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公开(公告)号：US4914198A
公开(公告)日：1990-04-03
申请号：US946842
申请日：1986-12-29
申请人： Hirofumi Nakano , Mitsunobu Hara , Yoshinori Yamashita , Isao Kawamoto , Katsuhiko Ando , Hiroshi Sano , Toru Yasuzawa , Katsuichi Shuto
发明人： Hirofumi Nakano , Mitsunobu Hara , Yoshinori Yamashita , Isao Kawamoto , Katsuhiko Ando , Hiroshi Sano , Toru Yasuzawa , Katsuichi Shuto
CPC分类号： C12P33/00 , C07J71/001
摘要： Novel substance UCY1003 produced by culturing of a microorganism has the following chemical structure and analgesic, hypotensive and antifungal activities: ##STR1##
摘要翻译： 通过培养微生物产生的新物质UCY1003具有以下化学结构和镇痛，降血压和抗真菌活性：
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公开(公告)号：US4952576A
公开(公告)日：1990-08-28
申请号：US223193
申请日：1988-07-22
IPC分类号： A61K31/58 , A61P25/04 , C07D493/02 , C07D493/08 , C07D493/10 , C07J71/00
CPC分类号： C07D493/10 , C07J71/0005
摘要： Compounds having analgesic activity which have the formula ##STR1## wherein R.sub.1 -R.sub.6 represent hydrogen or a substituent and X and Y together represent inter alia as epoxyethylene, ethylene halohydrin, haloethylene or a --CH.dbd.CH-group.
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3.发明授权Pyrindamycins A and B and duocarmycin A antibiotics derived from certain streptomyces culture 失效来自某些链霉菌培养物的青霉素A和B以及二焦霉素A抗生素
公开(公告)号：US4923990A
公开(公告)日：1990-05-08
申请号：US242788
申请日：1988-09-09
申请人： Hirofumi Nakano , Isami Takahashi , Michio Ichimura , Isao Kawamoto , Kozo Asasno , Fusao Tomita , Hiroshi Sano , Toru Yasuzawa , Makoto Morimoto , Kazuhisa Fujimoto
发明人： Hirofumi Nakano , Isami Takahashi , Michio Ichimura , Isao Kawamoto , Kozo Asasno , Fusao Tomita , Hiroshi Sano , Toru Yasuzawa , Makoto Morimoto , Kazuhisa Fujimoto
CPC分类号： C12P1/06
摘要： The present invention relates to DC-88A and DC-89A1 and their production. These compounds are obtained by fermentation of microorganisms belonging to the genus Streptomyces. These compounds have antibacterial and anti-tumor activities and are useful as medicaments.
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公开(公告)号：US5223637A
公开(公告)日：1993-06-29
申请号：US889388
申请日：1992-05-28
申请人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
发明人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
IPC分类号： C07C323/20 , C07C327/26 , C12P7/00
CPC分类号： C07C323/20 , C07C327/26 , C12P7/00
摘要： KS-506a, KS-506x and KS-506g having an activity to inhibit cyclic nucleotide phosphodiesterase and KS-506m and KS-506h having an activity to inhibit histamine release are produced by culturing a microorganism belonging to the genus Mortierella.
摘要翻译： 通过培养属于被孢霉属属的微生物来产生具有抑制环核苷酸磷酸二酯酶的活性的KS-506a，KS-506x和KS-506g以及具有抑制组胺释放活性的KS-506m和KS-506h。
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公开(公告)号：US4990693A
公开(公告)日：1991-02-05
申请号：US465892
申请日：1990-01-16
申请人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
发明人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
CPC分类号： C12R1/645 , C07C35/48 , C07C45/58 , C07C47/46 , C07D303/48 , C12P17/02 , C12P7/02 , C12P7/24
摘要： Novel physiologically active substances KS-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.
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公开(公告)号：US5142096A
公开(公告)日：1992-08-25
申请号：US329329
申请日：1989-03-27
申请人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
发明人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
IPC分类号： C07C323/20 , C07C327/26 , C12P7/00
CPC分类号： C07C327/26 , C07C323/20 , C12P7/00
摘要： KS-506a, KS-506x and KS-506g having an activity to inhibit cyclic nucleotide phosphodiesterase and KS-506m and KS-506h having an activity to inhibit histamine release are produced by culturing a microorganism belonging to the genus Mortierella.
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7.发明授权Novel substances KS-504a, KS-504b, KS-504d and KS-504e and process for their preparation 失效新型物质KS-504a，KS-504b，KS-504d和KS-504e及其制备方法
公开(公告)号：US4983775A
公开(公告)日：1991-01-08
申请号：US465893
申请日：1990-01-16
申请人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
发明人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
CPC分类号： C12R1/645 , C07C35/48 , C07C45/58 , C07C47/46 , C07D303/48 , C12P17/02 , C12P7/02 , C12P7/24
摘要： Novel physiologically active substances Ks-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.
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8.发明授权Novel substances KS-504a, KS-504b, KS-504d and KS-504e and process for their preparation 失效新型物质KS-504a，KS-504b，KS-504d和KS-504e及其制备方法
公开(公告)号：US4912132A
公开(公告)日：1990-03-27
申请号：US181702
申请日：1988-04-14
申请人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
发明人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
CPC分类号： C12R1/645 , C07C35/48 , C07C45/58 , C07C47/46 , C07D303/48 , C12P17/02 , C12P7/02 , C12P7/24
摘要： Novel physiologically active substances KS-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.
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9.发明授权
公开(公告)号：US4868159A
公开(公告)日：1989-09-19
申请号：US165738
申请日：1988-03-09
申请人： Satoshi Nakanishi , Koji Yamada , Isao Kawamoto , Katsuhiko Ando , Hiroshi Sano , Toru Yasuzawa , Hiroshi Kase
发明人： Satoshi Nakanishi , Koji Yamada , Isao Kawamoto , Katsuhiko Ando , Hiroshi Sano , Toru Yasuzawa , Hiroshi Kase
IPC分类号： C07H15/203 , C12P19/44
CPC分类号： C07H15/203 , C12P19/44 , C12R1/645
摘要： Novel physiologically active substances KS-501 and KS-502 having inhibitory activity on serotonin release from platelets and/or platelet aggregation are produced by culturing a microorganism of the genus Sporothrix.
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公开(公告)号：US5101038A
公开(公告)日：1992-03-31
申请号：US458543
申请日：1989-12-28
申请人： Hirofumi Nakano , Isami Takahashi , Isao Kawamoto , Toru Yasuzawa , Keiichi Takahashi , Eiji Kobayashi
发明人： Hirofumi Nakano , Isami Takahashi , Isao Kawamoto , Toru Yasuzawa , Keiichi Takahashi , Eiji Kobayashi
IPC分类号： A61K31/40 , A61P35/00 , C07D487/04 , C07D487/10 , C12N1/20 , C12P17/18 , C12R1/465
CPC分类号： C07D487/10 , C12P17/182
摘要： A novel fermentation product, DC113, represented by the formula ##STR1## which has antimicrobial and antitumor activities.
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