公开(公告)号：US07002736B2

公开(公告)日：2006-02-21

申请号：US10837698

申请日：2004-05-04

Applicant: Hiroya Fukuyama ,  Takehiro Yoshida

Inventor： Hiroya Fukuyama ,  Takehiro Yoshida

IPC: G02B21/00

CPC classification number: G02B21/0032 ,  G02B21/0036 ,  G02B21/0048 ,  G02B21/0052 ,  G02B21/006 ,  G02B21/0072 ,  G02B21/0076 ,  G02B27/0068

Abstract: A scanning optical microscope using a wavefront converting element suffers minimum off-axis performance degradation and allows the wavefront converting element to be controlled by a simple method. Further, a pupil relay optical system is simple in arrangement or unnecessary. A laser scanning microscope includes a laser oscillator 6 and a wavefront converting element 5 for applying a desired wavefront conversion to a laser beam 15 emitted from the laser oscillator 6. An objective 7 collects a wavefront-converted approximately parallel laser beam 17 emerging from the wavefront converting element 5 onto a sample 9. A detector 29 detects signal light emitted from the sample 9. An actuator 8 scans the objective 7 along a direction perpendicular to the optical axis.

公开(公告)号：US20060007534A1

公开(公告)日：2006-01-12

申请号：US11225098

申请日：2005-09-14

Applicant: Hiroya Fukuyama ,  Takehiro Yoshida

Inventor： Hiroya Fukuyama ,  Takehiro Yoshida

IPC: G02B21/00

CPC classification number: G02B21/0032 ,  G02B21/0036 ,  G02B21/0048 ,  G02B21/0052 ,  G02B21/006 ,  G02B21/0072 ,  G02B21/0076 ,  G02B27/0068

Abstract: A scanning optical microscope using a wavefront converting element suffers minimum off-axis performance degradation and allows the wavefront converting element to be controlled by a simple method. Further, a pupil relay optical system is simple in arrangement or unnecessary. A laser scanning microscope includes a laser oscillator and a wavefront converting element for applying a desired wavefront conversion to a laserbeam emitted from the laser oscillator. An objective collects a wavefront-converted approximately parallel laser beam emerging from the wavefront converting element onto a sample. A detector detects signal light emitted from the sample. An actuator scans the objective along a direction perpendicular to the optical axis.

Abstract translation: 使用波前转换元件的扫描光学显微镜具有最小的离轴性能劣化，并且允许通过简单的方法来控制波前转换元件。 此外，光瞳继电器光学系统的布置简单或不必要。 激光扫描显微镜包括激光振荡器和波前转换元件，用于将期望的波前转换应用于从激光振荡器发射的激光束。 目标收集从波前转换元件出现的波前转换的近似平行的激光束到样品上。 检测器检测从样品发出的信号光。 致动器沿垂直于光轴的方向扫描物镜。

公开(公告)号：US06751016B2

公开(公告)日：2004-06-15

申请号：US10025973

申请日：2001-12-26

Applicant: Hiroya Fukuyama ,  Takehiro Yoshida

Inventor： Hiroya Fukuyama ,  Takehiro Yoshida

IPC: G02B2100

CPC classification number: G02B21/0032 ,  G02B21/0036 ,  G02B21/0048 ,  G02B21/0052 ,  G02B21/006 ,  G02B21/0072 ,  G02B21/0076 ,  G02B27/0068

Abstract: A scanning optical microscope using a wavefront converting element suffers minimum off-axis performance degradation and allows the wavefront converting element to be controlled by a simple method. Further, a pupil relay optical system is simple in arrangement or unnecessary. A laser scanning microscope includes a laser oscillator 6 and a wavefront converting element 5 for applying a desired wavefront conversion to a laser beam 15 emitted from the laser oscillator 6. An objective 7 collects a wavefront-converted approximately parallel laser beam 17 emerging from the wavefront converting element 5 onto a sample 9. A detector 29 detects signal light emitted from the sample 9. An actuator 8 scans the objective 7 along a direction perpendicular to the optical axis.

