公开(公告)号：US20080085890A1

公开(公告)日：2008-04-10

申请号：US11728897

申请日：2007-03-26

申请人： Hwei-Ru Tsou ,  Semiramis Ayral-Kaloustian ,  Gary Birnberg ,  Middleton Floyd ,  Joshua Kaplan ,  Kristina Kutterer ,  Xiaoxiang Liu ,  Ramaswamy Nilakantan ,  Mercy Otteng ,  Zhilian Tang ,  Arie Zask ,  Tritin Tran ,  Scott Mayer ,  Annette Banker ,  Marvin Reich

发明人： Hwei-Ru Tsou ,  Semiramis Ayral-Kaloustian ,  Gary Birnberg ,  Middleton Floyd ,  Joshua Kaplan ,  Kristina Kutterer ,  Xiaoxiang Liu ,  Ramaswamy Nilakantan ,  Mercy Otteng ,  Zhilian Tang ,  Arie Zask ,  Tritin Tran ,  Scott Mayer ,  Annette Banker ,  Marvin Reich

IPC分类号： A61K31/55 ,  A61K31/47 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61P1/00 ,  A61P17/06 ,  A61P3/10 ,  A61P31/12 ,  C07D295/00 ,  C07D241/02 ,  C07D239/02 ,  C07D237/26 ,  C07D237/02 ,  C07D223/02 ,  C07D217/00 ,  A61P9/00 ,  A61P35/00 ,  A61P31/10 ,  A61P19/02 ,  A61P11/00 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541

CPC分类号： C07D217/24 ,  C07D237/28 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D487/04

摘要： This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.

摘要翻译： 本发明提供式（I）化合物，其具有如下结构：其中G 1，G 2，G 3，G 4， / SUP>，A 1，A 2，Y 1，Y 2，L 1， / SUP>，Z，e和f如本文所定义，或其药学上可接受的盐，其可用于治疗或预防癌症。

公开(公告)号：US07713994B2

公开(公告)日：2010-05-11

申请号：US11728897

申请日：2007-03-26

申请人： Hwei-Ru Tsou ,  Semiramis Ayral-Kaloustian ,  Gary Harold Birnberg ,  Middleton Brawner Floyd ,  Joshua Kaplan ,  Kristina M. Kutterer ,  Xiaoxiang Liu ,  Ramaswamy Nilakantan ,  Mercy Adufa Otteng ,  Zhilian Tang ,  Arie Zask ,  Tritin Tran ,  Scott Christian Mayer ,  Annette L. Banker ,  Marvin Reich

发明人： Hwei-Ru Tsou ,  Semiramis Ayral-Kaloustian ,  Gary Harold Birnberg ,  Middleton Brawner Floyd ,  Joshua Kaplan ,  Kristina M. Kutterer ,  Xiaoxiang Liu ,  Ramaswamy Nilakantan ,  Mercy Adufa Otteng ,  Zhilian Tang ,  Arie Zask ,  Tritin Tran ,  Scott Christian Mayer ,  Annette L. Banker ,  Marvin Reich

IPC分类号： A61K31/47 ,  C07D217/08

CPC分类号： C07D217/24 ,  C07D237/28 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D487/04

摘要： This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.

摘要翻译： 本发明提供具有本文定义的G1，G2，G3，G4，A1，A2，Y1，Y2，L1，Z，e和f的结构的式（I）化合物或其药学上可接受的盐， 可用于治疗或预防癌症。

公开(公告)号：US20140047106A1

公开(公告)日：2014-02-13

申请号：US13814851

申请日：2012-08-08

申请人： Henry Leung ,  Xiaoxiang Liu

发明人： Henry Leung ,  Xiaoxiang Liu

IPC分类号： H04L12/26

CPC分类号： H04L69/04 ,  H04L41/142 ,  H04L41/5012 ,  H04L41/5096 ,  H04L43/08 ,  H04L43/10 ,  H04L43/12

摘要： Technologies are presented for implementing a compressive-sensing-based data collection system in a cloud environment. In some examples, high-dimensional sensor data may be compressed using sparsity transforms and compressive sampling. The resulting low-dimensional data messages may be steered through a switch network to a cloud service manager, which then reconstructs the compressed messages for subsequent analysis, reporting, and/or comparable actions.

