公开(公告)号：US20230320619A1

公开(公告)日：2023-10-12

申请号：US18031668

申请日：2021-10-14

Applicant: IMEC VZW

Inventor： Ahmed TAHER ,  Benjamin JONES ,  Peter PEUMANS

IPC: A61B5/08 ,  A61B5/091 ,  G01N1/22

CPC classification number: A61B5/082 ,  A61B5/091 ,  G01N1/2208 ,  G01N2001/2244

Abstract: A collecting device (200) for collecting airborne particles comprises: a first (202) and second layer (220) spaced apart for forming a particle collection chamber (240) therebetween, wherein inlets (210) extend through the first layer (202) for transporting a flow of air into the particle collection chamber (240); wherein ends (214) of the inlets (210) face a first surface (222) of the second layer (220) for capturing airborne particles by impaction; wherein outlets (230) extend through the second layer (220) for transporting the flow of air out of the particle collection chamber (240); wherein the inlets (210) and outlets (230) are staggered such that the center axes of the inlets (210) and outlets (230) are displaced from each other; wherein the flow of air experiences a pressure drop lower than 3 kPa at a flow rate of 0.5 liters per second, when the flow of air passes the collecting device (200).

公开(公告)号：US20220062850A1

公开(公告)日：2022-03-03

申请号：US17416465

申请日：2019-12-16

Applicant: IMEC VZW ,  Katholieke Universiteit Leuven

Inventor： Peter PEUMANS ,  Ahmed TAHER ,  Nicolas VERGAUWE ,  Benjamin JONES

IPC: B01J19/00 ,  B01L3/00

Abstract: The present invention provides a micro-reactor (1) adapted to host chemical reactions having at least one microfluidic layer, said micro-reactor (1) comprising a fluid inlet (2) and a fluid outlet (3); a plurality of micro-reaction chambers (10) arranged in rows (7) and columns (6), each micro-reaction chamber comprising a chamber inlet (10a) and a chamber outlet (10b); a plurality of supply channels (4) for supplying fluid to from said fluid inlet (2) to said micro-reaction chambers (10) and further arranged for draining said micro-reaction chambers (10) to said fluid outlet (3), said supply channels (10) extending in a first direction (D1) along the columns (6) of micro-reaction chambers (10) and arranged such that there is one supply channel (4) between adjacent columns (6). The micro-reaction chambers (10) in the columns (6) are arranged such that the chamber inlets (10a) of a column are in fluid contact with the same supply channel (4) and the chamber outlets (10b) are in fluid contact with the supply channel (4) adjacent to the supply channel (4) arranged in fluidic contact with the chamber inlets (10a). Further, the plurality of supply channels (4) comprises a first end supply channel (4a) arranged for supplying fluid to a first end column (6a) of the micro-reaction chambers (10) and a second end supply channel (4b) arranged for draining fluid from the second, opposite, end column (6b) of said micro-reaction chambers (10); and wherein the micro-reactor (1) further comprises at least one reagent inlet (8) in fluid contact with the first end supply channel 4a and a reagent outlet (9) in fluid contact with the second end supply channel such that reagents introduced to the at least one reagent inlet (8) fill the plurality of micro-reaction chambers (10) in a second direction (D2) along the rows (7) of micro-reaction chambers (10) to the reagent outlet (9).

公开(公告)号：US20210187504A1

公开(公告)日：2021-06-24

申请号：US17127985

申请日：2020-12-18

Applicant: IMEC VZW

Inventor： Ahmed TAHER ,  Benjamin JONES

IPC: B01L3/00

Abstract: A microfluidic device (100) comprises: a reaction chamber (102); at least a first and a second supply channel (110a, 110b) for allowing transport of a first fluid and a second fluid, respectively, from a fluid supply source (112a, 112b) into the reaction chamber (102), wherein each of the first and the second supply channels (110a, 110b) comprises a side drain (114a, 114b) connected to the supply channel (110a, 110b) between the fluid supply source (112a, 112b) and the reaction chamber (102), wherein the side drain (114a, 114b) is configured to prevent undesired diffusion of the fluid in the supply channel (110a, 110b) into the reaction chamber (102); at least a first and a second outlet (120a, 120b) connected to the reaction chamber (102) for allowing transport of fluid from the reaction chamber (102), wherein the first and second outlets (120a, 120b) have different dimensions to provide different hydraulic resistance.

