公开(公告)号：US4876354A

公开(公告)日：1989-10-24

申请号：US191756

申请日：1988-05-03

申请人： Herbert Siegel ,  Klaus-Dieter Kampe ,  Hans G. Alpermann ,  Hermann J. Gerhards ,  Patricia Usinger ,  Ulrich Schacht ,  Margret Leven ,  Wolfgang Raether ,  Walter Dittmar ,  Burkhard Sachse

发明人： Herbert Siegel ,  Klaus-Dieter Kampe ,  Hans G. Alpermann ,  Hermann J. Gerhards ,  Patricia Usinger ,  Ulrich Schacht ,  Margret Leven ,  Wolfgang Raether ,  Walter Dittmar ,  Burkhard Sachse

IPC分类号： A61K31/41 ,  A61K31/415 ,  C07D233/60 ,  C07D233/64 ,  C07D249/08 ,  C07D521/00

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： Arylmethylazoles of the formula I ##STR1## in which Aryl is (substituted) phenyl or naphthyl;Z is CH or N;R.sup.1 and Q are H or alkyl;R.sup.2 is H, alk(en)yl or alkynyl;R.sup.3 and R.sup.4 are H, alkyl or other hydrocarbons; orR.sup.3 and R.sup.4 together are a --(CH.sub.2).sub.2-11 chain or a bridged --(CH.sub.2).sub.4-5 chain, and their acid addition salts, stereoisomers and optically active enantiomers possess outstanding antimycotic and antidepressant activity.They are obtained, inter alia, from arylmethylazoles II ##STR2## which are reacted with a strong base and then with a carbonyl compound III O.dbd.CR.sup.3 R.sup.4 ; thereafter, the product is reacted with the protic acid or with an alkyl halide IV R.sup.2 Hal.If desired, the products are converted to the acid addition salts, or the stereoisomers or optically active enantiomers are resolved.

摘要翻译： 芳基甲基唑，其中芳基是（取代的）苯基或萘基; Z是CH或N; R1和Q是H或烷基; R2是H，烷（烯）基或炔基; R3和R4是H，烷基或其他烃; 或R 3和R 4一起是 - （CH 2）2-11链或桥连 - （CH 2）4-5链，并且它们的酸加成盐，立体异构体和旋光对映异构体具有突出的抗真菌和抗抑郁活性。 它们特别由芳基甲基唑II II获得，它们与强碱反应，然后与羰基化合物III = CR 3 R 4反应; 此后，产物与质子酸或烷基卤IVR 2 Hal反应。 如果需要，将产物转化成酸加成盐，或者立体异构体或光学活性对映体被分解。

公开(公告)号：US5100890A

公开(公告)日：1992-03-31

申请号：US411256

申请日：1989-09-25

申请人： Herbert Siegel ,  Klaus-Dieter Kampe ,  Hans-Georg Alpermann ,  Hermann J. Gerhards ,  Patricia Usinger ,  Ulrich Schacht ,  Margret Leven ,  Wolfgang Raether ,  Walter Dittmar ,  Burkhard Sachse

发明人： Herbert Siegel ,  Klaus-Dieter Kampe ,  Hans-Georg Alpermann ,  Hermann J. Gerhards ,  Patricia Usinger ,  Ulrich Schacht ,  Margret Leven ,  Wolfgang Raether ,  Walter Dittmar ,  Burkhard Sachse

IPC分类号： A61K31/41 ,  A61K31/415 ,  C07D233/60 ,  C07D233/64 ,  C07D249/08 ,  C07D521/00

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： Arylmethylazoles of the formula I ##STR1## in which Aryl is (substituted) phenyl or naphthyl;Z is CH or N;R.sup.1 and Q are H or alkyl;R.sup.2 is H, alk(en)yl or alkynyl;R.sup.3 and R.sup.4 are H, alkyl or other hydrocarbons; orR.sup.3 and R.sup.4 together are a--(CH.sub.2).sub.2-11 chain or a bridged--(CH.sub.2).sub.4-5 chain,and their acid addition salts, stereoisomers and optically active enantiomers possess outstanding antimycotic and antidepressant activity.They are obtained, inter alia, from arylmethylazoles II ##STR2## which are reacted with a strong base and then with a carbonyl compound III O.dbd.CR.sup.3 R.sup.4 ; thereafter, the product is reacted with the protic acid or with an alkyl halide IV R.sup.2 Hal.If desired, the products are converted to the acid addition salts, or the stereoisomers or optically active enantiomes are resolved.

