公开(公告)号：US20100317919A1

公开(公告)日：2010-12-16

申请号：US12446304

申请日：2007-10-22

申请人： Hideyuki Takaoka ,  Shinya Matsumoto

发明人： Hideyuki Takaoka ,  Shinya Matsumoto

IPC分类号： A61B1/04

CPC分类号： A61B1/043 ,  A61B1/00057 ,  A61B1/045

摘要： When using a spectral endoscope, the spectral characteristic can be precisely set to be suitable for use conditions. There is provided a spectral endoscope (1) comprising: a channel (3) arranged along a longitudinal direction in an insertion unit to be inserted into a body cavity; an image pickup section (8) which captures an image in a vicinity of the distal end of the insertion unit (2); a variable spectral section (7) capable of changing the wavelength of light to be incident into the image pickup section (8); a reference light member (10) which emits light of a known wavelength characteristic, or has a known absorption characteristic, and is to be introduced into a field-of-view range of the image pickup section (8) through the channel (3); a control unit (11) which controls the image pickup section (8) to capture an image of the reference light member (10) that has been introduced through the channel (3), while controlling the variable spectral section (7) to change the wavelength of light to be incident into the image pickup section (8); and a calibration unit (12) which calibrates the spectral characteristic of the variable spectral section (7) according to the image of the reference light member (10) that has been captured by the image pickup section (8).

摘要翻译： 当使用光谱内窥镜时，可以将光谱特性精确地设置为适合使用条件。 提供了一种光谱内窥镜（1），包括：在插入单元中沿纵向布置的插入体腔的通道（3） 拍摄所述插入单元（2）的前端附近的图像的摄像部（8）; 能够改变要入射到图像拾取部分（8）中的光的波长的可变光谱部分（7）; 发射已知波长特性或具有已知吸收特性的光的参考光部件（10），并通过通道（3）被引入到摄像部分（8）的视野范围内， ; 控制单元（11），其控制图像拾取部分（8）以捕获通过通道（3）引入的参考光部件（10）的图像，同时控制可变光谱部分（7）以改变 要入射到图像拾取部分（8）中的光的波长; 以及校准单元（12），其根据由图像拾取部分（8）捕获的参考光部件（10）的图像来校准可变光谱部分（7）的光谱特性。

公开(公告)号：US08214025B2

公开(公告)日：2012-07-03

申请号：US12521201

申请日：2007-12-27

申请人： Hideyuki Takaoka ,  Koki Morishita

发明人： Hideyuki Takaoka ,  Koki Morishita

IPC分类号： A61B1/00

CPC分类号： A61B1/043 ,  A61B1/00009 ,  A61B1/00186 ,  A61B1/0638 ,  A61B5/0071 ,  A61B5/0084

摘要： Provided is a fluorescence endoscope system for observing fluorescence from a fluorochrome attached to or absorbed in biological tissue, including an excitation light source that emits excitation light that excites the fluorochrome; an image-acquisition section that acquires fluorescence emitted from the biological tissue when irradiated with the excitation light from the excitation light source; an autofluorescence signal setting section that sets an autofluorescence signal intensity to be emitted from the biological tissue when irradiated with the excitation light; and an image compensation section that compensates fluorescence image information acquired by the image-acquisition section on the basis of the autofluorescence signal intensity set by the autofluorescence signal setting section.

摘要翻译： 本发明提供一种荧光内窥镜系统，用于观察附着于生物组织或吸收生物组织的荧光染料的荧光，包括发射激发荧光体的激发光的激发光源; 图像获取部，其从激发光源照射激发光时获取从生物体组织发出的荧光; 自发荧光信号设定部，其设定当用激发光照射时从生物组织发射的自发荧光信号强度; 以及图像补偿部，其基于由所述自发荧光信号设定部设定的自发荧光信号强度来补偿由所述图像获取部获取的荧光图像信息。

公开(公告)号：US5929713A

公开(公告)日：1999-07-27

申请号：US24217

申请日：1998-02-17

申请人： Kenji Kubo ,  Hideyuki Takaoka

发明人： Kenji Kubo ,  Hideyuki Takaoka

IPC分类号： G06F1/06 ,  G06F1/08 ,  H03K3/03 ,  H03B5/00

CPC分类号： G06F1/08 ,  H03K3/0315

摘要： Oscillating circuitry built in integrated circuitry (1) comprises a ring oscillator (31) for generating a first clock, an external oscillator (40) capable of generating a second clock in either one of two oscillating modes which is determined according to an external circuit (12 and 13, or 6 through 8) connected to terminals (2 and 3) thereof, and an internal clock selection circuit (41) which delivers the first clock as an internal clock to the integrated circuitry (1) just after the integrated circuitry (1) is activated or reset, stops the delivery of the first clock and simultaneously furnishes a signal held at a logic high level as the internal clock in response to a control signal for instructing a selection of the second clock, and then determines whether or not the external oscillator (40) is generating the second clock properly, and which furnishes the second clock as the internal clock when it determines that the external oscillator (40) is generating the second clock properly.

