公开(公告)号：US07873411B2

公开(公告)日：2011-01-18

申请号：US11214600

申请日：2005-08-30

申请人： Hideo Eda ,  Yasushi Terazono ,  Toshio Yanagida ,  Amami Kato ,  Masayuki Hirata ,  Masaaki Taniguchi ,  Takahito Baba ,  Toshiki Yoshimine

发明人： Hideo Eda ,  Yasushi Terazono ,  Toshio Yanagida ,  Amami Kato ,  Masayuki Hirata ,  Masaaki Taniguchi ,  Takahito Baba ,  Toshiki Yoshimine

IPC分类号： A61B5/04

CPC分类号： G06F3/015 ,  A61B5/14553

摘要： An interface device in accordance with the present claimed invention is an interface device 4 that intervenes between a measuring means 2 that measures brain activities of a subject H and an object 31 to be controlled, and that comprises a reference signal storing part D1 that stores a brain activity signal measured at a time when the subject H conducts predetermined thinking different from direct thinking in order to control the object 31 to be controlled in a desired mode as a reference signal, a discriminating part 41 that compares the brain activity signal measured by the measuring means 2 with the reference signal and discriminates whether or not the thinking of the subject H is the predetermined thinking, and a controlling part 42 that controls the object 31 to be controlled in the desired mode when the discriminating part 41 discriminates that the thinking of the subject H is the predetermined thinking.

摘要翻译： 根据本发明要求保护的发明的接口装置是介于测量对象H的大脑活动的测量装置2和要被控制的对象31之间的接口装置4，其包括存储部件D1的参考信号存储部分D1 当受试者H进行与直接思考不同的预定思考以便将对象31控制在期望模式中作为参考信号时测量的脑活动信号;鉴别部分41，其将由 具有参考信号的测量装置2，并且辨别被摄体H的想法是否是预定的思维;以及控制部分42，当辨别部分41区分对象31的想法时，控制对象31被控制在期望的模式 主题H是预定的思维。

公开(公告)号：US20060074822A1

公开(公告)日：2006-04-06

申请号：US11214600

申请日：2005-08-30

申请人： Hideo Eda ,  Yasushi Terazono ,  Toshio Yanagida ,  Amami Kato ,  Masayuki Hirata ,  Masaaki Taniguchi ,  Takahito Baba ,  Toshiki Yoshimine

发明人： Hideo Eda ,  Yasushi Terazono ,  Toshio Yanagida ,  Amami Kato ,  Masayuki Hirata ,  Masaaki Taniguchi ,  Takahito Baba ,  Toshiki Yoshimine

IPC分类号： G06F15/18

CPC分类号： G06F3/015 ,  A61B5/14553

摘要： An interface device in accordance with the present claimed invention is an interface device 4 that intervenes between a measuring means 2 that measures brain activities of a subject H and an object 31 to be controlled, and that comprises a reference signal storing part D1 that stores a brain activity signal measured at a time when the subject H conducts predetermined thinking different from direct thinking in order to control the object 31 to be controlled in a desired mode as a reference signal, a discriminating part 41 that compares the brain activity signal measured by the measuring means 2 with the reference signal and discriminates whether or not the thinking of the subject H is the predetermined thinking, and a controlling part 42 that controls the object 31 to be controlled in the desired mode when the discriminating part 41 discriminates that the thinking of the subject H is the predetermined thinking.

