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公开(公告)号：US07855291B2
公开(公告)日：2010-12-21
申请号：US11647517
申请日：2006-12-28
申请人： Hugh Alfred Burgoon, Jr. , Ramanaiah C. Kanamarlapudi , Iain Fraser Pickersgill , Zhi-Cai Shi , Wenxue Wu , Haiming Zhang
发明人： Hugh Alfred Burgoon, Jr. , Ramanaiah C. Kanamarlapudi , Iain Fraser Pickersgill , Zhi-Cai Shi , Wenxue Wu , Haiming Zhang
IPC分类号： C07D239/34 , C07D403/12 , A61K31/506 , A61K31/505 , A61P9/02
CPC分类号： A61K31/505 , C07D239/47
摘要： Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g., of Formula I) are disclosed:
摘要翻译： 公开了用于制备取代的苯丙氨酸类化合物（例如式I）的中间体和合成方法：
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公开(公告)号：US20090048280A1
公开(公告)日：2009-02-19
申请号：US11647517
申请日：2006-12-28
申请人： Hugh Alfred Burgoon, JR. , Ramanaiah C. Kanamarlapudi , Iain Fraser Pickersgill , Zhi-Cai Shi , Wenxue Wu , Haiming Zhang
发明人： Hugh Alfred Burgoon, JR. , Ramanaiah C. Kanamarlapudi , Iain Fraser Pickersgill , Zhi-Cai Shi , Wenxue Wu , Haiming Zhang
IPC分类号： A61K31/513 , C07D239/46
CPC分类号： A61K31/505 , C07D239/47
摘要： Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g., of Formula I) are disclosed:
摘要翻译： 公开了用于制备取代的苯丙氨酸类化合物（例如式I）的中间体和合成方法：
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3.发明授权公开(公告)号：US08450532B2
公开(公告)日：2013-05-28
申请号：US13024469
申请日：2011-02-10
申请人： Hugh Alfred Burgoon , Ramanaiah C. Kanamarlapudi , Iain Fraser Pickersgill , Zhi-Cai Shi , Wenxue Wu , Haiming Zhang , Matthew Mangzhu Zhao
发明人： Hugh Alfred Burgoon , Ramanaiah C. Kanamarlapudi , Iain Fraser Pickersgill , Zhi-Cai Shi , Wenxue Wu , Haiming Zhang , Matthew Mangzhu Zhao
IPC分类号： C07C33/34 , C07C43/205
CPC分类号： A61K31/505 , C07C43/23 , C07D239/42 , C07D239/47 , C07D239/48
摘要： Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g., of Formula I) are disclosed:
摘要翻译： 公开了用于制备取代的苯丙氨酸类化合物（例如式I）的中间体和合成方法：
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4.发明申请METHODS OF PREPARING 4-PHENYL-6-(2,2,2-TRIFLUORO-1-PHENYLETHOXY)PYRIMIDINE-BASED COMPOUNDS 有权制备4-苯基-6-（2,2,2-三氟-1-苯基乙基）吡啶基化合物的方法公开(公告)号：US20110301349A1
公开(公告)日：2011-12-08
申请号：US13160678
申请日：2011-06-15
申请人： Mark S. Bednarz , Hugh Alfred Burgoon, JR. , Shinya Iimura , Ramanaiah C. Kanamarlapudi , Qiuling Song , Wenxue Wu , Jie Yan , Haiming Zhang
发明人： Mark S. Bednarz , Hugh Alfred Burgoon, JR. , Shinya Iimura , Ramanaiah C. Kanamarlapudi , Qiuling Song , Wenxue Wu , Jie Yan , Haiming Zhang
IPC分类号： C07D239/42 , C07D231/12
CPC分类号： C07D403/12 , C07D231/12
摘要： Methods useful for preparing compounds of formula I: and salts thereof are disclosed. Also disclosed are intermediates useful in the preparation of such compounds.
摘要翻译： 公开了可用于制备式I化合物及其盐的方法。 还公开了可用于制备这些化合物的中间体。
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5.发明授权Methods of preparing 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds 有权制备4-苯基-6-（2,2,2-三氟-1-苯基乙氧基）嘧啶类化合物的方法公开(公告)号：US08575362B2
公开(公告)日：2013-11-05
申请号：US13160678
申请日：2011-06-15
申请人： Mark S. Bednarz , Hugh Alfred Burgoon, Jr. , Shinya Iimura , Ramanaiah C. Kanamarlapudi , Qiuling Song , Wenxue Wu , Jie Yan , Haiming Zhang
发明人： Mark S. Bednarz , Hugh Alfred Burgoon, Jr. , Shinya Iimura , Ramanaiah C. Kanamarlapudi , Qiuling Song , Wenxue Wu , Jie Yan , Haiming Zhang
IPC分类号： C07D231/12
CPC分类号： C07D403/12 , C07D231/12
摘要： Methods useful for preparing compounds of formula I: and salts thereof are disclosed. Also disclosed are intermediates useful in the preparation of such compounds.
