公开(公告)号：US06810872B1

公开(公告)日：2004-11-02

申请号：US09703794

申请日：2000-11-02

申请人： Hisatomo Ohki ,  Shigemi Nakamura ,  Kazunori Ishizeki ,  Yoshiyuki Yazawa ,  Akira Yanagawa

发明人： Hisatomo Ohki ,  Shigemi Nakamura ,  Kazunori Ishizeki ,  Yoshiyuki Yazawa ,  Akira Yanagawa

IPC分类号： A61M1500

CPC分类号： A61M15/0045 ,  A61M11/002 ,  A61M15/0033 ,  A61M15/0035 ,  A61M15/0048 ,  A61M2202/064 ,  A61M2206/16

摘要： A blister pack for a inhalant medicator has a plurality of medical powder storage chambers spaced apart from each other in a circumferential direction. The inhalant medicator includes a pricking tool with a pair of parallel pins that prick inflow and outflow holes in one of the medical powder storage chambers during a preliminary operation of inhalant medication. The inflow and outflow holes are spaced apart from each other by a predetermined distance in a direction parallel to a lid panel of the blister pack to produce turbulent airflow within the medical powder storage chamber during inhalation during which the medical powder is inhaled by a patient's breathing. The medical powder storage chambers are dimensioned and designed to properly regulate or control properties of the airflow passing through the medical storage chamber, to ensure the airflow is suitable for the medical powder storage chamber.

摘要翻译： 用于吸入剂的吸塑包装具有沿圆周方向彼此隔开的多个医用粉末储存室。 吸入剂包括具有一对平行销的穿刺工具，其在吸入药物的初步操作期间刺入一个医疗粉末储存室中的流入和流出孔。 流入和流出孔在平行于泡罩包装的盖板的方向上彼此隔开预定距离，以在吸入期间在医用粉末储存室内产生湍流气流，在此期间医疗粉末被患者的呼吸吸入 。 医疗粉末储存室的尺寸设计为适当地调节或控制通过医疗储存室的气流的特性，以确保气流适合于医用粉末储存室。

公开(公告)号：US06408846B1

公开(公告)日：2002-06-25

申请号：US09623457

申请日：2000-09-11

申请人： Hisatomo Ohki ,  Kazunori Ishizeki ,  Shigemi Nakamura ,  Yoshiyuki Yazawa ,  Akira Yanagawa

发明人： Hisatomo Ohki ,  Kazunori Ishizeki ,  Shigemi Nakamura ,  Yoshiyuki Yazawa ,  Akira Yanagawa

IPC分类号： A61M1500

CPC分类号： A61M15/0028 ,  A61M15/0033 ,  A61M15/0086 ,  A61M2202/064 ,  A61M2206/16

摘要： A diffusion chamber block 14 is provided in a block mounting hole 13A of an inhalant port 13, and a granular medicine diffusion chamber 17 is formed in the diffusion chamber block 14. The granular medicine diffusion chamber 17 is formed at a side of the inhalant port 13 with a granular medicine inflow opening 17A and at a side of a capsule housing hole 9 with a granular medicine outflow opening 17B. A diffusion chamber in flow passage 18 is provided to communicate an outflow air passageway 12 with the granular medicine inflow opening 17A, whereas a diffusion chamber outflow passage is provided to communicate the granular medicine outflow opening 17B with the inhalant port 13. When inhaling granular medicines in the capsule housing hole 9 via the inhalant port 13 by way of breathing action, there results in counter-flow vortex within the granular medicine diffusion chamber 17. The counter-flow cortex acts to finely break and atomize massive granular medicines, thus promoting atomization of the granular medicines.

摘要翻译： 扩散室块14设置在吸入口13的块安装孔13A中，并且在扩散室块14中形成有粒状药物扩散室17.粒状药物扩散室17形成在吸入口侧 13，其具有粒状药物流入口17A，并且在具有粒状药物流出口17B的胶囊容纳孔9的一侧。 设置流路18的扩散室，使流出空气通路12与粒状药剂流入口17A连通，设置扩散室流出通路，使粒状药物流出口17B与吸入口13连通。吸入粒状药物时 通过呼吸作用经由吸入口13在胶囊容纳孔9中，在颗粒状药物扩散室17内产生逆流涡流。逆流皮层用于细粒化颗粒状药物，从而促进雾化 的颗粒状药物。

公开(公告)号：US20050048003A1

公开(公告)日：2005-03-03

申请号：US10960575

申请日：2004-10-08

申请人： Hisatomo Ohki ,  Shigemi Nakamura ,  Kazunori Ishizeki ,  Yoshiyuki Yazawa ,  Akira Yanagawa