摘要翻译： 根据本发明要求保护的发明的接口装置是介于测量对象H的大脑活动的测量装置2和要被控制的对象31之间的接口装置4，其包括存储部分D 1的参考信号存储部分D 1 在受试者H进行与直接思维不同的预定思考以便以要求的方式控制对象31作为参考信号的时候测量的大脑活动信号;鉴别部分41，其比较由 测量装置2具有参考信号，并且辨别被摄体H的想法是否是预定的思维;以及控制部分42，当辨别部分41区分思维时，控制对象31被控制在期望的模式 主题H是预定的想法。

公开(公告)号：US20110218453A1

公开(公告)日：2011-09-08

申请号：US12799840

申请日：2010-05-03

申请人： Masayuki Hirata ,  Takufumi Yanagisawa ,  Yukiyasu Kamitani ,  Hiroshi Yokoi ,  Toshiki Yoshimine ,  Tetsu Goto ,  Ryohei Fukuma ,  Ryu Kato

发明人： Masayuki Hirata ,  Takufumi Yanagisawa ,  Yukiyasu Kamitani ,  Hiroshi Yokoi ,  Toshiki Yoshimine ,  Tetsu Goto ,  Ryohei Fukuma ,  Ryu Kato

IPC分类号： A61B5/0402

CPC分类号： A61B5/0402 ,  A61B5/7267

摘要： A machine control device includes: first decoders for estimating, from brain signal information, which one of body movements a user performs or images, based on learning using pairs of movements performed by the user and brain signal information, the body movements going toward one of first to nth body postures; second decoders for estimating from the brain signal information, an correct rate on the body movement estimation, based on learning using pairs of correct rates of the estimation of body movements and the brain signal information; and electric prosthetic arm control section for controlling an electric prosthetic arm to change stepwise its posture between first to nth postures via at least one intermediate posture therebetween, the first to nth postures corresponding to the first to nth body postures. The first decoders perform the estimation only when the estimated correct rate exceeds a threshold. When the first decoders estimate that the body movements goes toward a body posture different from the current one, the electric prosthetic arm control section changes the posture of the machine by performing a part of substeps of change from one of the first to nth body postures toward the posture associated with the body posture toward which the estimated body movement goes. This configuration allows a user to control a brain-signal-based machine to perform a natural movement without a long-term training and much brain information.

摘要翻译： 一种机器控制装置包括：第一解码器，用于基于使用用户执行的运动对的学习和脑信号信息来估计来自脑信号信息，用户执行的身体运动中的哪一个或图像，身体运动朝向 第一到第n身体姿势; 第二解码器，用于基于使用身体运动的估计的正确速率和脑信号信息的学习来从脑信号信息估计身体运动估计的正确率; 以及电动假肢臂控制部，其用于控制​​电动假肢臂，通过其间的至少一个中间姿势，在第一至第n姿势之间逐步地改变其姿势，所述第一至第n姿势对应于所述第一至第n体姿势。 第一解码器仅在估计的正确率超过阈值时执行估计。 当第一解码器估计身体运动朝向与当前身体姿势不同的身体姿势时，电假肢臂控制部通过执行从第一至第n体姿势中的一个朝向的部分子步骤改变机器的姿势 与所估计的身体运动所对应的身体姿势相关联的姿势。 该配置允许用户控制基于脑信号的机器执行自然运动，而无需长期训练和大量信息。

公开(公告)号：US20150289980A1

公开(公告)日：2015-10-15

申请号：US13510841

申请日：2011-03-10

申请人： Masayuki Hirata ,  Toshiki Yoshimine ,  Kojiro Matsushita ,  Tetsu Goto ,  Takufumi Yanagisawa ,  Takafumi Suzuki ,  Shinichi Yoshimura

发明人： Masayuki Hirata ,  Toshiki Yoshimine ,  Kojiro Matsushita ,  Tetsu Goto ,  Takufumi Yanagisawa ,  Takafumi Suzuki ,  Shinichi Yoshimura

IPC分类号： A61F2/28 ,  G06F17/50 ,  G05B19/4097 ,  A61N1/05

CPC分类号： A61F2/2875 ,  A61B17/688 ,  A61F2002/2835 ,  A61N1/0526 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0539 ,  A61N1/3758 ,  G05B19/4097 ,  G06F17/50

摘要： To allow an implantable device including an electronic circuit to be implanted in the head in a more preferable manner in terms of appearance and safely. This implantable device is used for a brain-machine interface or the like.A casing 16 of an implantable device 4 configured to be implanted in a human head has an outer convexity surface 30 matching an external shape of a resected skull 27 related to at least a craniotomy site 26 of the artificial bone 28 designed in accordance with a skull shape of each person in order to fill the craniotomy site 26. That is, the outer convexity surface 30 of the artificial bone 28 is provided with two functions: the original function of filling the craniotomy site 26 as the artificial bone 28 and a function of serving as the casing 16 of the implantable device 4.