公开(公告)号：US5023357A

公开(公告)日：1991-06-11

申请号：US411045

申请日：1989-09-21

申请人： Herbert Siegel ,  Klaus-Dieter Kampe ,  Hans-Georg Alpermann ,  Hermann J. Gerhards ,  Patricia Usinger ,  Ulrich Schacht ,  Margret Leven ,  Wolfgang Raether ,  Walter Dittmar ,  Burkhard Sachse

发明人： Herbert Siegel ,  Klaus-Dieter Kampe ,  Hans-Georg Alpermann ,  Hermann J. Gerhards ,  Patricia Usinger ,  Ulrich Schacht ,  Margret Leven ,  Wolfgang Raether ,  Walter Dittmar ,  Burkhard Sachse

IPC分类号： A61K31/41 ,  A61K31/415 ,  C07D233/60 ,  C07D233/64 ,  C07D249/08 ,  C07D521/00

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： Arylmethylazoles of the formula I ##STR1## in which Aryl is (substituted) phenyl or naphthyl;Z is CH or N;R.sup.1 and Q are H or alkyl;R.sup.2 is H, alk(en)yl or alkynyl;R.sup.3 l and R.sup.4 are H, alkyl or other hydrocarbons; orR.sup.3 and R.sup.4 together are a --(CH.sub.2).sub.2-11 chain or a bridged --(CH.sub.2).sub.4-5 chain,and their acid addition salts, stereoisomers and optically active enantiomers possess outstanding antimycotic and antidepressant activity.They are obtained, inter alia, from arylmethylazoles II ##STR2## which are reacted with a strong base and then with a carbonyl compound III 0=CR.sup.3 R.sup.4 ; thereafter, the product is reacted with the protic acid or with an alkyl halide IV R.sup.2 Hal.If desired, the products are converted to the acid addition salts, or the stereoisomers or optically active enantiomers are resolved.

公开(公告)号：US08681848B2

公开(公告)日：2014-03-25

申请号：US13284690

申请日：2011-10-28

申请人： Yaqi Hu ,  Yanli Fan ,  Huawen Jin ,  Ulrich Schacht ,  Karl Muth ,  Mark W. Morgan

发明人： Yaqi Hu ,  Yanli Fan ,  Huawen Jin ,  Ulrich Schacht ,  Karl Muth ,  Mark W. Morgan

IPC分类号： H03H7/30 ,  H03H7/40 ,  H03K5/159

CPC分类号： H04L27/01

摘要： An apparatus for equalizing channels is provided, which is generally transparent to link training. The apparatus generally includes equalization paths formed by an input circuit, a crossbar, and an output circuit and a controller. Each equalization path is coupled to at least one of the channels, and a controller has a VGA loop, a crossbar loop, and a driver loop. The AGC loop receives a first reference voltage and provides a gain control signal to the input circuit, and the gain control network comprises a replica of at least one of the equalization paths. The crossbar loop receives a second reference voltage and provides a crossbar control signal to the crossbar. The driver loop receives a third reference voltage and provides a driver control signal for the output circuit.

摘要翻译： 提供了用于均衡通道的装置，其对于链接训练通常是透明的。 该装置通常包括由输入电路，交叉开关和输出电路以及控制器形成的均衡路径。 每个均衡路径耦合到至少一个通道，并且控制器具有VGA环路，交叉开环和驱动器环路。 AGC环路接收第一参考电压并向输入电路提供增益控制信号，并且增益控制网络包括至少一个均衡路径的副本。 交叉开环接收第二参考电压，并向横杆提供交叉开关控制信号。 驱动器回路接收第三参考电压并为输出电路提供驱动器控制信号。

