利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

25 条记录 (耗时 0.021 秒)

    Novel N-acetylglucosaminyltransferase, nucleic acid coding for the same, and uses thereof for diagnosis of cancer or tumor
    5.
    发明申请
    Novel N-acetylglucosaminyltransferase, nucleic acid coding for the same, and uses thereof for diagnosis of cancer or tumor 审中-公开
    新型N-乙酰葡糖胺基转移酶，编码其的核酸及其用于诊断癌症或肿瘤的用途

    公开(公告)号：US20070178557A1

    公开(公告)日：2007-08-02

    申请号：US11727336

    申请日：2007-03-26

    申请人： Hisashi Narimatsu ,  Niro Inaba ,  Akira Togayachi

    发明人： Hisashi Narimatsu ,  Niro Inaba ,  Akira Togayachi

    IPC分类号： C12P21/06 ,  C07H21/04 ,  C12N9/10

    CPC分类号： C12N9/1051 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： Described are an enzyme having an activity to transfer N-acetylglucosamine to a non-reducing terminal of Galβ1-4Glc or Galβ1-4GlcNAc group through β1,3-linkage; nucleic acid coding for the enzyme; and method for diagnosis of a cancer and/or tumor, especially a cancer and/or tumor of a digestive organ, using the expression amount of the gene of the enzyme as an index. A gene coding for a novel enzyme having an activity to transfer N-acetylglucosamine to a non-reducing terminal of Galβ1-4Glc or Galβ1-4GlcNAc group through β1,3-linkage was cloned from human stomach cells, and sequenced, and the enzyme was expressed. Since this enzyme is not produced substantially or at all in cancer and/or tumor cells, especially in cancer or tumor cells of a digestive organ, the cancer and/or tumor may be diagnosed using the expression of the gene of the enzyme as an index.

    摘要翻译： 描述了具有通过β1,3键将N-乙酰葡糖胺转移到Galbeta1-4Glc或Galbeta1-4GlcNAc组的非还原末端的活性的酶; 编码该酶的核酸; 以及使用酶的基因的表达量作为指标诊断癌症和/或肿瘤，特别是消化器官的癌症和​​/或肿瘤的方法。 从人胃细胞中克隆编码具有通过β1,3键将N-乙酰葡糖胺转移到Galbeta1-4Glc或Galbeta1-4GlcNAc组的非还原末端的新型酶的基因，并测序，酶 表达。 由于这种酶在癌和/或肿瘤细胞，特别是消化器官的癌症或肿瘤细胞中基本上或根本没有产生，所以可以使用酶的基因的表达作为指标诊断癌症和/或肿瘤 。

    N-acetylglucosamine transferase, nucleic acid encoding the same and use thereof in diagnosing cancer and/or tumor
    7.
    发明授权
    N-acetylglucosamine transferase, nucleic acid encoding the same and use thereof in diagnosing cancer and/or tumor 有权
    N-乙酰葡糖胺转移酶，编码该核酸的核酸及其在诊断癌症和/或肿瘤中的用途

    公开(公告)号：US07223580B2

    公开(公告)日：2007-05-29

    申请号：US10507421

    申请日：2003-03-14

    申请人： Hisashi Narimatsu ,  Niro Inaba ,  Akira Togayachi

    发明人： Hisashi Narimatsu ,  Niro Inaba ,  Akira Togayachi

    IPC分类号： C12N9/10 ,  C12N15/70 ,  C12N5/16 ,  C12Q1/68 ,  C12P21/06 ,  C12P19/04 ,  C07H21/04

    CPC分类号： C12N9/1051 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： An enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Galβ1-4Glc or Galβ1-4GlcNAc-group via a β-1,3 bond; a nucleic acid encoding the same; and a method of diagnosing cancer and/or tumor, in particular, digestive cancer and/or tumor using the expression dose of a gene of the above enzyme as an indication. A gene of a novel enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal β1-4Glc or Gal β1-4GlcNAc-group via a β-1,3 bond is cloned from human stomach cells and its base sequence is determined. Then this enzyme is expressed. Since this enzyme is scarcely or never produced in cancer and/or tumor, in particular, digestive cancer and/or tumor cells, cancer and/or tumor can be diagnosed with the use of the expression of the enzyme gene as an indication.

    摘要翻译： 具有通过β-1,3键将N-乙酰葡糖胺转移至Galbeta1-4Glc或Galbeta1-4GlcNAc-基团的非还原末端的活性的酶; 编码该核酸的核酸; 以及使用上述酶的基因的表达剂量作为指标来诊断癌症和/或肿瘤，特别是消化癌和/或肿瘤的方法。 从人胃细胞及其碱基克隆出具有通过β-1,3键将N-乙酰葡糖胺转移至Galβ1-4Glc或Galβ1-4GlcNAc-基团的非还原端的活性的新型酶的基因 确定序列。 然后表达这种酶。 由于这种酶在癌症和/或肿瘤中几乎没有或从未产生，特别是消化癌和/或肿瘤细胞，所以可以用酶基因的表达作为指示诊断癌症和/或肿瘤。

    Novel n-acetylglucosamine transferase, nucleic acid encoding the same and use thereof in diagnosing cancer and/or tumor
    9.
    发明申请
    Novel n-acetylglucosamine transferase, nucleic acid encoding the same and use thereof in diagnosing cancer and/or tumor 有权
    新的正乙酰葡糖胺转移酶，编码相同的核酸和其在诊断癌症和/或肿瘤中的用途

    公开(公告)号：US20050186570A1

    公开(公告)日：2005-08-25

    申请号：US10507421

    申请日：2003-03-14

    申请人： Hisashi Narimatsu ,  Niro Inaba ,  Akira Togayachi

    发明人： Hisashi Narimatsu ,  Niro Inaba ,  Akira Togayachi

    IPC分类号： C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N9/10 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C12N9/1051 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： An enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal β1-4Glc or Gal β1-4GlcNAc-group via a β-1,3 bond; a nucleic acid encoding the same; and a method of diagnosing cancer and/or tumor, in particular, digestive cancer and/or tumor using the expression dose of a gene of the above enzyme as an indication. A gene of a novel enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal β1-4Glc or Gal β1-4GlcNAc-group via a β-1,3 bond is cloned from human stomach cells and its base sequence is determined. Then this enzyme is expressed. Since this enzyme is scarcely or never produced in cancer and/or tumor, in particular, digestive cancer and/or tumor cells, cancer and/or tumor can be diagnosed with the use of the expression of the enzyme gene as an indication.

    摘要翻译： 具有通过β-1,3键将N-乙酰葡糖胺转移至Galβ1-4Glc或Galβ1-4GlcNAc-基团的非还原末端的活性的酶; 编码该核酸的核酸; 以及使用上述酶的基因的表达剂量作为指标来诊断癌症和/或肿瘤，特别是消化癌和/或肿瘤的方法。 从人胃细胞及其碱基克隆具有通过β-1,3键将N-乙酰葡糖胺转移至Galβ1-4Glc或Galβ1-4GlcNAc-基团的非还原端的活性的新型酶的基因 确定序列。 然后表达这种酶。 由于这种酶在癌症和/或肿瘤中几乎没有或从未产生，特别是消化癌和/或肿瘤细胞，所以可以用酶基因的表达作为指示诊断癌症和/或肿瘤。