-
1.发明申请Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof 失效取代的异喹啉-1,3（2H，4H） - 二酮，1-硫代-1,4-二氢-2H-异喹啉-3-酮和1,4-二氢-3（2H） - 异喹诺酮及其使用方法公开(公告)号：US20080085890A1
公开(公告)日：2008-04-10
申请号：US11728897
申请日：2007-03-26
申请人： Hwei-Ru Tsou , Semiramis Ayral-Kaloustian , Gary Birnberg , Middleton Floyd , Joshua Kaplan , Kristina Kutterer , Xiaoxiang Liu , Ramaswamy Nilakantan , Mercy Otteng , Zhilian Tang , Arie Zask , Tritin Tran , Scott Mayer , Annette Banker , Marvin Reich
发明人： Hwei-Ru Tsou , Semiramis Ayral-Kaloustian , Gary Birnberg , Middleton Floyd , Joshua Kaplan , Kristina Kutterer , Xiaoxiang Liu , Ramaswamy Nilakantan , Mercy Otteng , Zhilian Tang , Arie Zask , Tritin Tran , Scott Mayer , Annette Banker , Marvin Reich
IPC分类号： A61K31/55 , A61K31/47 , A61K31/496 , A61K31/497 , A61K31/501 , A61P1/00 , A61P17/06 , A61P3/10 , A61P31/12 , C07D295/00 , C07D241/02 , C07D239/02 , C07D237/26 , C07D237/02 , C07D223/02 , C07D217/00 , A61P9/00 , A61P35/00 , A61P31/10 , A61P19/02 , A61P11/00 , A61K31/502 , A61K31/506 , A61K31/5377 , A61K31/541
CPC分类号： C07D217/24 , C07D237/28 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
摘要： This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.
摘要翻译： 本发明提供式（I）化合物，其具有如下结构：其中G 1，G 2，G 3，G 4， / SUP>，A 1，A 2，Y 1，Y 2，L 1， / SUP>，Z，e和f如本文所定义，或其药学上可接受的盐，其可用于治疗或预防癌症。
-
2.发明授权Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo,1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihyro-3 (2H)-isoquinolones and methods of use thereof 失效取代的异喹啉-1,3（2H，4H） - 二酮，1-硫代，1,4-二氢-2H-异喹啉-3-酮和1,4-二羟基-3（2H） - 异喹诺酮及其使用方法公开(公告)号：US07713994B2
公开(公告)日：2010-05-11
申请号：US11728897
申请日：2007-03-26
申请人： Hwei-Ru Tsou , Semiramis Ayral-Kaloustian , Gary Harold Birnberg , Middleton Brawner Floyd , Joshua Kaplan , Kristina M. Kutterer , Xiaoxiang Liu , Ramaswamy Nilakantan , Mercy Adufa Otteng , Zhilian Tang , Arie Zask , Tritin Tran , Scott Christian Mayer , Annette L. Banker , Marvin Reich
发明人： Hwei-Ru Tsou , Semiramis Ayral-Kaloustian , Gary Harold Birnberg , Middleton Brawner Floyd , Joshua Kaplan , Kristina M. Kutterer , Xiaoxiang Liu , Ramaswamy Nilakantan , Mercy Adufa Otteng , Zhilian Tang , Arie Zask , Tritin Tran , Scott Christian Mayer , Annette L. Banker , Marvin Reich
IPC分类号： A61K31/47 , C07D217/08
CPC分类号： C07D217/24 , C07D237/28 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
摘要： This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.
摘要翻译： 本发明提供具有本文定义的G1，G2，G3，G4，A1，A2，Y1，Y2，L1，Z，e和f的结构的式（I）化合物或其药学上可接受的盐， 可用于治疗或预防癌症。
-
3.发明授权2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof 失效具有雌激素活性的2,4,6-三取代吡啶及其固相合成方法公开(公告)号：US06503917B1
公开(公告)日：2003-01-07
申请号：US09703508
申请日：2000-11-01
申请人： Chingfan Chiu , Zhilian Tang , John W. Ellingboe
发明人： Chingfan Chiu , Zhilian Tang , John W. Ellingboe
IPC分类号： C07D21324
CPC分类号： C07D213/30 , C07D405/04 , C07D409/14
摘要： The present invention relates to novel substituted pyridine compounds of Formula (I) wherein the moiety Z, R1, R2 and R3 are as herein defined, having estrogenic activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, to methods of treatment and to pharmaceutical compositions thereof.