摘要翻译： 提出了在云环境中实现基于压缩感知的数据收集系统的技术。 在一些示例中，可以使用稀疏变换和压缩采样来压缩高维度传感器数据。 所得到的低维数据消息可以通过交换机网络被引导到云服务管理器，云服务管理器然后重构压缩的消息以用于后续的分析，报告和/或可比较的动作。

公开(公告)号：US08183252B2

公开(公告)日：2012-05-22

申请号：US12693874

申请日：2010-01-26

申请人： Zhaoning Zhu ,  Zhong-Yue Sun ,  Andrew Stamford ,  William J. Greenlee ,  Jared N. Cumming ,  Lingyan Wang ,  Ulrich Iserloh ,  Xiaoxiang Liu ,  Ying Huang ,  Guoqing Li ,  Jianping Pan

发明人： Zhaoning Zhu ,  Zhong-Yue Sun ,  Andrew Stamford ,  William J. Greenlee ,  Jared N. Cumming ,  Lingyan Wang ,  Ulrich Iserloh ,  Xiaoxiang Liu ,  Ying Huang ,  Guoqing Li ,  Jianping Pan

IPC分类号： A01N43/54 ,  A61K31/505 ,  C07D239/02

CPC分类号： C07D233/88 ,  A61K31/4168 ,  A61K31/4178 ,  C07D239/22 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/10 ,  C07D417/14 ,  C07D495/10

摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(═S)—, —S(O)—, —S(O)2—, —C(═O)—, —O—, —C(R6)(R7)—, —N(R5)— or —C(═N(R5))—; X is —O—, —N(R5)— or —C(R6)(R7)—; provided that when X is —O—, U is not —O—, —S(O)—, —S(O)2—, —C(═O)— or —C(═NR5)—; U is a bond, —S(O)—, —S(O)2—, —C(O)—, —O—, —P(O)(OR15)—, —C(═NR5)—, —(C(R6)(R7))b— or —N(R5)—; wherein b is 1 or 2; provided that when W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, U is not —S(O)—, —S(O)2—, —O—, or —N(R5)—; provided that when X is —N(R5)— and W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, then U is not a bond; and R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes.Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

公开(公告)号：US08168641B2

公开(公告)日：2012-05-01

申请号：US11759336

申请日：2007-06-07

申请人： Yusheng Wu ,  Ulrich Iserloh ,  Jared N. Cumming ,  Xiaoxiang Liu ,  Robert D. Mazzola ,  Zhong-Yue Sun ,  Ying Huang ,  Andrew Stamford ,  Brian McKittrick ,  Zhaoning Zhu

发明人： Yusheng Wu ,  Ulrich Iserloh ,  Jared N. Cumming ,  Xiaoxiang Liu ,  Robert D. Mazzola ,  Zhong-Yue Sun ,  Ying Huang ,  Andrew Stamford ,  Brian McKittrick ,  Zhaoning Zhu

IPC分类号： C07D239/20 ,  C07D239/22 ,  A61K31/497 ,  A61K31/513 ,  A61K31/506 ,  A61P9/00 ,  A61P25/28 ,  A61P31/18 ,  C07D495/20 ,  A61K31/527

CPC分类号： C07D239/20 ,  C07D401/04 ,  C07D401/10 ,  C07D403/04 ,  C07D405/04 ,  C07D409/14 ,  C07D411/04 ,  C07D417/04 ,  C07D417/14 ,  C07D495/20

摘要： Disclosed are compounds of formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, U, W, X, R1, R2, R6, R7, R30 and R31 are as described above in the specification. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

