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1.发明授权公开(公告)号：US09428721B2
公开(公告)日：2016-08-30
申请号：US12866581
申请日：2009-02-05
申请人： Hideki Taniguchi , Yun-Wen Zheng , Go Tazaki , Tomoko Kosaka , Hitoshi Tsuruta , Motohiro Fukuda
发明人： Hideki Taniguchi , Yun-Wen Zheng , Go Tazaki , Tomoko Kosaka , Hitoshi Tsuruta , Motohiro Fukuda
CPC分类号： C12M23/22 , C12M23/12 , G01N33/5073
摘要： Provided is a cell culture method whereby an in vivo function can be sustained over a long period of time and culture can be conducted using the minimum number of cells required. The cell culture method includes culturing undifferentiated cells in a layered state in a partitioned micro-space and obtains differentiated cells. When screening a pharmaceutical agent, undifferentiated cells capable of differentiating into liver cells, intestinal epithelial cells, nerve cells, myocardial cells and vascular endothelial cells are preferred. Particularly, in the prediction of pharmacokinetics or the like for humans, human cells are preferred.
摘要翻译： 本发明提供能够长期维持体内功能的细胞培养方法，并且可以使用所需的最少细胞数进行培养。 细胞培养方法包括在分层微空间中以分层状态培养未分化细胞，获得分化细胞。 当筛选药剂时，优选能够分化为肝细胞，肠上皮细胞，神经细胞，心肌细胞和血管内皮细胞的未分化细胞。 特别是在人体的药代动力学等的预测中，优选人细胞。
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公开(公告)号：US20110045500A1
公开(公告)日：2011-02-24
申请号：US12866581
申请日：2009-02-05
申请人： Hideki Taniguchi , Yun-Wen Zheng , Go Tazaki , Tomoko Kosaka , Hitoshi Tsuruta , Motohiro Fukuda
发明人： Hideki Taniguchi , Yun-Wen Zheng , Go Tazaki , Tomoko Kosaka , Hitoshi Tsuruta , Motohiro Fukuda
CPC分类号： C12M23/22 , C12M23/12 , G01N33/5073
摘要： Provided is a cell culture method whereby an in vivo function can be sustained over a long period of time and culture can be conducted using the minimum number of cells required. The cell culture method includes culturing undifferentiated cells in a layered state in a partitioned micro-space and obtains differentiated cells. When screening a pharmaceutical agent, undifferentiated cells capable of differentiating into liver cells, intestinal epithelial cells, nerve cells, myocardial cells and vascular endothelial cells are preferred. Particularly, in the prediction of pharmacokinetics or the like for humans, human cells are preferred.
摘要翻译： 本发明提供能够长期维持体内功能的细胞培养方法，并且可以使用所需的最少细胞数进行培养。 细胞培养方法包括在分层微空间中以分层状态培养未分化细胞，获得分化细胞。 当筛选药剂时，优选能够分化为肝细胞，肠上皮细胞，神经细胞，心肌细胞和血管内皮细胞的未分化细胞。 特别是在人体的药代动力学等的预测中，优选人细胞。
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公开(公告)号：US20110318829A1
公开(公告)日：2011-12-29
申请号：US13229087
申请日：2011-09-09
申请人： Go TAZAKI , Tomoko Kosaka , Motohiro Fukuda
发明人： Go TAZAKI , Tomoko Kosaka , Motohiro Fukuda
摘要： To provide a cell culture chamber and a cell culture method that are capable of effectively constructing an intercellular network in a culture space. A cell culture chamber (10) according to the present invention is a cell culture chamber (10) including a plurality of microchambers (11) formed on a surface thereof, characterized in that convex portions (side walls 12) that partition the microchambers (11) adjacent to each other are formed to prevent cells from being adhered to upper surfaces of the convex portions. Consequently, cells can be cultured exclusively within the microchambers (11), and an intercellular network can be constructed effectively.
摘要翻译： 提供能够有效地构建培养空间中的细胞间网络的细胞培养室和细胞培养方法。 根据本发明的细胞培养室（10）是包括形成在其表面上的多个微室（11）的细胞培养室（10），其特征在于，将微型室（11）分隔开的凸部（侧壁12） ）形成为防止细胞粘附到凸部的上表面。 因此，可以在微室（11）内专门培养细胞，并且可以有效地构建细胞间网络。
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公开(公告)号：US20100190253A1
公开(公告)日：2010-07-29
申请号：US12665474
申请日：2008-06-16
申请人： Go Tazaki , Tomoko Kosaka , Motohiro Fukuda
发明人： Go Tazaki , Tomoko Kosaka , Motohiro Fukuda
摘要： To provide a cell culture chamber and a cell culture method that are capable of effectively constructing an intercellular network in a culture space. A cell culture chamber (10) according to the present invention is a cell culture chamber (10) including a plurality of microchambers (11) formed on a surface thereof, characterized in that convex portions (side walls 12) that partition the microchambers (11) adjacent to each other are formed to prevent cells from being adhered to upper surfaces of the convex portions. Consequently, cells can be cultured exclusively within the microchambers (11), and an intercellular network can be constructed effectively.
摘要翻译： 提供能够有效地构建培养空间中的细胞间网络的细胞培养室和细胞培养方法。 根据本发明的细胞培养室（10）是包括形成在其表面上的多个微室（11）的细胞培养室（10），其特征在于，将微型室（11）分隔开的凸部（侧壁12） ）形成为防止细胞粘附到凸部的上表面。 因此，可以在微室（11）内专门培养细胞，并且可以有效地构建细胞间网络。
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公开(公告)号：US08415157B2
公开(公告)日：2013-04-09
申请号：US13229087
申请日：2011-09-09
申请人： Go Tazaki , Tomoko Kosaka , Motohiro Fukuda
发明人： Go Tazaki , Tomoko Kosaka , Motohiro Fukuda
摘要： A cell culture chamber and a cell culture method that are capable of effectively constructing an intercellular network in a culture space are provided. A cell culture chamber (10)according to the present invention is a cell culture chamber (10)including a plurality of microchambers (11) formed on a surface thereof, characterized in that convex portions (side walls 12) that partition the microchambers (11) adjacent to each other are formed to prevent cells from being adhered to upper surfaces of the convex portions. Consequently, cells can be cultured exclusively within the microchambers (11), and an intercellular network can be constructed effectively.
摘要翻译： 提供了能够有效地构建培养空间中的细胞间网络的细胞培养室和细胞培养方法。 根据本发明的细胞培养室（10）是包括形成在其表面上的多个微室（11）的细胞培养室（10），其特征在于，将微型室（11）分隔开的凸部（侧壁12） ）形成为防止细胞粘附到凸部的上表面。 因此，可以在微室（11）内专门培养细胞，并且可以有效地构建细胞间网络。
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