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公开(公告)号：US20140220316A1
公开(公告)日：2014-08-07
申请号：US14240281
申请日：2012-08-22
申请人： Hidetoshi Inoue , Zenya Ashitaka , Hiroyuki Kusai , Yasushi Takebayashi , Ryo Morishita , Yasuo Oka
发明人： Hidetoshi Inoue , Zenya Ashitaka , Hiroyuki Kusai , Yasushi Takebayashi , Ryo Morishita , Yasuo Oka
IPC分类号： G01N33/50
CPC分类号： G01N33/50 , C23C8/60 , C23C22/00 , G01N21/01 , G01N21/65 , G01N33/54306 , G01N33/553 , Y10T428/24851 , Y10T428/31678
摘要： A substrate for biochips, which does not induce autofluorescence, which can immobilize a biologically relevant substance(s) easily, which can prevent the undesirable spread of a liquid spot which is added dropwise on the biochips when using the biochips, in which the adhesion between a carbon-containing layer and an aluminum material is high, and which can be produced at lower cost than the known substrate for biochips; a method for producing the substrate; and a biochip including the substrate are disclosed. The substrate for biochips comprises a carbon-coated aluminum material, wherein the carbon-coated aluminum material comprises an aluminum material and a carbon-containing layer formed on at least one surface of the aluminum material, and further comprises an interposing layer which is formed between the aluminum material and the carbon-containing layer, and which interposing layer contains aluminum element and carbon element.
摘要翻译： 用于生物芯片的底物，其不诱导自发荧光，其可以容易地固定生物相关物质，其可以防止在使用生物芯片时滴加在生物芯片上的液斑的不期望的扩散，其中粘附 含碳层和铝材料高，并且可以以比已知的生物芯片基板更低的成本生产; 一种生产该基材的方法; 并且公开了包括衬底的生物芯片。 用于生物芯片的基材包括碳涂覆的铝材料，其中碳涂覆的铝材料包括铝材料和形成在铝材料的至少一个表面上的含碳层，并且还包括中间层， 铝材料和含碳层，并且所述中间层包含铝元素和碳元素。
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公开(公告)号：US09164082B2
公开(公告)日：2015-10-20
申请号：US14240281
申请日：2012-08-22
申请人： Hidetoshi Inoue , Zenya Ashitaka , Hiroyuki Kusai , Yasushi Takebayashi , Ryo Morishita , Yasuo Oka
发明人： Hidetoshi Inoue , Zenya Ashitaka , Hiroyuki Kusai , Yasushi Takebayashi , Ryo Morishita , Yasuo Oka
IPC分类号： B32B3/00 , G01N33/50 , G01N21/01 , G01N21/65 , G01N33/553 , G01N33/543 , C23C22/00 , C23C8/60
CPC分类号： G01N33/50 , C23C8/60 , C23C22/00 , G01N21/01 , G01N21/65 , G01N33/54306 , G01N33/553 , Y10T428/24851 , Y10T428/31678
摘要： A substrate for biochips, which does not induce autofluorescence, which can immobilize a biologically relevant substance(s) easily, which can prevent the undesirable spread of a liquid spot which is added dropwise on the biochips when using the biochips, in which the adhesion between a carbon-containing layer and an aluminum material is high, and which can be produced at lower cost than the known substrate for biochips; a method for producing the substrate; and a biochip including the substrate are disclosed. The substrate for biochips comprises a carbon-coated aluminum material, wherein the carbon-coated aluminum material comprises an aluminum material and a carbon-containing layer formed on at least one surface of the aluminum material, and further comprises an interposing layer which is formed between the aluminum material and the carbon-containing layer, and which interposing layer contains aluminum element and carbon element.
