摘要:
Disclosed are peptides having SEQ ID NOs: 1 to 32 that can stimulate superoxide generation in human monocytes. Superoxide is the most important armory on the primary defense line of monocytes against invading pathogens, and the identification of new stimuli and the characterization of the regulatory mechanism of superoxide generation are of paramount importance.
摘要翻译:公开了具有可刺激人单核细胞中超氧化物产生的SEQ ID NO:1至32的肽。 超氧化物是单核细胞侵袭病原体的主要防御线上最重要的武器,新的刺激的鉴定和超氧化物产生的调节机制的表征是至关重要的。
摘要:
The present invention relates to a ligand to regulate immune response, i.e., PACAP27 which is one of pituitary adenylate cyclase-activating polypeptides and Serum amyloid A (SAA), and their novel use in treating or preventing diseases associated with immune response. More specifically, the present invention relates to a complex of PACAP27-FPRL1 having a regulatory effect on immune response, and a use thereof in regulating immune response. In another aspect, the present invention relates to a complex of SAA and FPRL1, and a use thereof in inhibiting synoviocyte hyperplasia and angiogenesis and treating or preventing inflammatory diseases including Rheumatoid arthritis (RA).
摘要:
The present invention relates to a method of regulating mammalian target-of-rapamycin (mTOR) by regulating a phospholipase D (PLD) activity that generates a complex with mTOR. Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
摘要:
The present invention relates to an glucose uptake modulator, a pharmaceutical composition comprising the glucose uptake modulator, and a method of treating a diabetes or diabetic complications in a mammal in need thereof, which comprises administering to said mammal an effecting amount of a glucose uptake modulator.
摘要:
The present invention relates to method of regulating mammalian target-of-rapamycin (mTOR) based on a novel finding of a regulating mechanism of mTOR by a phospholipase D (PLD), and Ras homolog enriched in brain (Rheb). Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibitin mTOR.
摘要:
The present invention relates to method of regulating mammalian target-of-rapamycin (mTOR) based on a novel finding of a regulating mechanism of mTOR by a phospholipase D (PLD), and Ras homolog enriched in brain (Rheb). Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
摘要:
The present invention relates to a method of regulating mammalian target-of-rapamycin (mTOR) by regulating a phospholipase D (PLD) activity that generates a complex with mTOR. Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
摘要:
The present invention relates to an glucose uptake modulator, a pharmaceutical composition comprising the glucose uptake modulator, and a method of treating a diabetes or diabetic complications in a mammal in need thereof, which comprises administering to said mammal an effecting amount of a glucose uptake modulator.
摘要:
Embodiments of the invention provide a method for compensating for an acceleration vector offset of an acceleration detector, a recording medium storing a program for executing the method, and an apparatus adapted to perform the method. The method comprises determining whether the acceleration detector is in a stable resting state; if the acceleration detector is determined to be in a stable resting state, then determining whether any one of at least two orthogonal axes is a main axis; and, if the acceleration detector is determined to be in a stable resting state and one of the at least two orthogonal axes is determined to be a main axis, performing an acceleration vector compensation operation to compensate for the acceleration vector offset of the acceleration detector.
摘要:
Disclosed are an embroidery fabric clamping unit for use with an embroidery machine, and an embroidery machine comprising the same, which allow the embroidering of even embroidery fabrics of arbitrary shape. The embroidery fabric clamping unit comprises: a unit body having a joining part provided for attachment to and detachment from a work table of the embroidery machine; an embroidery fabric support table which is linked to the unit body and supports the embroidery fabric to be embroidered by the embroidery machine; a lever which is supported on the unit body, with the embroidery fabric placed in between, and is able to apply pressure to and release pressure from the embroidery fabric support table; and a lever driving part for driving the lever.