公开(公告)号：US06458946B1

公开(公告)日：2002-10-01

申请号：US09582642

申请日：2000-07-28

申请人： Hideaki Maeda ,  Toshio Yamada ,  Hiroshi Sato ,  Yutaka Noda

发明人： Hideaki Maeda ,  Toshio Yamada ,  Hiroshi Sato ,  Yutaka Noda

IPC分类号： C07H1904

CPC分类号： C07H19/10 ,  C07H21/02

摘要： The invention provides crystals of p1,P4-di(uridine 5′-) tetraphosphate or a salt thereof; a process for producing the crystals; and a process for producing P1,P4-di(uridine 5′-) tetraphosphate (U2P4) or a salt thereof from UMP serving as a starting material and by use of DPC and PPi, which process comprises at least one of the following treatment steps: (a) adding UMP diphenylphosphate (UMP-DPP) in divided portions during a step of reaction of UMP-DPP with a PPi-organic alkali salt; (b) carrying out reaction of UMP-DPP with a PPi-organic alkali salt in the presence of a base; and (c) further treating the synthesized U2P4 with an alkali. The crystals of U2P4 or a salt thereof obtained through the process according to the invention have high purity and stability and a less hygroscopicity as compared with a lyophilized product, to thereby serve as a useful raw material for preparing a pharmaceutical. The process for producing U2P4 or a salt thereof according to the invention realizes high yield and enables large-scale synthesis.

摘要翻译： 本发明提供了p1，P4-二（尿苷5'-）四磷酸盐或其盐的晶体; 制造晶体的方法; 以及由作为起始原料的UMP生产P1，P4-二（尿苷5'-）四磷酸（U2P4）或其盐的方法，并且使用DPC和PPi，该方法包括以下处理步骤中的至少一个 ：（a）在UMP-DPP与PPi-有机碱盐反应的步骤期间，分份加入UMP二苯基磷酸酯（UMP-DPP）; （b）在碱的存在下进行UMP-DPP与PPi-有机碱盐的反应; 和（c）用碱进一步处理合成的U2P4。 通过本发明的方法获得的U2P4或其盐的结晶与冻干产品相比具有高纯度和稳定性以及较少的吸湿性，从而用作制备药物的有用原料。 根据本发明的制备U2P4或其盐的方法实现高产率并且能够进行大规模合成。

公开(公告)号：US06780988B2

公开(公告)日：2004-08-24

申请号：US10120367

申请日：2002-04-12

申请人： Hideaki Maeda ,  Toshio Yamada ,  Hiroshi Sato ,  Yutaka Noda

发明人： Hideaki Maeda ,  Toshio Yamada ,  Hiroshi Sato ,  Yutaka Noda

IPC分类号： C07H2102

CPC分类号： C07H19/10 ,  C07H21/02

摘要： The invention describes a process for producing P1,P4-di(uridine-5′-)tetraphosphate (U2P4) or a salt thereof from uridine 5′-monophosphate (UMP); wherein the process comprises at least one of the steps (a) and (b): (a) adding UMP diphenylphosphate (UMP-DPP) in divided portions during a step of reacting UMP-DPP with an organic alkali salt of pyrophosphate (PP1) to produce a reaction mixture; wherein at least one equivalent of a first base is present during one portion of the reaction; (b) reacting UMP-DPP with a PPi-organic alkali salt in the presence of at least one equivalent of a second base to produce a reaction mixture, wherein the first base and the second base may be the same or different; (c) subsequently adding water to the reaction mixture to produce an aqueous reaction mixture; and optionally (d) adding an alkali to the aqueous reaction mixture.

摘要翻译： 本发明描述了从尿苷5'-单磷酸（UMP）生产P 1，P 4 - 二（尿苷-5' - ）四磷酸（U2P4）或其盐的方法; 其中所述方法包括步骤（a）和（b）中的至少一个步骤：（a）在使UMP-DPP与焦磷酸酯（PP1）的有机碱金属盐反应的步骤期间，分开加入UMP二苯基磷酸酯（UMP-DPP） 以产生反应混合物; 其中在反应的一部分期间存在至少一当量的第一碱基; （b）在至少一当量的第二碱的存在下使UMP-DPP与PPi-有机碱金属盐反应以产生反应混合物，其中第一碱和第二碱可以相同或不同; （c）随后向反应混合物中加入水以产生水性反应混合物; 和（d）向反应混合物中加入碱。

公开(公告)号：US06617444B1

公开(公告)日：2003-09-09

申请号：US09700728

申请日：2000-11-30

申请人： Kenya Mori ,  Takanori Miyashita ,  Hideaki Maeda ,  Hiroshi Sato ,  Yutaka Noda