发明人： Hisatomo Ohki ,  Shigemi Nakamura ,  Kazunori Ishizeki ,  Yoshiyuki Yazawa ,  Akira Yanagawa

IPC分类号： A61M15/00 ,  A61L9/04 ,  A61K9/14 ,  A61M11/00

CPC分类号： A61M15/0045 ,  A61M11/002 ,  A61M15/0033 ,  A61M15/0035 ,  A61M15/0048 ,  A61M2202/064 ,  A61M2206/16

摘要： A blister pack for an inhalant medicator has a plurality of medical powder storage chambers spaced apart from each other in a circumferential direction. The inhalant medicator includes a pricking tool with a pair of parallel pins that prick inflow and outflow holes in one of the medical powder storage chambers during a preliminary operation of inhalant medication. The inflow and outflow holes are spaced apart from each other by a predetermined distance in a direction parallel to a lid panel of the blister pack to produce turbulent airflow within the medical powder storage chamber during inhalation during which the medical powder is inhaled by a patient's breathing. The medical powder storage chambers are dimensioned and designed to properly regulate or control properties of the airflow passing through the medical storage chamber, to ensure the airflow is suitable for the medical powder stored in the storage chamber.

摘要翻译： 用于吸入剂的泡罩包装体具有沿圆周方向彼此隔开的多个医用粉末储存室。 吸入剂包括具有一对平行销的穿刺工具，其在吸入药物的初步操作期间刺入一个医疗粉末储存室中的流入和流出孔。 流入和流出孔在平行于泡罩包装的盖板的方向上彼此隔开预定距离，以在吸入期间在医用粉末储存室内产生湍流气流，在此期间医疗粉末被患者的呼吸吸入 。 医疗粉末储存室的尺寸设计成适当地调节或控制通过医疗储存室的气流的特性，以确保气流适用于存储在储存室中的医用粉末。

公开(公告)号：US5752505A

公开(公告)日：1998-05-19

申请号：US820654

申请日：1997-03-18

申请人： Hisatomo Ohki ,  Shigemi Nakamura ,  Kazunori Ishizeki ,  Yoshiyuki Yazawa ,  Akira Yanagawa

发明人： Hisatomo Ohki ,  Shigemi Nakamura ,  Kazunori Ishizeki ,  Yoshiyuki Yazawa ,  Akira Yanagawa

IPC分类号： A61K9/72 ,  A61M15/00

CPC分类号： A61M15/0028 ,  A61M15/0015 ,  A61M15/0036 ,  A61M2202/064

摘要： An inhalation type medication delivery device includes a dispenser body having a powder containment chamber at one axial side thereof and an inhalation port for drawing in a powder type medication on the another. An attached lid is provided on the dispenser body for opening and/or closing the powder containment chamber. In addition, an air passage is defined in the body allowing a powder type medication to be introduced into an airflow toward the inhalation port according to inhalation by a user. One end of the air passage opens through the lid towards the outside atmosphere and the other end communicates with the inhalation port while passing through the powder containment chamber. Also, a check valve is installed in the lid to prevent air drawn into said inhalation port from flowing in an outward direction opposite a medication delivery direction toward the inhalation port. Additional efficiency may be achieved by further providing a supplementary passage communicating between the inhalation port and the outside atmosphere independently of the air passage to generate additional suction force during inhalation.

摘要翻译： 吸入型药物输送装置包括：分配器本体，其具有在其一个轴向侧的粉末容纳室和用于吸入粉末型药物的吸入口。 在分配器主体上设置附接的盖，用于打开和/或关闭粉末容纳室。 此外，空气通道被限定在体内，允许粉末型药物根据使用者的吸入被引入朝向吸入口的气流中。 空气通道的一端通过盖朝向外部大气开放，另一端在通过粉末容纳室的同时与吸入口连通。 此外，止回阀安装在盖中，以防止吸入所述吸入口的空气朝向与吸入口相反的药物输送方向的向外方向流动。 通过进一步提供在吸入口和外部气氛之间连通的补充通道，可独立于空气通道来实现额外的效率，以在吸入期间产生额外的吸力。

公开(公告)号：US06273086B1

公开(公告)日：2001-08-14

申请号：US09355759

申请日：1999-08-04

申请人： Hisatomo Ohki ,  Yoshiyuki Yazawa ,  Shigemi Nakamura ,  Kazunori Ishizeki ,  Akira Yanagawa

