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    ASSAYS INVOLVING COLORIMETRIC AND OTHER SIGNALING
    1.
    发明申请
    ASSAYS INVOLVING COLORIMETRIC AND OTHER SIGNALING 审中-公开
    涉及彩色和其他信号的测定

    公开(公告)号：US20100330703A1

    公开(公告)日：2010-12-30

    申请号：US12822393

    申请日：2010-06-24

    申请人： Howard Bernstein ,  Donald E. Chickering, III ,  Timothy M. Blicharz

    发明人： Howard Bernstein ,  Donald E. Chickering, III ,  Timothy M. Blicharz

    IPC分类号： G01N33/543 ,  G01N21/00 ,  G01N21/62

    CPC分类号： G01N33/54313 ,  G01N21/78 ,  G01N21/783 ,  G01N21/80 ,  G01N21/82 ,  G01N2021/7783 ,  G01N2021/7786

    摘要： The present invention generally relates to particles and, in particular, to methods of determining binding involving particles, e.g., using colorimetric and other signaling techniques. In one aspect, a mixture of particles of different colors (e.g., at least a first color and a second color) is provided that exhibits a first collective color, e.g., due to the presence of the different colors of particles within the mixture. The mixture can then be exposed to a medium containing a binding partner able to preferentially bind to some of the particles, e.g., particles of a first color relative to particles of a second color. The bound particles can be separated in some fashion (e.g., filtration, gravity, magnetism, centrifugal separation, etc.), such that the mixture exhibits a second collective color, e.g., due to the presence of a greater number of particles of the second color relative to the number of particles of the first color. Accordingly, by visualizing or otherwise determining a color change, a binding event may be determined. Other aspects of the invention relate to kits involving such particles, methods of promoting the making or use of such particles, or the like.

    摘要翻译： 本发明一般涉及颗粒，特别是关于确定涉及颗粒的结合的方法，例如使用比色和其它信号传导技术。 在一个方面，提供了不同颜色（例如，至少第一颜色和第二颜色）的颗粒的混合物，其表现出第一集合颜色，例如由于在混合物内存在不同颜色的颗粒。 然后可以将混合物暴露于含有能够优先结合一些颗粒的结合配偶体的介质，例如相对于第二种颜色的颗粒的第一种颜色的颗粒。 结合的颗粒可以以某种方式分离（例如，过滤，重力，磁性，离心分离等），使得混合物呈现第二集合颜色，例如由于存在更多数量的第二 颜色相对于第一种颜色的颗粒数。 因此，通过可视化或以其他方式确定颜色变化，可以确定结合事件。 本发明的其它方面涉及涉及这种颗粒的试剂盒，促进制造或使用这种颗粒的方法等。

    DEVICES AND METHODS FOR DELIVERY AND/OR WITHDRAWAL OF FLUIDS AND PRESERVATION OF WITHDRAWN FLUIDS
    2.
    发明申请
    DEVICES AND METHODS FOR DELIVERY AND/OR WITHDRAWAL OF FLUIDS AND PRESERVATION OF WITHDRAWN FLUIDS 审中-公开
    用于输送和/或取出流体和保存流体的装置和方法

    公开(公告)号：US20120271125A1

    公开(公告)日：2012-10-25

    申请号：US13443016

    申请日：2012-04-10

    申请人： Howard Bernstein ,  Timothy M. Blicharz

    发明人： Howard Bernstein ,  Timothy M. Blicharz

    IPC分类号： A61B5/157 ,  A61B5/145

    CPC分类号： A61B5/1519 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150175 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150946 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15107 ,  A61B5/15117 ,  A61B5/15119 ,  A61B5/15123 ,  A61B5/15125 ,  A61B50/30 ,  A61B2010/008 ,  A61M2037/0023

    摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus.

    摘要翻译： 本发明一般涉及用于递送和/或从皮肤和/或皮肤下方的受试者递送和/或从物质或诸如血液或间质液体中取出物质的方法。 一方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从例如皮肤和/或从皮肤下面抽取或提取血液的装置和方法 ）和在接收血液之前具有小于大气压的内部压力的储存室。 在一些情况下，该装置可以是独立的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者中抽出血液。 然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液内的分析物。