摘要翻译： 在外观上和安全性方面，允许将包括电子电路的可植入装置以更优选的方式植入头部。 该可植入装置用于脑机接口等。 构造成植入人体头部的可植入装置4的壳体16具有与根据颅骨设计的至少与人造骨28的开颅部位26相关的切除的颅骨27的外部形状的外凸面30。 为了填充开颅部位26，也就是说，人造骨28的外凸面30具有以下功能：作为人造骨28填充开颅手术部位26的原有功能， 用作可植入装置4的壳体16。

公开(公告)号：US08396546B2

公开(公告)日：2013-03-12

申请号：US12799840

申请日：2010-05-03

申请人： Masayuki Hirata ,  Takufumi Yanagisawa ,  Yukiyasu Kamitani ,  Hiroshi Yokoi ,  Toshiki Yoshimine ,  Tetsu Goto ,  Ryohei Fukuma ,  Ryu Kato

发明人： Masayuki Hirata ,  Takufumi Yanagisawa ,  Yukiyasu Kamitani ,  Hiroshi Yokoi ,  Toshiki Yoshimine ,  Tetsu Goto ,  Ryohei Fukuma ,  Ryu Kato

IPC分类号： A61B5/04

CPC分类号： A61B5/0402 ,  A61B5/7267

摘要： A machine control device includes: first decoders for estimating, from brain signal information, which one of body movements a user performs or images, based on learning using pairs of movements performed by the user and brain signal information, the body movements going toward one of first to nth body postures; second decoders for estimating from the brain signal information, an correct rate on the body movement estimation, based on learning using pairs of correct rates of the estimation of body movements and the brain signal information; and electric prosthetic arm control section for controlling an electric prosthetic arm to change stepwise its posture between first to nth postures via at least one intermediate posture therebetween, the first to nth postures corresponding to the first to nth body postures. The first decoders perform the estimation only when the estimated correct rate exceeds a threshold. When the first decoders estimate that the body movements goes toward a body posture different from the current one, the electric prosthetic arm control section changes the posture of the machine by performing a part of substeps of change from one of the first to nth body postures toward the posture associated with the body posture toward which the estimated body movement goes. This configuration allows a user to control a brain-signal-based machine to perform a natural movement without a long-term training and much brain information.

摘要翻译： 一种机器控制装置包括：第一解码器，用于基于使用用户执行的运动对的学习和脑信号信息来估计来自脑信号信息，用户执行的身体运动中的哪一个或图像，身体运动朝向 第一到第n身体姿势; 第二解码器，用于基于使用身体运动的估计的正确速率和脑信号信息的学习来从脑信号信息估计身体运动估计的正确率; 以及电动假肢臂控制部，其用于控制​​电动假肢臂，通过其间的至少一个中间姿势，在第一至第n姿势之间逐步地改变其姿势，所述第一至第n姿势对应于所述第一至第n体姿势。 第一解码器仅在估计的正确率超过阈值时执行估计。 当第一解码器估计身体运动朝向与当前身体姿势不同的身体姿势时，电假肢臂控制部通过执行从第一至第n体姿势中的一个朝向的部分子步骤改变机器的姿势 与所估计的身体运动所对应的身体姿势相关联的姿势。 该配置允许用户控制基于脑信号的机器执行自然运动，而无需长期训练和大量信息。

公开(公告)号：US07860577B2

公开(公告)日：2010-12-28

申请号：US12378695

申请日：2009-02-18

申请人： Masayuki Hirata ,  Toshiki Yoshimine ,  Youichi Saitoh ,  Takufumi Yanagisawa ,  Testu Goto ,  Yoshihiro Watanabe ,  Toshiaki Saito