摘要翻译： 用于生物芯片的底物，其不诱导自发荧光，其可以容易地固定生物相关物质，这可以防止在使用生物芯片时滴加在生物芯片上的液斑的不期望的扩散，其中粘附 含碳层和铝材料高，并且可以以比已知的生物芯片基板更低的成本生产; 一种生产该基材的方法; 并且公开了包括衬底的生物芯片。 用于生物芯片的基材包括碳涂覆的铝材料，其中碳涂覆的铝材料包括铝材料和形成在铝材料的至少一个表面上的含碳层，并且还包括中间层， 铝材料和含碳层，并且所述中间层包含铝元素和碳元素。
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公开(公告)号：US08822607B2
公开(公告)日：2014-09-02
申请号：US13001923
申请日：2009-06-30
IPC分类号： C08L79/02
CPC分类号： G01N33/545 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00635 , B01J2219/00637 , B01L3/50 , C08J3/28 , C12Q1/6837 , G01N33/54353 , G01N33/54393 , Y10T428/273
摘要： A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.
摘要翻译： 用于生物芯片的底物，其具有高的探针加载量和均匀的固定密度，并且当用作用于固定化探针的生物芯片的基底时，通过防止蛋白质的非特异性吸附进一步具有高检测灵敏度和高重现性 的生物相关物质，如蛋白质和核酸。 通过将含氨基的聚合物共价固定在基材的表面上，氨基可以均匀地以高密度和稳定地结合到基材的表面。 探针固定率高，固定化密度均匀，通过利用氨基固定由生物相关物质如蛋白质或核酸组成的探针。 此外，通过抑制蛋白质的非特异性吸附，检测灵敏度和再现性高。
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公开(公告)号：US20110152409A1
公开(公告)日：2011-06-23
申请号：US13001923
申请日：2009-06-30
CPC分类号： G01N33/545 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00635 , B01J2219/00637 , B01L3/50 , C08J3/28 , C12Q1/6837 , G01N33/54353 , G01N33/54393 , Y10T428/273
摘要： A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.
摘要翻译： 用于生物芯片的底物，其具有高的探针加载量和均匀的固定密度，并且当用作用于固定化探针的生物芯片的基底时，通过防止蛋白质的非特异性吸附进一步具有高检测灵敏度和高重现性 的生物相关物质，如蛋白质和核酸。 通过将含氨基的聚合物共价固定在基材的表面上，氨基可以均匀地以高密度和稳定地结合到基材的表面。 探针固定率高，固定化密度均匀，通过利用氨基固定由生物相关物质如蛋白质或核酸组成的探针。 此外，通过抑制蛋白质的非特异性吸附，检测灵敏度和再现性高。
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公开(公告)号：US08057743B2
公开(公告)日：2011-11-15
申请号：US12664621
申请日：2008-06-13
申请人： Kiyoshi Nokihara , Yasuo Oka
发明人： Kiyoshi Nokihara , Yasuo Oka
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00819 , B01J2219/00831 , B01J2219/0086 , B01J2219/00873 , B01L3/502707 , B01L2200/0689 , B01L2300/0883 , B01L2300/12 , B81B2201/051 , B81B2201/058 , B81B2203/0307 , B81C3/001 , B81C2203/0109 , B81C2203/032
摘要： Means for overcoming the problems which the conventional glass microchannel chips have are disclosed. That is, a microchannel chip in which microchannels can be formed at a low cost, and which has a high chemical resistance is disclosed. The microchannel chip is constituted by a substrate made of carbon, which has a channel in its surface; and a cover composed of a glass plate bonded to the substrate. The cover is bonded to the substrate by heating at least a part of the contact surface at which the substrate is in contact with the cover.
摘要翻译： 公开了克服传统玻璃微通道芯片所存在的问题的手段。 也就是说，公开了一种微通道芯片，其中可以以低成本形成微通道，并且具有高耐化学性。 微通道芯片由碳表面构成，其表面具有通道; 以及由与基板结合的玻璃板构成的盖。 通过加热基板与盖接触的接触表面的至少一部分，将盖结合到基板。
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公开(公告)号：US20100130380A1
公开(公告)日：2010-05-27
申请号：US11922108
申请日：2006-06-16
申请人： Kiyoshi Nokihara , Yasuo Oka
发明人： Kiyoshi Nokihara , Yasuo Oka
CPC分类号： G01N33/54393 , B01L3/5085 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0893 , B01L2300/0896 , B01L2300/12 , B82Y30/00 , C40B60/14
摘要： A biochip substrate which is free from cross-contamination due to spot spreading or contact with spots adjacent to each other, and a biochip using the same. A biochip substrate on which multiple valleys for immobilizing biological substances are formed so as to prevent cross-contamination due to spot spreading or contact with spots adjacent to each other, and a biochip using the same are provided. Moreover, it is found out that a desired binding in a target molecule contained in a test sample occurs at a detectable level in a solution system even in the case where a valley have such a small capacity as 1 nL to 10 nL.
