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    Method for diagnosis of heart failure
    4.
    发明申请
    Method for diagnosis of heart failure 审中-公开
    心力衰竭诊断方法

    公开(公告)号：US20070065850A1

    公开(公告)日：2007-03-22

    申请号：US11501810

    申请日：2006-08-10

    申请人： Tetuo Minamino ,  Masatsugu Hori ,  Ken-ichiro Okada ,  Masafumi Kitakaze

    发明人： Tetuo Minamino ,  Masatsugu Hori ,  Ken-ichiro Okada ,  Masafumi Kitakaze

    IPC分类号： C12Q1/68 ,  G01N33/567

    CPC分类号： G01N33/6875 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2800/325

    摘要： A method for diagnosis of heart failure in a human subject, which comprises the step of: measuring an endoplasmic reticulum (ER)-initiated apoptotic signal such as CHOP in a biological sample originated from the subject is disclosed. According to the invention, by employing the new marker in stead of or in addition to a conventional cardiac marker such as BNP, more accurate diagnosis of heart failure can be attained.

    摘要翻译： 公开了一种用于诊断人类受试者心脏衰竭的方法，其包括以下步骤：测量源自受试者的生物样品中的内质网（ER）诱导的凋亡信号如CHOP。 根据本发明，通过采用新的标记物代替常规心脏标志物例如BNP或除常规心脏标志物如BNP之外，可以更准确地诊断心力衰竭。

    Method of judging inflammatory disease
    9.
    发明授权
    Method of judging inflammatory disease 失效
    炎症性疾病的诊断方法

    公开(公告)号：US07754422B2

    公开(公告)日：2010-07-13

    申请号：US10523723

    申请日：2003-08-08

    申请人： Toshihiro Tanaka ,  Yozo Ohnishi ,  Koichi Ozaki ,  Aritoshi Iida ,  Yusuke Nakamura ,  Masatsugu Hori

    发明人： Toshihiro Tanaka ,  Yozo Ohnishi ,  Koichi Ozaki ,  Aritoshi Iida ,  Yusuke Nakamura ,  Masatsugu Hori

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The object of the present invention is to determine inflammatory diseases such as myocardial infarction by identifying single nucleotide polymorphisms (SNPs) associated with myocardial infarction and utilizing these SNPs. The present invention provides a method for determining an inflammatory disease, which comprises detecting at least one gene polymorphism existing in at least one gene selected from the group consisting of a lymphotoxin-α (LT-α) gene, an I Kappa B-like (IKBL) gene, and a BAT1 gene; an oligonucleotide used in said method; a kit for diagnosing an inflammatory disease which comprises said oligonucleotide; and use thereof. The present invention further provides a method for treating an inflammatory disease; and a method for screening for a therapeutic agent for an inflammatory disease.

    摘要翻译： 本发明的目的是通过鉴定与心肌梗塞相关的单核苷酸多态性（SNP）和利用这些SNP来确定诸如心肌梗死的炎性疾病。 本发明提供了一种测定炎性疾病的方法，该方法包括检测至少一种存在于选自淋巴毒素-α（LT-α）基因，IκB样（LT-α） IKBL）基因和BAT1基因; 所述方法中使用的寡核苷酸; 用于诊断包含所述寡核苷酸的炎性疾病的试剂盒; 及其用途。 本发明还提供一种治疗炎性疾病的方法; 以及筛选炎性疾病治疗剂的方法。