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1.发明申请公开(公告)号：US20100068342A1
公开(公告)日：2010-03-18
申请号：US12312513
申请日：2007-11-15
IPC分类号： A23L1/305 , A23L1/0562
CPC分类号： C07K14/78 , A23J3/06 , A23J3/341 , A23L2/52 , A23L29/284 , A23L33/18 , A23V2002/00 , A61K38/014 , A23V2200/316 , A23V2250/5422
摘要： An object of the present invention is to elucidate a collagen peptide composed of oligopeptides having ability to enter the blood higher than that of conventional collagen peptides and thus to provide a food or beverage mixed with the collagen peptide. The present invention provides a collagen peptide composition obtainable by digesting a collagen or gelatin with protease, which comprises 70% to 100% by weight of peptides with a molecular weight 500 or more to 3000 or less, less than 10% by weight of peptides with a molecular weight of less than 500, and less than 20% by weight of peptides with a molecular weight of more than 3000, based on the total weight of the composition, wherein the ratio of N-terminal glycine residues to total of the N-terminal amino acid residues of the peptides in the composition is 33 mol % or more to 65 mol % or less.
摘要翻译： 本发明的目的是阐明由具有比常规胶原肽更高的进入血液的能力的寡肽构成的胶原肽，从而提供与胶原肽混合的食品或饮料。 本发明提供了一种通过用蛋白酶消化胶原蛋白或明胶获得的胶原肽组合物，其包含70％至100％重量的分子量为500或更多至3000或更小，少于10重量％ 基于组合物的总重量，分子量小于500且小于20重量％的分子量大于3000的肽，其中N-末端甘氨酸残基与N- 组合物中肽的末端氨基酸残基为33摩尔％以上至65摩尔％以下。
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2.发明授权Carbonyl reductases, polynucleotides comprising DNA encoding the same, methods for producing the same, and methods for producing optically active alcohol utilizing the same 失效羰基还原酶，包含编码该DNA的多核苷酸，其制备方法和利用其制备光学活性醇的方法公开(公告)号：US07083962B2
公开(公告)日：2006-08-01
申请号：US10826081
申请日：2004-04-15
CPC分类号： C12N9/0006 , C12P7/22
摘要： An objective of the present invention is to provide methods for efficiently producing (S)-1-(3,4-dimethoxyphenyl)-2-propanol at a high optical purity. Another objective is to provide novel reductases which reduce 3,4-dimethoxyphenylacetone, using NADPH as a coenzyme, to produce (S)-1-(3,4-dimethoxyphenyl)-2-propanol with a high optical purity.The inventors found that a 3,4-dimethoxyphenylacetone-reducing enzyme present in Torulaspora delbrueckii is a novel carbonyl reductase that reduces various carbonyls. This novel enzyme reduces 3,4-dimethoxyphenylacetone in a reduction reaction to produce (S)-1-(3,4-dimethoxyphenyl)-2-propanol with a high optical purity and at a high yield. Furthermore, the inventors isolated a DNA that encodes the present enzyme, and generated a recombinant bacterium which highly expresses the present enzyme. Thus, the present inventors established a simple and highly economical method of obtaining optically active alcohols with a high optical purity and at a high yield.
摘要翻译： 本发明的目的是提供以高光学纯度有效生产（S）-1-（3,4-二甲氧基苯基）-2-丙醇的方法。 另一个目标是提供使用NADPH作为辅酶还原3,4-二甲氧基苯丙酮的新型还原酶，以产生具有高光学纯度的（S）-1-（3,4-二甲氧基苯基）-2-丙醇。 本发明人发现存在于Torulaspora delbrueckii中的3,4-二甲氧基苯丙酮还原酶是一种可以还原各种羰基的新型羰基还原酶。 这种新型的酶在还原反应中还原3,4-二甲氧基苯丙酮，得到具有高光学纯度和高收率的（S）-1-（3,4-二甲氧基苯基）-2-丙醇。 此外，本发明人分离出编码本发明酶的DNA，并生成高表达本发明酶的重组细菌。 因此，本发明人建立了以高光学纯度和高收率获得光学活性醇的简单和高效的方法。
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公开(公告)号：US20060009524A1
公开(公告)日：2006-01-12
申请号：US11165466
申请日：2005-06-22
IPC分类号： A61K31/195 , C07C227/14
CPC分类号： C12P13/04 , C12P41/001
摘要： An objective of the present invention is to provide efficient methods for producing D-β-hydroxyamino acids (formula 2 or 4), such as D-erythro-2-amino-3-cyclohexyl-3-hydroxypropionic acid, which are useful as intermediates in the synthesis of pharmaceutical products and others. The present invention makes it possible to efficiently produce D-erythro-2-amino-3-cyclohexyl-3-hydroxypropionic acid by cleaving unnecessary L-erythro-2-amino-3-cyclohexyl-3-hydroxypropionic acid in industrially feasible concentrations of DL-erythro-2-amino-3-cyclohexyl-3-hydroxypropionic acid used as starting material by using Pseudomonas putida-derived L-phenylserine aldolase.
