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    Radiographic image capturing apparatus, radiographic image capturing method, and position calculating method
    1.
    发明申请
    Radiographic image capturing apparatus, radiographic image capturing method, and position calculating method 审中-公开
    射线照相图像拍摄装置，放射线图像拍摄方法和位置计算方法

    公开(公告)号：US20110075791A1

    公开(公告)日：2011-03-31

    申请号：US12923160

    申请日：2010-09-07

    申请人： Hiroki Nakayama ,  Hajime Nakata ,  Naoyuki Okada ,  Takao Yoshida

    发明人： Hiroki Nakayama ,  Hajime Nakata ,  Naoyuki Okada ,  Takao Yoshida

    IPC分类号： A61B6/00 ,  G01N23/00

    CPC分类号： A61B6/022 ,  A61B6/12 ,  A61B6/502 ,  A61B6/583

    摘要： A radiographic image capturing apparatus includes a radiation source that outputs radiation, a radiation detector for detecting the radiation and converting such radiation into a radiographic image, and a reference point, which is disposed in a removable manner between the radiation source and the radiation detector. The reference point is disposed at the position of a center of rotation of the radiation source, which is set between the radiation source and the radiation detector. By rotating the radiation source about the position of the center of rotation, the radiation source applies radiation with respect to the reference point from at least two different angles.

    摘要翻译： 射线照相图像拍摄装置包括输出辐射的辐射源，用于检测辐射并将这种辐射转换成放射线照相图像的辐射检测器以及以可移除的方式设置在辐射源和辐射检测器之间的参考点。 参考点设置在放射源和放射线检测器之间的辐射源的旋转中心的位置。 通过围绕旋转中心的位置旋转辐射源，辐射源从至少两个不同的角度相对于参考点施加辐射。

    Radiographic image capturing apparatus
    2.
    发明授权
    Radiographic image capturing apparatus 有权
    射线照相摄影装置

    公开(公告)号：US08838207B2

    公开(公告)日：2014-09-16

    申请号：US12840810

    申请日：2010-07-21

    申请人： Hiroki Nakayama ,  Hajime Nakata ,  Naoyuki Okada ,  Takao Yoshida

    发明人： Hiroki Nakayama ,  Hajime Nakata ,  Naoyuki Okada ,  Takao Yoshida

    IPC分类号： A61B6/04 ,  A61B6/00

    CPC分类号： A61B6/0414 ,  A61B6/4494 ,  A61B6/469 ,  A61B6/502 ,  A61B10/0275

    摘要： In a radiographic image capturing apparatus, an object to be examined is compressed and secured between a compression plate and an image capturing base, at a position off-center from a central position of the image capturing base near a subject in a direction along the subject. An opening is defined in the compression plate so as to confront the object to be examined in the off-center position. The radiation source irradiates the object to be examined as well as the opening with radiation from a central angle of the radiation source, which is aligned with a vertical axis of the image capturing base, and which passes through the central position from a predetermined angle that is angularly spaced from the central angle about the central position.

    摘要翻译： 在放射线照相图像拍摄装置中，将被检查物体压缩并固定在压缩板和摄像基座之间，在与被摄体附近的摄像基板的中心位置偏离中心的位置，沿着被检体的方向 。 在压缩板中限定开口，以便在偏心位置与待检查对象相对。 辐射源用与辐射源的中心角度的放射线照射被检查物体，该辐射源与图像捕获基底的垂直轴对齐，并从预定角度穿过中心位置， 围绕中心位置与中心角度成角度地间隔开。

    Radiographic image capturing apparatus and radiographic image capturing method
    3.
    发明授权
    Radiographic image capturing apparatus and radiographic image capturing method 失效
    射线照相图像拍摄装置和放射摄影图像拍摄方法

    公开(公告)号：US08467495B2

    公开(公告)日：2013-06-18

    申请号：US12923556

    申请日：2010-09-28

    申请人： Naoyuki Okada ,  Hajime Nakata ,  Hiroki Nakayama ,  Takao Yoshida

    发明人： Naoyuki Okada ,  Hajime Nakata ,  Hiroki Nakayama ,  Takao Yoshida

    IPC分类号： A61B6/02 ,  G21K1/04

    CPC分类号： A61B6/0414 ,  A61B6/022 ,  A61B6/06 ,  A61B6/12 ,  A61B6/469 ,  A61B6/488 ,  A61B6/502 ,  A61B6/542 ,  A61B10/0283 ,  A61B2090/376

