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公开(公告)号：US08349840B2
公开(公告)日：2013-01-08
申请号：US12970690
申请日：2010-12-16
申请人： Hiroshi Yamashita , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Hideaki Kuroda , Haruka Takahashi , Satoshi Shimizu , Tatsuyoshi Tanaka
发明人： Hiroshi Yamashita , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Hideaki Kuroda , Haruka Takahashi , Satoshi Shimizu , Tatsuyoshi Tanaka
IPC分类号： A61K31/496
CPC分类号： A61K31/496 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
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![Derivatives of 4-piperazin-1-yl-4-benzo[B]thiophene suitable for the treatment of CNS disorders](/abs-image/US/2011/12/06/US08071600B2/abs.jpg.150x150.jpg)
2.发明授权Derivatives of 4-piperazin-1-yl-4-benzo[B]thiophene suitable for the treatment of CNS disorders 有权适用于治疗CNS疾病的4-哌嗪-1-基-4-苯并[b]噻吩的衍生物公开(公告)号：US08071600B2
公开(公告)日：2011-12-06
申请号：US11991146
申请日：2006-08-31
申请人： Hiroshi Yamashita , Hideaki Kuroda , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Haruka Takahashi , Tae Fukushima , Satoshi Shimizu , Kazumi Kondo , Yohji Sakurai , Takeshi Kuroda , Shinichi Taira , Motohiro Itotani , Tatsuyoshi Tanaka
发明人： Hiroshi Yamashita , Hideaki Kuroda , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Haruka Takahashi , Tae Fukushima , Satoshi Shimizu , Kazumi Kondo , Yohji Sakurai , Takeshi Kuroda , Shinichi Taira , Motohiro Itotani , Tatsuyoshi Tanaka
IPC分类号： A61K31/496 , A61K31/55 , A61K31/551 , C07D333/54 , C07D409/12 , C07D409/14 , A61K31/536 , A61K31/5415 , C07D407/12 , C07D413/12 , C07D417/12
CPC分类号： C07D409/12 , C07D333/54 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/08 , C07D491/113
摘要： A heterocyclic compound or a salt thereof represented by the formula (1): where R2 represents a hydrogen atom or a lower alkyl group; A represents a lower alkylene group or lower alkenylene group; and R1 represents an aromatic group or a heterocyclic group. The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
摘要翻译： 由式（1）表示的杂环化合物或其盐：其中R 2表示氢原子或低级烷基; A表示低级亚烷基或低级亚烯基; R1表示芳基或杂环基。 本发明的化合物具有广泛的精神障碍治疗范围，包括中枢神经系统疾病，无副作用和高安全性。
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![Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of cns disorders](/abs-image/US/2009/10/22/US20090264404A1/abs.jpg.150x150.jpg)
3.发明申请Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of cns disorders 有权适用于治疗cns病症的4-哌嗪-1-基-4-苯并[b]噻吩的衍生物公开(公告)号：US20090264404A1
公开(公告)日：2009-10-22
申请号：US11991146
申请日：2006-08-31
申请人： Hiroshi Yamashita , Hideaki Kuroda , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Haruka Takahashi , Tae Fukushima , Satoshi Shimizu , Kazumi Kondo , Yohji Sakurai , Takeshi Kuroda , Shinichi Taira , Motohiro Itotani , Tatsuyoshi Tanaka
发明人： Hiroshi Yamashita , Hideaki Kuroda , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Haruka Takahashi , Tae Fukushima , Satoshi Shimizu , Kazumi Kondo , Yohji Sakurai , Takeshi Kuroda , Shinichi Taira , Motohiro Itotani , Tatsuyoshi Tanaka
IPC分类号： A61K31/496 , C07D409/14 , C07D265/36 , C07D223/08 , C07D243/08 , C07D267/14 , A61K31/536 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/397 , A61P25/00
CPC分类号： C07D409/12 , C07D333/54 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/08 , C07D491/113
摘要： A heterocyclic compound or a salt thereof represented by the formula (1): where R2 represents a hydrogen atom or a lower alkyl group; A represents a lower alkylene group or lower alkenylene group; and R1 represents an aromatic group or a heterocyclic group. The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
摘要翻译： 由式（1）表示的杂环化合物或其盐：其中R 2表示氢原子或低级烷基; A表示低级亚烷基或低级亚烯基; R1表示芳基或杂环基。 本发明的化合物具有广泛的精神障碍治疗范围，包括中枢神经系统疾病，无副作用和高安全性。
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![DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZO[B]THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS](/abs-image/US/2012/02/02/US20120028920A1/abs.jpg.150x150.jpg)
4.发明申请DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZO[B]THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS 失效适用于治疗CNS病症的4-哌啶-1-基-4-苯并[b]噻吩的衍生物公开(公告)号：US20120028920A1
公开(公告)日：2012-02-02
申请号：US13270544
申请日：2011-10-11
