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公开(公告)号:US5536850A
公开(公告)日:1996-07-16
申请号:US392886
申请日:1995-03-01
申请人: Hirofumi Nakano , Noboru Fujii , Tamio Mizukami , Youichi Uosaki , Katsunori Kita , Eiji Kobayashi
发明人: Hirofumi Nakano , Noboru Fujii , Tamio Mizukami , Youichi Uosaki , Katsunori Kita , Eiji Kobayashi
IPC分类号: A61K31/35 , A61P31/04 , A61P35/00 , C07D493/04 , C12P17/18 , C07D311/78 , C07D311/94
CPC分类号: C07D493/04 , C12P17/181
摘要: The present invention relates to a novel substance DC114-A1 represented by the following formula (I): ##STR1##
摘要翻译: PCT No.PCT / JP94 / 00956 Sec。 371 1995年3月1日 102(e)1995年3月1日PCT 1994年6月14日PCT公布。 第WO95 / 01981号公报 1995年1月19日。本发明涉及由下式(I)表示的新型物质DC114-A1:
(I) -
公开(公告)号:US5717110A
公开(公告)日:1998-02-10
申请号:US836314
申请日:1997-05-12
申请人: Tamio Mizukami , Akira Asai , Yoshinori Yamashita , Hirofumi Nakano , Shingo Kakita , Youichi Uosaki , Keiko Ochiai , Tadashi Ashizawa , Akira Mihara
发明人: Tamio Mizukami , Akira Asai , Yoshinori Yamashita , Hirofumi Nakano , Shingo Kakita , Youichi Uosaki , Keiko Ochiai , Tadashi Ashizawa , Akira Mihara
IPC分类号: C07D207/34 , C07D207/00
CPC分类号: C07D207/34
摘要: This invention relates to UCH15 compounds of the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a hydroxyl group.
摘要翻译: PCT No.PCT / JP96 / 02587第 371日期:1997年5月12日 102(e)日期1997年5月12日PCT提交1996年9月11日PCT公布。 公开号WO97 / 10208 PCT 日本公开号为1997年3月20日本发明涉及式(I)的UCH15化合物:其中R 1表示氢原子或羟基。
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公开(公告)号:US5366966A
公开(公告)日:1994-11-22
申请号:US070962
申请日:1993-06-04
申请人: Hirofumi Nakano , Noboru Fujii , Yoshinori Yamashita , Youichi Uosaki , Shigeru Chiba , Shigeo Katsumata , Yukari Tsuji
发明人: Hirofumi Nakano , Noboru Fujii , Yoshinori Yamashita , Youichi Uosaki , Shigeru Chiba , Shigeo Katsumata , Yukari Tsuji
摘要: A compound represented by formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is provided, which has an excellent antitumor activity.
摘要翻译: 提供由式(I)表示的化合物:其具有优异的抗肿瘤活性。
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公开(公告)号:US5719179A
公开(公告)日:1998-02-17
申请号:US772941
申请日:1996-12-24
申请人: Tamio Mizukami , Yasushi Sakai , Tetsuo Yoshida , Youichi Uosaki , Keiko Ochiai , Shiro Akinaga
发明人: Tamio Mizukami , Yasushi Sakai , Tetsuo Yoshida , Youichi Uosaki , Keiko Ochiai , Shiro Akinaga
IPC分类号: C07D407/06 , C07D407/14 , C12P17/06 , C07D407/04 , A61K31/35
CPC分类号: C07D407/06 , C07D407/14 , C12P17/06
摘要: Disclosed is Compound GEX1 of formula (I), having excellent antitumor activity: ##STR1## wherein R.sup.1 represents hydroxy or ##STR2## R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen or hydroxy; R.sup.5 represents hydroxyl or lower alkoxy; provided that when R.sup.1 is hydroxy and R.sup.5 is methoxy, then at least one of R.sup.2, R.sup.3 and R.sup.4 is the group except for hydrogen, and pharmaceutically acceptable salts thereof.
摘要翻译: 公开了具有优异抗肿瘤活性的式(I)化合物GEX1:其中R 1表示羟基或R 2,R 3和R 4各自独立地表示氢或羟基; R5代表羟基或低级烷氧基; 条件是当R 1为羟基且R 5为甲氧基时,则R 2,R 3和R 4中的至少一个为氢以外的基团,及其药学上可接受的盐。
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公开(公告)号:US5070092A
公开(公告)日:1991-12-03
申请号:US545579
申请日:1990-06-29
申请人: Yutaka Kanda , Youichi Uosaki , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto , Satoru Nagamura
发明人: Yutaka Kanda , Youichi Uosaki , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto , Satoru Nagamura
IPC分类号: A61K31/40 , A61K31/445 , A61K31/495 , A61P35/00 , C07D487/04 , C07D487/10
CPC分类号: C07D487/04 , C07D487/10
摘要: DC-88A derivatives represented by the general formula: ##STR1## wherein X represents hydrogen or CO.sub.2 R.sup.1 (in which R.sup.1 represents hydrogen, a straight-chain or branched alkyl having 1 to 4 carbon atoms, allyl, or benzyl); and ##STR2## have an excellent anti-tumor activity and are useful as anti-tumor agents.