    摘要： In a radiographic image capturing apparatus, a biopsy region positional information calculator calculates a three-dimensional position of a biopsy region in an object to be examined based on two radiographic images which are acquired in a stereographic image capturing process, an irradiated field calculator calculates a new irradiated field covering the biopsy region based on the calculated three-dimensional position of the biopsy region and two angles at which a radiation source is disposed in the stereographic image capturing process, and a collimator controller controls a collimator to change the irradiated field of the radiation to the new irradiated field in a next stereographic image capturing process.

    摘要翻译： 在放射线照相图像拍摄装置中，活检区域位置信息计算器基于在立体图像拍摄处理中获取的两个放射线照相图像，计算待检体中的活检区域的三维位置，照射场计算器计算 基于所计算的活检区域的三维位置和在立体图像捕获过程中放置​​辐射源的两个角度覆盖活检区域的新的照射场，准直仪控制器控制准直仪，以改变照射场的照射场 在下一个立体图像拍摄过程中对新的照射场的辐射。

    Radiographic image capturing apparatus and radiographic image capturing method
    4.
    发明申请
    Radiographic image capturing apparatus and radiographic image capturing method 失效
    射线照相图像拍摄装置和放射摄影图像拍摄方法

    公开(公告)号：US20110075799A1

    公开(公告)日：2011-03-31

    申请号：US12923556

    申请日：2010-09-28

    申请人： Naoyuki Okada ,  Hajime Nakata ,  Hiroki Nakayama ,  Takao Yoshida

    发明人： Naoyuki Okada ,  Hajime Nakata ,  Hiroki Nakayama ,  Takao Yoshida

    IPC分类号： A61B6/02

    CPC分类号： A61B6/0414 ,  A61B6/022 ,  A61B6/06 ,  A61B6/12 ,  A61B6/469 ,  A61B6/488 ,  A61B6/502 ,  A61B6/542 ,  A61B10/0283 ,  A61B2090/376

    摘要： In a radiographic image capturing apparatus, a biopsy region positional information calculator calculates a three-dimensional position of a biopsy region in an object to be examined based on two radiographic images which are acquired in a stereographic image capturing process, an irradiated field calculator calculates a new irradiated field covering the biopsy region based on the calculated three-dimensional position of the biopsy region and two angles at which a radiation source is disposed in the stereographic image capturing process, and a collimator controller controls a collimator to change the irradiated field of the radiation to the new irradiated field in a next stereographic image capturing process.

    摘要翻译： 在放射线照相图像拍摄装置中，活检区域位置信息计算器基于在立体图像拍摄处理中获取的两个放射线照相图像，计算待检体中的活检区域的三维位置，照射场计算器计算 基于所计算的活检区域的三维位置和在立体图像捕获过程中放置​​辐射源的两个角度覆盖活检区域的新的照射场，准直仪控制器控制准直仪，以改变照射场的照射场 在下一个立体图像拍摄过程中对新的照射场的辐射。

    USE OF AN EFFICACY MARKER FOR OPTIMIZING THERAPEUTIC EFFICACY OF AN ANTI-HUMAN PD-1 ANTIBODY ON CANCERS
    7.
    发明申请
    USE OF AN EFFICACY MARKER FOR OPTIMIZING THERAPEUTIC EFFICACY OF AN ANTI-HUMAN PD-1 ANTIBODY ON CANCERS 有权
    使用有效标记来优化抗人PD-1抗体对癌症的治疗效果

    公开(公告)号：US20110123550A1

    公开(公告)日：2011-05-26

    申请号：US13001875

    申请日：2009-07-03

    申请人： Shiro Shibayama ,  Takao Yoshida ,  Tamon Hayashi ,  Akio Hayashi ,  Jun Murai

    发明人： Shiro Shibayama ,  Takao Yoshida ,  Tamon Hayashi ,  Akio Hayashi ,  Jun Murai