发明人： Hisatomo Ohki ,  Yoshiyuki Yazawa ,  Shigemi Nakamura ,  Kazunori Ishizeki ,  Akira Yanagawa

IPC分类号： A61M1500

CPC分类号： A61M15/0028 ,  A61M15/002 ,  A61M15/0033 ,  A61M2202/064 ,  A61M2206/16

摘要： An inhalant medicator comprises a medicator body having a granular medicine accommodation chamber and an inhalant port, and air passageways disposed in the medicator body and communicating the inhalant port via the granular medicine accommodation chamber to the atmosphere for supplying granular medicines into the inhalant port. Also provided is a granular medicine diffusion means located downstream of the granular medicine accommodation chamber for efficiently diffusing the granular medicines. A cylindrical adapter 10 is detachably installed in the inhalant port 9. The granular medicine diffusion means comprises a granular medicine diffusion chamber 11 formed in the adapter, an adapter inlet passageway tangentially radially extending from the circumference of the diffusion chamber 11 for creating turbulent flow in the diffusion chamber, and an adapter outlet passageway intercommunicating the diffusion chamber and the inhalant port and having a diametrically-enlarged outlet passage portion, for good dispersion of the granulated medicines flowing out of the diffusion chamber into the inhalant port.

摘要翻译： 吸入药剂包括具有粒状药物容纳室和吸入口的药剂体，以及设置在药剂体内的空气通路，并且经由粒状药物容纳室将吸入口连通到用于向吸入口供给粒状药剂的气氛。 还提供了一种位于粒状药物容纳室下游的用于有效扩散颗粒状药物的颗粒状药物扩散装置。 圆柱形适配器10可拆卸地安装在吸入口9中。颗粒状药物扩散装置包括形成在适配器中的颗粒状药物扩散室11，从扩散室11的圆周切向径向延伸的适配器入口通道，用于产生湍流 扩散室和将扩散室和吸入口相互连通并具有径向扩大的出口通道部分的适配器出口通道，用于将从扩散室流出的粒状药物良好分散到吸入口中。

公开(公告)号：US5989217A

公开(公告)日：1999-11-23

申请号：US823314

申请日：1997-03-21

申请人： Hisatomo Ohki ,  Shigemi Nakamura ,  Kazunori Ishizeki ,  Yoshiyuki Yazawa ,  Akira Yanagawa

发明人： Hisatomo Ohki ,  Shigemi Nakamura ,  Kazunori Ishizeki ,  Yoshiyuki Yazawa ,  Akira Yanagawa

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61M13/00 ,  A61M15/00 ,  A61M15/08 ,  A61M31/00 ,  A61M11/00

CPC分类号： A61M15/0028 ,  A61M15/0033 ,  A61M2202/064 ,  A61M2205/075 ,  A61M31/00

摘要： A medicine administering device for nasal cavities, comprising a capsule holding section formed with a capsule containing powder-state medicine. An air supply section is connected to the lower end of the capsule holding section and formed with an air supply passage which is in communication with the capsule accommodating chamber. A branched passage section is connected to the upper end of the capsule holding section and has an air flow passage in communication with the capsule accommodating chamber. The air flow passage is bifurcated to form first and second outlet passage portions which are arranged to form a generally Y-shape. First and second medicine passages are formed such that air from the branched passage section flows therethrough to carry the medicine in the capsule into right-side and left-side nasal cavities of a patient. The first and second passages are respectively in communication with the first and second outlet passages of the branched passage section. First and second spraying holes are respectively in communication with the first and second medicine passages, the medicine from the first medicine passage and the medicine from the second medicine passage being sprayed respectively from the first and second spraying holes. The first and second spraying holes respectively have first and second axes which are separate from each other by a distance ranging from 12 to 25 mm.

摘要翻译： 一种用于鼻腔的给药装置，包括形成有包含粉末状药物的胶囊的胶囊保持部。 空气供应部分连接到胶囊保持部分的下端，并且形成有与胶囊容纳室连通的供气通道。 分支通道部分连接到胶囊保持部分的上端，并且具有与胶囊容纳室连通的空气流动通道。 气流通道分叉形成第一和第二出口通道部分，它们被布置为形成大致Y形。 第一和第二药物通道形成为使得来自分支通道部分的空气流过其中以将胶囊中的药物运送到患者的右侧和左侧鼻腔中。 第一通道和第二通道分别与分支通道部分的第一和第二出口通道连通。 第一和第二喷孔分别与第一和第二药物通道连通，来自第一药物通道的药物和来自第二药物通道的药物分别从第一和第二喷射孔喷洒。 第一和第二喷孔分别具有彼此分离距离为12至25mm的第一和第二轴。

