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公开(公告)号：US20140220316A1
公开(公告)日：2014-08-07
申请号：US14240281
申请日：2012-08-22
申请人： Hidetoshi Inoue , Zenya Ashitaka , Hiroyuki Kusai , Yasushi Takebayashi , Ryo Morishita , Yasuo Oka
发明人： Hidetoshi Inoue , Zenya Ashitaka , Hiroyuki Kusai , Yasushi Takebayashi , Ryo Morishita , Yasuo Oka
IPC分类号： G01N33/50
CPC分类号： G01N33/50 , C23C8/60 , C23C22/00 , G01N21/01 , G01N21/65 , G01N33/54306 , G01N33/553 , Y10T428/24851 , Y10T428/31678
摘要： A substrate for biochips, which does not induce autofluorescence, which can immobilize a biologically relevant substance(s) easily, which can prevent the undesirable spread of a liquid spot which is added dropwise on the biochips when using the biochips, in which the adhesion between a carbon-containing layer and an aluminum material is high, and which can be produced at lower cost than the known substrate for biochips; a method for producing the substrate; and a biochip including the substrate are disclosed. The substrate for biochips comprises a carbon-coated aluminum material, wherein the carbon-coated aluminum material comprises an aluminum material and a carbon-containing layer formed on at least one surface of the aluminum material, and further comprises an interposing layer which is formed between the aluminum material and the carbon-containing layer, and which interposing layer contains aluminum element and carbon element.
摘要翻译： 用于生物芯片的底物，其不诱导自发荧光，其可以容易地固定生物相关物质，其可以防止在使用生物芯片时滴加在生物芯片上的液斑的不期望的扩散，其中粘附 含碳层和铝材料高，并且可以以比已知的生物芯片基板更低的成本生产; 一种生产该基材的方法; 并且公开了包括衬底的生物芯片。 用于生物芯片的基材包括碳涂覆的铝材料，其中碳涂覆的铝材料包括铝材料和形成在铝材料的至少一个表面上的含碳层，并且还包括中间层， 铝材料和含碳层，并且所述中间层包含铝元素和碳元素。
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公开(公告)号：US09164082B2
公开(公告)日：2015-10-20
申请号：US14240281
申请日：2012-08-22
申请人： Hidetoshi Inoue , Zenya Ashitaka , Hiroyuki Kusai , Yasushi Takebayashi , Ryo Morishita , Yasuo Oka
发明人： Hidetoshi Inoue , Zenya Ashitaka , Hiroyuki Kusai , Yasushi Takebayashi , Ryo Morishita , Yasuo Oka
IPC分类号： B32B3/00 , G01N33/50 , G01N21/01 , G01N21/65 , G01N33/553 , G01N33/543 , C23C22/00 , C23C8/60
CPC分类号： G01N33/50 , C23C8/60 , C23C22/00 , G01N21/01 , G01N21/65 , G01N33/54306 , G01N33/553 , Y10T428/24851 , Y10T428/31678
摘要： A substrate for biochips, which does not induce autofluorescence, which can immobilize a biologically relevant substance(s) easily, which can prevent the undesirable spread of a liquid spot which is added dropwise on the biochips when using the biochips, in which the adhesion between a carbon-containing layer and an aluminum material is high, and which can be produced at lower cost than the known substrate for biochips; a method for producing the substrate; and a biochip including the substrate are disclosed. The substrate for biochips comprises a carbon-coated aluminum material, wherein the carbon-coated aluminum material comprises an aluminum material and a carbon-containing layer formed on at least one surface of the aluminum material, and further comprises an interposing layer which is formed between the aluminum material and the carbon-containing layer, and which interposing layer contains aluminum element and carbon element.
摘要翻译： 用于生物芯片的底物，其不诱导自发荧光，其可以容易地固定生物相关物质，这可以防止在使用生物芯片时滴加在生物芯片上的液斑的不期望的扩散，其中粘附 含碳层和铝材料高，并且可以以比已知的生物芯片基板更低的成本生产; 一种生产该基材的方法; 并且公开了包括衬底的生物芯片。 用于生物芯片的基材包括碳涂覆的铝材料，其中碳涂覆的铝材料包括铝材料和形成在铝材料的至少一个表面上的含碳层，并且还包括中间层， 铝材料和含碳层，并且所述中间层包含铝元素和碳元素。
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公开(公告)号：US08822607B2
公开(公告)日：2014-09-02
申请号：US13001923
申请日：2009-06-30
IPC分类号： C08L79/02
CPC分类号： G01N33/545 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00635 , B01J2219/00637 , B01L3/50 , C08J3/28 , C12Q1/6837 , G01N33/54353 , G01N33/54393 , Y10T428/273
摘要： A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.
摘要翻译： 用于生物芯片的底物，其具有高的探针加载量和均匀的固定密度，并且当用作用于固定化探针的生物芯片的基底时，通过防止蛋白质的非特异性吸附进一步具有高检测灵敏度和高重现性 的生物相关物质，如蛋白质和核酸。 通过将含氨基的聚合物共价固定在基材的表面上，氨基可以均匀地以高密度和稳定地结合到基材的表面。 探针固定率高，固定化密度均匀，通过利用氨基固定由生物相关物质如蛋白质或核酸组成的探针。 此外，通过抑制蛋白质的非特异性吸附，检测灵敏度和再现性高。
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公开(公告)号：US20110152409A1
公开(公告)日：2011-06-23
申请号：US13001923
申请日：2009-06-30
CPC分类号： G01N33/545 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00635 , B01J2219/00637 , B01L3/50 , C08J3/28 , C12Q1/6837 , G01N33/54353 , G01N33/54393 , Y10T428/273
摘要： A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.
摘要翻译： 用于生物芯片的底物，其具有高的探针加载量和均匀的固定密度，并且当用作用于固定化探针的生物芯片的基底时，通过防止蛋白质的非特异性吸附进一步具有高检测灵敏度和高重现性 的生物相关物质，如蛋白质和核酸。 通过将含氨基的聚合物共价固定在基材的表面上，氨基可以均匀地以高密度和稳定地结合到基材的表面。 探针固定率高，固定化密度均匀，通过利用氨基固定由生物相关物质如蛋白质或核酸组成的探针。 此外，通过抑制蛋白质的非特异性吸附，检测灵敏度和再现性高。
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