摘要翻译： 本发明的目的是提供用于生产可用作中间体的D-β-羟基氨基酸（式2或4）的有效方法，例如D-赤式-2-氨基-3-环己基-3-羟基丙酸 在制药产品的合成等方面。 本发明使得可以在工业上可行的DL浓度下切割不需要的L-赤式-2-氨基-3-环己基-3-羟基丙酸来有效地制备D-赤式-2-氨基-3-环己基-3-羟基丙酸 红假单胞菌2-氨基-3-环己基-3-羟基丙酸作为原料使用恶臭假单胞菌来源的L-苯基丝氨酸醛缩酶。
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公开(公告)号：US5006276A
公开(公告)日：1991-04-09
申请号：US397445
申请日：1989-08-03
申请人： Masaharu Kaneko , Takanori Nakajima
发明人： Masaharu Kaneko , Takanori Nakajima
CPC分类号： C09K19/603 , C09B1/32 , C09B1/503 , C09B1/62
摘要： ##STR1## A liquid crystal composition and a display element using the same are disclosed. The composition contains at least one dichroic dye represented by general formula (I), at least one dichroic dye represented by general formula (II), and at least one dichroic dye represented by general formula (III). In formula (I), R1 to R3 each represent a hydrogen atom, an alkyl group, an optionally substituted cycloalkyl group, an alkoxyalkyl group, an alkoxy group or a halogen atom; and A represents (a); in formula (II), R4 and R5 each represents a hydrogen atom, an alkyl group, an optionally substituted cycloalkyl group, an alkoxyalkyl group, an alkoxy group or a halogen atom; in formula (III), R6 represents a hydrogen atom, an alkyl group, an optionally substituted cycloalkyl group, an alkoxyalkyl group, an alkoxy group or a halogen atom. R7 represents a hydrogen atom or (b), and R8 represents a hydrogen atom, an alkyl group, an optionally substituted cycloalkyl group, an alkoxyalkyl, an alkoxy group or a halogen atom.
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5.发明申请RECOMBINANT MICROORGANISMS WITH 1,3-BUTANEDIOL-PRODUCING FUNCTION AND USES THEREOF 审中-公开具有1,3-丁二醇生产功能的重组微生物及其用途公开(公告)号：US20120276606A1
公开(公告)日：2012-11-01
申请号：US13504391
申请日：2010-10-29
摘要： An objective of the present invention is to provide recombinant microorganisms efficiently producing optically active 1,3-butanediol, which is useful as a material for synthesizing pharmaceuticals and such, and provide methods for efficiently producing optically active 1,3-butanediol using the recombinant microorganisms. As a result of dedicated research for achieving the above objective, the present inventors succeeded in producing recombinant microorganisms in which the activity of an enzyme catalyzing the reduction reaction represented by Formula 1 is enhanced and which produce a diol compound represented by Formula 2. (wherein R represents a C1-3 alkyl group or hydrogen) (wherein R represents a C1-3 alkyl group or hydrogen)
摘要翻译： 本发明的目的是提供有效地制备光学活性1,3-丁二醇的重组微生物，其可用作合成药物等的材料，并提供使用重组微生物有效生产光学活性1,3-丁二醇的方法 。 作为实现上述目的的专门研究的结果，本发明人成功地生产了其中催化由式1表示的还原反应的酶的活性增强并且产生由式2表示的二醇化合物的重组微生物（其中 R表示C 1-3烷基或氢）（其中R表示C 1-3烷基或氢）
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公开(公告)号：US07282356B2
公开(公告)日：2007-10-16
申请号：US10746796
申请日：2003-12-23
CPC分类号： C12N9/80 , C12P13/227
摘要： The present invention provides mutant D-aminoacylases and use thereof. The mutant D-aminoacylases are hard to be inhibited by the substrate and, comprise the amino acid sequences of the D-aminoacylase derived from Alcaligenes denitrificans subsp. xylosoxydans MI-4 strain, wherein amino acid residues at specific sites have been modified. The mutants of the present invention have high reaction specificity as well as resistance to inhibition by the substrate. The present invention enables high-yield production of D-amino acids using higher concentrations of N-acyl-DL-amino acid as the substrate. The mutants of the present invention are useful in producing D-tryptophan in particular.
