公开(公告)号：US4490029A

公开(公告)日：1984-12-25

申请号：US505597

申请日：1983-06-20

申请人： Harumi Tanaka ,  Hiroshi Ueda ,  Keisuke Maeda ,  Akira Yoshizaki

发明人： Harumi Tanaka ,  Hiroshi Ueda ,  Keisuke Maeda ,  Akira Yoshizaki

IPC分类号： G03B15/00 ,  G03B9/64 ,  G03B17/06 ,  G03B17/18 ,  G03B17/24 ,  G03B13/02

CPC分类号： G03B17/18 ,  G03B17/06 ,  G03B17/24 ,  G03B9/64 ,  G03B2217/243

摘要： A framing mirror provided on the front part of a camera for enabling observation of the range of the scene to be photographed from the front of the camera is used for various displays by a liquid crystal display device. Various operation modes are set by a mode selection member and the state of the display portion of the liquid crystal display device arranged in front of the framing mirror changes in accordance with the set operation mode to effect various displays. In at least one of the operation modes the whole display portion of the liquid crystal display device becomes transparent, whereby it is possible to observe the framing mirror from the front of the camera. Alternatively, the framing mirror has a transparent portion at a marginal position and the liquid crystal display device is arranged behind the transparent portion so as to be observable from the front of the camera. The liquid crystal display device displays the same data as displayed by another liquid crystal display device which is arranged behind the framing mirror, for recording data on a photographic film.

摘要翻译： 在液晶显示装置的各种显示器上，使用设置在相机前部的框架镜，用于观察从相机前方拍摄的场景的范围。 通过模式选择部件设定各种操作模式，并且布置在框架镜前面的液晶显示装置的显示部分的状态根据设定的操作模式而改变，以实现各种显示。 在至少一个操作模式中，液晶显示装置的整个显示部分变得透明，从而可以从相机前部观察框架镜。 或者，框架镜在边缘位置具有透明部分，并且液晶显示装置布置在透明部分的后面，以便可以从照相机的前部观察。 液晶显示装置显示与配置在框架镜后面的另一液晶显示装置所显示的数据相同的数据，用于在照相胶片上记录数据。

公开(公告)号：US4596452A

公开(公告)日：1986-06-24

申请号：US722921

申请日：1985-04-12

申请人： Hiroshi Ueda ,  Akira Yoshizaki ,  Harumi Tanaka

发明人： Hiroshi Ueda ,  Akira Yoshizaki ,  Harumi Tanaka

IPC分类号： G03B19/02 ,  G03B17/02

CPC分类号： G03B19/023

摘要： A disc camera for use with a disc film cartridge includes upper and lower camera walls spaced from one another by a distance less than the height of the cartridge housed in a cartridge chamber. The upper wall is formed with an opening which allows a part of the cartridge housed in the cartridge chamber to project therefrom. A frame is formed in the cartridge chamber so as to be fitted with an exposure aperture of the cartridge when a rear cover of the camera is closed. The frame serves to prevent exposure of a film in the cartridge to unwanted light. A covering member which protects the projecting part of the cartridge against impact which might be applied thereto also prevents entry of dust into the cartridge chamber.The opening may be formed on a lower camera wall or on both of the upper and lower camera walls.

摘要翻译： 与光盘暗盒一起使用的光盘相机包括彼此间隔开的距离小于容纳在暗盒室中的墨盒的高度的上部和下部相机壁。 上壁形成有允许容纳在暗盒室中的墨盒的一部分从其突出的开口。 当相机的后盖关闭时，在盒室中形成框架以便装配盒的曝光孔。 该框架用于防止墨盒中的胶片暴露于不需要的光线。 保护盒的突出部分的防止构件可能被施加到其上的冲击也可防止灰尘进入暗盒室。 开口可以形成在下摄像机壁上或上下摄像机壁上。

公开(公告)号：US4074291A

公开(公告)日：1978-02-14

申请号：US699375

申请日：1976-06-24

申请人： Hiroshi Ueda ,  Akira Yoshizaki

发明人： Hiroshi Ueda ,  Akira Yoshizaki

IPC分类号： G03B7/089 ,  G03B7/00 ,  G03B7/083 ,  G03B9/36 ,  G03B19/12 ,  G03B7/08

CPC分类号： G03B7/083

摘要： A single lens reflex camera in which the diaphragm aperture is stopped-down to a preset position before measuring the image light for use in the automatic exposure control mechanism of the camera. A mirror, which is provided in the camera along its optical path, is movable between a viewing position and a retracted photographing position. The camera has a focal plane shutter with two curtains. Upon exposure, the curtains travel in sequence in the same direction in which the mirror is retracted. Initiation of the movement of the first curtain begins before the mirror is fully retracted, thereby enabling the time lag between a shutter release operation and exposure to be reduced.

