Crystals of diuridine tetraphosphate or salt thereof, process for producing the crystals, and process for producing the compounds
    1.
    发明授权
    Crystals of diuridine tetraphosphate or salt thereof, process for producing the crystals, and process for producing the compounds 有权
    二氢吖啶四磷酸的晶体或其盐,晶体的制造方法,以及该化合物的制造方法

    公开(公告)号:US06458946B1

    公开(公告)日:2002-10-01

    申请号:US09582642

    申请日:2000-07-28

    IPC分类号: C07H1904

    CPC分类号: C07H19/10 C07H21/02

    摘要: The invention provides crystals of p1,P4-di(uridine 5′-) tetraphosphate or a salt thereof; a process for producing the crystals; and a process for producing P1,P4-di(uridine 5′-) tetraphosphate (U2P4) or a salt thereof from UMP serving as a starting material and by use of DPC and PPi, which process comprises at least one of the following treatment steps: (a) adding UMP diphenylphosphate (UMP-DPP) in divided portions during a step of reaction of UMP-DPP with a PPi-organic alkali salt; (b) carrying out reaction of UMP-DPP with a PPi-organic alkali salt in the presence of a base; and (c) further treating the synthesized U2P4 with an alkali. The crystals of U2P4 or a salt thereof obtained through the process according to the invention have high purity and stability and a less hygroscopicity as compared with a lyophilized product, to thereby serve as a useful raw material for preparing a pharmaceutical. The process for producing U2P4 or a salt thereof according to the invention realizes high yield and enables large-scale synthesis.

    摘要翻译: 本发明提供了p1,P4-二(尿苷5'-)四磷酸盐或其盐的晶体; 制造晶体的方法; 以及由作为起始原料的UMP生产P1,P4-二(尿苷5'-)四磷酸(U2P4)或其盐的方法,并且使用DPC和PPi,该方法包括以下处理步骤中的至少一个 :(a)在UMP-DPP与PPi-有机碱盐反应的步骤期间,分份加入UMP二苯基磷酸酯(UMP-DPP); (b)在碱的存在下进行UMP-DPP与PPi-有机碱盐的反应; 和(c)用碱进一步处理合成的U2P4。 通过本发明的方法获得的U2P4或其盐的结晶与冻干产品相比具有高纯度和稳定性以及较少的吸湿性,从而用作制备药物的有用原料。 根据本发明的制备U2P4或其盐的方法实现高产率并且能够进行大规模合成。

    Processes for producing P1,P4-diuridine-5′-tetraphosphate
    2.
    发明授权
    Processes for producing P1,P4-diuridine-5′-tetraphosphate 有权
    生产P1,P4-尿嘧啶-5'-四磷酸的方法

    公开(公告)号:US06780988B2

    公开(公告)日:2004-08-24

    申请号:US10120367

    申请日:2002-04-12

    IPC分类号: C07H2102

    CPC分类号: C07H19/10 C07H21/02

    摘要: The invention describes a process for producing P1,P4-di(uridine-5′-)tetraphosphate (U2P4) or a salt thereof from uridine 5′-monophosphate (UMP); wherein the process comprises at least one of the steps (a) and (b): (a) adding UMP diphenylphosphate (UMP-DPP) in divided portions during a step of reacting UMP-DPP with an organic alkali salt of pyrophosphate (PP1) to produce a reaction mixture; wherein at least one equivalent of a first base is present during one portion of the reaction; (b) reacting UMP-DPP with a PPi-organic alkali salt in the presence of at least one equivalent of a second base to produce a reaction mixture, wherein the first base and the second base may be the same or different; (c) subsequently adding water to the reaction mixture to produce an aqueous reaction mixture; and optionally (d) adding an alkali to the aqueous reaction mixture.