公开(公告)号：US07224523B2

公开(公告)日：2007-05-29

申请号：US11225098

申请日：2005-09-14

Applicant: Hiroya Fukuyama ,  Takehiro Yoshida

Inventor： Hiroya Fukuyama ,  Takehiro Yoshida

IPC: G02B21/06

CPC classification number: G02B21/0032 ,  G02B21/0036 ,  G02B21/0048 ,  G02B21/0052 ,  G02B21/006 ,  G02B21/0072 ,  G02B21/0076 ,  G02B27/0068

Abstract: A scanning optical microscope using a wavefront converting element suffers minimum off-axis performance degradation and allows the wavefront converting element to be controlled by a simple method. Further, a pupil relay optical system is simple in arrangement or unnecessary. A laser scanning microscope includes a laser oscillator and a wavefront converting element for applying a desired wavefront conversion to a laser beam emitted from the laser oscillator. An objective collects a wavefront-converted approximately parallel laser beam emerging from the wavefront converting element onto a sample. A detector detects signal light emitted from the sample. An actuator scans the objective along a direction perpendicular to the optical axis.

Abstract translation: 使用波前转换元件的扫描光学显微镜具有最小的离轴性能劣化，并且允许通过简单的方法来控制波前转换元件。 此外，光瞳继电器光学系统的布置简单或不必要。 激光扫描显微镜包括激光振荡器和用于将所需波前转换应用于从激光振荡器发射的激光束的波前转换元件。 目标收集从波前转换元件出现的波前转换的近似平行的激光束到样品上。 检测器检测从样品发出的信号光。 致动器沿垂直于光轴的方向扫描物镜。

公开(公告)号：US20100002291A1

公开(公告)日：2010-01-07

申请号：US12310127

申请日：2007-08-02

Applicant: Hiroya Fukuyama

Inventor： Hiroya Fukuyama

IPC: G02B21/06 ,  F21V3/04 ,  G02B27/20

CPC classification number: G02B21/16 ,  B82Y20/00 ,  G02B1/007 ,  G02B21/002 ,  G02B21/082

Abstract: Light emitter excitation light (108) of a wavelength λ1 emitted by a light source (101) is collected on a light emitter (107) by a collective lens (102). The light emitter (107) is held on a substrate (104), and emits fluorescent light of a wavelength λ2 when the light emitter excitation light (108) of the wavelength λ1 is irradiated. A diameter of the light emitter (107) being formed to be smaller than the wavelength λ2, this fluorescent light includes evanescent waves, and advances through the substrate (104) as an object illuminating light (109) having the light emitter (107) as a point light source. A negative refraction lens (105) is disposed such that an image of the light emitter (107) is formed on a surface of an object 106, and accordingly, not only a propagating-light component included but also a evanescent-wave component in the object illuminating light (109) is also collected simultaneously, and a minute beam spot of a size almost same as of the light emitter (107) is formed on the surface of the object (106).

Abstract translation: 由光源（101）发射的波长λ1的发光体激发光（108）通过集体透镜（102）收集在发光体（107）上。 当照射波长λ1的发光体激发光（108）时，光发射器（107）被保持在基板（104）上，并且发射波长λ2的荧光。 光发射器（107）的直径形成为小于波长λ2，该荧光包​​括ev逝波，并且作为具有发光体（107）的物体照明光（109）前进到基板（104） 点光源。 负折射透镜（105）被设置为使得发光体（107）的图像形成在物体106的表面上，因此不仅包括传播光分量，而且还包括衍射光成分 同时收集物体照明光（109），并且在物体（106）的表面上形成与发光体（107）大致相同尺寸的微小光斑。

公开(公告)号：US20080106786A1

公开(公告)日：2008-05-08

申请号：US12001547

申请日：2007-12-11

Applicant: Nobuyuki Nagasawa ,  Yasunori Makara ,  Hiroya Fukuyama ,  Yoshihisa Tanikawa

Inventor： Nobuyuki Nagasawa ,  Yasunori Makara ,  Hiroya Fukuyama ,  Yoshihisa Tanikawa

IPC: G02B21/26

CPC classification number: A61B5/0059 ,  A61B5/0064 ,  A61B5/6835 ,  A61B5/6844 ,  A61B5/6886 ,  A61B2503/40 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/16