申请人： Hiroshi YAMASHITA , Hideaki Kuroda , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Haruka Takahashi , Tae Fukushima , Satoshi Shimizu , Kazumi Kondo , Yohji Sakurai , Takeshi Kuroda , Shinichi Taira , Motohiro Itotani , Tatsuyoshi Tanaka
发明人： Hiroshi YAMASHITA , Hideaki Kuroda , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Haruka Takahashi , Tae Fukushima , Satoshi Shimizu , Kazumi Kondo , Yohji Sakurai , Takeshi Kuroda , Shinichi Taira , Motohiro Itotani , Tatsuyoshi Tanaka
IPC分类号： A61K31/496 , C07D409/10 , C07D417/14 , C07D413/14 , A61K31/538 , A61K31/517 , A61K31/506 , A61K31/55 , A61K31/5415 , A61K31/553 , C07F7/18 , A61K31/695 , A61P25/18 , A61P25/24 , A61P25/00 , C07D409/14
CPC分类号： C07D409/12 , C07D333/54 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/08 , C07D491/113
摘要： A heterocyclic compound or a salt thereof represented by the formula (1): where R2 represents a hydrogen atom or a lower alkyl group; A represents a lower alkylene group or lower alkenylene group; and R1 represents an aromatic group or a heterocyclic group. The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
摘要翻译： 由式（1）表示的杂环化合物或其盐：其中R 2表示氢原子或低级烷基; A表示低级亚烷基或低级亚烯基; R1表示芳基或杂环基。 本发明的化合物具有广泛的精神障碍治疗范围，包括中枢神经系统疾病，无副作用和高安全性。
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5.发明申请公开(公告)号：US20110152286A1
公开(公告)日：2011-06-23
申请号：US12970690
申请日：2010-12-16
申请人： Hiroshi YAMASHITA , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Hideaki Kuroda , Haruka Takahashi , Satoshi Shimizu , Tatsuyoshi Tanaka
发明人： Hiroshi YAMASHITA , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Hideaki Kuroda , Haruka Takahashi , Satoshi Shimizu , Tatsuyoshi Tanaka
IPC分类号： A61K31/497 , C07D401/14 , A61P25/18 , A61P25/24 , A61P25/22 , A61P25/28 , A61P25/14 , A61P25/16
CPC分类号： A61K31/496 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
摘要翻译： 本发明提供由通式（1）表示的杂环化合物：本发明化合物具有广泛的精神障碍治疗谱，包括中枢神经系统疾病，副作用高，安全性高。
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6.发明授权公开(公告)号：US07888362B2
公开(公告)日：2011-02-15
申请号：US11659005
申请日：2006-04-12
申请人： Hiroshi Yamashita , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Hideaki Kuroda , Haruka Takahashi , Satoshi Shimizu , Tatsuyoshi Tanaka
发明人： Hiroshi Yamashita , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Hideaki Kuroda , Haruka Takahashi , Satoshi Shimizu , Tatsuyoshi Tanaka
IPC分类号： A61K31/496 , C07D409/12
CPC分类号： C07D409/12 , C07D409/14
摘要： The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
摘要翻译： 本发明提供由通式（1）表示的杂环化合物：本发明化合物具有广泛的精神障碍治疗谱，包括中枢神经系统疾病，副作用高，安全性高。
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7.发明申请公开(公告)号：US20100179322A1
公开(公告)日：2010-07-15
申请号：US11659005
申请日：2006-04-12
申请人： Hiroshi Yamashita , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Hideaki Kuroda , Haruka Takahashi , Satoshi Shimizu , Tatsuyoshi Tanaka
发明人： Hiroshi Yamashita , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Hideaki Kuroda , Haruka Takahashi , Satoshi Shimizu , Tatsuyoshi Tanaka
IPC分类号： C07D409/14
CPC分类号： C07D409/12 , C07D409/14
摘要： The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
摘要翻译： 本发明提供由通式（1）表示的杂环化合物：本发明化合物具有广泛的精神障碍治疗谱，包括中枢神经系统疾病，副作用高，安全性高。
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公开(公告)号：US20130053341A1
公开(公告)日：2013-02-28
申请号：US13520018
申请日：2010-12-30
申请人： Masaki Suzuki , Kazumi Kondo , Muneaki Kurimura , Krishna Reddy Valluru , Akira Takahashi , Takeshi Kuroda , Haruka Takahashi , Tae Fukushima , Shin Miyamura , Indranath Ghosh , Abhishek Dogra , Geraldine Harriman , Amy Elder , Satoshi Shimizu , Kevin J. Hodgetts , Jason S. Newcom
发明人： Masaki Suzuki , Kazumi Kondo , Muneaki Kurimura , Krishna Reddy Valluru , Akira Takahashi , Takeshi Kuroda , Haruka Takahashi , Tae Fukushima , Shin Miyamura , Indranath Ghosh , Abhishek Dogra , Geraldine Harriman , Amy Elder , Satoshi Shimizu , Kevin J. Hodgetts , Jason S. Newcom
IPC分类号： A61K31/517 , C07D413/14 , A61K31/5377 , A61K31/538 , C07D417/14 , A61K31/541 , A61K31/695 , A61P25/00 , A61P25/18 , A61P25/28 , A61K31/496 , A61K31/5513 , A61K31/519 , A61K31/554 , A61K31/5415 , C07D401/04
CPC分类号： C07D401/04 , A61K31/517 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要： Methods of treating disorders using compounds that modulate striatal-enriched tyrosine phosphatase (STEP) are de-scribed herein. Exemplary disorders include schizophrenia and cognitive deficit.
