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25 条记录 (耗时 0.015 秒)

    2-(1-piperazinyl)-4-substituted phenylquinoline derivatives, processes for the preparation thereof, and pharmaceutical composition containing the same
    1.
    发明授权
    2-(1-piperazinyl)-4-substituted phenylquinoline derivatives, processes for the preparation thereof, and pharmaceutical composition containing the same 失效
    2-（1-哌嗪基）-4-取代苯基喹啉衍生物，其制备方法和含有它们的药物组合物

    公开(公告)号：US4758566A

    公开(公告)日：1988-07-19

    申请号：US893311

    申请日：1986-07-28

    申请人： Hitoshi Uno ,  Katsuhiko Hino ,  Toshiaki Kadokawa ,  Katsuyoshi Kawashima

    发明人： Hitoshi Uno ,  Katsuhiko Hino ,  Toshiaki Kadokawa ,  Katsuyoshi Kawashima

    IPC分类号： A61K31/47 ,  A61P1/04 ,  C07D215/38 ,  A61K31/495 ,  C07D401/02

    CPC分类号： C07D215/38

    摘要： Compounds of the formula: ##STR1## wherein R.sub.1 represents fluorine atom at the para position, chlorine atom at the para position, methyl group at the para position or trifluoromethyl group at the para or meta position; and R.sub.2 represents hydrogen atom, methyl group, ethyl group, 2-hydroxyethyl group or 3-hydroxypropyl group, provided that R.sub.2 represents ethyl group, 2-hydroxyethyl group or 3-hydroxypropyl group when R.sub.1 represents fluorine atom at the para position, methyl group at the para position or trifluoromethyl group at the para position, and a pharmaceutically acceptable salt therof, process for the preparation thereof, and pharmaceutical composition containing the same. The compounds and pharmaceutically acceptable salts thereof show excellent cytoprotective effect and useful for prophylaxis and treatment of peptic ulcer and inflammatory gastrointestinal diseases.

    摘要翻译： PCT No.PCT / JP85 / 00654 Sec。 371日期1986年7月28日第 102（e）日期1986年7月28日PCT提交1985年11月27日PCT公布。 公开号WO86 / 03198 日期：1986年6月5日。下式的化合物：其中R1表示对位的氟原子，对位的氯原子，对位的甲基或对位或间位的三氟甲基; R2表示氢原子，甲基，乙基，2-羟乙基或3-羟丙基，条件是当R1表示对位的氟原子时，R2表示乙基，2-羟基乙基或3-羟丙基，甲基 在对位或在对位的三氟甲基，和其药学上可接受的盐，其制备方法和含有它们的药物组合物。 所述化合物及其药学上可接受的盐显示出优异的细胞保护作用并且可用于预防和治疗消化性溃疡和炎性胃肠道疾病。

    Anti-peptic ulcer agent
    2.
    发明授权
    Anti-peptic ulcer agent 失效
    抗消化性溃疡剂

    公开(公告)号：US4677107A

    公开(公告)日：1987-06-30

    申请号：US784215

    申请日：1985-10-04

    申请人： Toshiaki Kadokawa ,  Katsuyoshi Kawashima ,  Hitoshi Uno ,  Katsuhiko Hino

    发明人： Toshiaki Kadokawa ,  Katsuyoshi Kawashima ,  Hitoshi Uno ,  Katsuhiko Hino

    IPC分类号： A61K31/47 ,  C07D215/38 ,  A61K31/495

    CPC分类号： C07D215/38 ,  A61K31/47 ,  Y10S514/926 ,  Y10S514/927

    摘要： Use of a compound of the formula: ##STR1## wherein R is hydrogen atom or ethyl group, or a pharmaceutically acceptable salt thereof for prophylaxis and/or treatment of peptic ulcer, and a method for prophylaxis and/or treatment of peptic ulcer disease which comprises administering an effective amount of the above-mentioned compound to warm blooded aninal, especially human. Said active compounds have excellent pharmacological activities such as inhibition of ulceration and inhibition of gastric secretion, and hence, are useful as an anti-peptic ulcer agent.

