利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

25 条记录 (耗时 0.025 秒)

    Novel N-acetylglucosaminyltransferase, nucleic acid coding for the same, and uses thereof for diagnosis of cancer or tumor
    7.
    发明申请
    Novel N-acetylglucosaminyltransferase, nucleic acid coding for the same, and uses thereof for diagnosis of cancer or tumor 审中-公开
    新型N-乙酰葡糖胺基转移酶，编码其的核酸及其用于诊断癌症或肿瘤的用途

    公开(公告)号：US20070178557A1

    公开(公告)日：2007-08-02

    申请号：US11727336

    申请日：2007-03-26

    申请人： Hisashi Narimatsu ,  Niro Inaba ,  Akira Togayachi

    发明人： Hisashi Narimatsu ,  Niro Inaba ,  Akira Togayachi

    IPC分类号： C12P21/06 ,  C07H21/04 ,  C12N9/10

    CPC分类号： C12N9/1051 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： Described are an enzyme having an activity to transfer N-acetylglucosamine to a non-reducing terminal of Galβ1-4Glc or Galβ1-4GlcNAc group through β1,3-linkage; nucleic acid coding for the enzyme; and method for diagnosis of a cancer and/or tumor, especially a cancer and/or tumor of a digestive organ, using the expression amount of the gene of the enzyme as an index. A gene coding for a novel enzyme having an activity to transfer N-acetylglucosamine to a non-reducing terminal of Galβ1-4Glc or Galβ1-4GlcNAc group through β1,3-linkage was cloned from human stomach cells, and sequenced, and the enzyme was expressed. Since this enzyme is not produced substantially or at all in cancer and/or tumor cells, especially in cancer or tumor cells of a digestive organ, the cancer and/or tumor may be diagnosed using the expression of the gene of the enzyme as an index.

    摘要翻译： 描述了具有通过β1,3键将N-乙酰葡糖胺转移到Galbeta1-4Glc或Galbeta1-4GlcNAc组的非还原末端的活性的酶; 编码该酶的核酸; 以及使用酶的基因的表达量作为指标诊断癌症和/或肿瘤，特别是消化器官的癌症和​​/或肿瘤的方法。 从人胃细胞中克隆编码具有通过β1,3键将N-乙酰葡糖胺转移到Galbeta1-4Glc或Galbeta1-4GlcNAc组的非还原末端的新型酶的基因，并测序，酶 表达。 由于这种酶在癌和/或肿瘤细胞，特别是消化器官的癌症或肿瘤细胞中基本上或根本没有产生，所以可以使用酶的基因的表达作为指标诊断癌症和/或肿瘤 。

    N-acetylglucosamine transferase, nucleic acid encoding the same and use thereof in diagnosing cancer and/or tumor
    8.
    发明授权
    N-acetylglucosamine transferase, nucleic acid encoding the same and use thereof in diagnosing cancer and/or tumor 有权
    N-乙酰葡糖胺转移酶，编码该核酸的核酸及其在诊断癌症和/或肿瘤中的用途

    公开(公告)号：US07223580B2

    公开(公告)日：2007-05-29

    申请号：US10507421

    申请日：2003-03-14

    申请人： Hisashi Narimatsu ,  Niro Inaba ,  Akira Togayachi

    发明人： Hisashi Narimatsu ,  Niro Inaba ,  Akira Togayachi

    IPC分类号： C12N9/10 ,  C12N15/70 ,  C12N5/16 ,  C12Q1/68 ,  C12P21/06 ,  C12P19/04 ,  C07H21/04

    CPC分类号： C12N9/1051 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： An enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Galβ1-4Glc or Galβ1-4GlcNAc-group via a β-1,3 bond; a nucleic acid encoding the same; and a method of diagnosing cancer and/or tumor, in particular, digestive cancer and/or tumor using the expression dose of a gene of the above enzyme as an indication. A gene of a novel enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal β1-4Glc or Gal β1-4GlcNAc-group via a β-1,3 bond is cloned from human stomach cells and its base sequence is determined. Then this enzyme is expressed. Since this enzyme is scarcely or never produced in cancer and/or tumor, in particular, digestive cancer and/or tumor cells, cancer and/or tumor can be diagnosed with the use of the expression of the enzyme gene as an indication.