Abstract: An easily viewable examination image in which blurring occurring in an image is reduced without operating an examination optical system in real time matching the motion of a specimen is obtained. There is provided an examination method comprising, prior to examining an examination site of a specimen, acquiring an image of the specimen surface of an examination region including the examination site, over a predetermined time range; extracting a plurality of feature points by processing the acquired image of the specimen surface; calculating a motion trajectory for each of the extracted feature points over the time range; and disposing an optical axis of an examination optical system at a position where the motion trajectory of a feature point disposed in the examination site is minimized.

Abstract translation: 获得其中在图像中发生模糊的轻松可见的检查图像，而不用实际地检查检体光学系统来匹配检体的运动。 提供了一种检查方法，其包括在检查样本的检查部位之前，在预定时间范围内获取包括检查部位的检查区域的样本表面的图像; 通过处理获得的样本表面的图像来提取多个特征点; 在时间范围内计算每个提取的特征点的运动轨迹; 并且将检查光学系统的光轴布置在设置在检查部位的特征点的运动轨迹最小化的位置。

公开(公告)号：US20050270641A1

公开(公告)日：2005-12-08

申请号：US11085503

申请日：2005-03-22

Applicant: Tadashi Hirata ,  Hiroya Fukuyama

Inventor： Tadashi Hirata ,  Hiroya Fukuyama

IPC: G02B21/00 ,  G02B21/06

CPC classification number: G02B21/0072 ,  G02B21/002 ,  G02B21/0028

Abstract: A compact laser-scanning microscope that allows in-vivo observation, particularly of cells, with wavelengths ranging from the visible to the infra-red, can be provided. The laser-scanning microscope includes a laser light source unit, an optical fiber, a collimator optical system, an optical scanning unit, a pupil projection optical system, an objective optical system, and a detection optical system that detects fluorescence or reflected light from the specimen, via the objective optical system, the pupil projection optical system, the optical scanning unit, the collimator optical system and the optical fiber. The objective optical system can be attached to and detached from the pupil projection optical system near the intermediate image position.

Abstract translation: 可以提供一种紧凑的激光扫描显微镜，其允许具有从可见光到红外线的波长的体内观察，特别是细胞的观察。 激光扫描显微镜包括激光光源单元，光纤，准直光学系统，光学扫描单元，瞳孔投影光学系统，物镜光学系统和检测光学系统，其检测来自 标本，通过物镜光学系统，光瞳投影光学系统，光学扫描单元，准直仪光学系统和光纤。 物镜光学系统可以在中间图像位置附近附着到瞳孔投影光学系统并从其分离。

公开(公告)号：US20050200947A1

公开(公告)日：2005-09-15

申请号：US11057165

申请日：2005-02-15

Applicant: Tadashi Hirata ,  Hiroya Fukuyama ,  Masato Fujiwara ,  Yoshihiro Kawano

Inventor： Tadashi Hirata ,  Hiroya Fukuyama ,  Masato Fujiwara ,  Yoshihiro Kawano

IPC: G02B21/00

CPC classification number: G02B21/0004 ,  G02B21/02

Abstract: A microscope system includes a light source and an objective unit. The objective unit includes an objective optical system, including a small-diameter distal optical system arranged at an end brought near to or into contact with a specimen, for focusing light from the light source onto the specimen; a threaded mount at a coupling position; and an outer cylinder enclosing the small-diameter distal optical system. The microscope system further includes an imaging optical system for forming an image of light from the specimen through the objective optical system and a microscope main body for housing the imaging optical system. The objective unit is detachable from and attachable to the microscope main body with the threaded mount. Conditional expression Df/Da≦0.3 is satisfied, where Df represents the outer diameter of the outer cylinder and Da represents the outer diameter of the threaded mount.