    摘要翻译: 本发明描述了从尿苷5'-单磷酸(UMP)生产P 1,P 4 - 二(尿苷-5' - )四磷酸(U2P4)或其盐的方法; 其中所述方法包括步骤(a)和(b)中的至少一个步骤:(a)在使UMP-DPP与焦磷酸酯(PP1)的有机碱金属盐反应的步骤期间,分开加入UMP二苯基磷酸酯(UMP-DPP) 以产生反应混合物; 其中在反应的一部分期间存在至少一当量的第一碱基; (b)在至少一当量的第二碱的存在下使UMP-DPP与PPi-有机碱金属盐反应以产生反应混合物,其中第一碱和第二碱可以相同或不同; (c)随后向反应混合物中加入水以产生水性反应混合物; 和(d)向反应混合物中加入碱。

    Dinucleotide tetraphosphate crystals
    3.
    发明授权
    Dinucleotide tetraphosphate crystals 有权
    二核苷酸四磷酸晶体

    公开(公告)号:US06617444B1

    公开(公告)日:2003-09-09

    申请号:US09700728

    申请日:2000-11-30

    IPC分类号: C07H1910

    CPC分类号: C07H21/00 C07H1/06

    摘要: The present invention is directed to crystals of P1-(2′-deoxycytidine 5′-)P4-(uridine 5′-)tetraphosphate (dCP4U) or a salt thereof and to a process for producing the crystals. The present invention also provides a process for producing dCP4U involving reacting uridine 5′-monophosphate (UMP), 2′-deoxycytidine 5′-monophosphate (dCMP), diphenyl phosphorochloridate (DPC), and pyrophosphate (PPi). The crystals of dCP4U obtained through the process according to the present invention have high purity and high stability and no hygroscopicity as compared with a freeze-dried product, and thereby serve as a useful raw material for preparing a pharmaceutical. The process for producing dCP4U according to the present invention permits use of inexpensive UMP as a raw material and realizes high yield. Thus, the process is suitable for large-scale synthesis of dCP4U.

    摘要翻译: 本发明涉及P1-(2'-脱氧胞苷5' - )P4-(尿苷5' - )四磷酸(dCP4U)或其盐的晶体和晶体的制造方法。 本发明还提供一种生产dCP4U的方法,其涉及使尿苷5'-单磷酸(UMP),2'-脱氧胞苷5'-单磷酸(dCMP),二苯基氯代磷酸酯(DPC)和焦磷酸酯(PPi)反应。 通过本发明的方法获得的dCP4U的结晶与冷冻干燥产物相比具有高纯度和高稳定性和无吸湿性,从而用作制备药物的有用原料。 根据本发明的制备dCP4U的方法允许使用廉价的UMP作为原料,并且实现高产率。 因此,该方法适用于大规模合成dCP4U。

    Ball capturing apparatus, solder ball disposing apparatus, ball capturing method, and solder ball disposing method
    4.
    发明授权
    Ball capturing apparatus, solder ball disposing apparatus, ball capturing method, and solder ball disposing method 有权
    球捕获装置,焊球配置装置,球捕获方法和焊球配置方法

    公开(公告)号:US07717317B2

    公开(公告)日:2010-05-18

    申请号:US11864600

    申请日:2007-09-28

    IPC分类号: B23K31/02 B23K37/00

    摘要: The present invention relates to a ball capturing apparatus and method of capturing one ball from plural balls having the same size, and to a solder ball disposing apparatus and method of disposing a solder ball containing solder in a predetermined position on a circuit board, thereby reliably capturing one ball from the plural balls having the same size. The apparatus includes: a holding member 111 including a holding wall 111a air-tightly closing a space S that holds a plurality of balls B having the same size and in which a hole 1111 larger than a size of one ball and smaller than a size of two balls is formed in an upper part of the holding wall; blowup means 112 for blowing the balls B held in the holding member 111 upward; and capturing means 12 for capturing a ball B blown up by the blowup means 112 and reached the hole.

    摘要翻译: 本发明涉及一种从具有相同尺寸的多个球捕获一个球的球捕获装置和方法,以及一种焊球设置装置和将含有焊料的焊球放置在电路板上的预定位置的方法,从而可靠地 从具有相同尺寸的多个球捕获一个球。 该装置包括:保持构件111,其包括保持壁111a,气密地封闭保持具有相同尺寸的多个球B的空间S,并且其中具有比一个球的尺寸大的孔1111,并且小于 在保持壁的上部形成有两个球; 用于将保持在保持构件111中的球B向上吹的吹出装置112; 以及捕获装置12,用于捕获由喷射装置112吹起的球B并到达该孔。

    Electrically conductive paste and method of making the same
    6.
    发明申请
    Electrically conductive paste and method of making the same 审中-公开
    导电胶及其制作方法