公开(公告)号：US4560261A

公开(公告)日：1985-12-24

申请号：US491846

申请日：1983-05-05

申请人： Hiroshi Ueda ,  Akira Yoshizaki ,  Yasuo Masaki

发明人： Hiroshi Ueda ,  Akira Yoshizaki ,  Yasuo Masaki

IPC分类号： G03B17/06 ,  G03B19/02 ,  G03B13/02 ,  G03B13/14

CPC分类号： G03B19/023 ,  G03B17/06

摘要： A camera for use with a disk film having a take lens window provided in the front side of a parallelepipedal housing closer to one lateral side thereof and a mirror device disposed at the center of the front side adjacent the window for observing the object. The mirror device is variable in its inclination to correct the parallax due to a variation in the distance of the object and has framing marks for indicating the field of view of the lens which differs with the object distance. The mirror device further has a coverage recognition sign which is observable only from a predetermined position within the coverage where an image of the object can be accurately observed on the device.

摘要翻译： 一种用于具有设置在更靠近其一个侧面的平行六面体壳体的前侧中的带有镜头窗口的盘片的照相机，以及设置在靠近窗口的正面中心处的镜装置，用于观察物体。 反射镜装置的倾斜度是可变的，以便由于物体的距离的变化而校正视差，并且具有用于指示与物体距离不同的透镜的视场的成帧标记。 反射镜装置还具有覆盖识别符号，其仅能够在覆盖范围内可以在装置上准确地观察物体的图像的预定位置处观察到。

公开(公告)号：US4142787A

公开(公告)日：1979-03-06

申请号：US752234

申请日：1976-12-20

申请人： Hiroshi Ueda ,  Akira Yoshizaki

发明人： Hiroshi Ueda ,  Akira Yoshizaki

IPC分类号： G03B7/087 ,  G03B7/08 ,  G03B19/12

CPC分类号： G03B7/087

摘要： A mechanism for automatically controlling the diaphragm aperture of a single lens reflex camera in response to scene brightness, has a photo-electric element disposed within camera body outside the photographic light path to receive light coming from the scene through the objective and diaphragm aperture and reflected from light reflective surfaces of shutter curtain and/or film. After the reflex mirror has retracted from its viewing position, the diaphragm is gradually stopped down with the photo-electric element receiving scene light therethrough until a diaphragm control circuit detects a suitable diaphragm aperture and interrupts the stopping down operation. Exposure time may be controlled by an electric circuit in accordance with the output of the photoelectric element receiving scene light through the diaphragm aperture adjusted by the diaphragm control circuit.

摘要翻译： 用于响应于场景亮度自动控制单个镜头反光相机的光圈孔径的机构具有设置在摄影光路外部的照相机体内的光电元件，以接收通过物镜和光阑孔径从场景发出的光并反射 从快门帘和/或胶片的光反射表面。 在反射镜已经从其观察位置缩回之后，光电子元件接收场景光直到膜片控制电路检测到合适的光阑孔径并中断停止操作，逐渐停止光阑。 曝光时间可以通过根据由光阑控制电路调节的光阑孔径接收场景光的光电元件的输出的电路来控制。

公开(公告)号：US4075640A

公开(公告)日：1978-02-21

申请号：US725470

申请日：1976-09-22

申请人： Hiroshi Ueda ,  Akira Yoshizaki

发明人： Hiroshi Ueda ,  Akira Yoshizaki

IPC分类号： G03B7/099 ,  G03B7/0997 ,  G03B17/18 ,  G03B7/08

CPC分类号： G03B7/09974

摘要： An exposure control mechanism for a camera which includes a light measuring circuit having a photosensitive element disposed for receiving scene light reflected at substantially the entire area of both the surface of a film and a leading curtain of a focal plane shutter after the light has passed through an objective and a diaphragm. An operable member is provided for moving a light restricting member from a non-operative to an operative position where the member respectively permits the scene light reflected at the entire area or the scene light reflected at a small predetermined area of the surface to be received by the photosensitive element. An alternative light measuring circuit has a plurality of photosensitive elements respectively disposed for receiving the scene light reflected at different small predetermined areas of the surface. In this case, switches are provided for selectively activating the photosensitive elements of the light measuring circuit.

