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公开(公告)号：US07229827B2
公开(公告)日：2007-06-12
申请号：US10475056
申请日：2002-04-19
申请人： Hyun-Soo Kim , Hee-Hoon Yoon
发明人： Hyun-Soo Kim , Hee-Hoon Yoon
CPC分类号： C12N5/0622 , A61K35/12 , C12N5/0619 , C12N2501/11 , C12N2501/115 , C12N2501/12 , C12N2506/1353
摘要： A method for differentiating mesenchymal stem cells of bone marrow into neural cells comprises culturing the mesenchymal stem cells in a medium containing epidermal growth factor(EGF), basic fibroblast growth factor(bFGF) and hepatocyte growth factor(HGF), and the neural cells produced thereby can be employed for the treatment of a neural disease.
摘要翻译： 将骨髓间充质干细胞分化为神经细胞的方法包括在含有表皮生长因子（EGF），碱性成纤维细胞生长因子（bFGF）和肝细胞生长因子（HGF）的培养基中培养间充质干细胞，并产生神经细胞 从而可用于治疗神经疾病。
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公开(公告)号：US20100126923A1
公开(公告)日：2010-05-27
申请号：US12593864
申请日：2008-03-28
申请人： Jung Keug Park , Sung Koo Kim , Suk Koo Lee , Young-Jin Kim , Doo-Hoon Lee , Ji-Hyun Lee , Hee-Hoon Yoon , Jae-Nam Ryu , Choon-Hyuck Kwon , Jeong-Kwon Noh , Hey-Jung Park
发明人： Jung Keug Park , Sung Koo Kim , Suk Koo Lee , Young-Jin Kim , Doo-Hoon Lee , Ji-Hyun Lee , Hee-Hoon Yoon , Jae-Nam Ryu , Choon-Hyuck Kwon , Jeong-Kwon Noh , Hey-Jung Park
CPC分类号： A61M1/3472 , A61M1/1698 , A61M1/3489 , C12N5/0671 , C12N2533/74
摘要： The present invention discloses a bioartificial liver system comprising a fixed-bed bioreactor packed with gel beads containing hepatocytes of an animal, a plasma reservoir, a plasma separator, and an efflux chamber, wherein the plasma reservoir is located at a position higher than the bioreactor, a ventilation filter in contact with atmosphere is provided at the top of the plasma reservoir, and the top of the plasma reservoir is directly connected to the efflux chamber via a connecting line. The inventive system satisfactorily performs the essential liver functions without the problems of gel bead damage or channeling.
摘要翻译： 本发明公开了一种生物人造肝系统，其包括固定床生物反应器，该固定床生物反应器填充有含有动物肝细胞，血浆储存器，血浆分离器和流出室的凝胶珠，其中等离子体储存器位于高于生物反应器 在等离子体容器的顶部设置有与气氛接触的通风过滤器，并且等离子体容器的顶部经由连接线直接连接到流出室。 本发明的系统令人满意地执行必要的肝功能，而没有凝胶珠损伤或引流的问题。
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3.发明授权Method for the preparation of a dermal papilla tissue having hair follicle inductive potency 有权用于制备具有毛囊诱导效力的真皮乳头组织的方法公开(公告)号：US07635589B2
公开(公告)日：2009-12-22
申请号：US11720217
申请日：2005-11-29
申请人： Jung-Keug Park , Doo-Hoon Lee , Hee-Hoon Yoon , Youn-Ho Shin , Young Jin Kim
发明人： Jung-Keug Park , Doo-Hoon Lee , Hee-Hoon Yoon , Youn-Ho Shin , Young Jin Kim
IPC分类号： C12N5/06
CPC分类号： C12N5/0627 , C12N2500/32 , C12N2501/12 , C12N2501/135 , C12N2501/155 , C12N2501/165
摘要： The inventive method for the preparation of a dermal papilla tissue in accordance with the present invention makes it possible to form a quantity of the dermal papilla tissues having hair follicle inductive ability, and accordingly, it can be effectively used for the treatment of alopecia through cell transplantation.
摘要翻译： 根据本发明的用于制备真皮乳头组织的本发明的方法使得可以形成一定量的具有毛囊诱导能力的真皮乳头组织，因此可以有效地用于通过细胞治疗脱发 移植。
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4.发明申请Method For the Preparation of a Dermal Papilla Tissue Having Hair Follicle Inductive Potency 有权用于制备具有毛囊感染效力的真皮乳头组织的方法公开(公告)号：US20080145929A1
公开(公告)日：2008-06-19
申请号：US11720217
申请日：2005-11-29
申请人： Jung-Keug Park , Doo-Hoon Lee , Hee-Hoon Yoon , Youn-Ho Shin , Young Jin Kim
发明人： Jung-Keug Park , Doo-Hoon Lee , Hee-Hoon Yoon , Youn-Ho Shin , Young Jin Kim
IPC分类号： C12N5/00
CPC分类号： C12N5/0627 , C12N2500/32 , C12N2501/12 , C12N2501/135 , C12N2501/155 , C12N2501/165
摘要： The inventive method for the preparation of a dermal papilla tissue in accordance with the present invention makes it possible to form a quantity of the dermal papilla tissues having hair follicle inductive ability, and accordingly, it can be effectively used for the treatment of alopecia through cell transplantation.