摘要翻译： 内置在集成电路（1）中的振荡电路包括用于产生第一时钟的环形振荡器（31），能够根据外部电路确定的两种振荡模式之一产生第二时钟的外部振荡器（40） 连接到其端子（2和3）的外部时钟选择电路（41），以及内部时钟选择电路（41），其将第一时钟作为内部时钟传递到集成电路（1）之后的集成电路 1）被激活或复位，响应于用于指示选择第二时钟的控制信号，停止第一时钟的传送并同时提供保持在逻辑高电平的信号作为内部时钟，然后确定是否 外部振荡器（40）正确地产生第二时钟，并且当确定外部振荡器（40）正确地产生第二时钟时，第二时钟作为内部时钟提供 。

公开(公告)号：US09510742B2

公开(公告)日：2016-12-06

申请号：US13037731

申请日：2011-03-01

申请人： Hiroyuki Nishida ,  Hideyuki Takaoka

发明人： Hiroyuki Nishida ,  Hideyuki Takaoka

IPC分类号： A61B1/04 ,  A61B1/06 ,  A61B1/05 ,  A61B1/00 ,  A61B5/00

CPC分类号： A61B1/0638 ,  A61B1/00009 ,  A61B1/00124 ,  A61B1/00163 ,  A61B1/041 ,  A61B1/05 ,  A61B1/06 ,  A61B5/0062 ,  A61B5/0084 ,  A61B5/418

摘要： The invention relates to an internal body observation device which includes an ordinary observation light source, an ordinary observation irradiation optical system, a special observation light source, a special observation irradiation optical system, an observation optical system for transmitting the light from an observation target, a detection means configured to detect the light transmitted from the observation optical system as a detection signal, and a processing unit for separating the detection signal in the respective light sources and making the detection signal into images, wherein the light from any one of the ordinary observation light source and the special observation light source is modulated, and the modulated light can be radiated to the observation target together with the light from the other light source, and the detection signal detected by the detection means is separated by the processing unit based on the frequency of the modulation.

摘要翻译： 本发明涉及一种内部身体观察装置，其包括普通观察光源，普通观察照射光学系统，特殊观察光源，特殊观察照射光学系统，用于透射来自观察目标的光的观察光学系统， 检测装置，被配置为检测从观察光学系统发射的光作为检测信号，以及处理单元，用于分离各个光源中的检测信号并使检测信号成为图像，其中来自任何一个普通 观察光源和特殊观察光源被调制，并且调制光可以与来自另一光源的光一起被辐射到观察目标，并且由检测装置检测的检测信号由处理单元分离，基于 调制频率。

公开(公告)号：US20100268091A1

公开(公告)日：2010-10-21

申请号：US12782000

申请日：2010-05-18

申请人： Hideyuki Takaoka

发明人： Hideyuki Takaoka

IPC分类号： A61B1/06 ,  G01J1/58 ,  A61B6/00

CPC分类号： A61B1/05 ,  A61B1/0005 ,  A61B1/00096 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  A61B5/0071 ,  A61B5/0084 ,  G01J1/58 ,  G01J3/10 ,  G01N21/64 ,  G01N21/6456

摘要： A site to be observed, such as a lesion, is easily observed by means of bright fluorescence images without increasing the output of a light source. Provided is a fluorescence imaging apparatus (1) including a wideband excitation portion (7) that radiates wideband excitation light capable of exciting a plurality of fluorescent substances contained in a subject (A); a narrow-band excitation portion (8) that radiates narrow-band excitation light capable of exciting at least one fluorescent substance among the fluorescent substances; an excitation-band switching unit (9) that performs switching between the wideband excitation portion (7) and the narrow-band excitation portion (8); and a fluorescence detector (15) having a detection wavelength band enabling detection of any kind of fluorescence from the subject (A) caused by the wideband excitation light and the narrow-band excitation light.