公开(公告)号：US09023835B2

公开(公告)日：2015-05-05

申请号：US13390058

申请日：2010-08-09

申请人： Hiroshi Ueda

发明人： Hiroshi Ueda

IPC分类号： A61K38/22 ,  A61K45/06

CPC分类号： A61K38/2292 ,  A61K45/06 ,  A61K2300/00

摘要： The invention provides a method of ameliorating a blood-brain barrier disorder, as well as a method of treating a disease accompanied by a blood-brain barrier disorder and a method of treating a cerebral ischemic disease, by administering a prothymosin α, or a protein or polypeptide possessing the same function as the prothymosin α. The invention also provides polypeptides useful in the context of the aforesaid methods.

摘要翻译： 本发明提供一种改善血脑屏障障碍的方法，以及治疗伴有血脑屏障障碍的疾病的方法和治疗脑缺血疾病的方法，通过施用孕激素α或蛋白质 或具有与胸腺素α相同功能的多肽。 本发明还提供了在上述方法的上下文中有用的多肽。

公开(公告)号：US20130203738A1

公开(公告)日：2013-08-08

申请号：US13578230

申请日：2011-02-09

申请人： Yoshifumi Nishimura ,  Aritaka Nagadoi ,  Yuuka Hirao ,  Yoshio Goshima ,  Naoya Yamashita ,  Naoki Miyata ,  Takayoshi Suzuki ,  Ryuta Hiraishi ,  Hiroshi Ueda

发明人： Yoshifumi Nishimura ,  Aritaka Nagadoi ,  Yuuka Hirao ,  Yoshio Goshima ,  Naoya Yamashita ,  Naoki Miyata ,  Takayoshi Suzuki ,  Ryuta Hiraishi ,  Hiroshi Ueda

IPC分类号： C07D211/16 ,  C07D211/10 ,  C07D265/30 ,  C07D207/06 ,  C07D223/04 ,  C07D225/02 ,  C07D211/14 ,  C07C233/65

CPC分类号： C07D211/16 ,  A61K31/445 ,  C07C233/65 ,  C07C233/66 ,  C07C2601/14 ,  C07D207/06 ,  C07D211/10 ,  C07D211/14 ,  C07D211/96 ,  C07D223/04 ,  C07D225/02 ,  C07D265/30 ,  C07D295/192

摘要： The present invention identifies a compound which binds to the PAH1 domain of mSin3B that specifically binds to neural restrictive silencer factor NRSF, and uses the compound as a prophylactic and/or a therapeutic for diseases associated with abnormal expression of neural restrictive silencer factor NRSF/REST or abnormal expression of genes targeted by NRSF/REST, such as Huntington's disease, medulloblastoma and neuropathic pain.The present invention provides a pharmaceutical composition comprising a substance capable of binding to the PAH1 domain of mSin3B, e.g., a compound represented by the following formula (I), a pharmacologically acceptable salt thereof, or a pharmacologically acceptable ester thereof: wherein n represents 0 or 1; R1, R2, R3, R4 and R5 each independently represent a hydrogen atom, a hydrocarbon group or a functional group; Y represents a single bond, a carbonyl group, —CONH—, —NHCO— or a sulfonyl group; and Z represents a nitrogen-containing heterocyclic group which may have a substituent, an amino group which may have a hydrocarbon group or an aromatic hydrocarbon group, or a nitrogen and oxygen-containing heterocyclic group which may have a substituent.

摘要翻译： 本发明鉴定了与特异性结合神经限制性沉默因子NRSF的mSin3B的PAH1结构域结合的化合物，并且将该化合物用作与神经限制性消音因子NRSF / REST的异常表达相关的疾病的预防和/或治疗 或NRSF / REST靶向的基因异常表达，如亨廷顿氏病，成神经管细胞瘤和神经性疼痛。 本发明提供一种药物组合物，其包含能够结合mSin3B的PAH1结构域的物质，例如下式（I）表示的化合物，其药理学上可接受的盐或其药理学上可接受的酯：其中n表示0 或1; R1，R2，R3，R4和R5各自独立地表示氢原子，烃基或官能团; Y表示单键，羰基，-CONH-，-NHCO-或磺酰基; Z表示可以具有取代基的含氮杂环基，可以具有烃基或芳香族烃基的氨基或可以具有取代基的含氮和含氧杂环基。