发明人： Masayuki Hirata ,  Toshiki Yoshimine ,  Youichi Saitoh ,  Takufumi Yanagisawa ,  Testu Goto ,  Yoshihiro Watanabe ,  Toshiaki Saito

IPC分类号： A61N1/00

CPC分类号： A61N1/0531 ,  A61B5/0478 ,  A61N1/36017 ,  A61N1/36071 ,  B33Y80/00

摘要： With use of three-dimensional data of a brain shape, a mold for forming a sheet-shaped structure having a three-dimensional shape of the gyrus or sulcus surface, or the interhemispheric fissure or interlobar fissure surface is formed. With use of the mold, a sheet-shaped silicone structure 2 having a three-dimensional shape of the gyrus or sulcus surface, or the interhemispheric fissure or interlobar fissure surface is formed. An electrode 3 is arranged on at least one side of the silicone structure 2. With this configuration, an intracranial electrode 1 in which the electrode 3 is arranged on the sheet-shaped silicone structure 2 having the three-dimensional shape of the gyrus or sulcus surface, or the interhemispheric fissure or interlobar fissure surface can be produced.

摘要翻译： 利用脑形状的三维数据，形成具有回回表面的三维形状的片状结构的模具，或者是大脑半球裂隙或间隙的裂缝面。 通过使用该模具，形成具有回回或表面的三维形状的片状硅酮结构体2，或者是大脑间裂隙或间隙裂隙面。 电极3设置在硅酮结构体2的至少一侧。利用这种结构，将电极3配置在片状硅树脂结构体2上的颅内电极1，该片状硅氧烷结构体2具有回棱或沟的三维形状 可以产生表面，或者产生大脑间裂隙或间隙裂隙表面。

公开(公告)号：US20090228066A1

公开(公告)日：2009-09-10

申请号：US12378695

申请日：2009-02-18

申请人： Masayuki Hirata ,  Toshiki Yoshimine ,  Youichi Saitoh ,  Takufumi Yanagisawa ,  Testu Goto ,  Yoshihiro Watanabe ,  Toshiaki Saito

发明人： Masayuki Hirata ,  Toshiki Yoshimine ,  Youichi Saitoh ,  Takufumi Yanagisawa ,  Testu Goto ,  Yoshihiro Watanabe ,  Toshiaki Saito

IPC分类号： A61N1/05 ,  G06F17/00 ,  B29C43/00

CPC分类号： A61N1/0531 ,  A61B5/0478 ,  A61N1/36017 ,  A61N1/36071 ,  B33Y80/00

摘要： With use of three-dimensional data of a brain shape, a mold for forming a sheet-shaped structure having a three-dimensional shape of the gyrus or sulcus surface, or the interhemispheric fissure or interlobar fissure surface is formed. With use of the mold, a sheet-shaped silicone structure 2 having a three-dimensional shape of the gyrus or sulcus surface, or the interhemispheric fissure or interlobar fissure surface is formed. An electrode 3 is arranged on at least one side of the silicone structure 2. With this configuration, an intracranial electrode 1 in which the electrode 3 is arranged on the sheet-shaped silicone structure 2 having the three-dimensional shape of the gyrus or sulcus surface, or the interhemispheric fissure or interlobar fissure surface can be produced.

