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公开(公告)号：US5447820A
公开(公告)日：1995-09-05
申请号：US262322
申请日：1994-06-17
申请人： Hiroshi Hayakawa , Toshihide Ezoe , Toshiaki Kubo
发明人： Hiroshi Hayakawa , Toshihide Ezoe , Toshiaki Kubo
IPC分类号： G03C1/06
CPC分类号： G03C1/061
摘要： Disclosed is a silver halide photographic light-sensitive material for plate making which has an excellent rapid processing performance and a high processing stability. The silver halide photographic light-sensitive material comprises a support having provided thereon at least one silver halide light-sensitive emulsion layer, wherein at least one of (i) the at least one emulsion layer and (ii) another hydrophilic colloid layers(s) contains a compound represented by Formula (I).
摘要翻译： 公开了一种用于制版的卤化银照相感光材料，其具有优异的快速加工性能和高的加工稳定性。 卤化银照相感光材料包括其上提供有至少一个卤化银感光乳剂层的载体，其中（i）至少一个乳剂层和（ii）另一亲水胶体层中的至少一个， 含有式（I）表示的化合物。
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公开(公告)号：US20050158850A1
公开(公告)日：2005-07-21
申请号：US11020254
申请日：2004-12-27
申请人： Toshiaki Kubo , Toshihide Ezoe
发明人： Toshiaki Kubo , Toshihide Ezoe
CPC分类号： G01N21/553 , Y10S436/805
摘要： It is an object of the present invention to provide a biosensor, which is not significantly affected by the baseline fluctuation and suppresses nonspecific adsorption. The present invention provides a biosensor, which comprises a metal surface or metal film coated with a hydrophobic polymer, and has two or more types of different surfaces in a region coated with a hydrophobic polymer.
摘要翻译： 本发明的目的是提供一种不受基线波动的显着影响并抑制非特异性吸附的生物传感器。 本发明提供了一种生物传感器，其包括涂覆有疏水性聚合物的金属表面或金属膜，并且在涂覆有疏水性聚合物的区域中具有两种或更多种不同的表面。
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公开(公告)号：US08585972B2
公开(公告)日：2013-11-19
申请号：US12778555
申请日：2010-05-12
IPC分类号： G01N33/53
CPC分类号： G01N33/54353 , G01N33/54373
摘要： One object of the present invention is to provide a biosensor and a production method therefor, by which hydrogel that enables immobilization of a physiologically active substance can be conveniently produced using safe raw materials. The present invention provides a biosensor which comprises a substrate having a metal layer on its surface, wherein a hydrophilic polymer having a reactive functional group capable of reacting with a hydroxyl group or an amino group of a physiologically active substance is bound to the metal layer directly or indirectly via an intermediate layer.
摘要翻译： 本发明的一个目的是提供一种生物传感器及其生产方法，通过该生物传感器及其生产方法，可以使用安全的原料方便地生产能够固定生理活性物质的水凝胶。 本发明提供一种生物传感器，其包括在其表面具有金属层的基材，其中具有能够与生理活性物质的羟基或氨基反应的反应性官能团的亲水性聚合物直接结合到金属层 或间接经由中间层。
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公开(公告)号：US20060211137A1
公开(公告)日：2006-09-21
申请号：US11362354
申请日：2006-02-27
申请人： Toshihide Ezoe , Toshiaki Kubo , Masashi Hakamata
发明人： Toshihide Ezoe , Toshiaki Kubo , Masashi Hakamata
IPC分类号： G01N33/543 , C12M1/34
CPC分类号： G01N33/54373
摘要： It is an object of the present invention to provide a biosensor wherein a reference unit and a measurement unit can be prepared by performing only a single operation for immobilizing a physiologically active substance and wherein unnecessary electric charge does not remain in the reference unit. The present invention provides a biosensor which comprises a substrate composed of a metal surface or metal film coated with a hydrophilic polymer compound, and which has a surface for retaining a physiologically active substance and a surface that does not retain a physiologically active substance on a single plane of the substrate.
摘要翻译： 本发明的目的是提供一种生物传感器，其中通过仅执行用于固定生理活性物质的单一操作并且其中不必要的电荷不残留在参考单元中，可以制备参考单元和测量单元。 本发明提供了一种生物传感器，其包括由涂覆有亲水性高分子化合物的金属表面或金属膜构成的基板，并且具有用于保持生理活性物质的表面和不保留生理活性物质的表面 基板的平面。
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公开(公告)号：US20060040410A1
公开(公告)日：2006-02-23
申请号：US11205183
申请日：2005-08-17
申请人： Taisei Nishimi , Toshihide Ezoe , Toshiaki Kubo
发明人： Taisei Nishimi , Toshihide Ezoe , Toshiaki Kubo
IPC分类号： C12M1/34 , G01N33/553
CPC分类号： G01N33/54393 , G01N33/54373
摘要： It is an object of the present invention to provide a technique of converting carboxylic acid into an active ester with no generation of air bubbles and a technique of stabilizing the obtained active ester. The present invention provides a biosensor wherein a carboxyl group existing on the surface of a substrate thereof is activated with any one compound selected from an uronium salt, a phosphonium salt or a triazine derivative which are defined in the present application, so as to form a carboxylic acid amide group.