摘要翻译： 本发明涉及式（I）的新型取代的吡啶化合物，其中Z，R1，R2和R3如本文所定义，具有雌激素活性，其制备方法，组合文库和制备文库的固相方法 的化合物，利用用于药物发现的化合物的文库，治疗方法及其药物组合物。
-
4.发明授权2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis 失效具有雌激素活性的2,4,6-三取代吡啶和用于固相合成的方法公开(公告)号：US06384057B1
公开(公告)日：2002-05-07
申请号：US09703386
申请日：2000-11-01
申请人： Chingfan Chiu , Zhilian Tang , John W. Ellingboe
发明人： Chingfan Chiu , Zhilian Tang , John W. Ellingboe
IPC分类号： A61K31444
CPC分类号： C07D213/30 , C07D405/04 , C07D409/14
摘要： The present invention relates to novel substituted pyridine compounds of Formula (I) wherein the moiety Z, R1, R2 and R3 are as herein defined, having estrogenic activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, to methods of treatment and to pharmaceutical compositions thereof.
摘要翻译： 本发明涉及式（I）的新型取代的吡啶化合物，其中Z，R1，R2和R3如本文所定义，具有雌激素活性，其制备方法，组合文库和制备文库的固相方法 的化合物，利用用于药物发现的化合物的文库，治疗方法及其药物组合物。
-
5.发明授权2,4,6-trisbstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof 失效具有雌激素活性的2,4,6-三取代吡啶和其固相合成方法公开(公告)号：US06384060B1
公开(公告)日：2002-05-07
申请号：US09703297
申请日：2000-11-01
申请人： Chingfan Chiu , Zhilian Tang , John W. Ellingboe
发明人： Chingfan Chiu , Zhilian Tang , John W. Ellingboe
IPC分类号： C07D40504
CPC分类号： C07D213/30 , C07D405/04 , C07D409/14
摘要： The present invention relates to novel substituted pyridine compounds of Formula (I) wherein the moiety Z, R1, R2 and R3 are as herein defined, having estrogenic activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, to methods of treatment and to pharmaceutical compositions thereof.
摘要翻译： 本发明涉及式（I）的新型取代的吡啶化合物，其中Z，R1，R2和R3如本文所定义，具有雌激素活性，其制备方法，组合文库和制备文库的固相方法 的化合物，利用用于药物发现的化合物的文库，治疗方法及其药物组合物。
-
6.发明授权2,4,6-trisubstituted pryridines with estrogenic activity and methods for the solid phase synthesis thereof 失效具有雌激素活性的2,4,6-三取代吡啶并用于其固相合成的方法公开(公告)号：US06384058B1
公开(公告)日：2002-05-07
申请号：US09703519
申请日：2000-11-01
申请人： Chingfan Chiu , Zhilian Tang , John W. Ellingboe
发明人： Chingfan Chiu , Zhilian Tang , John W. Ellingboe
IPC分类号： C07D40104
CPC分类号： C07D213/30 , C07D405/04 , C07D409/14
摘要： The present invention relates to novel substituted pyridine compounds of Formula (I) wherein the moiety Z, R1, R2 and R3 are as herein defined, having estrogenic activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, to methods of treatment and to pharmaceutical compositions thereof.
摘要翻译： 本发明涉及式（I）的新型取代的吡啶化合物，其中Z，R1，R2和R3如本文所定义，具有雌激素活性，其制备方法，组合文库和制备文库的固相方法 的化合物，利用用于药物发现的化合物的文库，治疗方法及其药物组合物。
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.058 秒)