摘要翻译： 根据本发明的用于制备真皮乳头组织的本发明的方法使得可以形成一定量的具有毛囊诱导能力的真皮乳头组织，因此可以有效地用于通过细胞治疗脱发 移植。
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5.发明申请Method For The Preparation Of Dermal Papilla Tissue Employing Mesenchymal Stem Cells 有权制备使用间充质干细胞的真皮乳头组织的方法公开(公告)号：US20100261276A1
公开(公告)日：2010-10-14
申请号：US12282760
申请日：2007-07-20
申请人： Jung-Keug Park , Hee-Hoon Yoon , Bo-Young Yoo , Young-Jin Kim , Youn-Ho Shin
发明人： Jung-Keug Park , Hee-Hoon Yoon , Bo-Young Yoo , Young-Jin Kim , Youn-Ho Shin
CPC分类号： C12N5/0627 , C12N2500/32 , C12N2500/38 , C12N2501/12 , C12N2501/39 , C12N2502/025 , C12N2502/1358 , C12N2502/1382 , C12N2502/1388
摘要： A method for the preparation of dermal papilla tissue comprising the step of culturing mesenchymal stem cells in a medium having a specific composition is provided. The method makes it possible to form in vitro a quantity of dermal papilla tissues having hair follicle inducting ability and, accordingly, it can be effectively used for the treatment of alopecia through cell transplantation.
摘要翻译： 提供了一种制备真皮乳头组织的方法，包括在具有特定组成的培养基中培养间充质干细胞的步骤。 该方法能够体外形成具有毛囊诱导能力的真皮乳头组织，因此可以有效地用于通过细胞移植治疗脱发。
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公开(公告)号：US08329457B2
公开(公告)日：2012-12-11
申请号：US12593864
申请日：2008-03-28
申请人： Jung Keug Park , Sung Koo Kim , Suk Koo Lee , Young-Jin Kim , Doo-Hoon Lee , Ji-Hyun Lee , Hee-Hoon Yoon , Jae-Nam Ryu , Choon-Hyuck Kwon , Jeong-Kwon Noh , Hey-Jung Park
发明人： Jung Keug Park , Sung Koo Kim , Suk Koo Lee , Young-Jin Kim , Doo-Hoon Lee , Ji-Hyun Lee , Hee-Hoon Yoon , Jae-Nam Ryu , Choon-Hyuck Kwon , Jeong-Kwon Noh , Hey-Jung Park
CPC分类号： A61M1/3472 , A61M1/1698 , A61M1/3489 , C12N5/0671 , C12N2533/74
摘要： The present invention discloses a bioartificial liver system comprising a fixed-bed bioreactor packed with gel beads containing hepatocytes of an animal, a plasma reservoir, a plasma separator, and an efflux chamber, wherein the plasma reservoir is located at a position higher than the bioreactor, a ventilation filter in contact with atmosphere is provided at the top of the plasma reservoir, and the top of the plasma reservoir is directly connected to the efflux chamber via a connecting line. The inventive system satisfactorily performs the essential liver functions without the problems of gel bead damage or channeling.
摘要翻译： 本发明公开了一种生物人造肝系统，其包括固定床生物反应器，该固定床生物反应器填充有含有动物肝细胞，血浆储存器，血浆分离器和流出室的凝胶珠，其中等离子体储存器位于高于生物反应器 在等离子体容器的顶部设置有与气氛接触的通风过滤器，并且等离子体容器的顶部经由连接线直接连接到流出室。 本发明的系统令人满意地执行必要的肝功能，而没有凝胶珠损伤或引流的问题。
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7.发明授权Method for the preparation of dermal papilla tissue employing mesenchymal stem cells 有权使用间充质干细胞制备真皮乳头组织的方法公开(公告)号：US08017390B2
公开(公告)日：2011-09-13
申请号：US12282760
申请日：2007-07-20
申请人： Jung-Keug Park , Hee-Hoon Yoon , Bo-Young Yoo , Young-Jin Kim , Youn-Ho Shin
发明人： Jung-Keug Park , Hee-Hoon Yoon , Bo-Young Yoo , Young-Jin Kim , Youn-Ho Shin
CPC分类号： C12N5/0627 , C12N2500/32 , C12N2500/38 , C12N2501/12 , C12N2501/39 , C12N2502/025 , C12N2502/1358 , C12N2502/1382 , C12N2502/1388
摘要： A method for the preparation of dermal papilla tissue comprising the step of culturing mesenchymal stem cells in a medium having a specific composition is provided. The method makes it possible to form in vitro a quantity of dermal papilla tissues having hair follicle inducting ability and, accordingly, it can be effectively used for the treatment of alopecia through cell transplantation.
摘要翻译： 提供了一种制备真皮乳头组织的方法，包括在具有特定组成的培养基中培养间充质干细胞的步骤。 该方法能够体外形成具有毛囊诱导能力的真皮乳头组织，因此可以有效地用于通过细胞移植治疗脱发。
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