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公开(公告)号:US5187186A
公开(公告)日:1993-02-16
申请号:US755760
申请日:1991-09-06
申请人: Yutaka Kanda , Youichi Uosaki , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto , Satoru Nagamura
发明人: Yutaka Kanda , Youichi Uosaki , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto , Satoru Nagamura
IPC分类号: C07D487/04 , C07D487/10
CPC分类号: C07D487/04 , C07D487/10
摘要: DC-88A derivatives represented by the general formula: ##STR1## wherein X represents hydrogen or CO.sub.2 R.sup.1 (in which R.sup.1 represents hydrogen, a straight-chain or branched alkyl having 1 to 4 carbon atoms, allyl, or benzyl); and ##STR2## have an excellent anti-tumor activity and are useful as anti-tumor agents.
摘要翻译: 其中X表示氢或CO 2 R 1(其中R 1表示氢,具有1至4个碳原子的直链或支链烷基,烯丙基或苄基)表示的DC-88A衍生物。 和
具有优异的抗肿瘤活性,可用作抗肿瘤剂。 -
公开(公告)号:US5804599A
公开(公告)日:1998-09-08
申请号:US534852
申请日:1995-09-27
申请人: Takeo Tanaka , Eiji Tsukuda , Keiko Ochiai , Katsuhiko Ando , Hidemasa Kondo , Youichi Uosaki , Yutaka Saitoh , Yuzuru Matsuda , Fumito Koizumi , Tsutomu Agatsuma
发明人: Takeo Tanaka , Eiji Tsukuda , Keiko Ochiai , Katsuhiko Ando , Hidemasa Kondo , Youichi Uosaki , Yutaka Saitoh , Yuzuru Matsuda , Fumito Koizumi , Tsutomu Agatsuma
IPC分类号: A61K31/335 , A61K31/336 , A61P1/00 , A61P1/16 , A61P9/00 , A61P9/10 , A61P13/02 , A61P15/00 , A61P19/06 , A61P19/10 , A61P29/00 , A61P31/04 , A61P43/00 , C07D303/46 , C12P17/02 , C12R1/465 , A01N43/20 , A01N37/18 , A01N43/24 , A61K31/16
CPC分类号: C12R1/465 , C07D303/46 , C12P17/02
摘要: Provided is an Interleukin-1 production inhibiting compound represented by formula (I) ##STR1## wherein R denotes 4-methyl-1-pentenyl, 5-methyl-1,3-heptadienyl or 1-methylpentanyl.
摘要翻译: 本发明提供由式(I)表示的白细胞介素-1产生抑制化合物,其中R表示4-甲基-1-戊烯基,5-甲基-1,3-庚二烯基或1-甲基戊基。
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公开(公告)号:US5776739A
公开(公告)日:1998-07-07
申请号:US596262
申请日:1996-07-05
申请人: Kazuo Aisaka , Yutaka Saitoh , Youichi Uosaki
发明人: Kazuo Aisaka , Yutaka Saitoh , Youichi Uosaki
摘要: A process for producing a disaccharide which comprises: conducting the condensation reaction of .beta.-glucose-1-phosphate with a monosaccharide in an aqueous medium in the presence of an enzyme source which is derived from a microorganism belonging to the genus Catellatospora, Kineosporia, Propionibacterium, or Enterococcus and which has sugar phosphorylase activity; and recovering the disaccharide formed in the aqueous medium, as well as a novel disaccharide obtained by the process. The disaccharide obtained by the present invention is useful as a stabilizer for medicine, food, cosmetic and enzyme.
摘要翻译: PCT No.PCT / JP94 / 02060 Sec。 371日期:1996年7月5日第 102(e)日期1996年7月5日PCT 1994年12月8日PCT公布。 出版物WO95 / 34570 日期1995年12月21日一种制备二糖的方法,该方法包括:在衍生自属于该属的微生物的酶源的存在下,在水性介质中进行β-葡萄糖-1-磷酸与单糖的缩合反应 卡氏菌属,活细胞菌属,丙酸杆菌属或肠球菌属,具有糖磷酸化酶活性; 并回收在水性介质中形成的二糖,以及通过该方法获得的新型二糖。 通过本发明获得的二糖可用作药物,食品,化妆品和酶的稳定剂。
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