摘要翻译： 公开了可用于制备式I化合物及其盐的方法。 还公开了可用于制备这些化合物的中间体。
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公开(公告)号：US07968729B2
公开(公告)日：2011-06-28
申请号：US12732311
申请日：2010-03-26
申请人： Mark S. Bednarz , Hugh Alfred Burgoon, Jr. , Shinya Iimura , Ramanaiah C. Kanamarlapudi , Qiuling Song , Wenxue Wu , Jie Yan , Haiming Zhang
发明人： Mark S. Bednarz , Hugh Alfred Burgoon, Jr. , Shinya Iimura , Ramanaiah C. Kanamarlapudi , Qiuling Song , Wenxue Wu , Jie Yan , Haiming Zhang
IPC分类号： C07D231/10
CPC分类号： C07D403/12 , C07D231/12
摘要： Methods useful for preparing compounds of formula I: and salts thereof are disclosed. Also disclosed are intermediates useful in the preparation of such compounds.
摘要翻译： 公开了可用于制备式I化合物及其盐的方法。 还公开了可用于制备这些化合物的中间体。
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7.发明申请METHODS OF PREPARING 4-PHENYL-6-(2,2,2-TRIFLUORO-1-PHENYLETHOXY)PYRIMIDINE-BASED COMPOUNDS 审中-公开制备4-苯基-6-（2,2,2-三氟-1-苯基乙基）吡啶基化合物的方法公开(公告)号：US20090062540A1
公开(公告)日：2009-03-05
申请号：US12196341
申请日：2008-08-22
申请人： Mark S. Bednarz , Hugh Alfred Burgoon, JR. , Shinya Iimura , Ramanaiah C. Kanamarlapudi , Qiuling Song , Wenxue Wu , Jie Yan , Haiming Zhang
发明人： Mark S. Bednarz , Hugh Alfred Burgoon, JR. , Shinya Iimura , Ramanaiah C. Kanamarlapudi , Qiuling Song , Wenxue Wu , Jie Yan , Haiming Zhang
IPC分类号： C07D403/12 , C07D231/12
CPC分类号： C07D403/12 , C07D231/12
摘要： Methods useful for preparing compounds of formula I: and salts thereof are disclosed. Also disclosed are intermediates useful in the preparation of such compounds.
摘要翻译： 公开了可用于制备式I化合物及其盐的方法。 还公开了可用于制备这些化合物的中间体。
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公开(公告)号：US20100240906A1
公开(公告)日：2010-09-23
申请号：US12732311
申请日：2010-03-26
申请人： Mark S. Bednarz , Hugh Alfred Burgoon, JR. , Shinya Iimura , Ramanaiah C. Kanamarlapudi , Qiuling Song , Wenxue Wu , Jie Yan , Haiming Zhang
发明人： Mark S. Bednarz , Hugh Alfred Burgoon, JR. , Shinya Iimura , Ramanaiah C. Kanamarlapudi , Qiuling Song , Wenxue Wu , Jie Yan , Haiming Zhang
IPC分类号： C07D233/60
CPC分类号： C07D403/12 , C07D231/12
摘要： Methods useful for preparing compounds of formula I: and salts thereof are disclosed. Also disclosed are intermediates useful in the preparation of such compounds.
摘要翻译： 公开了可用于制备式I化合物及其盐的方法。 还公开了可用于制备这些化合物的中间体。
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公开(公告)号：US07919618B2
公开(公告)日：2011-04-05
申请号：US11832738
申请日：2007-08-02
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
CPC分类号： C07D401/04
摘要： Novel methods of synthesizing piperazines, piperidines and related compounds are disclosed, as are compounds useful for their preparation.
摘要翻译： 公开了合成哌嗪，哌啶和相关化合物的新方法，以及可用于其制备的化合物。
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公开(公告)号：US06642390B2
公开(公告)日：2003-11-04
申请号：US10193591
申请日：2002-07-11
申请人： Hartmuth C. Kolb , Cullen Cavallaro , Zhi-Cai Shi , Alexander Gontcharov , Zhi-Min Wang , Paul F. Richardson , Ramanaiah C. Kanamarlapudi
发明人： Hartmuth C. Kolb , Cullen Cavallaro , Zhi-Cai Shi , Alexander Gontcharov , Zhi-Min Wang , Paul F. Richardson , Ramanaiah C. Kanamarlapudi
IPC分类号： C07D24904
CPC分类号： C07D249/04
摘要： Disclosed is a one step method for preparing a 1,2,3-triazole carboxylic acid by treating an azide with a &bgr;-ketoester in the presence of a base.
摘要翻译： 公开了通过在碱存在下用β-酮酯处理叠氮化物来制备1,2,3-三唑羧酸的一步法。
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