    摘要翻译： 下式化合物：其中R是氢原子或乙基的化合物或其药学上可接受的盐用于消化性溃疡的预防和/或治疗，以及预防和/或治疗消化性溃疡疾病的方法，其中 包括将有效量的上述化合物给予温血的阴性，特别是人。 所述活性化合物具有优异的药理活性，例如抑制溃疡和抑制胃分泌，因此可用作抗消化性溃疡剂。

    Acetic acid derivatives and composition containing the same
    5.
    发明授权
    Acetic acid derivatives and composition containing the same 失效
    乙酸衍生物及含有其的组合物

    公开(公告)号：US4356186A

    公开(公告)日：1982-10-26

    申请号：US246114

    申请日：1981-03-20

    申请人： Hitoshi Uno ,  Mikio Kurokawa ,  Hideo Nakamura

    发明人： Hitoshi Uno ,  Mikio Kurokawa ,  Hideo Nakamura

    IPC分类号： A61K31/34 ,  A61K31/38 ,  A61P29/00 ,  C07D313/12 ,  C07D337/12 ,  C07D337/14 ,  C07D405/06 ,  C07D409/06 ,  A61K31/335

    CPC分类号： C07C323/00 ,  C07D313/12 ,  C07D337/12 ,  Y10S514/825 ,  Y10S514/916

    摘要： Novel acetic acid derivatives of the formula: ##STR1## wherein X is oxygen or sulfur; R.sub.1 is hydrogen or a lower alkyl; R.sub.2 is hydroxy, an alkoxy, an alkenyloxy, a cycloalkyloxy, an aryloxy, a substituted aryloxy, an aryl-lower alkoxy, a substituted aryl-lower alkoxy, an aryl-lower alkenyloxy, a substituted aryl-lower alkenyloxy, an .omega.-disubstituted amino-lower alkoxy, a lower alkoxycrbonyl-lower alkoxy, a lower alkoxy-lower alkoxy, a hydroxy-lower alkoxy-lower alkoxy, an acyl-lower alkoxy, or a group ##STR2## wherein R.sub.3 is hydrogen, hydroxy, a lower alkyl, an aryl-lower alkyl, a hydroxy-lower alkyl, or a carboxy-lower alkyl, R.sub.4 is hydrogen, a lower alkyl or a hydroxy-lower alkyl, or the R.sub.3 and R.sub.4 may combine together with the nitrogen atom to which they are joined to form a heterocyclic group; and the group --CH(R.sub.1)COR.sub.2 is joined to the carbon atom at 2- or 3-position, and pharmaceutically acceptable salts thereof, processes for their preparation, and pharmaceutical compositions containing these compounds. They have excellent anti-inflammatory, analgesic and antipyretic activities with weak ulcerogenicity in the gastrointestinal tract and toxicity.

    摘要翻译： 下式的新型乙酸衍生物：其中X是氧或硫; R1是氢或低级烷基; R2是羟基，烷氧基，烯氧基，环烷氧基，芳氧基，取代的芳氧基，芳基 - 低级烷氧基，取代的芳基 - 低级烷氧基，芳基 - 低级烯氧基，取代的芳基 - 低级烯氧基，ω-二取代 氨基 - 低级烷氧基，低级烷氧基羰基 - 低级烷氧基，低级烷氧基 - 低级烷氧基，羟基 - 低级烷氧基 - 低级烷氧基，酰基 - 低级烷氧基或基团，其中R3是氢，羟基，低级烷基 ，芳基 - 低级烷基，羟基 - 低级烷基或羧基 - 低级烷基，R 4是氢，低级烷基或羟基 - 低级烷基，或者R 3和R 4可以与它们所在的氮原子结合在一起 连接形成杂环基; 并且基团-CH（R 1）COR 2与2-或3-位的碳原子及其药学上可接受的盐连接，其制备方法和含有这些化合物的药物组合物。 它们具有优良的抗炎，止痛和解热活性，肠胃道溃疡性弱，毒性低。