发明人： Kenya Mori ,  Takanori Miyashita ,  Hideaki Maeda ,  Hiroshi Sato ,  Yutaka Noda

IPC分类号： C07H1910

CPC分类号： C07H21/00 ,  C07H1/06

摘要： The present invention is directed to crystals of P1-(2′-deoxycytidine 5′-)P4-(uridine 5′-)tetraphosphate (dCP4U) or a salt thereof and to a process for producing the crystals. The present invention also provides a process for producing dCP4U involving reacting uridine 5′-monophosphate (UMP), 2′-deoxycytidine 5′-monophosphate (dCMP), diphenyl phosphorochloridate (DPC), and pyrophosphate (PPi). The crystals of dCP4U obtained through the process according to the present invention have high purity and high stability and no hygroscopicity as compared with a freeze-dried product, and thereby serve as a useful raw material for preparing a pharmaceutical. The process for producing dCP4U according to the present invention permits use of inexpensive UMP as a raw material and realizes high yield. Thus, the process is suitable for large-scale synthesis of dCP4U.

摘要翻译： 本发明涉及P1-（2'-脱氧胞苷5' - ）P4-（尿苷5' - ）四磷酸（dCP4U）或其盐的晶体和晶体的制造方法。 本发明还提供一种生产dCP4U的方法，其涉及使尿苷5'-单磷酸（UMP），2'-脱氧胞苷5'-单磷酸（dCMP），二苯基氯代磷酸酯（DPC）和焦磷酸酯（PPi）反应。 通过本发明的方法获得的dCP4U的结晶与冷冻干燥产物相比具有高纯度和高稳定性和无吸湿性，从而用作制备药物的有用原料。 根据本发明的制备dCP4U的方法允许使用廉价的UMP作为原料，并且实现高产率。 因此，该方法适用于大规模合成dCP4U。

公开(公告)号：US08717708B2

公开(公告)日：2014-05-06

申请号：US12315523

申请日：2008-12-03

申请人： Mao Nishiyama ,  Shuji Nishida ,  Hideaki Maeda ,  Masafumi Mochizuki

发明人： Mao Nishiyama ,  Shuji Nishida ,  Hideaki Maeda ,  Masafumi Mochizuki

IPC分类号： G11B5/127

CPC分类号： G11B5/3166 ,  G11B5/1278 ,  G11B5/3116 ,  G11B5/315 ,  G11B5/3169 ,  Y10T428/1171 ,  Y10T428/1193

摘要： Embodiments of the present invention provide a magnetic head for perpendicular magnetic recording, and a magnetic disk apparatus capable of preventing data erasure caused by alignment marks. In an embodiment, the magnetic head includes a head element including at least a main pole having a pole face on a flying surface and an auxiliary pole; alignment marks made of a magnetic material and used to detect the amount of lapping work when lapping the pole face of the main pole; and members made of a magnetic material, continuously extending in either direction with respect to the position of the main pole from within the alignment marks outward at least beyond the alignment marks.

摘要翻译： 本发明的实施例提供一种用于垂直磁记录的磁头，以及能够防止由对准标记引起的数据擦除的磁盘装置。 在一个实施例中，磁头包括头元件，头元件至少包括在飞行表面上具有极面的主极和辅助极; 由磁性材料制成的对准标记，用于在研磨主极的极面时检测研磨作业的数量; 以及由磁性材料制成的构件，其在相对于主极的位置的任一方向上从对准标记内部至少超过对准标记向外延伸。

公开(公告)号：US08107180B2

公开(公告)日：2012-01-31

申请号：US12505085

申请日：2009-07-17

申请人： Shuji Nishida ,  Yasutaka Nishida ,  Masafumi Mochizuki ,  Hideaki Maeda

发明人： Shuji Nishida ,  Yasutaka Nishida ,  Masafumi Mochizuki ,  Hideaki Maeda

IPC分类号： G11B5/09 ,  G11B27/36

CPC分类号： G11B5/09 ,  B82Y10/00 ,  G11B5/59616 ,  G11B5/743 ,  G11B20/10009 ,  G11B20/10435 ,  G11B20/1879 ,  G11B2220/2516 ,  G11B2220/252

摘要： A hard-disk drive. The hard-disk drive includes a magnetic-recording disk including tracks on which a plurality of patterned bit-cells that are isolated magnetically are aligned at predetermined alignment pitches. The hard-disk drive includes a magnetic-recording head which is configured to follow tracks, and to write and to read data. The hard-disk drive includes a signal-processing unit which is configured to generate a recording signal based on a write-clock signal with cycles corresponding to alignment pitches of patterned bit-cells, and to output a recording signal. The hard-disk drive includes a phase-detecting unit which is configured to detect a phase of the write-clock signal when the magnetic-recording head reaches an end point of a predetermined range. The hard disk drive includes a determination-processing unit which is configured to determine success of data writing based on a difference between an expected value and a detected value of the phase of the write-clock signal.

