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    Method And System For Phasing Individual Genomes In The Context Of Clinical Interpretation
    2.
    发明申请
    Method And System For Phasing Individual Genomes In The Context Of Clinical Interpretation 有权
    临床解释背景下个体基因组分型方法与系统

    公开(公告)号：US20130085728A1

    公开(公告)日：2013-04-04

    申请号：US13487064

    申请日：2012-06-01

    申请人： Hua Tang ,  Michael Snyder ,  Jennifer Li-Pook-Than ,  Konrad J. Karczewski ,  Nicholas Johnson ,  Wing H. Wong

    发明人： Hua Tang ,  Michael Snyder ,  Jennifer Li-Pook-Than ,  Konrad J. Karczewski ,  Nicholas Johnson ,  Wing H. Wong

    IPC分类号： G06F19/00

    CPC分类号： G06F19/22 ,  G06F19/18 ,  G06F19/24 ,  G06F19/34 ,  G16H20/10

    摘要： The present disclosure presents a unified system to phase a personal genome for downstream clinical interpretation. In an embodiment, an initial phasing is generated using public datasets, such as haplotypes from the 1000 Genomes Project, and a phasing toolkit. A local perturbation algorithm is applied to improve long range phasing. If available, a Mendelian inheritance pipeline is applied to identify phasing of novel and rare variants. These datasets are merged, followed by correction by any experimental data. This allows for full clinical interpretation of the role of a group of variants in a gene, whether inherited or de novo variants.

    摘要翻译： 本公开提供了一个统一的系统，用于将个体基因组分阶段用于下游临床解释。 在一个实施例中，使用公共数据集（例如来自1000基因组计划的单倍型）和定相工具包来生成初始定相。 应用局部扰动算法来改善长距离定相。 如果可用，应用孟德尔遗传管道来识别新颖和罕见的变种的定相。 合并这些数据集，然后通过任何实验数据进行校正。 这允许对基因中的一组变体的作用的全面临床解释，无论是遗传的还是从头的变体。

    Method and System for Accurate Construction Of Long Range Haplotype
    3.
    发明申请
    Method and System for Accurate Construction Of Long Range Haplotype 审中-公开
    准确构建长距离单倍型的方法与系统

    公开(公告)号：US20130297221A1

    公开(公告)日：2013-11-07

    申请号：US13486982

    申请日：2012-06-01

    申请人： Nicholas Johnson ,  Wing H. Wong ,  Hua Tang

    发明人： Nicholas Johnson ,  Wing H. Wong ,  Hua Tang

    IPC分类号： G06F19/22

    CPC分类号： G16B30/00 ,  G06F19/34 ,  G16B20/00 ,  G16B40/00 ,  G16H20/10

    摘要： In an embodiment of the present invention, a modified version of the PHASE model is implemented that is substantially more accurate than the FastPHASE model. Modifications in an embodiment of the present invention include using a parameterization EM algorithm similar to that of the FastPHASE model, and to perform optimization on haplotypes rather than MCMC sampling. In an embodiment, the imputed haplotypes themselves are used as hidden states in the HMM because this is believed to be important for the PHASE model's accuracy. This increase in accuracy becomes more pronounced with increasing sample size. This difference is attributed to the PHASE model's likelihood which produces long, shared haplotypes between pairs of individuals.

    摘要翻译： 在本发明的一个实施例中，实现了比FastPHASE模型更准确的PHASE模型的修改版本。 本发明实施例中的修改包括使用与FastPHASE模型类似的参数化EM算法，并对单倍型而不是MCMC采样执行优化。 在一个实施方案中，估算的单体型本身被用作HMM中的隐藏状态，因为这被认为对于PHASE模型的准确度是重要的。 随着样品量的增加，精度的提高变得更加显着。 这种差异归因于PHASE模型的可能性，其在个体对之间产生长的共享单倍型。

    Optical apparatus with dual illuminating devices
    4.
    发明授权
    Optical apparatus with dual illuminating devices 失效
    具有双重照明装置的光学装置

    公开(公告)号：US07455434B2

    公开(公告)日：2008-11-25

    申请号：US11765071

    申请日：2007-06-19

    申请人： Hua Tang ,  Feng Zhao

    发明人： Hua Tang ,  Feng Zhao

    IPC分类号： F21V9/10

    CPC分类号： G02B21/06

    摘要： An optical apparatus with dual illuminating devices includes a body, a first lighting device, a pivoting arm, an actuating pin, a switch and a second lighting device. The body has a joint portion. The first lighting device is mounted in the body. The pivoting arm has a first end and a second end. The first end is pivotally mounted on the joint portion so that the pivoting arm can be adjusted between a first position and a second position relative to the body. The second lighting device is mounted on the second end of the pivoting arm. Rotating the pivoting arm drives the actuating pin to press the switch, which turns off the second lighting device and turns simultaneously on the first lighting device.

