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1.Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof 失效
标题翻译: 取代的异喹啉-1,3(2H,4H) - 二酮,1-硫代-1,4-二氢-2H-异喹啉-3-酮和1,4-二氢-3(2H) - 异喹诺酮及其使用方法公开(公告)号:US20080085890A1
公开(公告)日:2008-04-10
申请号:US11728897
申请日:2007-03-26
申请人: Hwei-Ru Tsou , Semiramis Ayral-Kaloustian , Gary Birnberg , Middleton Floyd , Joshua Kaplan , Kristina Kutterer , Xiaoxiang Liu , Ramaswamy Nilakantan , Mercy Otteng , Zhilian Tang , Arie Zask , Tritin Tran , Scott Mayer , Annette Banker , Marvin Reich
发明人: Hwei-Ru Tsou , Semiramis Ayral-Kaloustian , Gary Birnberg , Middleton Floyd , Joshua Kaplan , Kristina Kutterer , Xiaoxiang Liu , Ramaswamy Nilakantan , Mercy Otteng , Zhilian Tang , Arie Zask , Tritin Tran , Scott Mayer , Annette Banker , Marvin Reich
IPC分类号: A61K31/55 , A61K31/47 , A61K31/496 , A61K31/497 , A61K31/501 , A61P1/00 , A61P17/06 , A61P3/10 , A61P31/12 , C07D295/00 , C07D241/02 , C07D239/02 , C07D237/26 , C07D237/02 , C07D223/02 , C07D217/00 , A61P9/00 , A61P35/00 , A61P31/10 , A61P19/02 , A61P11/00 , A61K31/502 , A61K31/506 , A61K31/5377 , A61K31/541
CPC分类号: C07D217/24 , C07D237/28 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
摘要: This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.
摘要翻译: 本发明提供式(I)化合物,其具有如下结构:其中G 1,G 2,G 3,G 4, / SUP>,A 1,A 2,Y 1,Y 2,L 1, / SUP>,Z,e和f如本文所定义,或其药学上可接受的盐,其可用于治疗或预防癌症。