公开(公告)号：US20130107933A1

公开(公告)日：2013-05-02

申请号：US13284690

申请日：2011-10-28

申请人： Yaqi Hu ,  Yanli Fan ,  Huawen Jin ,  Ulrich Schacht ,  Karl Muth ,  Mark W. Morgan

发明人： Yaqi Hu ,  Yanli Fan ,  Huawen Jin ,  Ulrich Schacht ,  Karl Muth ,  Mark W. Morgan

IPC分类号： H03H7/40 ,  H03F3/68 ,  H03F3/45

CPC分类号： H04L27/01

摘要： An apparatus for equalizing channels is provided, which is generally transparent to link training. The apparatus generally includes equalization paths formed by an input circuit, a crossbar, and an output circuit and a controller. Each equalization path is coupled to at least one of the channels, and a controller has a VGA loop, a crossbar loop, and a driver loop. The AGC loop receives a first reference voltage and provides a gain control signal to the input circuit, and the gain control network comprises a replica of at least one of the equalization paths. The crossbar loop receives a second reference voltage and provides a crossbar control signal to the crossbar. The driver loop receives a third reference voltage and provides a driver control signal for the output circuit.

摘要翻译： 提供了用于均衡通道的装置，其对于链接训练通常是透明的。 该装置通常包括由输入电路，交叉开关和输出电路以及控制器形成的均衡路径。 每个均衡路径耦合到至少一个通道，并且控制器具有VGA环路，交叉开环和驱动器环路。 AGC环路接收第一参考电压并向输入电路提供增益控制信号，并且增益控制网络包括至少一个均衡路径的副本。 交叉开环接收第二参考电压，并向横杆提供交叉开关控制信号。 驱动器回路接收第三参考电压并为输出电路提供驱动器控制信号。

公开(公告)号：US4185105A

公开(公告)日：1980-01-22

申请号：US910781

申请日：1978-05-30

申请人： Karl Schmitt ,  Irmgard Hoffmann ,  Ulrich Schacht

发明人： Karl Schmitt ,  Irmgard Hoffmann ,  Ulrich Schacht

IPC分类号： C07D217/18 ,  A61K31/47 ,  A61K31/472 ,  A61P25/24 ,  A61P25/26 ,  C07D217/04 ,  C07D217/02

CPC分类号： C07D217/04

摘要： 4-Phenyl-8-amino-tetrahydroisoquinolines of the formula ##STR1## in which R.sub.1 stands for bromine and R.sub.2 stands for hydrogen or both R.sub.1 and R.sub.2 represent chlorine, and their salts with physiologically tolerated acids, pharmaceutical preparations prepared therefrom, process for the manufacture of these preparations and their use for the treatment of depressive conditions.

摘要翻译： 式“IMAGE”的4-苯基-8-氨基 - 四氢异喹啉，其中R1代表溴，R2代表氢，R2和R2代表氯，它们与生理上耐受的酸的盐，由其制备的药物制剂用于 制备这些制剂及其用于治疗抑郁症状的用途。

公开(公告)号：US5173498A

公开(公告)日：1992-12-22

申请号：US680255

申请日：1991-04-04

申请人： Gerhard Beck ,  Ulrich Schacht ,  Kurt Kebeler ,  Ernold Granzer

发明人： Gerhard Beck ,  Ulrich Schacht ,  Kurt Kebeler ,  Ernold Granzer

IPC分类号： A61K31/35 ,  A61K31/352 ,  A61P3/06 ,  A61P9/10 ,  A61P31/00 ,  C07D211/20 ,  C07D311/30

CPC分类号： C07D311/30

摘要： Substituted 3-thia- and 3-oxa-alkylflavones of formula I ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4 X, m and n have the indicated meanings, a process for the preparation of these compounds and their use as medicaments and pharmaceutical preparations are described. In addition, new intermediates for the preparation of the compounds of formula I are described.

摘要翻译： 式I的取代的3-硫杂和3-氧杂 - 烷基黄酮其中R，R 1，R 2，R 3，R 4 + L，X，m和n具有指定的含义，制备这些化合物的方法和 描述了它们作为药物和药物制剂的用途。 另外，描述了用于制备式I化合物的新中间体。