摘要翻译： 通过亮荧光图像容易观察到要观察的部位，例如病变，而不增加光源的输出。 本发明提供一种荧光成像装置（1），其包括宽带激发部（7），其辐射能够激发被检体（A）中所含的多种荧光物质的宽带激发光; 辐射能够激发荧光物质中的至少一种荧光物质的窄带激发光的窄带激发部分（8）; 激励频带切换单元（9），其在所述宽带激励部（7）与所述窄带激励部（8）之间进行切换; 以及荧光检测器（15），其具有能够检测由宽带激发光和窄带激发光引起的来自被摄体（A）的任何种类的荧光的检测波长带。

公开(公告)号：US20080039695A1

公开(公告)日：2008-02-14

申请号：US11890964

申请日：2007-08-08

申请人： Hideyuki Takaoka ,  Akira Hasegawa

发明人： Hideyuki Takaoka ,  Akira Hasegawa

IPC分类号： A61B1/06

CPC分类号： A61B5/0071 ,  A61B1/043 ,  A61B1/0638 ,  A61B5/0084

摘要： The invention provides a fluorescence endoscope system, a fluoroscopy apparatus, a fluoroscopy method, a fluorescence-information processing apparatus, and a fluorescence-information processing method which allow superior fluoroscopy by reducing the effect of autofluorescence. Provided are an excitation-light radiating part for irradiating an object under examination in a body cavity with excitation light having a wavelength included in an absorption spectrum of a fluorescent dye deposited on or absorbed in the object under examination in a state where the fluorescent dye is not deposited on or absorbed in the object under examination; a correction-information acquiring part for acquiring correction information that can be used to correct for the effect of autofluorescence of the object under examination on observation results of fluorescence emitted from the fluorescent dye deposited on or absorbed in the object under examination upon irradiation with the excitation light, based on observation results of the object under examination upon irradiation with the excitation light by the excitation-light radiating part.

摘要翻译： 本发明提供荧光内窥镜系统，荧光透视装置，荧光透视法，荧光信息处理装置和荧光信息处理方法，其通过降低自体荧光的效果而允许优异的荧光透视。 提供一种激发光辐射部件，其用于在荧光染料为荧光染料的状态下，在体腔内照射被检查物体沉积于被检体内的荧光染料的吸收光谱中包含的波长的激发光， 不存放在被检体内或被吸收的物体中; 校正信息获取部分，用于获取校正信息，该校正信息可以用于校正被检查物体的自发荧光的影响，所述观察结果是在激发照射时沉积在被检查物体上或被吸收的荧光染料发出的荧光的观察结果 基于通过激发光辐射部分的激发光照射时检查对象的观察结果。

公开(公告)号：US07236251B2

公开(公告)日：2007-06-26

申请号：US10006621

申请日：2001-12-10

申请人： Hideyuki Takaoka

发明人： Hideyuki Takaoka

IPC分类号： G01B9/02

CPC分类号： G02B21/0056 ,  G01N21/4795 ,  G02B21/0048 ,  G02B21/0072

摘要： An optical system and optical apparatus prevent degradation of the S/N ratio due to switching between OCT and OCM observation modes and attain a high S/N ratio in both the observation modes. The optical system includes a light source 1 and a light-branching member 2 for branching light from the light source 1 into a reference light path and a signal light path. An objective 3 is placed in the signal light path. A light-scanning system 5 scans light in the signal light path with respect to a sample 4 placed in the signal light path. A beam diameter changing optical system 6 changes the beam diameter of light entering or exiting the light-scanning system 5. A light-combining member 7 combines together the reference light path and the signal light path. A light-detecting element 8 detects light combined by the light-combining member 7.

摘要翻译： 光学系统和光学装置防止由于OCT和OCM观察模式之间的切换导致的S / N比的降低，并且在两种观察模式下都能获得高S / N比。 光学系统包括光源1和用于将来自光源1的光分支为参考光路和信号光路的光分支构件2。 物镜3放置在信号光路中。 光扫描系统5相对于放置在信号光路中的样本4扫描信号光路中的光。 光束直径改变光学系​​统6改变进入或离开光扫描系统5的光束的光束直径。 光合组件7将参考光路和信号光路组合在一起。 光检测元件8检测由光合成部件7组合的光。

公开(公告)号：US06577886B1

公开(公告)日：2003-06-10

申请号：US09930416

申请日：2001-08-15

申请人： Hideyuki Takaoka ,  Uma Maheswari Rajagopalan ,  Manabu Tanifuji ,  Tomio Endo