Abstract translation: 显微镜系统包括光源和目标单元。 目标单元包括物镜光学系统，其包括设置在靠近或与样本接触的端部的小直径远端光学系统，用于将来自光源的光聚焦到样本上; 在联接位置的螺纹安装座; 以及包围小直径远端光学系统的外筒。 显微镜系统还包括用于通过物镜光学系统形成来自样本的光的图像的成像光学系统和用于容纳成像光学系统的显微镜主体。 目标单元可与螺纹安装座分离并附接到显微镜主体。 条件表达式Df / Da <= 0.3，其中Df表示外筒的外径，Da表示螺纹安装座的外径。

公开(公告)号：US08169724B2

公开(公告)日：2012-05-01

申请号：US12488950

申请日：2009-06-22

Applicant: Tadashi Hirata ,  Hiroya Fukuyama

Inventor： Tadashi Hirata ,  Hiroya Fukuyama

IPC: G02B7/02

CPC classification number: A61B1/04 ,  A61B1/00096 ,  A61B1/00101 ,  A61B1/00177 ,  A61B1/05 ,  A61B1/0615 ,  G02B23/24 ,  G02B23/2423

Abstract: High-precision observation is made possible while allowing contact between a distal end of an objective lens and an optical element without damaging the distal end of the objective lens and the optical element even when attaching to and detaching from the distal end of the objective lens. Provided is an objective lens adapter including a fixed member that is fixed to a lens tube of an objective lens, a distal-end member including an optical element that is made to be placed in contact with the distal-end surface of the objective lens, and an elastic member that is disposed between the distal-end member and the fixed member and that urges the optical element in a direction that causes the optical element to contact the distal-end surface of the objective lens.

Abstract translation: 高精度观察是可能的，同时允许物镜的远端和光学元件之间的接触，而不会损坏物镜的远端和光学元件，即使当附着到物镜的远端并与物镜分离时。 本发明提供一种物镜适配器，其包括：固定在物镜的透镜管上的固定部件，包括被配置为与物镜的前端面接触的光学元件的前端部件; 以及弹性构件，其设置在所述前端构件和所述固定构件之间，并且沿着使所述光学元件与所述物镜的远端表面接触的方向推压所述光学元件。

公开(公告)号：US20110263955A1

公开(公告)日：2011-10-27

申请号：US12978932

申请日：2010-12-27

Applicant: Toshiharu Narita ,  Ken Fujinuma ,  Ryosuke Ito ,  Kenji Taira ,  Hideyuki Takaoka ,  Shinichi Takimoto ,  Hiroyuki Nishida ,  Hiroya Fukuyama

Inventor： Toshiharu Narita ,  Ken Fujinuma ,  Ryosuke Ito ,  Kenji Taira ,  Hideyuki Takaoka ,  Shinichi Takimoto ,  Hiroyuki Nishida ,  Hiroya Fukuyama

IPC: A61B5/1455 ,  A61B1/06 ,  G01N33/48 ,  G01N21/49

CPC classification number: A61B5/0086 ,  A61B1/00009 ,  A61B1/00045 ,  A61B1/00071 ,  A61B1/0008 ,  A61B1/00096 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/04 ,  A61B1/042 ,  A61B1/0661 ,  A61B1/07 ,  A61B1/3137 ,  A61B5/0062 ,  A61B5/0064 ,  A61B5/0073 ,  A61B5/02007 ,  A61B5/1455 ,  A61B5/4887 ,  A61B5/489 ,  A61B5/7225 ,  A61B5/7278 ,  A61B2562/0233 ,  G01N21/4795

Abstract: There is provided an inside observation apparatus of an endoscope and the like which can perform an inside observation for irradiating an illumination light to a minute area of a surface of an object (for example, a living tissue) having a light scattering property and detecting a back-scattered light of the illumination light, can increase a detected light amount by a simply and low cost configuration by making an area of a detection region larger than an illumination region, and can reduce a time necessary to detect an body (for example, a blood vessel) to be observed and detect a region deeper than a conventional region.

Abstract translation: 提供了一种内窥镜等的内部观察装置，其能够进行向具有光散射性的物体（例如，活体组织）的表面的微小的面积照射照明光的内部观察，并且检测 通过使检测区域的面积大于照明区域，能够通过简单且低成本的构造来增加检测光量，并且可以减少检测身体所需的时间（例如， 血管），并且检测比常规区域更深的区域。