摘要翻译： 本发明的目的是提供一种不产生气泡而将羧酸转化成活性酯的技术，以及稳定所得活性酯的技术。 本发明提供一种生物传感器，其中存在于其底物表面上的羧基由选自本申请中定义的铀盐，鏻盐或三嗪衍生物的任何一种化合物活化，从而形成 羧酸酰胺基。
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公开(公告)号：US20070048796A1
公开(公告)日：2007-03-01
申请号：US11508904
申请日：2006-08-24
CPC分类号： G01N33/54393 , B82Y15/00 , B82Y30/00 , B82Y40/00
摘要： It is an object of the present invention to provide a biosensor with an improved recovery yield of a test substance interacting with a physiologically active substance. The present invention provides a biosensor having a flow channel formed on a substrate, which is composed of a detection surface for detecting the interaction of a physiologically active substance with a test substance and a non-detection surface that does not detect said interaction, wherein the detection surface and non-detection surface are modified in such a way that the physiologically active substance can be immobilized thereon.
摘要翻译： 本发明的目的是提供一种与生理活性物质相互作用的测试物质的回收率提高的生物传感器。 本发明提供一种生物传感器，其具有形成在基板上的流路，该流路由用于检测生理活性物质与检测物质的相互作用的检测面和不检测所述相互作用的非检测面构成， 检测表面和非检测表面以使生理活性物质固定在其上的方式被修饰。
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公开(公告)号：US5744279A
公开(公告)日：1998-04-28
申请号：US595478
申请日：1996-02-01
申请人： Toshihide Ezoe , Toshiaki Kubo , Hiroshi Takeuchi , Kazunobu Katoh , Shigeo Hirano , Kazuki Yamazaki , Takashi Hoshimiya , Minoru Sakai , Tetsuo Yoshida
发明人： Toshihide Ezoe , Toshiaki Kubo , Hiroshi Takeuchi , Kazunobu Katoh , Shigeo Hirano , Kazuki Yamazaki , Takashi Hoshimiya , Minoru Sakai , Tetsuo Yoshida
摘要： A silver halide photographic material is disclosed, comprising a support having provided thereon at least one silver halide emulsion layer, at least one layer of the emulsion layer and other hydrophilic colloid layers containing at least one hydrazine-type nucleating agent having, in the vicinity of the hydrazine group, an anionic group or a nonionic group which forms an intramolecular hydrogen bond with a hydrogen atom of the hydrazine, and also containing at least one of the onium salt compounds represented by formulae (a), (b) and (c), or at least one of the amine compounds represented by formulae (d), (e), (f), (g), (h), (i) and (j). Also disclosed is a method for processing, after exposure, the silver halide photographic material described above with a developer containing a reductone-type developing agent and having a pH of 12 or less.
摘要翻译： 公开了一种卤化银照相材料，其包括在其上设置有至少一个卤化银乳剂层的支撑体，至少一层乳剂层和其它含有至少一种肼型成核剂的亲水胶体层，所述肼型成核剂在 肼基，与肼的氢原子形成分子内氢键的阴离子基团或非离子基团，还含有由式（a），（b）和（c）表示的至少一种鎓盐化合物， ，或者由式（d），（e），（f），（g），（h），（i）和（j）表示的至少一种胺化合物。 还公开了一种在曝光后用含有还原酮型显影剂并且pH为12以下的显影剂处理上述卤化银照相材料的方法。
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公开(公告)号：US07501289B2
公开(公告)日：2009-03-10
申请号：US11020254
申请日：2004-12-27
申请人： Toshiaki Kubo , Toshihide Ezoe
发明人： Toshiaki Kubo , Toshihide Ezoe
IPC分类号： G01N33/543
CPC分类号： G01N21/553 , Y10S436/805
摘要： It is an object of the present invention to provide a biosensor, which is not significantly affected by the baseline fluctuation and suppresses nonspecific adsorption. The present invention provides a biosensor, which comprises a metal surface or metal film coated with a hydrophobic polymer, and has two or more types of different surfaces in a region coated with a hydrophobic polymer.
摘要翻译： 本发明的目的是提供一种不受基线波动的显着影响并抑制非特异性吸附的生物传感器。 本发明提供了一种生物传感器，其包括涂覆有疏水性聚合物的金属表面或金属膜，并且在涂覆有疏水性聚合物的区域中具有两种或更多种不同的表面。
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公开(公告)号：US20060257933A1
公开(公告)日：2006-11-16
申请号：US11378380
申请日：2006-03-20
申请人： Taisei Nishimi , Toshiaki Kubo , Toshihide Ezoe
发明人： Taisei Nishimi , Toshiaki Kubo , Toshihide Ezoe
CPC分类号： G01N33/54373
摘要： It is an object of the present invention to provide a biosensor used to easily produce a hydrogel capable of immobilizing a physically active substance, using safe materials; and a method for producing the same. The present invention provides a biosensor which comprises a substrate having a metal layer on the surface thereof, wherein an acetoacetyl group-containing hydrophilic polymer is bound to said metal layer directly or via an intermediate layer.
摘要翻译： 本发明的目的是提供一种用于容易地生产能够使用安全的材料固定活性物质的水凝胶的生物传感器。 及其制造方法。 本发明提供一种生物传感器，其包括其表面具有金属层的基板，其中含有乙酰乙酰基的亲水性聚合物直接或经由中间层与所述金属层结合。
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公开(公告)号：US20060240478A1
公开(公告)日：2006-10-26
申请号：US11358107
申请日：2006-02-22
CPC分类号： G01N33/54353 , G01N33/54373
摘要： One object of the present invention is to provide a biosensor and a production method therefor, by which hydrogel that enables immobilization of a physiologically active substance can be conveniently produced using safe raw materials. The present invention provides a biosensor which comprises a substrate having a metal layer on its surface, wherein a hydrophilic polymer having a reactive functional group capable of reacting with a hydroxyl group or an amino group of a physiologically active substance is bound to the metal layer directly or indirectly via an intermediate layer.
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