摘要翻译： 本发明提供了突变体D-氨基酰基酶及其用途。 突变体D-氨基酸酰基酶难以被底物抑制，并且包含衍生自产碱假单胞菌副产物的D-氨基酰化酶的氨基酸序列。 xylosoxydans MI-4菌株，其中特定位点处的氨基酸残基已被修饰。 本发明的突变体具有高反应特异性以及耐基质抑制性。 本发明能够使用更高浓度的N-酰基-DL-氨基酸作为底物，高产量生产D-氨基酸。 本发明的突变体尤其可用于生产D-色氨酸。
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7.发明授权公开(公告)号：US07203558B2
公开(公告)日：2007-04-10
申请号：US10162415
申请日：2002-06-03
IPC分类号： G06F17/00
CPC分类号： G10L17/26 , G10H1/0041 , G10H2210/076 , G10H2240/061 , G10H2240/085
摘要： A method and a device for computing sense data, which automatically compute data relating to feelings or senses generated by the human sensations by analyzing signals, such as audio signals, relating to the sensations. In the device, a MP3 decoder storing unit stores digital sound data which has been recorded using MP3 system. A decompression unit decompresses MP3 data which has been decompressed, and outputs as sound pressure value data at each frequency area. A sense data computation unit includes a feeling analysis unit and a rhythm analysis unit. The rhythm analysis unit obtains count of beats per unit time based on the sound pressure value data. The feeling analysis unit obtains a few kinds of feeling parameter values based on the sound pressure value data, determines the kind and level of feelings based on the value of feeling parameter and the count of beats per unit time, and writes the results thereof into a sense data accumulation unit.
摘要翻译： 一种用于计算感测数据的方法和装置，其通过分析与感觉相关的诸如音频信号的信号来自动计算与人感觉产生的感觉或感觉有关的数据。 在该设备中，MP3解码器存储单元存储使用MP3系统记录的数字声音数据。 解压缩单元对已经解压缩的MP3数据进行解压缩，并在每个频率区域作为声压值数据输出。 感测数据计算单元包括感觉分析单元和节奏分析单元。 节奏分析单元基于声压值数据获得每单位时间的节拍数。 感觉分析单元基于声压值数据获得几种感觉参数值，基于感觉参数的值和每单位时间的节拍数来确定感觉的种类和水平，并将其结果写入 感测数据累积单元。
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8.发明申请Carbonyl reductases, polynucleotides comprising DNA encoding the same, methods for producing the same, and methods for producing optically active alcohol utilizing the same 失效羰基还原酶，包含编码该DNA的多核苷酸，其制备方法和利用其制备光学活性醇的方法公开(公告)号：US20050148057A1
公开(公告)日：2005-07-07
申请号：US10826081
申请日：2004-04-15
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/04 , C12P7/02 , C12P7/22 , C07H21/04 , C12N1/18 , C12N15/74 , C12P21/04
CPC分类号： C12N9/0006 , C12P7/22
摘要： An objective of the present invention is to provide methods for efficiently producing (S)-1-(3,4-dimethoxyphenyl)-2-propanol at a high optical purity. Another objective is to provide novel reductases which reduce 3,4-dimethoxyphenylacetone, using NADPH as a coenzyme, to produce (S)-1-(3,4-dimethoxyphenyl)-2-propanol with a high optical purity. The inventors found that a 3,4-dimethoxyphenylacetone-reducing enzyme present in Torulaspora delbrueckii is a novel carbonyl reductase that reduces various carbonyls. This novel enzyme reduces 3,4-dimethoxyphenylacetone in a reduction reaction to produce (S)-1-(3,4-dimethoxyphenyl)-2-propanol with a high optical purity and at a high yield. Furthermore, the inventors isolated a DNA that encodes the present enzyme, and generated a recombinant bacterium which highly expresses the present enzyme. Thus, the present inventors established a simple and highly economical method of obtaining optically active alcohols with a high optical purity and at a high yield.
摘要翻译： 本发明的目的是提供以高光学纯度有效生产（S）-1-（3,4-二甲氧基苯基）-2-丙醇的方法。 另一个目标是提供使用NADPH作为辅酶还原3,4-二甲氧基苯丙酮的新型还原酶，以产生具有高光学纯度的（S）-1-（3,4-二甲氧基苯基）-2-丙醇。 本发明人发现存在于Torulaspora delbrueckii中的3,4-二甲氧基苯丙酮还原酶是一种可以还原各种羰基的新型羰基还原酶。 该新型酶在还原反应中还原3,4-二甲氧基苯丙酮，以产生具有高光学纯度和高收率的（S）-1-（3,4-二甲氧基苯基）-2-丙醇。 此外，本发明人分离出编码本发明酶的DNA，并生成高表达本发明酶的重组细菌。 因此，本发明人建立了以高光学纯度和高收率获得光学活性醇的简单和高效的方法。
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