摘要翻译： 利用脑形状的三维数据，形成具有回回表面的三维形状的片状结构的模具，或者是大脑半球裂隙或间隙的裂缝面。 通过使用该模具，形成具有回回或表面的三维形状的片状硅酮结构体2，或者是大脑间裂隙或间隙裂隙面。 电极3设置在硅酮结构体2的至少一侧。利用这种结构，将电极3配置在片状硅树脂结构体2上的颅内电极1，该片状硅氧烷结构体2具有回棱或沟的三维形状 可以产生表面，或者产生大脑间裂隙或间隙裂隙表面。

公开(公告)号：US20060135449A1

公开(公告)日：2006-06-22

申请号：US10509799

申请日：2002-03-29

申请人： Yoshiki Sawa ,  Ryuichi Morishita ,  Yasufumi Kaneda ,  Hikaru Matsuda ,  Toshiki Yoshimine

发明人： Yoshiki Sawa ,  Ryuichi Morishita ,  Yasufumi Kaneda ,  Hikaru Matsuda ,  Toshiki Yoshimine

IPC分类号： A61K48/00 ,  A61K9/127

CPC分类号： A61K9/0019 ,  A61K9/127 ,  A61K31/711 ,  A61K48/005 ,  A61K48/0075 ,  C07K14/4705 ,  C12N15/1131 ,  C12N15/115 ,  C12N15/86 ,  C12N2310/13 ,  C12N2310/315 ,  C12N2760/18811

摘要： The present invention provides introduction of NF-κB decoy oligodeoxynucleotide into rat cranial nerve through a carotid artery during global brain ischemia. Polymerase chain reaction demonstrated that one hour after global brain ischemia, transfected NF-κB decoy oligodeoxynucleotide effectively suppressed expression of tumor necrosis factor α, interleukin 1β and intracellular adhesion molecule 1 messenger RNAs. Terminal deoxynucleotidyl transferase-mediated deoxyuridine nick-end labeling staining and immunohistochemistry using microtubule-associated protein 2 demonstrated that transfected NF-κB decoy oligodeoxynucleotide significantly attenuated neuronal damage seven days after global brain ischemia. Therapeutic transfection of NF-κB decoy oligodeoxynucleotide during brain ischemia may be effective for attenuation of neuronal damage, suggesting a strategy for protecting the cerebrum from global ischemia.

摘要翻译： 本发明提供了在全脑缺血期间通过颈动脉将NF-κB诱饵寡脱氧核苷酸引入大鼠颅神经中。 聚合酶链反应表明，全球脑缺血后1小时，转染的NF-κB诱饵寡脱氧核苷酸有效抑制肿瘤坏死因子α，白细胞介素1β和细胞内粘附分子1信使RNA的表达。 末端脱氧核苷酸转移酶介导的脱氧尿苷切口标记染色和使用微管相关蛋白2的免疫组织化学证实，转染的NF-κB诱饵寡脱氧核苷酸在全脑缺血后7天显着减弱神经元损伤。 在脑缺血期间，NF-κB诱饵寡脱氧核苷酸的治疗转染对于减少神经元损伤可能是有效的，这表明保护大脑免受全身缺血的策略。

公开(公告)号：US20080207552A1

公开(公告)日：2008-08-28

申请号：US11982970

申请日：2007-11-05

申请人： Yoshiki Sawa ,  Ryuichi Morishita ,  Yasufumi Kaneda ,  Hikaru Matsuda ,  Toshiki Yoshimine

发明人： Yoshiki Sawa ,  Ryuichi Morishita ,  Yasufumi Kaneda ,  Hikaru Matsuda ,  Toshiki Yoshimine

IPC分类号： A61K31/7088 ,  A61P9/10

CPC分类号： A61K9/0019 ,  A61K9/127 ,  A61K31/711 ,  A61K48/005 ,  A61K48/0075 ,  C07K14/4705 ,  C12N15/1131 ,  C12N15/115 ,  C12N15/86 ,  C12N2310/13 ,  C12N2310/315 ,  C12N2760/18811

摘要： The present invention provides introduction of NF-κB decoy oligodeoxynucleotide into rat cranial nerve through a carotid artery during global brain ischemia. Polymerase chain reaction demonstrated that one hour after global brain ischemia, transfected NF-κB decoy oligodeoxynucleotide effectively suppressed expression of tumor necrosis factor α, interleukin 1β and intracellular adhesion molecule 1 messenger RNAs. Terminal deoxynucleotidyl transferase-mediated deoxyuridine nick-end labeling staining and immunohistochemistry using microtubule-associated protein 2 demonstrated that transfected NF-κB decoy oligodeoxynucleotide significantly attenuated neuronal damage seven days after global brain ischemia. Therapeutic transfection of NF-κB decoy oligodeoxynucleotide during brain ischemia may be effective for attenuation of neuronal damage, suggesting a strategy for protecting the cerebrum from global ischemia.

