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公开(公告)号：US20170328965A1
公开(公告)日：2017-11-16
申请号：US15588214
申请日：2017-05-05
申请人： IMEC VZW , Universiteit Hasselt
CPC分类号： G01R33/26 , G01R33/3607 , G01R33/3614 , G01R33/60
摘要： The disclosure relates to a magnetometer sensor with negatively charged nitrogen-vacancy centers in diamond. One example embodiment is a magnetometer sensor. The magnetometer sensor includes a diamond crystal with one or more negatively charged nitrogen-vacancy centers. The magnetometer sensor also includes one or more light sources. Further, the magnetometer sensor includes an electrode. In addition, the magnetometer sensor includes a read-out module. The read-out module includes a read-out circuit configured to read-out a photocurrent from the electrode and a lock-in amplifier. The lock-in amplifier includes a first input, a second input, and an output. The magnetometer sensor additionally includes a microwave source configured to apply a microwave field to the negatively charged nitrogen-vacancy centers. The microwave source includes a microwave generator for generating continuous wave microwaves and a microwave modulator configured to modulate the continuous wave microwaves. Still further, the magnetometer sensor includes a processor.
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公开(公告)号：US20160178622A1
公开(公告)日：2016-06-23
申请号：US14972399
申请日：2015-12-17
申请人： Universiteit Hasselt , IMEC VZW
IPC分类号： G01N33/543 , G01N25/18 , G01N33/53
CPC分类号： G01N33/54366 , G01N25/18 , G01N33/5308 , G01N33/54373
摘要： The present disclosure relates to a biosensor device for detecting a predetermined target analyte. The device comprises a substrate. An aptamer bioreceptor for specifically binding to the predetermined target analyte is exposed at a functionalized surface of the substrate. The device also comprises a heat source for heating the substrate via a back surface thereof. The device further comprises a first temperature sensing element for sensing a temperature at the back side of the substrate and a second temperature sensing element for sensing a temperature at the functionalized side of the substrate. The device also comprises a signal processing unit for calculating a heat transfer resistivity value based on temperature values obtained from the first and the second temperature sensing element and the heating power generated by the heat source.
摘要翻译： 本公开涉及用于检测预定目标分析物的生物传感器装置。 该装置包括基板。 用于特异性结合预定靶分析物的适体生物受体暴露在基底的官能化表面。 该装置还包括用于通过其背面加热衬底的热源。 该装置还包括用于感测衬底背面温度的第一温度感测元件和用于感测衬底功能化侧的温度的第二温度感测元件。 该装置还包括信号处理单元，用于基于从第一和第二温度感测元件获得的温度值和由热源产生的加热功率计算传热电阻率值。
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公开(公告)号：US20180180609A1
公开(公告)日：2018-06-28
申请号：US15814026
申请日：2017-11-15
申请人： IMEC VZW , Universiteit Hasselt
发明人： Patricia Losada-Pérez , Derick Yongabi , Mehran Khorshid , Ward De Ceuninck , Ronald Thoelen , Patrick Wagner
IPC分类号： G01N33/557 , G01N33/543 , G01N25/18 , G01N33/569 , G01N33/68
摘要： The present disclosure relates to a method for characterizing and identifying a bioparticle. The method comprises introducing the sample to a substrate having a surface comprising a plurality of binding sites whereon bioparticles can be bound, determining, for at least one temperature, data representative for the interface thermal resistance of the surface of the substrate sufficiently long to include the detachment process of the bioparticles, and deriving, for the at least one temperature, a bioparticle retention time and/or detachment rate from the data representative for the interface thermal resistance data. The present disclosure also relates to a bio-sensing device suitable for the detection and/or characterization of target bioparticles.
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公开(公告)号：US20140335274A1
公开(公告)日：2014-11-13
申请号：US14361377
申请日：2012-11-29
申请人： IMEC , UNIVERSITEIT HASSELT
发明人： Thijs Vandenryt , Lars Grieten , Ward De Ceuninck , Ronald Thoelen , Michaël Daenen , Patrick Wagner
CPC分类号： B05D1/32 , C01B32/25 , C01P2004/03 , C01P2004/62
摘要： The present invention relates to a method (1) for creating a diamond structure (38) on a substrate (31). This method comprises the steps of providing (2) a substrate (31), providing (3) a mold (25) on the substrate (31), providing (4) a diamond seed solution (34) in the mold (25), and removing (6) the mold (25) such that a diamond structure (38) remains on the substrate (31).