公开(公告)号：US08411196B2

公开(公告)日：2013-04-02

申请号：US12095818

申请日：2006-11-30

申请人： Hiroshi Ueda ,  Kenichi Honjo ,  Naoto Yumiki ,  Toshio Makabe ,  Kenji Maeda ,  Kaoru Mokunaka ,  Kazuhiko Ishimaru

发明人： Hiroshi Ueda ,  Kenichi Honjo ,  Naoto Yumiki ,  Toshio Makabe ,  Kenji Maeda ,  Kaoru Mokunaka ,  Kazuhiko Ishimaru

IPC分类号： H04N5/232

CPC分类号： H04N5/23203 ,  G03B19/00 ,  G03B19/12 ,  H04N5/2254 ,  H04N5/23212 ,  H04N5/23245 ,  H04N5/23293 ,  H04N5/238

摘要： A digital camera of the present invention includes a microcomputer 110 having a live view mode controlling so that image data generated by a CMOS sensor 130 or image data obtained by subjecting the image data generated by the CMOS sensor 130 to predetermined processing is displayed on a liquid crystal monitor 150 as a moving image in real time, wherein when a release button 141 receives an instruction regarding start of an autofocus operation in a live view mode, the microcomputer 110 controls a movable mirror to enter an optical path to measure by an AF sensor 132, and thereafter, allow the movable mirror to retract from the optical path to return the digital camera to the live view mode. Due to this configuration, in a digital camera that includes a movable mirror and is capable of displaying a subject image in a live view through an electronic viewfinder, the operability thereof can be enhanced.

摘要翻译： 本发明的数码相机包括具有实时取景模式控制的微型计算机110，使得由CMOS传感器130生成的图像数据或通过对由CMOS传感器130生成的图像数据进行预定处理而获得的图像数据显示在液体 晶体监视器150作为运动图像实时地实现，其中当释放按钮141接收到关于在实时取景模式中的自动对焦操作的开始的指令时，微型计算机110控制可移动反射镜进入光学路径以由AF传感器 132，然后允许可移动镜从光路缩回以将数字照相机返回到实时取景模式。 由于这种结构，在包括可移动镜并且能够通过电子取景器在实时取景中显示被摄体图像的数码相机中，可以提高其可操作性。

公开(公告)号：US20120270338A1

公开(公告)日：2012-10-25

申请号：US13510105

申请日：2010-11-19

申请人： Hiroshi Ueda ,  Ryoji Abe ,  Masaki Ihara ,  Hiroaki Takagi

发明人： Hiroshi Ueda ,  Ryoji Abe ,  Masaki Ihara ,  Hiroaki Takagi

IPC分类号： G01N21/76 ,  C07K17/02

CPC分类号： G01N33/582 ,  A61K49/0058 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/92 ,  G01N21/6428 ,  G01N33/6857 ,  G01N2021/6439

摘要： An object is to provide an immunoassay method requiring neither a solid-phase immobilization step nor a washing step, enabling quick and simple quantitative measurement of a target substance in a liquid phase and capable of visualizing an antigen. Such an object is attained by measuring the concentration of a target antigen present in a test substance by sequentially performing a step (a) of bringing an antibody light-chain variable region polypeptide and an antibody heavy-chain variable region polypeptide labeled with a fluorescent dye into contact with an antigen in a test substance in a liquid phase; or bringing an antibody heavy-chain variable region polypeptide and an antibody light-chain variable region polypeptide labeled with a fluorescent dye into contact with an antigen in a test substance in a liquid phase; a step (b) of measuring the fluorescence intensity of the fluorescent dye; and a step (c) of computationally obtaining the level of the antigen contained in the test substance with reference to a positive correlation between the concentration of the antigen in a liquid phase and the fluorescence intensity of the fluorescent dye.

摘要翻译： 本发明的目的是提供一种不需要固相固定步骤和洗涤步骤的免疫测定方法，能够快速和简单地定量测定液相中的目标物质并能够使抗原呈现。 通过依次进行使荧光染料标记的抗体轻链可变区多肽和抗体重链可变区多肽的步骤（a），测定待测物质中存在的靶抗原的浓度， 与液相中测试物质中的抗原接触; 或使用荧光染料标记的抗体重链可变区多肽和抗体轻链可变区多肽与液相中的测试物质中的抗原接触; 测量荧光染料的荧光强度的步骤（b）; 和（c）参考在液相中的抗原浓度与荧光染料的荧光强度之间的正相关性来计算获得测试物质中含有的抗原水平的步骤（c）。