    摘要翻译： 具有双重照明装置的光学装置包括主体，第一照明装置，枢转臂，致动销，开关和第二照明装置。 身体有一个关节部分。 第一个照明装置安装在主体内。 枢转臂具有第一端和第二端。 第一端枢转地安装在接头部分上，使得枢转臂可以相对于主体在第一位置和第二位置之间调节。 第二照明装置安装在枢转臂的第二端。 旋转枢转臂驱动致动销以按压开关，其关闭第二照明装置并同时在第一照明装置上转动。

    Optical Apparatus with Dual Illuminating Devices
    5.
    发明申请
    Optical Apparatus with Dual Illuminating Devices 失效
    具有双重照明装置的光学装置

    公开(公告)号：US20080239720A1

    公开(公告)日：2008-10-02

    申请号：US11765071

    申请日：2007-06-19

    申请人： Hua Tang ,  Feng Zhao

    发明人： Hua Tang ,  Feng Zhao

    IPC分类号： F21V21/26

    CPC分类号： G02B21/06

    摘要： An optical apparatus with dual illuminating devices includes a body, a first lighting device, a pivoting arm, an actuating pin, a switch and a second lighting device. The body has a joint portion. The first lighting device is mounted in the body. The pivoting arm has a first end and a second end. The first end is pivotally mounted on the joint portion so that the pivoting arm can be adjusted between a first position and a second position relative to the body. The second lighting device is mounted on the second end of the pivoting arm. Rotating the pivoting arm drives the actuating pin to press the switch, which turns off the second lighting device and turns simultaneously on the first lighting device.

    摘要翻译： 具有双重照明装置的光学装置包括主体，第一照明装置，枢转臂，致动销，开关和第二照明装置。 身体有一个关节部分。 第一个照明装置安装在主体内。 枢转臂具有第一端和第二端。 第一端枢转地安装在接头部分上，使得枢转臂可以相对于主体在第一位置和第二位置之间调节。 第二照明装置安装在枢转臂的第二端。 旋转枢转臂驱动致动销以按压开关，其关闭第二照明装置并同时在第一照明装置上转动。

    Processing of floating point multiply-accumulate instructions using multiple operand pathways
    8.
    发明授权
    Processing of floating point multiply-accumulate instructions using multiple operand pathways 有权
    使用多个操作数路径处理浮点乘法累加指令

    公开(公告)号：US08443030B1

    公开(公告)日：2013-05-14

    申请号：US12045609

    申请日：2008-03-10

    申请人： Hua Tang

    发明人： Hua Tang

    IPC分类号： G06F7/38

    CPC分类号： G06F9/3838 ,  G06F7/5443 ,  G06F9/3001 ,  G06F9/3893

    摘要： Floating point multiply-accumulate (FMAC) instructions are processed by a logic circuit. A register file stores operands for a FMAC instruction. A multiplier multiplies an operand S1 and an operand S2 from the register file to produce a resultant operand St. An adder adds two operands St and Sd (which is the result of a prior accumulation) to produce the result Sd of the FMAC instruction. A reorder buffer (ROB) stores and reorders entries corresponding to FMAC instructions, and a hazard-checking block detects whether the FMAC instruction contains a potential hazard. A selector selects an output value from the ROB. The operands St and Sd can be supplied via one of a plurality of paths based on a priority of the paths, and the priority for the paths is based in part on output from the hazard-checking block and contents of the ROB.

    摘要翻译： 浮点乘法累加（FMAC）指令由逻辑电路处理。 寄存器文件存储FMAC指令的操作数。 乘法器将寄存器文件中的操作数S1与操作数S2相乘以产生合成的操作数。圣加法器将两个操作数St和Sd（其是先前累加的结果）相加，以产生FMAC指令的结果Sd。 重新排序缓冲器（ROB）存储和重新排列与FMAC指令相对应的条目，并且危险检查块检测FMAC指令是否包含潜在的危险。 选择器从ROB中选择一个输出值。 操作数St和Sd可以基于路径的优先级通过多个路径之一提供，并且路径的优先级部分地基于来自危险检查块的输出和ROB的内容。