摘要翻译： 本发明涉及一种用于在基板（31）上形成金刚石结构（38）的方法（1）。 该方法包括以下步骤：提供（2）基材（31），在基材（31）上提供（3）模具（25），在模具（25）中提供（4）金刚石种子溶液（34） 以及去除（6）所述模具（25），使得金刚石结构（38）保留在所述基底（31）上。
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公开(公告)号：US09429539B2
公开(公告)日：2016-08-30
申请号：US14567792
申请日：2014-12-11
申请人： IMEC , Universiteit Hasselt
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , G01N27/327 , C12Q1/68 , G01N27/02 , B01L3/00 , G05B15/02
CPC分类号： G01N27/327 , B01L3/50273 , B01L3/502738 , B01L2300/023 , B01L2300/0636 , C12Q1/6825 , C12Q1/6827 , C12Q1/6832 , G01N25/4873 , G01N27/021 , G01N27/3275 , G05B15/02 , Y10T436/11 , Y10T436/143333 , C12Q2527/101 , C12Q2527/113 , C12Q2565/607
摘要： A method an system is disclosed for the detection and/or allocation of at least one point mutation in target DNA and/or RNA duplexes. The method comprises obtaining a functionalized surface which is coated with probe DNA and/or RNA whereto target DNA and/or RNA duplexes are attached, contacting said functionalized surface to an electrolytic solution having a neutral pH in a flow cell and measuring a first impedance value within said electrolytic solution, and then adding a chemical to the electrolytic solution which is able to achieve denaturation of the target DNA and/or RNA. The method further comprises measuring a second impedance value within the flow cell after completion of the denaturation of the DNA and/or RNA target, and then obtaining a value representative for the impact of the chemical on the impedance of the electrolytic solution. The amount and/or allocation of point mutation(s) within the target DNA and/or RNA is then determined by calculating the denaturation-time constant based on the difference between the first and second impedance value and taking into account the impact of the chemical by third impedance value.
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公开(公告)号：US10705083B2
公开(公告)日：2020-07-07
申请号：US15814026
申请日：2017-11-15
申请人： IMEC VZW , Universiteit Hasselt
发明人： Patricia Losada-Pérez , Derick Yongabi , Mehran Khorshid , Ward De Ceuninck , Ronald Thoelen , Patrick Wagner
IPC分类号： G01N33/557 , G01N25/18 , G01N33/543 , G01N33/569 , G01N33/68 , G01N33/487
摘要： The present disclosure relates to a method for characterizing and identifying a bioparticle. The method comprises introducing the sample to a substrate having a surface comprising a plurality of binding sites whereon bioparticles can be bound, determining, for at least one temperature, data representative for the interface thermal resistance of the surface of the substrate sufficiently long to include the detachment process of the bioparticles, and deriving, for the at least one temperature, a bioparticle retention time and/or detachment rate from the data representative for the interface thermal resistance data. The present disclosure also relates to a bio-sensing device suitable for the detection and/or characterization of target bioparticles.
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公开(公告)号：US10274551B2
公开(公告)日：2019-04-30
申请号：US15588214
申请日：2017-05-05
申请人： IMEC VZW , Universiteit Hasselt
摘要： The disclosure relates to a magnetometer sensor with negatively charged nitrogen-vacancy centers in diamond. One example embodiment is a magnetometer sensor. The magnetometer sensor includes a diamond crystal with one or more negatively charged nitrogen-vacancy centers. The magnetometer sensor also includes one or more light sources. Further, the magnetometer sensor includes an electrode. In addition, the magnetometer sensor includes a read-out module. The read-out module includes a read-out circuit configured to read-out a photocurrent from the electrode and a lock-in amplifier. The lock-in amplifier includes a first input, a second input, and an output. The magnetometer sensor additionally includes a microwave source configured to apply a microwave field to the negatively charged nitrogen-vacancy centers. The microwave source includes a microwave generator for generating continuous wave microwaves and a microwave modulator configured to modulate the continuous wave microwaves. Still further, the magnetometer sensor includes a processor.
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公开(公告)号：US20150219584A1
公开(公告)日：2015-08-06
申请号：US14567792
申请日：2014-12-11
申请人： IMEC , UNIVERSITEIT HASSELT
IPC分类号： G01N27/327 , G05B15/02 , B01L3/00
CPC分类号： G01N27/327 , B01L3/50273 , B01L3/502738 , B01L2300/023 , B01L2300/0636 , C12Q1/6825 , C12Q1/6827 , C12Q1/6832 , G01N25/4873 , G01N27/021 , G01N27/3275 , G05B15/02 , Y10T436/11 , Y10T436/143333 , C12Q2527/101 , C12Q2527/113 , C12Q2565/607
摘要： A method an system is disclosed for the detection and/or allocation of at least one point mutation in target DNA and/or RNA duplexes. The method comprises obtaining a functionalized surface which is coated with probe DNA and/or RNA whereto target DNA and/or RNA duplexes are attached, contacting said functionalized surface to an electrolytic solution having a neutral pH in a flow cell and measuring a first impedance value within said electrolytic solution, and then adding a chemical to the electrolytic solution which is able to achieve denaturation of the target DNA and/or RNA. The method further comprises measuring a second impedance value within the flow cell after completion of the denaturation of the DNA and/or RNA target, and then obtaining a value representative for the impact of the chemical on the impedance of the electrolytic solution. The amount and/or allocation of point mutation(s) within the target DNA and/or RNA is then determined by calculating the denaturation-time constant based on the difference between the first and second impedance value and taking into account the impact of the chemical by third impedance value.
摘要翻译： 公开了用于检测和/或分配靶DNA和/或RNA双链体中的至少一个点突变的方法。 所述方法包括获得涂覆有靶DNA和/或RNA双链体的探针DNA和/或RNA的功能化表面，使所述功能化表面与流动池中具有中性pH的电解溶液接触并测量第一阻抗值 在所述电解液中，然后向能够实现靶DNA和/或RNA变性的电解液中加入化学物质。 该方法还包括在完成DNA和/或RNA靶变性后测量流动池内的第二阻抗值，然后获得代表该化学物质对电解溶液阻抗的影响的值。 然后通过基于第一和第二阻抗值之间的差异计算变性 - 时间常数并考虑到化学品的影响来确定靶DNA和/或RNA内的点突变的量和/或分配 通过第三阻抗值。
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