摘要翻译： 本发明提供了在全脑缺血期间通过颈动脉将NF-κB诱饵寡脱氧核苷酸引入大鼠颅神经中。 聚合酶链反应表明，全球脑缺血后1小时，转染的NF-κB诱饵寡脱氧核苷酸有效抑制肿瘤坏死因子α，白细胞介素1β和细胞内粘附分子1信使RNA的表达。 末端脱氧核苷酸转移酶介导的脱氧尿苷切口末端标记染色和使用微管相关蛋白2的免疫组织化学证实，转染的NF-κB诱饵寡脱氧核苷酸在全脑缺血后7天显着减弱神经元损伤。 在脑缺血期间，NF-κB诱饵寡脱氧核苷酸的治疗转染对于减少神经元损伤可能是有效的，这表明保护大脑免受全身缺血的策略。

公开(公告)号：US5800390A

公开(公告)日：1998-09-01

申请号：US900135

申请日：1997-07-25

申请人： Toru Hayakawa ,  Toshiki Yoshimine ,  Hiromu Yamamoto ,  Akira Sato ,  Tsunemasa Irie ,  Keiji Fujioka ,  Yoshihiro Takada ,  Yoshio Sasaki

发明人： Toru Hayakawa ,  Toshiki Yoshimine ,  Hiromu Yamamoto ,  Akira Sato ,  Tsunemasa Irie ,  Keiji Fujioka ,  Yoshihiro Takada ,  Yoshio Sasaki

IPC分类号： A61M37/00 ,  A61M39/02 ,  A61M11/00

CPC分类号： A61M37/00 ,  A61M39/0208 ,  A61M2210/0693

摘要： Equipment for intracerebral administration of preparations is composed of a preparation-administering device (1) holding a preparation (2), and a plunger (4) removably arranged in the preparation-administering device adapted to push the preparation held therein toward one end of the preparation-administering device. The intracerebral preparation-administration equipment is inserted into a preparation-introducing guide (5) previously implanted in the head of a patient to introduce the preparation into its guide hole (26). The preparation is then guided to a site of administration through a flexible guide tube (23) communicated with the guide hole of the preparation-introducing guide. The equipment for intracerebral administration of preparations may be composed of a tubular preparation-retaining member (30) having a preparation contained therein, and a holder (32) for holding the tubular preparation-retaining member along with a push rod (31) inserted thereinto as an integral part thereof. In this case, the administration equipment itself is inserted into and held in the preparation-introducing guide (5).

摘要翻译： PCT No.PCT / JP92 / 00658 Sec。 371日期：1993年11月24日 102（e）日期1993年11月24日PCT提交1992年5月22日PCT公布。 第WO92 / 20400号公报 日期：1992年11月26日制剂的脑内给药设备由保持制剂（2）的制剂给药装置（1）和可移除地布置在准备投与装置中的柱塞（4）组成，其适于推动保持在其中的制剂 朝向准备给药装置的一端。 将脑内准备给药装置插入预先植入患者头部的制剂引入导向件（5）中，以将制剂引入其引导孔（26）。 然后将制剂通过与制剂引入导向件的引导孔连通的柔性引导管（23）引导到给药部位。 脑内给药制剂的装置可以由其中容纳有制剂的管状制剂保持构件（30）和用于将管状制剂保持构件与插入其中的推杆（31）保持的保持器（32）组成。 作为其组成部分。 在这种情况下，管理设备本身被插入并保持在准备导入引导件（5）中。