摘要翻译： 公开了式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物，U，W，X，R 1，R 2，R 6，R 7，R 30和R 31如上文在说明书中所述。 还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经变性疾病的方法。 还公开了使用式I化合物与胆碱酯酶抑制剂或毒蕈碱m1激动剂或m2拮抗剂组合治疗认知或神经变性疾病的方法。

公开(公告)号：US20110216192A1

公开(公告)日：2011-09-08

申请号：US12719797

申请日：2010-03-08

申请人： Henry Leung ,  Xiaoxiang Liu

发明人： Henry Leung ,  Xiaoxiang Liu

IPC分类号： H04N5/225 ,  H04N7/18

CPC分类号： G06T7/0042 ,  G06T7/246 ,  G06T7/73 ,  G06T19/006 ,  H04N5/225 ,  H04N7/18

摘要： Technologies are generally described for a broadband passive sensing and tracking system that may employ a number of passive receivers that each have the capability of sensing electromagnetic waves (e.g., Radio Frequency “RF” signals) from surrounding broadcast sources. Each passive receiver may be adapted to sense through one or more antennas. Multiple receivers at different positions may be utilized to form a broadband sensing network adapted to perform collaborative tracking of a scene of interest. According to some examples, a beam-forming algorithm may be applied over the broadband sensing network utilizing an antenna array formed by the passive receivers to localize and track objects.

摘要翻译： 技术通常被描述用于宽带被动感测和跟踪系统，其可以使用多个无源接收机，每个无源接收机具有感测来自周围广播源的电磁波（例如，射频“RF”信号）的能力。 每个无源接收机可以适于通过一个或多个天线进行感测。 可以利用不同位置处的多个接收器来形成适于执行感兴趣的场景的协作跟踪的宽带感测网络。 根据一些示例，波束形成算法可以利用由无源接收器形成的天线阵列在宽带感测网络上应用，以定位和跟踪对象。

公开(公告)号：US08629155B2

公开(公告)日：2014-01-14

申请号：US13421396

申请日：2012-03-15

申请人： Yusheng Wu ,  Ulrich Iserloh ,  Jared N. Cumming ,  Xiaoxiang Liu ,  Robert D. Mazzola ,  Zhong-Yue Sun ,  Ying Huang ,  Andrew Stamford ,  Brian McKittrick ,  Zhaoning Zhu

发明人： Yusheng Wu ,  Ulrich Iserloh ,  Jared N. Cumming ,  Xiaoxiang Liu ,  Robert D. Mazzola ,  Zhong-Yue Sun ,  Ying Huang ,  Andrew Stamford ,  Brian McKittrick ,  Zhaoning Zhu

IPC分类号： C07D239/70 ,  C07D513/20 ,  A01N43/54 ,  A61P31/18 ,  A61P25/28 ,  A61P9/00

CPC分类号： C07D239/20 ,  C07D401/04 ,  C07D401/10 ,  C07D403/04 ,  C07D405/04 ,  C07D409/14 ,  C07D411/04 ,  C07D417/04 ,  C07D417/14 ,  C07D495/20

摘要： Disclosed are compounds of formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, U, W, X, R1, R2, R6, R7, R30 and R31 are as described above in the specification. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

摘要翻译： 公开了式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物，U，W，X，R 1，R 2，R 6，R 7，R 30和R 31如上文在说明书中所述。 还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经变性疾病的方法。 还公开了使用式I化合物与胆碱酯酶抑制剂或毒蕈碱m1激动剂或m2拮抗剂组合治疗认知或神经变性疾病的方法。

公开(公告)号：US08541427B2

公开(公告)日：2013-09-24

申请号：US12988461

申请日：2009-04-21

申请人： Andrew W. Stamford ,  Zhaoning Zhu ,  Mihirbaran Mandal ,  Yusheng Wu ,  Jared N. Cumming ,  Xiaoxiang Liu ,  Guoqing Li ,  Ulrich Iserloh

发明人： Andrew W. Stamford ,  Zhaoning Zhu ,  Mihirbaran Mandal ,  Yusheng Wu ,  Jared N. Cumming ,  Xiaoxiang Liu ,  Guoqing Li ,  Ulrich Iserloh

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/28 ,  A61P3/10

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides certain 2-imino-3-methyl pyrrolo pyrimidone compounds, including compounds Formula (II): and include tautomers, steroisomers, or pharmaceutically acceptable salts or solvates of said compounds, stereoisomers, or said tautomers, wherein R2, R3, R4, R5, R6, R7, R8, and R9 are each selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds, and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's Disease, are also disclosed.