    公开(公告)号:US20080102294A1

    公开(公告)日:2008-05-01

    申请号:US11790136

    申请日:2007-04-24

    摘要: Metallic powder particles disperse in paste matrix made of resin material. The metallic powder particles each defines a dissolved surface layer having reacted with acid solution. The metallic powder particles having reacted with acid solution is allowed to have a high electrical conductivity. The electrically conductive paste containing the mentioned metallic powder particles is also allowed to exhibit a sufficiently high electrical conductivity. The electrically conductive paste can thus be used for establishment of a fine wiring pattern and establishment of a wiring pattern for a high speed signal, for example. Moreover, the electrically conductive paste can easily be applied to a resin sheet in a predetermined pattern based on silk-screen printing, for example. The electrically conductive paste can be employed in various applications.

    摘要翻译: 金属粉末颗粒分散在由树脂材料制成的糊状基质中。 金属粉末颗粒各自限定了与酸溶液反应的溶解表面层。 与酸溶液反应的金属粉末颗粒被允许具有高导电性。 含有所述金属粉末颗粒的导电性糊料也可以表现出足够高的导电性。 因此,导电性糊剂可以用于建立精细布线图案,并且例如建立用于高速信号的布线图案。 此外,例如,导电性糊剂可以容易地以基于丝网印刷的预定图案施加到树脂片材上。 导电糊可用于各种应用。

    Thermal printer
    8.
    发明授权
    Thermal printer 失效
    热敏打印机

    公开(公告)号:US07456854B2

    公开(公告)日:2008-11-25

    申请号:US11327428

    申请日:2006-01-09

    IPC分类号: B41J2/38

    CPC分类号: B41J2/355 B41J2/365

    摘要: A thermal printer includes a control part; a thermal head that is heated upon a heating instruction from the control part and stops heating upon a heating-ending instruction from the control part; a temperature detector that detects a temperature of the thermal head upon a temperature detection instruction from the control part; and a feed motor that is driven upon a conveyance instruction from the control part and stops the conveyance upon a conveyance-ending instruction from the control part. The control part issues, prior to printing, the heating instruction and the conveyance instruction such that the heating of the thermal head and the conveyance of the paper are performed in parallel. The control part issues the temperature detection instruction as an interrupt every predetermined period of time after the heating instruction is issued, and issues the heating-ending instruction when the temperature of the thermal head reaches a predetermined preheat-ending temperature.

    摘要翻译: 热敏打印机包括控制部分; 根据来自控制部的加热指示加热的热敏头,并根据来自控制部的加热结束指示停止加热; 温度检测器,其根据来自所述控制部的温度检测指示来检测所述热敏头的温度; 以及馈送电动机,其根据来自控制部分的传送指令而被驱动,并且根据来自控制部分的传送结束指令来停止传送。 控制部分在打印之前发出加热指令和输送指令,使得并行地进行热敏头的加热和纸的输送。 控制部分在发出加热指令之后的每个预定时间段发出温度检测指令作为中断,并且当热敏头的温度达到预定的预热温度时发出加热结束指令。

    OPTICAL MODULE
    9.
    发明申请
    OPTICAL MODULE 有权
    光学模块

    公开(公告)号:US20080101746A1

    公开(公告)日:2008-05-01

    申请号:US11553743

    申请日:2006-10-27

    IPC分类号: G02B6/12

    摘要: An optical module has a substrate having a substrate surface provided with terminal pads and landing pads, and an optical element package having terminals and mounted on the substrate surface with a gap formed therebetween. The gap between the optical element package and the substrate surface is determined by the landing pads when the optical element package is mounted on the substrate surface. The terminal pads and the landing pads are exposed in a state where the optical element package is mounted on the substrate surface, and the terminal pads are electrically connected to corresponding terminals by solder.

    摘要翻译: 光学模块具有具有设置有端子焊盘和着陆焊盘的基板表面的基板,以及具有端子的光学元件封装,并且安装在基板表面上,其间形成有间隙。 当光学元件封装安装在基板表面上时,光学元件封装和基板表面之间的间隙由着陆焊盘确定。 端子焊盘和着陆焊盘在光学元件封装安装在基板表面上的状态下露出,并且端子焊盘通过焊料电连接到相应的端子。