    IPC分类号： A61K39/395 ,  G01N33/53 ,  G01N33/50 ,  A61P35/00

    CPC分类号： C07K16/2818 ,  A61K2039/505 ,  G01N2800/52

    摘要： A purpose of the present invention is to provide a method capable of more effectively prescribing an anti-human PD-1 antibody for anti-cancer therapy, a method for estimating or optimizing therapeutic efficacy thereof, and further an efficacy marker that can be used in methods thereof. The present invention enables selection of the cancer patient in whom the therapeutic efficacy of the anti-human PD-1 antibody can be expected in future, by measuring the change which is more than a certain level of several kinds of efficacy markers in blood after administering the initial dose or doses of the anti-human PD-1 antibody compared to that prior to administering the initial dose, and provides a new prescription of the anti-human PD-1 antibody for anti-cancer therapy.

    摘要翻译： 本发明的目的是提供一种能够更有效地制备用于抗癌治疗的抗人PD-1抗体的方法，用于估计或优化其治疗功效的方法，以及可用于 方法。 本发明能够通过测量在施用后多于血液中的几种功效标记物的一定水平的变化来选择将来能够预期抗人PD-1抗体的治疗功效的癌症患者的选择 与施用初始剂量之前的抗人PD-1抗体的初始剂量或剂量相比较，并且提供了用于抗癌治疗的抗人PD-1抗体的新处方。

    BAGLIKE CONTAINER FOR CENTRIFUGATION AND METHOD OF GENE TRANSFER USING THE SAME
    9.
    发明申请
    BAGLIKE CONTAINER FOR CENTRIFUGATION AND METHOD OF GENE TRANSFER USING THE SAME 失效
    用于离心的巴格莱集装箱和使用该方法的基因转移方法

    公开(公告)号：US20100136680A1

    公开(公告)日：2010-06-03

    申请号：US12377234

    申请日：2006-08-23

    申请人： Hideto Chono ,  Junichi Mineno ,  Kazutoh Takesako ,  Takao Yoshida ,  Takashi Morimura ,  Kenji Sakai ,  Shin-ichi Yamada ,  Noritsugu Yabe ,  Yuko Taguchi

    发明人： Hideto Chono ,  Junichi Mineno ,  Kazutoh Takesako ,  Takao Yoshida ,  Takashi Morimura ,  Kenji Sakai ,  Shin-ichi Yamada ,  Noritsugu Yabe ,  Yuko Taguchi

    IPC分类号： C12N5/10 ,  B04B7/12

    CPC分类号： A61J1/10 ,  B01L3/5021 ,  B01L3/505 ,  C12M23/14 ,  C12M35/04 ,  C12N15/87

    摘要： Baglike container (1) that is fitted in a centrifuge to thereby allow centrifugation of any dispersion liquid placed therein. The baglike container for centrifugation is one comprising a main frame constituted of first container wall (3) with recess portion (6) formed so as to allow fitting in a centrifuge and with flange portion (7) provided on an open face border of the recess portion (6) and constituted of flexible second container wall (4) having its peripheral portion sealed mutually with the flange portion (7) of the first container wall (3) so as to define storing space (6′) for dispersion liquid in cooperation with the recess portion (6) and further comprising port (5) fitted to the main frame in a fashion allowing communication with the storing space (6′), wherein the recess portion (6) defining the storing space (6′) can be set in the centrifuge so that centrifugal force perpendicular to the bottom plane of the recess portion (6) applies. Moreover, there is disclosed a method of gene introduction using this baglike container.

    摘要翻译： 袋状容器（1），其装配在离心机中，从而允许离心分离任何分散液体。 用于离心的袋状容器是包括由具有凹部（6）的第一容器壁（3）构成的主框架，所述第一容器壁（3）形成为能够安装在离心机中，并且具有设置在凹部的开放面边界上的凸缘部（7） 部分（6），并且由具有与第一容器壁（3）的凸缘部分（7）相互密封的周边部分的柔性第二容器壁（4）构成，以便在合作中限定用于分散液体的储存空间（6'） 与所述凹部（6）相连并且还包括以允许与所述存放空间（6'）连通的方式装配到所述主框架的端口（5），其中限定所述存储空间（6'）的所述凹部（6）可以 设置在离心机中，使得垂直于凹部（6）的底面的离心力适用。 此外，公开了使用该袋状容器的基因导入方法。