摘要翻译： 在其许多实施方案中，本发明提供某些2-亚氨基-3-甲基吡咯烷酮化合物，包括式（II）化合物：并且包括所述化合物，立体异构体或所述互变异构体的互变异构体，立体异构体或药学上可接受的盐或溶剂化物， 其中R2，R3，R4，R5，R6，R7，R8和R9各自独立地并如本文所定义。 还公开了包含一种或多种这样的化合物的药物组合物，及其制备和用于治疗与包括阿尔茨海默病在内的淀粉样蛋白β（Abeta）蛋白相关的病理学的方法。

公开(公告)号：US08093254B2

公开(公告)日：2012-01-10

申请号：US12517744

申请日：2007-12-10

申请人： Zhaoning Zhu ,  Andrew Stamford ,  Mihirbaran Mandal ,  Xiaoxiang Liu

发明人： Zhaoning Zhu ,  Andrew Stamford ,  Mihirbaran Mandal ,  Xiaoxiang Liu

IPC分类号： A01N43/54 ,  A61K31/505 ,  C07D239/70 ,  C07D471/00 ,  C07D471/22 ,  C07D487/00 ,  C07D491/00

CPC分类号： C07D471/14 ,  C07D239/95

摘要： Disclosed are compounds of formula I (Chemical formula should be inserted here as it appears on abstract in paper form) Formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, R4, R14, V, W, X, Y, Z, p, and ring A are as described in the specification. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

摘要翻译： 公开了式I的化合物（化学式应该在此插入，如其以纸的形式呈现）式I或其立体异构体，互变异构体或其药学上可接受的盐或溶剂化物，其中R1，R2，R3，R4，R14，V ，W，X，Y，Z，p和环A如说明书中所述。 还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经变性疾病的方法。 还公开了使用式I化合物与胆碱酯酶抑制剂或毒蕈碱m1激动剂或m2拮抗剂组合治疗认知或神经变性疾病的方法。

公开(公告)号：US07868000B2

公开(公告)日：2011-01-11

申请号：US11451541

申请日：2006-06-12

申请人： Zhaoning Zhu ,  Brian McKittrick ,  Andrew Stamford ,  William J. Greenlee ,  Xiaoxiang Liu ,  Mihirbaran Mandal ,  Johannes H. Voigt ,  Corey O. Strickland

发明人： Zhaoning Zhu ,  Brian McKittrick ,  Andrew Stamford ,  William J. Greenlee ,  Xiaoxiang Liu ,  Mihirbaran Mandal ,  Johannes H. Voigt ,  Corey O. Strickland

IPC分类号： A61K31/55 ,  A61K31/53 ,  A61K31/519 ,  A01N43/62 ,  A01N43/64 ,  A01N43/90 ,  C07D253/08 ,  C07D487/00 ,  C07D491/00 ,  C07D513/00 ,  C07D515/00

CPC分类号： C07D487/04

摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein j, k, U, W, R, R1, R2, R3, R4, R6, R7 and R7a are as described above in the specification. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

摘要翻译： 公开了式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物，其中j，k，U，W，R，R1，R2，R3，R4，R6，R7和R7a如上所述 规格。 还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经变性疾病的方法。 还公开了使用式I化合物与胆碱酯酶抑制剂或毒蕈碱m1激动剂或m2拮抗剂组合治疗认知或神经变性疾病的方法。