摘要翻译： 硬盘驱动器。 硬盘驱动器包括磁记录盘，磁盘包括轨道，磁道上分离出多个图案化的位单元，以预定的对准间距排列。 硬盘驱动器包括磁记录头，其被配置为跟随轨道，并且写入和读取数据。 硬盘驱动器包括信号处理单元，其被配置为基于具有对应于图案化位单元的对准间距的周期的写时钟信号产生记录信号，并输出记录信号。 硬盘驱动器包括相位检测单元，其被配置为当磁记录头达到预定范围的终点时检测写时钟信号的相位。 硬盘驱动器包括确定处理单元，其被配置为基于期望值和写入时钟信号的相位的检测值之间的差来确定数据写入的成功。

公开(公告)号：US07927745B2

公开(公告)日：2011-04-19

申请号：US12004102

申请日：2007-12-20

申请人： Tetsuo Tokita ,  Hideaki Maeda ,  Naoya Kobayashi ,  Sung-Soo Kim

发明人： Tetsuo Tokita ,  Hideaki Maeda ,  Naoya Kobayashi ,  Sung-Soo Kim

IPC分类号： H01M4/58 ,  H01M4/48 ,  H01M10/52

CPC分类号： H01M4/131 ,  H01M4/485 ,  H01M10/0525 ,  H01M10/4235

摘要： A negative electrode for a rechargeable lithium battery includes a current collector and a negative active mass disposed on the current collector. The negative active mass includes a negative active material including a lithium vanadium composite oxide and a crystalline structure aid for inhibiting deterioration of a crystalline structure. The negative active material can inhibit an irreversible crystalline structure change during charge and discharge, and does not incur decomposition of an electrolyte resulting in improvement of a cycle-life of a rechargeable lithium battery.

摘要翻译： 用于可再充电锂电池的负极包括设置在集电器上的集电器和负极活性物质。 负极活性物质包括负极活性物质，其包括锂钒复合氧化物和用于抑制晶体结构劣化的晶体结构助剂。 负极活性物质可以抑制充放电期间的不可逆晶体结构变化，不会导致电解质分解，导致可再充电锂电池的循环寿命提高。

公开(公告)号：US07747336B2

公开(公告)日：2010-06-29

申请号：US11902201

申请日：2007-09-19

申请人： Hideaki Maeda ,  Shinya Nakamura ,  Akira Horiuchi

发明人： Hideaki Maeda ,  Shinya Nakamura ,  Akira Horiuchi

IPC分类号： G05B19/4093

CPC分类号： G05B19/40937 ,  G05B2219/36263 ,  G05B2219/45136 ,  G05B2219/49226 ,  Y02P90/265 ,  Y10T409/303808

摘要： One element is taken from a machined shape. When the element is a straight line element, whether or not the distance D between the start point and the end point of the element in a direction orthogonal to the axis of rotation of the workpiece is equal to or greater than a preset value Ds is determined. In addition, whether or not an angle A that the straight line element makes with the Z-axis is equal to or greater than a preset angle Aa is determined. When the distance D is equal to or greater than the preset value Ds and the angle A is equal to or greater than the preset angle Aa, a program is created with the cutting direction reversed from the profile direction.

摘要翻译： 一个元素取自加工形状。 当元件是直线元件时，确定元件在与工件的旋转轴线正交的方向上的起始点和终点之间的距离D是否等于或大于预设值Ds 。 此外，确定直线元件与Z轴形成的角度A是否等于或大于预设角度Aa。 当距离D等于或大于预设值Ds并且角度A等于或大于预设角度Aa时，产生具有与轮廓方向相反的切割方向的程序。

公开(公告)号：US07486485B2

公开(公告)日：2009-02-03

申请号：US11262531

申请日：2005-10-28

申请人： Takehiko Hamaguchi ,  Yoshihisa Kamo ,  Hideaki Maeda ,  Yukiya Shimizu ,  Ikuya Tagawa ,  Tetsuo Yuki

发明人： Takehiko Hamaguchi ,  Yoshihisa Kamo ,  Hideaki Maeda ,  Yukiya Shimizu ,  Ikuya Tagawa ,  Tetsuo Yuki

IPC分类号： G11B5/127

CPC分类号： G11B5/3143 ,  G11B5/11 ,  G11B5/1278

摘要： Embodiments of the invention prevent a decrease in magnetization or demagnetization from occurring to recording magnetization regardless of a direction in which a stray field is applied. In one embodiment, an apparatus for data storage system comprises a head having a magnetic field shield in the vicinity of a main pole, and a cover of the device, using a constituent material with a magnetic field shielding effect, across the cover, or at part thereof. When a stray field in a direction perpendicular to a recording medium is applied, the effect of the magnetic field is alleviated by the magnetic field shield installed in the vicinity of the main pole. In such a case, it need only be sufficient to form the magnetic field shield in a shape optimum for removing the stray field in the perpendicular direction only. When a stray field in a direction horizontal in relation to the recording medium is applied, the magnetic field acting on the recording medium is removed by the cover of the device comprising a magnetic component.

