公开(公告)号：US20240082839A1

公开(公告)日：2024-03-14

申请号：US18272792

申请日：2021-01-22

申请人： Hewlett-Packard Development Company, L.P.

发明人： Carson DENISON ,  Erik D. TORNIAINEN ,  Richard W. SEAVER ,  Pavel KORNILOVICH ,  Alexander GOVYADINOV ,  Anand Samuel JEBAKUMAR

IPC分类号： B01L3/00

CPC分类号： B01L3/502746 ,  B01L2200/0642 ,  B01L2200/0684 ,  B01L2300/0848 ,  B01L2300/0874 ,  B01L2400/086

摘要： A microfluidic device includes a chamber having sidewalls, a floor, a ceiling, and an inlet. The microfluidic device includes pillars extending from the floor to the ceiling of the chamber. Each pillar has an orientation relative to the inlet defined by a leading surface and a trailing corner opposite the leading corner. The trailing corner has an angle less than a threshold angle that is based on a fluidic contact angle. The orientations of the pillars relative to the inlet promote fluid flow from the inlet throughout the chamber without trapping gas at the sidewalls of the chamber.

公开(公告)号：US20230330675A1

公开(公告)日：2023-10-19

申请号：US17721724

申请日：2022-04-15

申请人： Hewlett-Packard Development Company, L.P.

发明人： Oumnia El Fajri ,  Richard W. SEAVER ,  Erik D. TORNIAINEN ,  Anand Samuel JEBAKUMAR ,  Pavel KORNILOVICH ,  Alexander GOVYADINOV ,  Carson DENISON

IPC分类号： B01L3/00

CPC分类号： B01L3/502784 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0406

摘要： An example microfluidic structure can include a first microfluidic channel segment in a first elevation plane, a second microfluidic channel segment in a second elevation plane, and a transverse microfluidic channel segment connecting the first microfluidic channel segment to the second microfluidic channel segment. An interior pillar can be positioned at the transverse microfluidic channel segment. The interior pillar can have a tapered downstream edge. The tapered downstream edge can be angled in the first or second elevation plane at an acute angle. A fluid cross-sectional area can increase in the fluid flow direction along the tapered downstream edge.

公开(公告)号：US20230330673A1

公开(公告)日：2023-10-19

申请号：US17721650

申请日：2022-04-15

申请人： Hewlett-Packard Development Company, L.P.

发明人： Oumnia El Fajri ,  Richard W. SEAVER ,  Erik D. TORNIAINEN ,  Anand Samuel JEBAKUMAR ,  Pavel KORNILOVICH ,  Alexander GOVYADINOV ,  Carson DENISON

IPC分类号： B01L3/00

CPC分类号： B01L3/502753 ,  B01L3/50273 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2400/0406 ,  B01L2300/12

摘要： An example microfluidic structure can include a first microfluidic channel segment in a first elevation plane, a second microfluidic channel segment in a second elevation plane, and a transverse microfluidic channel segment connecting the first microfluidic channel segment to the second microfluidic channel segment. An angled exterior wall segment can be at the transverse microfluidic channel segment. The angled exterior wall segment can be angled in the first or second elevation plane at an acute angle with respect to a direction of fluid flow through the first or second microfluidic channel segment. A fluid cross-sectional area can increase in the fluid flow direction along the angled exterior wall segment.

公开(公告)号：US20240181449A1

公开(公告)日：2024-06-06

申请号：US18550286

申请日：2021-04-06

申请人： Hewlett-Packard Development Company, L.P.

发明人： Carson DENISON ,  Pavel KORNILOVICH ,  Richard W. SEAVER ,  Anand Samuel JEBAKUMAR ,  Erik D. TORNIANEN ,  Alexander GOVYADINOV

IPC分类号： B01L3/00

CPC分类号： B01L3/502715 ,  B01L2300/0864 ,  B01L2300/161 ,  B01L2400/0406

摘要： A microfluidic device includes a first channel, second channels, and a transition channel splitting the first channel into the second channels. The transition has a first end fluidically connected to the first channel and a second end fluidically connected to the second channels. The transition channel expands in width from a width of the first channel at the first end to no less than a sum of widths of the second channels at the second end so as to promote fluid flow from the first channel to the second channels.

公开(公告)号：US20240165617A1

公开(公告)日：2024-05-23

申请号：US18550353

申请日：2021-04-06

申请人： Hewlett-Packard Development Company, L.P.

发明人： Erik D. TORNIANEN ,  Carson DENISON ,  Richard W. SEAVER ,  Anand Samuel JEBAKUMAR ,  Pavel KORNILOVICH ,  Alexander GOVYADINOV

IPC分类号： B01L3/00

CPC分类号： B01L3/50273 ,  B01L2300/0877 ,  B01L2400/0406

摘要： A microfluidic device includes a first channel having a first width and a second channel having a second width greater than the first width. The microfluidic device includes a transition channel having a first end fluidically connected to the first channel and a second end fluidically connected to the second channel. The transition channel expands in width from the first width to the second width so as to promote fluid flow from the first channel to the second channel.

公开(公告)号：US20230131184A1

公开(公告)日：2023-04-27

申请号：US17912189

申请日：2020-03-30

申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

发明人： Carson DENISON ,  Erik TORNIAINEN ,  Richard SEAVER

IPC分类号： B01L7/00 ,  C12Q1/686

摘要： Intermittent warming of a biologic sample including a nucleic acid includes receiving at a first end of a channel of a microfluidic device, a biologic sample including a nucleic acid, and warming a subset of a plurality of heating elements disposed adjacent to the channel. The method includes warming the heating elements to a particular temperature of a particular warming and cooling protocol. The method includes moving the biologic sample from the first end of the channel to a second end of the channel opposite the first end at a particular flow rate associated with the warming and cooling protocol, and intermittently warming the biologic sample using the subset of heating elements while the biologic sample moves from the first end of the channel to the second end of the channel.