摘要翻译： 一种生物芯片基板，其由于点扩散或与彼此相邻的点接触而没有交叉污染，并且使用该生物芯片。 其上形成有用于固定生物物质的多个谷的生物芯片基板，以防止由于点扩散或彼此相邻的点的接触而产生的交叉污染，并且提供了使用该生物体的生物芯片。 此外，发现测试样品中包含的靶分子中期望的结合在溶液体系中发生在可检测的水平，即使在谷具有如1nL至10nL这样小的容量的情况下也是如此。
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公开(公告)号：US4548682A
公开(公告)日：1985-10-22
申请号：US618512
申请日：1984-06-08
申请人： Koichi Yoshida , Yoshio Hirayama , Yasuo Oka , Takashi Kajiyama
发明人： Koichi Yoshida , Yoshio Hirayama , Yasuo Oka , Takashi Kajiyama
CPC分类号： C25D11/18 , G11B5/84 , Y10S205/917
摘要： A magnetic recording medium having excellent magnetic properties and a uniform recording envelope suitable for, in particular, high-density recording is obtained by packing a magnetic substance in the micro pores of anodic oxide film formed on an aluminum substrate by subjecting the same to an anodic oxidation treatment to produce an anodic oxide film having a thickness of at least 4 .mu.m. The recording medium can be improved by immersing the anodized aluminum substrate in an acid or alkali bath to chemically dissolve a part of the anodic oxide film, and thereby enlarge the micro pores in the anodic oxide film to a pore diameter in the range of 300 .ANG. to 1,400 .ANG., optionally applying an electric current to the aluminum substrate in the immersion bath if necessary to control the thickness of the barrier layer in the anodic oxide film, before subjecting the treated substrate to an electrolytic treatment in a bath containing ions of a magnetic substance to deposit the magnetic substance in the enlarged micro pores. Thereafter, the surface of the anodic oxide film, and any excess deposited magnetic material thereon, is physically ground to expose the packed magnetic substance at the surface of the film.
摘要翻译： 通过将形成在铝基板上的阳极氧化膜的微孔中的磁性物质包裹在阳极氧化膜上，获得具有优异的磁特性和适用于特别是高密度记录的均匀记录膜的磁记录介质 进行氧化处理，制作厚度为4μm以上的阳极氧化膜。 可以通过将阳极氧化铝基板浸渍在酸或碱浴中以化学溶解阳极氧化膜的一部分，从而将阳极氧化膜中的微孔扩大到300AG范围内的孔径，可以改善记录介质 如果需要，可以在浸渍浴中的铝基板上施加电流以控制阳极氧化膜中的阻挡层的厚度，然后在经过处理的基板在含有磁性离子的浴中进行电解处理 物质将磁性物质沉积在扩大的微孔中。 此后，阳极氧化膜的表面和其上的任何过量的沉积的磁性材料被物理研磨以在膜的表面露出包装的磁性物质。
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公开(公告)号：US4540449A
公开(公告)日：1985-09-10
申请号：US584996
申请日：1984-03-01
申请人： Koichi Yoshida , Yoshio Hirayama , Yasuo Oka , Takashi Kajiyama , Kunihiko Hotta
发明人： Koichi Yoshida , Yoshio Hirayama , Yasuo Oka , Takashi Kajiyama , Kunihiko Hotta
IPC分类号： G11B5/82 , C22C21/06 , C25D11/04 , C25D11/06 , G11B5/73 , G11B5/733 , G11B5/735 , G11B5/738 , H05K1/05 , B21C1/00
CPC分类号： G11B5/735 , C22C21/06 , G11B5/7315 , H05K1/053 , Y10T428/1259
摘要： An aluminum substrate for magnetic recording media such as magnetic disks, etc., is composed of an aluminum alloy plate containing 2 to 6% by weight magnesium and impurities in only limited amounts and having on the surface an anodic oxidation film with thickness more than 3 .mu.m formed by a chromic acid process. In the thus-anodized aluminum substrate, the occurrence of black spot defects is greatly reduced and the formation of cracks upon heating the substrate to high temperatures is prevented in spite of the thicker anodic oxidation film.
