公开(公告)号：US10577643B2

公开(公告)日：2020-03-03

申请号：US15286374

申请日：2016-10-05

Applicant: ILLUMINA, INC.

Inventor： Li Teng ,  Chia-Ling Hsieh ,  Charles Lin ,  Han-Yu Chuang

IPC: C12Q1/68 ,  C07H21/00 ,  C12Q1/6806

Abstract: Presented herein are methods and compositions for enhancing specific enrichment of target sequences in a nucleic acid library. Off-target hybridization probes may be used to reduce binding and/or capture of off-target regions of a nucleic acid library in a targeted sequencing workflow. The off-target hybridization probes may be specific for locations known to generate off-target sequencing reads for a particular set of hybridization probes.

公开(公告)号：US20230193357A1

公开(公告)日：2023-06-22

申请号：US18165153

申请日：2023-02-06

Applicant: ILLUMINA, INC.

Inventor： Li Teng ,  Chia-Ling Hsieh ,  Charles Lin ,  Han-Yu Chuang

IPC: C12Q1/6806

CPC classification number: C12Q1/6806

Abstract: Presented herein are methods and compositions for enhancing specific enrichment of target sequences in a nucleic acid library. Off-target hybridization probes may be used to reduce binding and/or capture of off-target regions of a nucleic acid library in a targeted sequencing workflow. The off-target hybridization probes may be specific for locations known to generate off-target sequencing reads for a particular set of hybridization probes.

公开(公告)号：US11624084B2

公开(公告)日：2023-04-11

申请号：US16782833

申请日：2020-02-05

Applicant: ILLUMINA, INC.

Inventor： Li Teng ,  Chia-Ling Hsieh ,  Charles Lin ,  Han-Yu Chuang

IPC: C12Q1/6806

Abstract: Presented herein are methods and compositions for enhancing specific enrichment of target sequences in a nucleic acid library. Off-target hybridization probes may be used to reduce binding and/or capture of off-target regions of a nucleic acid library in a targeted sequencing workflow. The off-target hybridization probes may be specific for locations known to generate off-target sequencing reads for a particular set of hybridization probes.

公开(公告)号：US20170101676A1

公开(公告)日：2017-04-13

申请号：US15286374

申请日：2016-10-05

Applicant: ILLUMINA, INC.

Inventor： Li Teng ,  Chia-Ling Hsieh ,  Charles Lin ,  Han-Yu Chuang

IPC: C12Q1/68

CPC classification number: C12Q1/6806 ,  C12Q2535/122 ,  C12Q2537/159 ,  C12Q2537/163 ,  C12Q2563/131

Abstract: Presented herein are methods and compositions for enhancing specific enrichment of target sequences in a nucleic acid library. Off-target hybridization probes may be used to reduce binding and/or capture of off-target regions of a nucleic acid library in a targeted sequencing workflow. The off-target hybridization probes may be specific for locations known to generate off-target sequencing reads for a particular set of hybridization probes.