12-dehydrodigoxin产生。

公开(公告)号：US4092416A

公开(公告)日：1978-05-30

申请号：US746551

申请日：1976-12-01

申请人： Werner Winter ,  Max Thiel ,  Kurt Stach, deceased ,  Androniki Roesch ,  by Werner Plattner, administrator ,  Wolfgang Schaumann

发明人： Werner Winter ,  Max Thiel ,  Kurt Stach, deceased ,  Androniki Roesch ,  by Werner Plattner, administrator ,  Wolfgang Schaumann

IPC分类号： A61K31/495 ,  A61P37/08 ,  C07C45/71 ,  C07D295/108 ,  C07D295/15 ,  C07D309/12 ,  C07D311/22 ,  C07D317/22 ,  C07D295/10

CPC分类号： C07D295/108 ,  C07C45/71 ,  C07D295/15 ,  C07D309/12 ,  C07D311/22 ,  C07D317/22

摘要： Benzopyrones of the formula ##STR1## wherein R.sub.1 is a hydrogen or halogen atom or a hydroxyl, lower alkyl, alkoxy, alkylthio or trifluoromethyl radical,R.sub.2, r.sub.3, r.sub.4 and R.sub.5 each independently is hydrogen, a halogen atom, a hydroxyl radical, a lower alkyl or lower alkoxy radical, or a lower alkyl or lower alkoxy radical substituted by at least one of hydroxyl, halogen, mesyloxy or tosyloxy or by an oxirane, dioxane or dioxolane ring,A is a lower alkylene radical, andn is 0, 1 or 2,And salts thereof exhibit anti-allergic activity.

摘要翻译： 其中R1是氢原子或卤原子或羟基，低级烷基，烷氧基，烷硫基或三氟甲基的式为“IMAGE”的苯并吡喃酮，R 2，R 3，R 4和R 5各自独立地是氢，卤原子，羟基， 或被羟基，卤素，甲磺酰氧基或甲苯磺酰氧基中的至少一个取代的低级烷基或低级烷氧基，或由环氧乙烷，二恶烷或二氧戊环形成的环，A为低级亚烷基，N为0， 1或2，以及其展示抗过敏活性。

公开(公告)号：US4086347A

公开(公告)日：1978-04-25

申请号：US737507

申请日：1976-11-02

申请人： Walter-Gunar Friebe ,  Max Thiel ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Otto-Henning Wilhelms ,  Erika VON Mullendorff ,  Gisbert Sponer

发明人： Walter-Gunar Friebe ,  Max Thiel ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Otto-Henning Wilhelms ,  Erika VON Mullendorff ,  Gisbert Sponer

IPC分类号： A61K31/52 ,  A61P3/00 ,  A61P9/12 ,  A61P29/00 ,  A61P37/08 ,  C07D401/06 ,  C07D401/14 ,  C07D473/34

CPC分类号： C07D473/34 ,  Y10S514/826 ,  Y10S514/87

摘要： 9-[3-(4-Phenoxymethylpiperidino)-propyl]-adenines of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl radical,R.sub.2 is a hydrogen atom, a ower alkyl radical optionally substituted by hydroxyl, or a cycloalkyl radical, orR.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a heterocyclic ring, andR.sub.3 is a hydrogen atom, a halogen atom, a lower alkyl radical or a lower alkoxy radical,In the form of the free base or a salt thereof, exhibit anti-allergic, anti-inflammatory, anti-oedematous and anti-hypertensive activity.

摘要翻译： 式[IMAGE]的9- [3-（4-苯氧基甲基哌啶子基） - 丙基] - 腺嘌呤，其中R 1为氢原子或低级烷基，R 2为氢原子，任选被羟基取代的烷基，或 环烷基或R 1和R 2与它们所连接的氮原子一起形成杂环，并且R 3是氢原子，卤素原子，低级烷基或低级烷氧基，在自由基的形式 或其盐，展示抗过敏，抗炎，抗氧化和抗高血压活性。