发明人： Hideyuki Takaoka ,  Uma Maheswari Rajagopalan ,  Manabu Tanifuji ,  Tomio Endo

IPC分类号： A61B505

CPC分类号： A61B5/00 ,  A61B5/16

摘要： A living body function measurement method comprises separating a light from a low coherence light source into a signal light and a reference light, modulating a frequency of at least one of the signal light and the reference light, irradiating the signal light to an observation area of a living body sample, giving a stimulation to the living body sample from an outside of the living body sample, synthesizing the signal light via the observation area and the reference light and detecting a heterodyne interference signal, and measuring a living body function of the observation area by measuring a change in the heterodyne interference signal when the stimulation is changed.

摘要翻译： 生物体功能测量方法包括将来自低相干光源的光分离成信号光和参考光，调制信号光和参考光中的至少一个的频率，将信号光照射到 生物体样品，从生物体样品的外部对生物体样品进行刺激，经由观察区域和参考光合成信号光，并检测外差干涉信号，并测量观察的生物体功能 当刺激改变时测量外差干扰信号的变化。

公开(公告)号：US6137626A

公开(公告)日：2000-10-24

申请号：US102767

申请日：1998-06-23

申请人： Hideyuki Takaoka

发明人： Hideyuki Takaoka

IPC分类号： G02B5/30 ,  G02B1/08 ,  G02B1/11 ,  G02B21/00 ,  G02B21/06 ,  G02B27/28

CPC分类号： G02B21/06 ,  G02B27/286

摘要： An optical system having a polarization compensating optical system capable of compensating for retardation with high accuracy. The polarization compensating optical system includes a half-wave plate (22), a first optical system (23a) having at least one uncoated refracting surface (26, 27), and a second optical system (23b) having at least one coated refracting surface (24, 25). The total rotation of the polarization plane introduced in rays passing through the entire optical system is reduced to approximately zero by rotation of the polarization plane produced by the first optical system (23a), and the total retardation introduced in the rays is reduced to approximately zero by retardation produced by the second optical system (23b).

摘要翻译： 一种具有能够以高精度补偿延迟的偏振补偿光学系统的光学系统。 偏振补偿光学系统包括半波片（22），具有至少一个未涂覆折射表面（26,27）的第一光学系统（23a）和具有至少一个涂覆折射表面的第二光学系统（23b） （24,25）。 在通过整个光学系统的射线中引入的偏振面的总旋转通过由第一光学系统（23a）产生的偏振平面的旋转而减小到大约零，并且在光线中引入的总延迟减小到大约零 由第二光学系统（23b）产生的延迟。

公开(公告)号：US5969853A

公开(公告)日：1999-10-19

申请号：US934058

申请日：1997-09-19

申请人： Hideyuki Takaoka

发明人： Hideyuki Takaoka

IPC分类号： G02B21/00 ,  G02B21/14

CPC分类号： G02B21/14

摘要： An optical microscope is provided with an aperture element 13 and an optical modulation element 14 that creates an image having the detecting sensitivity of the phase contrast imaging technique while simultaneously realizing an image having the three-dimensional sense provided by the modulation contrast imaging technique. There are four regions (two of which may have the same transmittance value and be contiguous in portions of the optical modulation element), are provided on a single optical modulation element 14, these regions including a first light absorbing region 14a having transmittance Ta, a second light absorbing region 14b having transmittance Tb and positioned adjacent to the first light absorbing region, a first light transmitting region 14c having a transmittance Tc and positioned adjacent to the first light absorbing region 14a, and a second light transmitting region 14d having a transmittance Td, wherein Ta is greater than Tb and less than Tc, Ta is less than Td, Tc is greater than 0.5, and Td is greater than 0.5.

摘要翻译： 光学显微镜设置有孔径元件13和光学调制元件14，其创建具有相位成像技术的检测灵敏度的图像，同时实现具有由调制对比度成像技术提供的三维感测的图像。 在单个光调制元件14上设置有四个区域（其中两个可以具有相同的透射率值并且在光调制元件的部分中连续），这些区域包括具有透射率Ta的第一光吸收区域14a， 具有透光率Tb并与第一光吸收区域相邻的第二光吸收区域14b具有透射率Tc并且邻近第一光吸收区域14a定位的第一透光区域14c和具有透射率Td的第二透光区域14d 其中Ta大于Tb且小于Tc，Ta小于Td，Tc大于0.5，Td大于0.5。