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公开(公告)号：US07026122B2
公开(公告)日：2006-04-11
申请号：US10226803
申请日：2002-08-21
申请人： Holger Beckmann , Marc Learned , Stuart Peltz , Kevin Czaplinski
发明人： Holger Beckmann , Marc Learned , Stuart Peltz , Kevin Czaplinski
IPC分类号： C12Q1/68 , C12N15/00 , G01N33/567 , G01N33/53 , C07H21/04
CPC分类号： G01N33/5008 , C12Q1/6897 , G01N2333/70503 , G01N2333/90 , G01N2500/00
摘要： The present application provides methods of assaying for compounds that inhibit premature translation termination and nonsense mediated RNA decay in cells.
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2.发明申请公开(公告)号：US20060134681A1
公开(公告)日：2006-06-22
申请号：US11318940
申请日：2005-12-22
申请人： Holger Beckmann , Marc Learned , Stuart Peltz , Kevin Czaplinski
发明人： Holger Beckmann , Marc Learned , Stuart Peltz , Kevin Czaplinski
CPC分类号： G01N33/5008 , C12Q1/6897 , G01N2333/70503 , G01N2333/90 , G01N2500/00
摘要： The present application provides methods of assaying for compounds that inhibit premature translation termination and nonsense mediated RNA decay in cells.
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3.发明授权Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay 有权测定抑制过早翻译终止和无义介导的RNA衰变的化合物的方法公开(公告)号：US06458538B1
公开(公告)日：2002-10-01
申请号：US09461508
申请日：1999-12-14
申请人： Holger Beckmann , Marc Learned , Stuart Peltz , Kevin Czaplinski
发明人： Holger Beckmann , Marc Learned , Stuart Peltz , Kevin Czaplinski
IPC分类号： C12Q168
CPC分类号： G01N33/5008 , C12Q1/6897 , G01N2333/70503 , G01N2333/90 , G01N2500/00
摘要： The present application provides methods of assaying for compounds that inhibit premature translation termination and nonsense mediated RNA decay in cells.
摘要翻译： 本申请提供了测定抑制细胞中过早翻译终止和无义介导的RNA衰变的化合物的方法。
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4.发明授权Subfamily of RNA helicases which are modulators of the fidelity of translation termination and uses thereof 有权RNA解旋酶的亚科，其是翻译终止保真度的调节剂及其用途公开(公告)号：US06630294B1
公开(公告)日：2003-10-07
申请号：US09359268
申请日：1999-07-22
IPC分类号： C12Q100
CPC分类号： C12Q1/533 , G01N2333/99 , G01N2500/10
摘要： This invention provides a method for modulating the efficiency of translation termination of messenger RNA. Also provided are methods of screening for compositions and agents capable of modulating translation termination.
摘要翻译： 本发明提供调节信使RNA翻译终止效率的方法。 还提供了筛选能够调节翻译终止的组合物和试剂的方法。
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5.发明授权Subfamily of RNA helicases which are modulators of the fidelity of translation termination and uses thereof 失效RNA解旋酶的亚科，其是翻译终止保真度的调节剂及其用途公开(公告)号：US06989256B2
公开(公告)日：2006-01-24
申请号：US10652334
申请日：2003-08-28
CPC分类号： C12Q1/533 , G01N2333/99 , G01N2500/10
摘要： An isolated multiprotein complex of S. cerevisiae components is provided that is effective to modulate peptidyl transferase activity during translation. This complex includes a Modulator of Translation Termination protein (Mtt1p, also referred to as helicase B), a Upf1 protein, a peptidyl eukaryotic release factor 1 (eRF1) and a peptidyl eukaryotic release factor 3 (eRF3).
摘要翻译： 提供了分离的酿酒酵母组分的多蛋白复合物，其在翻译期间有效调节肽基转移酶活性。 该复合物包括翻译终止蛋白调节剂（Mtt1p，也称为解旋酶B），Upf1蛋白，肽基真核生物释放因子1（eRF1）和肽基真核生物释放因子3（eRF3）。
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6.发明授权METHOD OF MODULATING THE EFFICIENCY OF TRANSLATION TERMINATION AND DEGRADATION OF ABERRANT MRNA INVOLVING A SURVEILLANCE COMPLEX COMPRISING HUMAN UPF1P, EUCARYOTIC RELEASE FACTOR 1 AND EUCARYOTIC RELEASE FACTOR 3 有权调节转录终止和涉及包含人UPF1P，真菌释放因子1和释放因子3的监测复合物的转录终止和降解效率的方法公开(公告)号：US06486305B1
公开(公告)日：2002-11-26
申请号：US09639987
申请日：2000-08-16
申请人： Stuart Peltz , Kevin Czaplinski , Youmin Weng
发明人： Stuart Peltz , Kevin Czaplinski , Youmin Weng
IPC分类号： A23J100
CPC分类号： C07K14/4703
摘要： This invention provides a method of modulating translation termination efficiency of mRNA and/or promoting degradation of abberant transcripts. Also, this invention provides a method of screening for a drug active involved in enhancing translation termination and a method for identifying a disease state involving defective the protein complex. This invention provides a purified complex comprising an amount of a human Upf1p protein, a peptidyl eucaryotic release factor 1 (eRF1) and a peptidyl eucaryotic release factor 3 (eRF3) effective to modulate translation termination. Further, this invention provides an expression vector which comprises a nucleic acid encoding a human Upf1p protein, a peptidyl eucaryotic release factor 1 (eRF1) and a peptidyl eucaryotic release factor 3 (eRF3) operably linked to a regulatory element. This invention provides an antibody which binds to the complex comprising an amount of a human Upf1p protein, a peptidyl eucaryotic release factor 1 (eRF1) and a peptidyl eucaryotic release factor 3 (eRF3) effective to modulate translation termination. This invention provides an agent which inhibits or modulates the binding of human Upf1p to eRF1 or eRF3 The agent may inhibit or facilitate the binding of human Upf1p to eRF1 or eRF3.
摘要翻译： 本发明提供了调节mRNA的翻译终止效率和/或促进不良转录物降解的方法。 此外，本发明提供了筛选涉及增强翻译终止的药物活性的方法以及鉴定涉及蛋白质复合物缺陷的疾病状态的方法。本发明提供了一种纯化的复合物，其包含一定量的人Upf1p蛋白，一种肽基真核 释放因子1（eRF1）和有效调节翻译终止的肽基真核生物释放因子3（eRF3）。 此外，本发明提供了一种表达载体，其包含编码人Upf1p蛋白的核酸，与调控元件可操作地连接的肽基真核生物释放因子1（eRF1）和肽基真核生物释放因子3（eRF3）。本发明提供抗体 其结合复合物，其包含一定量的人Upf1p蛋白，肽基真核生物释放因子1（eRF1）和有效调节翻译终止的肽基真核生物释放因子3（eRF3）。 本发明提供抑制或调节人Upf1p与eRF1或eRF3的结合的试剂。该试剂可抑制或促进人Upf1p与eRF1或eRF3的结合。
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