公开(公告)号：US06371111B1

公开(公告)日：2002-04-16

申请号：US09623478

申请日：2000-09-13

申请人： Hisatomo Ohki ,  Yoshiyuki Yazawa ,  Shigemi Nakamura ,  Kazunori Ishizeki ,  Akira Yanagawa

发明人： Hisatomo Ohki ,  Yoshiyuki Yazawa ,  Shigemi Nakamura ,  Kazunori Ishizeki ,  Akira Yanagawa

IPC分类号： A61M1500

CPC分类号： A61M15/0028 ,  A61M15/003 ,  A61M2202/064 ,  A61M2206/16

摘要： An inhalant medicator includes a medicator body 1 which is formed therein with a cylindrical fit hole 2, an inhalant port 3, an inflow air passageway 5, and an outflow air passageway 6, and a medical powder storage cylindrical member 8 which is installed or fitted into the cylindrical fit hole 2 in a manner so as to open or close the air passageways 5 and 6 with respect to a medical powder storage chamber 12. The inhalant medicator is constructed by two component parts, namely the medicator body 1 and the medical powder storage cylindrical member 8, thus ensuring simplified structure and reduced production costs. Additionally, powder-and-granular medicine or medical powder 16 is tightly encapsulated within the medical powder storage chamber 12 by means of the medical powder storage cylindrical member 8, thus preventing loss of flow of the medical powder 16.

摘要翻译： 吸入药剂包括形成有圆筒形配合孔2，吸入口3，流入空气通路5和流出空气通路6的药剂主体1，以及安装或安装的医疗用粉末储存筒状构件8 以相对于医用粉末储存室12打开或关闭空气通道5和6的方式进入圆柱形配合孔2中。吸入剂由两部分构成，即药物体1和医用粉末 从而确保了简化的结构并降低了生产成本。 此外，粉末状药物或医用粉末16通过医用粉末储存筒状构件8紧密地包封在医疗粉末储存室12内，从而防止药物粉末16的流失。

公开(公告)号：US06341605B1

公开(公告)日：2002-01-29

申请号：US09355737

申请日：1999-08-04

申请人： Hisatomo Ohki ,  Shigemi Nakamura ,  Kazunori Ishizeki ,  Yoshiyuki Yazawa ,  Akira Yanagawa

发明人： Hisatomo Ohki ,  Shigemi Nakamura ,  Kazunori Ishizeki ,  Yoshiyuki Yazawa ,  Akira Yanagawa

IPC分类号： A61M1600

CPC分类号： A61M15/0028 ,  A61M15/002 ,  A61M15/0033 ,  A61M2202/064

摘要： An inhalant medicator comprises a medicator body formed at one axial end with a capsule housing hole and at another axial end with an inhalant port, an inflow air passageway having an axial inflow passage extending in an axial direction of the medicator body and a first pin insertion hole extending in a radial direction of the medicator body for communicating the capsule housing hole with the atmosphere, an outflow air passageway having an outflow passage extending in the axial direction of the medicator body and a second pin insertion hole extending in the radial direction of the medicator body for communicating the capsule housing hole with the inhalant port, and a boring tool having pins insertable toward a capsule through the first and second insertion holes for pricking holes in the capsule accommodated in the capsule housing hole with the pins. Also provided is a flow-constriction orifice (15, 15; 24A, 24A; 37, 37, 38, 38; 24C, 24C; 23C, 23C; 15′, 15′) disposed in at least one of the inflow and outflow air passageways and having an orifice size less than a flow passage area of each of the holes H.

摘要翻译： 吸入药剂包括在一个轴向端部处形成有胶囊容纳孔并且在另一个轴向端部处具有吸入口的药剂体，具有沿药物体的轴向延伸的轴向流入通道的流入空气通道和第一销插入 用于使胶囊容纳孔与大气连通的沿着药剂体的径向延伸的孔，具有沿药物主体的轴向延伸的流出通路的流出气路和沿着药剂主体的径向延伸的第二销插入孔 用于使胶囊容纳孔与吸入口连通的药剂体，以及具有能够通过第一和第二插入孔朝向胶囊插入的钻孔工具，用于用容纳在胶囊容纳孔中的胶囊中的针刺入孔。 还设置有设置在至少一个流入和流出空气中的流动收缩孔（15,15; 24A，24A; 37,37,38,38; 24C，24C; 23C，23C; 15'，15' 通道并且具有小于每个孔H的流动通道面积的孔口尺寸。