摘要翻译： 本文描述了使用调节纹状体富含酪氨酸磷酸酶（STEP）的化合物治疗病症的方法。 示例性疾病包括精神分裂症和认知缺陷。
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公开(公告)号：US20150307477A1
公开(公告)日：2015-10-29
申请号：US14692434
申请日：2015-04-21
申请人： Masaki Suzuki , Kazumi Kondo , Muneaki Kurimura , Krishna Reddy Valluru , Akira Takahashi , Takeshi Kuroda , Haruka Takahashi , Tae Fukushima , Shin Miyamura , Indranath Ghosh , Abhishek Dogra , Geraldine Harriman , Amy Elder , Satoshi Shimizu , Kevin J. Hodgetts , Jason S. Newcom
发明人： Masaki Suzuki , Kazumi Kondo , Muneaki Kurimura , Krishna Reddy Valluru , Akira Takahashi , Takeshi Kuroda , Haruka Takahashi , Tae Fukushima , Shin Miyamura , Indranath Ghosh , Abhishek Dogra , Geraldine Harriman , Amy Elder , Satoshi Shimizu , Kevin J. Hodgetts , Jason S. Newcom
IPC分类号： C07D401/14 , A61K31/517 , A61K45/06 , C07D401/04
CPC分类号： C07D401/04 , A61K31/517 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要： Methods of treating disorders using compounds that modulate striatal-enriched tyrosine phosphatase (STEP) are described herein. Exemplary disorders include schizophrenia and cognitive deficit.
摘要翻译： 本文描述了使用调节纹状体富含酪氨酸磷酸酶的化合物（STEP）治疗病症的方法。 示例性疾病包括精神分裂症和认知缺陷。
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公开(公告)号：US09073890B2
公开(公告)日：2015-07-07
申请号：US13520018
申请日：2010-12-30
申请人： Masaki Suzuki , Kazumi Kondo , Muneaki Kurimura , Krishna Reddy Valluru , Akira Takahashi , Takeshi Kuroda , Haruka Takahashi , Tae Fukushima , Shin Miyamura , Indranath Ghosh , Abhishek Dogra , Geraldine Harriman , Amy Elder , Satoshi Shimizu , Kevin J. Hodgetts , Jason S. Newcom
发明人： Masaki Suzuki , Kazumi Kondo , Muneaki Kurimura , Krishna Reddy Valluru , Akira Takahashi , Takeshi Kuroda , Haruka Takahashi , Tae Fukushima , Shin Miyamura , Indranath Ghosh , Abhishek Dogra , Geraldine Harriman , Amy Elder , Satoshi Shimizu , Kevin J. Hodgetts , Jason S. Newcom
IPC分类号： A01N43/90 , A61K31/519 , A01N43/54 , A61K31/517 , C07D491/00 , C07D495/00 , C07D401/00 , C07D403/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
CPC分类号： C07D401/04 , A61K31/517 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要： Compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds to treat a disorder, e.g., schizophrenia and cognitive deficit, in a subject are described herein. The compounds disclosed herein include quinoline and quinazoline-containing compounds that modulate striatal-enriched tyrosine phosphatase (STEP) activity.
摘要翻译： 本文描述了化合物，含有化合物的药物组合物，以及使用该化合物治疗受试者中的精神分裂症和认知缺陷症的方法。 本文公开的化合物包括调节富含纹状体的酪氨酸磷酸酶（STEP）活性的喹啉和喹唑啉化合物。
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