摘要翻译： 本发明的实施例不管施加杂散场的方向如何，都防止磁化或退磁的发生发生到记录磁化。 在一个实施例中，一种用于数据存储系统的装置包括在主极附近具有磁场屏蔽的头部，以及使用具有磁场屏蔽效应的组成材料穿过该盖的装置的盖，或者在 的一部分。 当施加与记录介质垂直的方向上的杂散场时，通过安装在主极附近的磁场屏蔽来减轻磁场的影响。 在这种情况下，只需要使磁场屏蔽形成为仅在垂直方向上去除杂散场的最佳形状。 当施加相对于记录介质的水平方向的杂散场时，作用在记录介质上的磁场被包括磁性部件的装置的盖子去除。

公开(公告)号：US20090023070A1

公开(公告)日：2009-01-22

申请号：US12216467

申请日：2008-07-03

申请人： Tetsuo Tokita ,  Hideaki Maeda ,  Naoya Kobayashi ,  Sung-Soo Kim

发明人： Tetsuo Tokita ,  Hideaki Maeda ,  Naoya Kobayashi ,  Sung-Soo Kim

IPC分类号： H01M4/58 ,  C01G31/02

CPC分类号： H01M4/485 ,  C01G31/00 ,  C01G31/006 ,  C01P2002/74 ,  C01P2002/88 ,  Y10T29/49108

摘要： The method of preparing a negative active material for a non-aqueous electrolyte rechargeable battery includes mixing a vanadium compound and a lithium compound and then subjecting the mixture to first firing to obtain Li1.0(VxMy)1.0O2 having a layered halite type structure (where 0.5≦x≦1.0, 0≦y≦0.5, x+y=1, and M is selected from the group consisting of group 2 to 15 elements of the periodic table and combinations thereof); and adding a lithium compound to the Li1.0(VxMy)1.0O2 and then subjecting the resultant to second firing. The negative active material for a non-aqueous electrolyte rechargeable battery prepared according to the preparing method has high crystallinity, excellent charge and discharge characteristics at a high rate, and excellent charge and discharge cycle characteristics.

摘要翻译： 制备非水电解质可再充电电池用负极活性物质的方法包括混合钒化合物和锂化合物，然后对混合物进行首次烧成，得到具有层状卤化物型结构的Li1.0（VxMy）1.0O2（ 其中0.5 <= x <= 1.0,0 <= y <= 0.5，x + y = 1，M选自元素周期表第2至15族元素及其组合）; 并向Li1.0（VxMy）1.0O2中加入锂化合物，然后对所得物进行第二次烧制。 根据制备方法制备的非水电解质可再充电电池的负极活性材料具有高结晶度，高速率优异的充放电特性，以及良好的充放电循环特性。

公开(公告)号：US20080241688A1

公开(公告)日：2008-10-02

申请号：US12004102

申请日：2007-12-20

申请人： Tetsuo Tokita ,  Hideaki Maeda ,  Naoya Kobayashi ,  Sung-Soo Kim

发明人： Tetsuo Tokita ,  Hideaki Maeda ,  Naoya Kobayashi ,  Sung-Soo Kim

IPC分类号： H01M4/40 ,  H01M4/58 ,  H01M4/52

CPC分类号： H01M4/131 ,  H01M4/485 ,  H01M10/0525 ,  H01M10/4235

摘要： A negative electrode for a rechargeable lithium battery includes a current collector and a negative active mass disposed on the current collector. The negative active mass includes a negative active material including a lithium vanadium composite oxide and a crystalline structure aid for inhibiting deterioration of a crystalline structure. The negative active material can inhibit an irreversible crystalline structure change during charge and discharge, and does not incur decomposition of an electrolyte resulting in improvement of a cycle-life of a rechargeable lithium battery.

摘要翻译： 用于可再充电锂电池的负极包括设置在集电器上的集电器和负极活性物质。 负极活性物质包括负极活性物质，其包括锂钒复合氧化物和用于抑制晶体结构劣化的晶体结构助剂。 负极活性物质可以抑制充放电期间的不可逆晶体结构变化，不会导致电解质分解，导致可再充电锂电池的循环寿命提高。