    Burst mode digital data amplifier circuit unit and amplifier circuit
    8.
    发明授权
    Burst mode digital data amplifier circuit unit and amplifier circuit 失效
    突发模式数字数字放大器电路单元和放大电路

    公开(公告)号：US5955918A

    公开(公告)日：1999-09-21

    申请号：US997895

    申请日：1997-12-24

    申请人： Hitoshi Uno

    发明人： Hitoshi Uno

    IPC分类号： H03G11/00 ,  H03F3/08 ,  H03F3/45 ,  H03F1/02

    CPC分类号： H03F3/087

    摘要： An amplifier circuit unit is composed of an offset compensation circuit for equalizing and issuing a DC potential in data input period of one input signal of differential input signals, and a DC potential in data input period of other input signal, and an amplitude limiting amplifier circuit for receiving a differential output signal from this offset compensation circuit as an input signal, and issuing to a differential output terminal as a differential output signal kept in a constant output signal amplitude while amplifying in a linear region. This amplifier circuit unit is connected in cascade in plural stages as required, and is applied to an amplifier circuit of an optical receiving circuit and others.

    摘要翻译： 放大器电路单元由偏移补偿电路构成，用于在差分输入信号的一个输入信号的数据输入周期中平衡并发出DC电位，并且在其他输入信号的数据输入周期中的DC电位和限幅放大器电路 用于接收来自该偏移补偿电路的差分输出信号作为输入信号，并且在线性区域放大的同时，向差分输出端子发出作为保持在恒定输出信号幅度的差分输出信号。 该放大器电路单元根据需要以多级级联连接，并被应用于光接收电路等的放大电路。

    Dibenz[b,e]oxepin derivatives and pharmaceutical composition containing the same
    9.
    发明授权
    Dibenz[b,e]oxepin derivatives and pharmaceutical composition containing the same 失效
    二苯并[b，e] oxepin衍生物和含有它们的药物组合物

    公开(公告)号：US4889858A

    公开(公告)日：1989-12-26

    申请号：US180104

    申请日：1988-02-17

    申请人： Hitoshi Uno ,  Mikio Kurokawa ,  Fuminori Sato ,  Shunsuke Naruto ,  Yoshinobu Masuda

    发明人： Hitoshi Uno ,  Mikio Kurokawa ,  Fuminori Sato ,  Shunsuke Naruto ,  Yoshinobu Masuda

    IPC分类号： C07D313/12 ,  C07D401/12 ,  C07D409/12

    CPC分类号： C07D401/12 ,  C07D313/12 ,  C07D409/12

    摘要： The present invention relates to compounds represented by the general formula (I): ##STR1## wherein R.sub.1 is H or methoxy, R.sub.2 is H, methoxy, OH or F, R.sub.3 is H or F, R.sub.4 is H or F at 7-, 8- or 9-position, and .circle.Ar is a benzene, thiophene or pyridine ring, provided that (i) at least two of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are H, (ii) R.sub.2 or R.sub.3 is F when R.sub.4 is F, (iii) R.sub.1, R.sub.3 and R.sub.4 are H when R.sub.2 is methoxy or OH, (iv) R.sub.2 and R.sub.3 are not simultaneously F, and (v) R.sub.2 and R.sub.3 are H or F, and both R.sub.1 and R.sub.4 are H when .circle.Ar is a thiophene or pyridine ring, or a physiologically acceptable acid addition salt thereof. The compounds of the present invention have an excellent protective effect against cerebral anoxia and some of them have also an inhibitory effect on lipid peroxidation of mitochondrial membrane of brain and an anti-convulsant activity and are useful as an agent for prevention or treatment of cerebral diseases caused by hypoxia in mammals including human.