    摘要翻译： 具有通过β-1,3键将N-乙酰葡糖胺转移至Galbeta1-4Glc或Galbeta1-4GlcNAc-基团的非还原末端的活性的酶; 编码该核酸的核酸; 以及使用上述酶的基因的表达剂量作为指标来诊断癌症和/或肿瘤，特别是消化癌和/或肿瘤的方法。 从人胃细胞及其碱基克隆出具有通过β-1,3键将N-乙酰葡糖胺转移至Galβ1-4Glc或Galβ1-4GlcNAc-基团的非还原端的活性的新型酶的基因 确定序列。 然后表达这种酶。 由于这种酶在癌症和/或肿瘤中几乎没有或从未产生，特别是消化癌和/或肿瘤细胞，所以可以用酶基因的表达作为指示诊断癌症和/或肿瘤。

    Novel n-acetylglucosamine transferase, nucleic acid encoding the same and use thereof in diagnosing cancer and/or tumor
    9.
    发明申请
    Novel n-acetylglucosamine transferase, nucleic acid encoding the same and use thereof in diagnosing cancer and/or tumor 有权
    新的正乙酰葡糖胺转移酶，编码相同的核酸和其在诊断癌症和/或肿瘤中的用途

    公开(公告)号：US20050186570A1

    公开(公告)日：2005-08-25

    申请号：US10507421

    申请日：2003-03-14

    申请人： Hisashi Narimatsu ,  Niro Inaba ,  Akira Togayachi

    发明人： Hisashi Narimatsu ,  Niro Inaba ,  Akira Togayachi

    IPC分类号： C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N9/10 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C12N9/1051 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： An enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal β1-4Glc or Gal β1-4GlcNAc-group via a β-1,3 bond; a nucleic acid encoding the same; and a method of diagnosing cancer and/or tumor, in particular, digestive cancer and/or tumor using the expression dose of a gene of the above enzyme as an indication. A gene of a novel enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal β1-4Glc or Gal β1-4GlcNAc-group via a β-1,3 bond is cloned from human stomach cells and its base sequence is determined. Then this enzyme is expressed. Since this enzyme is scarcely or never produced in cancer and/or tumor, in particular, digestive cancer and/or tumor cells, cancer and/or tumor can be diagnosed with the use of the expression of the enzyme gene as an indication.

    摘要翻译： 具有通过β-1,3键将N-乙酰葡糖胺转移至Galβ1-4Glc或Galβ1-4GlcNAc-基团的非还原末端的活性的酶; 编码该核酸的核酸; 以及使用上述酶的基因的表达剂量作为指标来诊断癌症和/或肿瘤，特别是消化癌和/或肿瘤的方法。 从人胃细胞及其碱基克隆具有通过β-1,3键将N-乙酰葡糖胺转移至Galβ1-4Glc或Galβ1-4GlcNAc-基团的非还原端的活性的新型酶的基因 确定序列。 然后表达这种酶。 由于这种酶在癌症和/或肿瘤中几乎没有或从未产生，特别是消化癌和/或肿瘤细胞，所以可以用酶基因的表达作为指示诊断癌症和/或肿瘤。

    Glycosyltransferase, nucleic acid encoding the glycosyltransferase and method of testing canceration using the nucleic acid
    10.
    发明申请
    Glycosyltransferase, nucleic acid encoding the glycosyltransferase and method of testing canceration using the nucleic acid 审中-公开
    糖基转移酶，编码糖基转移酶的核酸和使用核酸测试癌变的方法

    公开(公告)号：US20090081668A1

    公开(公告)日：2009-03-26

    申请号：US12155320

    申请日：2008-06-02

    申请人： Hisashi Narimatsu ,  Takashi Kudo ,  Akira Togayachi ,  Toru Hiruma

    发明人： Hisashi Narimatsu ,  Takashi Kudo ,  Akira Togayachi ,  Toru Hiruma

    IPC分类号： C12Q1/68 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12P21/04 ,  C07K16/18

    CPC分类号： C12N9/1051

    摘要： A tumor marker nucleic acid of the present invention is concerned with a nucleic acid hybridizing under stringent conditions to a nucleotide sequence described in SEQ ID NO: 1 or a complementary nucleotide sequence thereof. A method of testing canceration of the present invention is a method comprising diagnosing a biological sample as being cancerous when the transcription level of the nucleic acid in the biological sample significantly exceeds that in a normal biological sample as a control. The present invention also relates to a β1,3-N-acetyl-D-glucosaminyltransferase protein having an activity of transferring N-acetyl-D-glucosamine from a donor substrate to an acceptor substrate through β1,3-linkage.

    摘要翻译： 本发明的肿瘤标志物核酸涉及在严格条件下与SEQ ID NO：1所述核苷酸序列或其互补核苷酸序列杂交的核酸。 测定本发明的癌症的方法是当生物样品中的核酸的转录水平显着超过作为对照的正常生物样品中的生物样品时，将生物样品诊断为癌变的方法。 本发明还涉及具有通过β1,3键将N-乙酰基-D-葡糖胺从供体底物转移到受体底物的活性的β1,3-N-乙酰基-D-葡糖胺基转移酶蛋白。