公开(公告)号：US06298846B1

公开(公告)日：2001-10-09

申请号：US09155248

申请日：1998-09-24

申请人： Hisatomo Ohki ,  Kazunori Ishizeki ,  Shigemi Nakamura ,  Yoshiyuki Yazawa ,  Akira Yanagawa

发明人： Hisatomo Ohki ,  Kazunori Ishizeki ,  Shigemi Nakamura ,  Yoshiyuki Yazawa ,  Akira Yanagawa

IPC分类号： A61M1500

CPC分类号： A61M15/0028 ,  A61M15/0033 ,  A61M2202/064

摘要： A cylindrical main body 3 of a medicine administering device main body 1 is formed with a holder accommodating section 5, in which a capsule holding section 9 of a capsule holder 8 is disposed to be able to get in and out of the holder accommodating section 5. Accordingly, the capsule can be installed in a capsule fitting depression 10 formed in the capsule holding section 9, or the capsule after use can be taken out at a drawn-out position where the capsule holding section is drawn out of the holder accommodating section 5, so that installation and taking-out operations for the capsule can be easily made without decomposing respective parts like in a conventional technique. Additionally, the capsule can be located at a pushed-in position by pushing the capsule holding section 9 in the holder accommodating section 5. Further, a burr releasing space is formed in a pin insertion hole located on an opposite side with respect to a perforating tool 25 so as to allow burr to be bent when a hole H1 is formed in the capsule K by a pin 27 of the perforating tool 25, thereby facilitating cleaning operation for removing broken pieces of the capsule K.

摘要翻译： 给药装置主体1的筒状主体3形成有保持架容纳部5，胶囊保持部8的胶囊保持部9被配置成能够进入保持架容纳部5 因此，胶囊可以安装在形成在胶囊保持部9中的胶囊配合用凹部10内，或者胶囊保持部从保持容纳部拉出的拉出位置被取出， 如图5所示，使得可以容易地进行胶囊的安装和取出操作，而不会像常规技术那样分解各个部件。 此外，通过将胶囊保持部9推入保持器容纳部5，胶囊可以位于推入位置。此外，在相对于穿孔的相反侧的销插入孔中形成有毛刺释放空间 工具25，以便当通过穿孔工具25的销27在胶囊K中形成孔H1时允许毛刺弯曲，从而有助于清除胶囊K的碎片的清洁操作。

公开(公告)号：US06595210B2

公开(公告)日：2003-07-22

申请号：US09908915

申请日：2001-07-20

申请人： Hisatomo Ohki ,  Yoshiyuki Yazawa ,  Shigemi Nakamura ,  Mitsuru Yokobori ,  Kazunori Ishizeki

发明人： Hisatomo Ohki ,  Yoshiyuki Yazawa ,  Shigemi Nakamura ,  Mitsuru Yokobori ,  Kazunori Ishizeki

IPC分类号： A61M1300

CPC分类号： A61M15/0028 ,  A61M11/001 ,  A61M15/003 ,  A61M15/0033 ,  A61M2202/064 ,  A61M2206/16

摘要： An inhalator including an inhalator body including a powder receiving chamber for receiving a powder, an air-powder mixture reservoir for temporarily storing an air-powder mixture flowing from the powder receiving chamber, and a diluent air passage for introducing a diluent air into the air-powder mixture reservoir. The air-powder mixture is formed within the powder receiving chamber when an air is introduced into the powder receiving chamber. The air-powder mixture within the air-powder mixture reservoir is admixed with a diluent air introduced thereinto through the diluent air passage. The diluted air-powder mixture is discharged from an air-powder mixture outlet into a user's oral or nasal cavity. A powder composition for inhalators includes at least two kinds of fine particles different in particle diameter.

摘要翻译： 一种吸入器，包括：吸入器主体，包括用于接收粉末的粉末接收室;用于临时存储从粉末接收室流出的空气 - 粉末混合物的空气 - 粉末混合物储存器;以及用于将稀释空气引入空气的稀释空气通道 粉末混合物储层。 当空气被引入到粉末接收室中时，空气 - 粉末混合物形成在粉末接收室内。 将空气 - 粉末混合物储存器内的空气 - 粉末混合物与通过稀释剂空气通道引入的稀释空气混合。 稀释的空气 - 粉末混合物从空气 - 粉末混合物出口排出到用户的口腔或鼻腔中。 用于吸入器的粉末组合物包括至少两种粒径不同的细颗粒。