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11 条记录 (耗时 0.044 秒)

    Tissue specific genes and gene clusters
    8.
    发明申请
    Tissue specific genes and gene clusters 有权
    组织特异性基因和基因簇

    公开(公告)号：US20060257868A1

    公开(公告)日：2006-11-16

    申请号：US10523479

    申请日：2003-08-04

    申请人： Magdalene Moran ,  Jayhong Chong ,  Ian Ramsey ,  David Clapham

    发明人： Magdalene Moran ,  Jayhong Chong ,  Ian Ramsey ,  David Clapham

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

    CPC分类号： A01K67/0278 ,  A01K2217/05 ,  A01K2217/072 ,  A01K2227/105 ,  A61K38/00 ,  C07K14/705 ,  C12Q1/025 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/5014 ,  G01N33/5044

    摘要： Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper3) are disclosed. The CatSper3 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper3 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper3 activity, methods of genotyping subjects with respect to CatSper3, and methods of diagnosing and treating CatSper3-mediated disorders, including infertility. Related business methods are also disclosed.

    摘要翻译： 公开了与精子特异性的阳离子通道相关的核酸和蛋白质序列（CatSper3）。 显示CatSper3蛋白在精子中特异性表达。 公开了与CatSper3基因和蛋白相关的核酸，载体，转化细胞，转基因动物，多肽和抗体。 还提供了体外受精和避孕方法，鉴定CatSper3活性调节剂的方法，关于CatSper3的受试者基因分型方法，以及诊断和治疗CatSper3介导的疾病包括不孕症的方法。 还公开了相关业务方法。

    Modulators of sperm hypermotility and uses thereof
    10.
    发明申请
    Modulators of sperm hypermotility and uses thereof 有权
    精子超能力调节剂及其用途

    公开(公告)号：US20070004785A1

    公开(公告)日：2007-01-04

    申请号：US11453475

    申请日：2006-06-15

    申请人： Jayhong Chong ,  Magdalene Moran

    发明人： Jayhong Chong ,  Magdalene Moran

    IPC分类号： A61K31/4245

    CPC分类号： C07D271/08 ,  A61F6/04 ,  A61K31/4245 ,  C07D413/14

    摘要： The invention provides novel compositions and compounds that inhibit CatSper channel activity, that preferentially inhibits sperm hyperactivity over sperm motility, or both. The compounds of the invention are useful as contraceptive agents that may be adminstered to males, females, or concurrently to both sexual partners. The invention further provides methods of conducting drug discovery business and of conducting a reproductive medicine business. The invention also provides methods of identifying compounds that modulate sperm hypermotility.

    摘要翻译： 本发明提供抑制CatSper通道活性的新型组合物和化合物，其优先抑制精子活力超过精子活力或两者。 本发明的化合物可用作可被施用于男性，女性或并发给两性的避孕药。 本发明还提供了进行药物发现业务和进行生殖医学业务的方法。 本发明还提供鉴定调节精子超运动性的化合物的方法。