公开(公告)号：US20180284110A1

公开(公告)日：2018-10-04

申请号：US15938217

申请日：2018-03-28

Applicant: IMRA AMERICA, INC.

Inventor： Kristin B. CEDERQUIST ,  Yuki ICHIKAWA ,  Bing LIU ,  Kori Michael FETTERS ,  Megan GRIMA ,  Nusayba TABBAH

IPC: G01N33/543 ,  G01N33/553 ,  G01N33/532 ,  G01N33/58

Abstract: Disclosed is a method for enhancing the optical signal of precious metal nanoparticles by introducing linker molecules for precious metal nanoparticles to form clusters in a stable colloidal suspension. The formation of clusters according to the present disclosure not only enhances the optical signal, but also can alter the optical spectrum, providing an alternative color for use in visual-based bioassays such as lateral flow immunoassays against the white test paper strips. The formed clusters are capable of passive adsorption of a variety of biomolecules which effectively bind onto the surface, requiring a minimum modification in the bio-assay protocol from that use for standard gold nanoparticles, which is being widely-used in lateral flow immunoassays.

公开(公告)号：US20160258940A1

公开(公告)日：2016-09-08

申请号：US15029462

申请日：2014-10-17

Applicant: IMRA AMERICA, INC. ,  JAPANESE FOUNDATION FOR CANCER RESEARCH

Inventor： Yuki ICHIKAWA ,  Kiyotaka SHIBA

IPC: G01N33/543 ,  G01N33/574 ,  G01N33/553 ,  A61K49/00

CPC classification number: G01N33/54346 ,  A61K9/14 ,  A61K38/10 ,  A61K47/02 ,  A61K47/10 ,  A61K49/0004 ,  G01N33/553 ,  G01N33/574 ,  G01N33/5748 ,  G01N33/57492 ,  G01N33/587 ,  G01N2333/705 ,  G01N2333/82

Abstract: Provide is a stable metallic nanostructure that causes no aggregation when surface-modified with biomolecule-reactive functional molecules. 30 to 90% of the surface of the metallic nanostructure is covered with at least one or more types of colloid-stabilizing functional molecules. Furthermore, the metallic nanostructure is covered with one or more types of biologically functional molecules.

Abstract translation: 提供一种稳定的金属纳米结构，当用生物分子反应性功能分子进行表面改性时，不会引起聚集。 金属纳米结构表面的30-90％被至少一种或多种胶体稳定功能分子覆盖。 此外，金属纳米结构被一种或多种类型的生物功能分子覆盖。

公开(公告)号：US20140314995A1

公开(公告)日：2014-10-23

申请号：US14323431

申请日：2014-07-03

Applicant: IMRA AMERICA, INC.

Inventor： Bing LIU ,  Yuki ICHIKAWA

IPC: B23K26/00

CPC classification number: B23K26/355 ,  B05D3/06 ,  B05D5/08 ,  B05D5/083 ,  B05D2451/00 ,  B23K26/009 ,  C21D1/09 ,  C21D10/00 ,  C21D2201/00 ,  Y10T428/24355 ,  B05D2401/32 ,  B05D2401/40

Abstract: A method of pulsed laser processing of solid surface for enhancing surface hydrophobicity is disclosed wherein the solid surface is covered with a transparent medium during laser processing and the laser beam incidents through the covering medium and irradiates the solid surface. Two effects are obtained simultaneously. One is the laser-induced texture formation directly under the laser irradiation. The other is the deposition of the laser-removed materials along the laser scan lines. Both effects introduce surface roughness on nanometer scales, and both enhance surface hydrophobicity, rendering superhydrophobicity on the surfaces of both the laser-irradiated solid and the covering medium. Because the beam scan line spacing can be larger than a single scan line width by multiple times, this method provides a high processing speed of square inch per minute and enables large area processing.

Abstract translation: 公开了一种用于提高表面疏水性的固体表面的脉冲激光加工方法，其中固体表面在激光加工期间被透明介质覆盖，并且激光束通过覆盖介质入射并照射固体表面。 同时获得两个效果。 一种是直接在激光照射下的激光诱导纹理形成。 另一种是激光去除材料沿着激光扫描线的沉积。 这两种效应都会在纳米尺度上引入表面粗糙度，同时增强表面疏水性，从而在激光照射的固体和覆盖介质的表面上产生超疏水性。 由于光束扫描线间距可以大于单个扫描线宽度多次，因此该方法提供了高达每分钟平方英寸的处理速度，可实现大面积处理。