公开(公告)号：US20240219272A1

公开(公告)日：2024-07-04

申请号：US18288501

申请日：2022-04-20

Applicant: IMEC VZW

Inventor： Ahmed TAHER ,  Benjamin JONES ,  Sophie ROTH

IPC: G01N1/22

CPC classification number: G01N1/2208 ,  G01N1/2214 ,  G01N1/2273 ,  G01N2001/2217 ,  G01N2001/2223

Abstract: A collecting device (200) for collecting airborne particles comprises: a first (202) and second layer (220) spaced apart for forming a particle collection chamber (240; 340) therebetween: wherein inlets (210; 310) and outlets (230; 330) are configured for transporting a flow of air (104) into and out of the particle collection chamber (240; 340) and configured for allowing capturing airborne particles by impaction. The collecting device (200) further comprises at least one liquid access port (260; 260a, 260b; 360a-360h) for filling the particle collection chamber (240; 340) with a reagent; and wherein the particle collection chamber (240; 340) comprises at least one side wall (246; 346) for defining flow of the reagent, such that a first portion (248a; 348a) and a second portion (248b; 348b) of the particle collection chamber (240; 340) are arranged on opposite sides of the at least one side wall (246; 346).

公开(公告)号：US20230380720A1

公开(公告)日：2023-11-30

申请号：US18031662

申请日：2021-10-14

Applicant: IMEC VZW

Inventor： Peter PEUMANS ,  Benjamin JONES ,  Xavier ROTTENBERG ,  Chengxun LIU ,  Ahmed TAHER

IPC: A61B5/097 ,  A61B5/00

CPC classification number: A61B5/097 ,  A61B5/0082

Abstract: A collecting device (200) for collection of particles and presentation of collected particles for analysis comprises: a first layer (202) and a second layer (220) spaced apart for defining a particle collection chamber (240); wherein the first layer (202) is configured to receive a flow of air (104) carrying airborne particles, wherein the first layer (202) comprises a plurality of inlet nozzles (210) configured to extend through the first layer (202) for transporting the flow of air (104) therethrough; wherein the inlet nozzles (210) are configured to face a first surface (222) of the second layer (220) for capturing airborne particles in the flow of air (104) entering the particle collection chamber (240) by impaction of airborne particles; wherein the collecting device (200) is configured to provide optical access for performing a measurement, based on light, of airborne particles collected in the particle collection chamber (240).

公开(公告)号：US20190201895A1

公开(公告)日：2019-07-04

申请号：US16233584

申请日：2018-12-27

Applicant: IMEC VZW

Inventor： Benjamin JONES

IPC: B01L3/00

CPC classification number: B01L3/502738 ,  B01L3/502746 ,  B01L2200/0605 ,  B01L2300/0627 ,  B01L2300/0867 ,  B01L2300/0896 ,  B01L2400/0605 ,  B01L2400/0688

Abstract: Described herein are sample loading systems for loading a sample into a processing and/or analysis system comprising: a sample reservoir for receiving a sample and a metering volume reservoir, the sample reservoir and a first side of the metering volume reservoir being interconnected through a first channel with a first flow resistance to allow filling of the metering volume reservoir with sample; a further reservoir for receiving a second fluid interconnected with the metering volume reservoir at the first side via a second channel having a smaller second flow resistance; a first valve for blocking flow of sample from the metering volume reservoir into the second channel; a second valve connected to a second side of the metering volume reservoir for controlling the blocking and flowing of sample; and a first timing circuitry for timing the opening of the second valve as a function of filling of the further reservoir.