摘要翻译： 用于诸如磁盘等的磁记录介质的铝基板由仅含有限量的含有2至6重量％的镁和杂质的铝合金板组成，并且在表面上具有厚度大于3的阳极氧化膜 由铬酸过程形成的微米。 在这样阳极氧化的铝基板中，尽管阳极氧化膜较厚，但是防止了黑斑缺陷的发生，并且在将基板加热到高温时形成裂缝。
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公开(公告)号：US4414077A
公开(公告)日：1983-11-08
申请号：US246922
申请日：1981-03-23
申请人： Kohichi Yoshida , Teruo Miyashita , Yasuo Oka , Takashi Kajiyama
发明人： Kohichi Yoshida , Teruo Miyashita , Yasuo Oka , Takashi Kajiyama
CPC分类号： C25D11/22 , C25D11/12 , Y10S204/09
摘要： The invention comprises an improved method for producing anodized aluminum articles colored by means of optical interference effects. The method comprises the steps of subjecting an aluminum article that has been anodized by conventional process to a treatment for modifying the pore structure of the anodic film, thereafter subjecting it while connected as anode to an electrolytic treatment for modifying the barrier layer between the oxide and the metal substrate and finally coloring the article while connected as cathode in an electrolyic bath containing one or more dissolved metal salts using DC current on which is superimposed a train of positive current pulses.
摘要翻译： 本发明包括一种通过光学干涉效应生产阳极氧化铝制品的改进方法。 该方法包括以下步骤：将通过常规方法阳极氧化的铝制品进行处理，以改性阳极膜的孔结构，然后在作为阳极连接的同时进行电解处理，以改性氧化物和 金属基底，最后着色该物品，同时在含有一个或多个溶解金属盐的电解槽中作为阴极连接，使用其上叠加一串正电流脉冲的直流电流。
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公开(公告)号：US08455400B2
公开(公告)日：2013-06-04
申请号：US11915366
申请日：2006-05-24
申请人： Kiyoshi Nokihara , Yasuo Oka
发明人： Kiyoshi Nokihara , Yasuo Oka
CPC分类号： G01N33/553 , B01J19/0046 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , G01N33/54353 , G01N33/551 , Y10T428/31678
摘要： A substrate for biochips with which immobilization is easy, which does not exhibit self-fluorescence, which is easy to manufacture, and which is excellent in flatness and surface precision, is disclosed. A substrate having a substrate body of the biochip, which is made of a metal, and a carbon layer having functional groups formed on the metal substrate body is used as a substrate for biochips. Since the substrate body of the substrate for biochips is made of a metal, the substrate is not only easy to manufacture, but also free from cracking and chipping, so that it allows easy handling, and high flatness and surface precision can be attained. Therefore, the problem that the optical system is hard to focus when detecting fluorescence does not occur. Moreover, since the substrate body is made of a metal, it does not emit fluorescence by itself. In addition, since the carbon layer has functional groups such as amino groups, biologically relevant substances can be easily immobilized.
摘要翻译： 公开了一种容易制造的生物芯片用基板，其固定化容易，不易发生自发荧光，平坦度和表面精度优异。 使用具有由金属制成的生物芯片的基板主体和在金属基板主体上形成有官能团的碳层的基板作为生物芯片的基板。 由于用于生物芯片的基板的基板主体由金属制成，所以基板不仅容易制造，而且没有破裂和碎裂，从而易于处理，并且可以获得高平坦度和表面精度。 因此，不发生检测荧光时光学系统难以聚焦的问题。 此外，由于基板主体由金属制成，它本身不会发出荧光。 此外，由于碳层具有诸如氨基的官能团，因此可以容易地固定生物相关的物质。
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