公开(公告)号：US20180284110A1

公开(公告)日：2018-10-04

申请号：US15938217

申请日：2018-03-28

申请人： IMRA AMERICA, INC.

发明人： Kristin B. CEDERQUIST ,  Yuki ICHIKAWA ,  Bing LIU ,  Kori Michael FETTERS ,  Megan GRIMA ,  Nusayba TABBAH

IPC分类号： G01N33/543 ,  G01N33/553 ,  G01N33/532 ,  G01N33/58

摘要： Disclosed is a method for enhancing the optical signal of precious metal nanoparticles by introducing linker molecules for precious metal nanoparticles to form clusters in a stable colloidal suspension. The formation of clusters according to the present disclosure not only enhances the optical signal, but also can alter the optical spectrum, providing an alternative color for use in visual-based bioassays such as lateral flow immunoassays against the white test paper strips. The formed clusters are capable of passive adsorption of a variety of biomolecules which effectively bind onto the surface, requiring a minimum modification in the bio-assay protocol from that use for standard gold nanoparticles, which is being widely-used in lateral flow immunoassays.

公开(公告)号：US20140314995A1

公开(公告)日：2014-10-23

申请号：US14323431

申请日：2014-07-03

申请人： IMRA AMERICA, INC.

发明人： Bing LIU ,  Yuki ICHIKAWA

IPC分类号： B23K26/00

CPC分类号： B23K26/355 ,  B05D3/06 ,  B05D5/08 ,  B05D5/083 ,  B05D2451/00 ,  B23K26/009 ,  C21D1/09 ,  C21D10/00 ,  C21D2201/00 ,  Y10T428/24355 ,  B05D2401/32 ,  B05D2401/40

摘要： A method of pulsed laser processing of solid surface for enhancing surface hydrophobicity is disclosed wherein the solid surface is covered with a transparent medium during laser processing and the laser beam incidents through the covering medium and irradiates the solid surface. Two effects are obtained simultaneously. One is the laser-induced texture formation directly under the laser irradiation. The other is the deposition of the laser-removed materials along the laser scan lines. Both effects introduce surface roughness on nanometer scales, and both enhance surface hydrophobicity, rendering superhydrophobicity on the surfaces of both the laser-irradiated solid and the covering medium. Because the beam scan line spacing can be larger than a single scan line width by multiple times, this method provides a high processing speed of square inch per minute and enables large area processing.

摘要翻译： 公开了一种用于提高表面疏水性的固体表面的脉冲激光加工方法，其中固体表面在激光加工期间被透明介质覆盖，并且激光束通过覆盖介质入射并照射固体表面。 同时获得两个效果。 一种是直接在激光照射下的激光诱导纹理形成。 另一种是激光去除材料沿着激光扫描线的沉积。 这两种效应都会在纳米尺度上引入表面粗糙度，同时增强表面疏水性，从而在激光照射的固体和覆盖介质的表面上产生超疏水性。 由于光束扫描线间距可以大于单个扫描线宽度多次，因此该方法提供了高达每分钟平方英寸的处理速度，可实现大面积处理。

公开(公告)号：US20130150231A1

公开(公告)日：2013-06-13

申请号：US13692410

申请日：2012-12-03

申请人： Imra America, Inc.

发明人： Kevin V. HAGEDORN ,  Bing LIU ,  Yong CHE

IPC分类号： B01J37/34 ,  B01J23/62

CPC分类号： B01J37/349 ,  B01J21/185 ,  B01J23/62 ,  B01J23/626 ,  B01J23/628 ,  B01J23/6447 ,  B01J23/6525 ,  B01J23/892 ,  B01J35/0013 ,  B01J35/002 ,  B01J35/1014 ,  B01J37/344 ,  B82Y30/00 ,  B82Y40/00 ,  H01M4/921 ,  Y10S977/773 ,  Y10S977/81 ,  Y10S977/889

摘要： At least one embodiment includes a method for fabricating a catalyst comprising a colloidal suspension of nanoparticles, the nanoparticles comprising intermetallics of two or more metals exhibiting long range superlattice crystal ordering. The method comprising the steps of: producing a bulk target of the intermetallics of two or more metals exhibiting long range crystal ordering and submerging the target in a solvent. A pulsed laser is used to ablate bulk target material and to produce nanoparticle of the intermetallics of two or more metals exhibiting long range crystal ordering. At least one embodiment includes a catalyst made with the method. The catalyst can exhibit some desirable properties. For example, the catalyst may remain suspended in solution, essentially without surface modification by ionic compounds. Furthermore, the concentration of elements other than those which comprise the solvent or the intermetallic compound may be less than about 1 ppm.

摘要翻译： 至少一个实施方案包括用于制造包含纳米颗粒的胶态悬浮液的催化剂的方法，所述纳米颗粒包含两种或更多种呈现长范围超晶格晶体排列的金属的金属间化合物。 该方法包括以下步骤：制备两种或多种金属间化合物的体积目标物，其显示长程晶体排序并将靶浸入溶剂中。 使用脉冲激光来消融体目标材料并产生呈现长程晶体排列的两种或多种金属的金属间化合物的纳米颗粒。 至少一个实施方案包括用该方法制备的催化剂。 催化剂可以表现出一些期望的性质。 例如，催化剂可以保持悬浮在溶液中，基本上没有通过离子化合物的表面改性。 此外，除了包含溶剂或金属间化合物的元素之外的元素的浓度可以小于约1ppm。

公开(公告)号：US20180283995A1

公开(公告)日：2018-10-04

申请号：US15938172

申请日：2018-03-28

申请人： IMRA AMERICA, INC.

发明人： Wei QIAN ,  Bing LIU

IPC分类号： G01N1/30 ,  G01N33/58 ,  G01N33/574 ,  G01N21/552

摘要： Disclosed is a method and a kit for multi-color cell imaging with dark field optical microscopy using noble metal conjugated nanoparticles. The noble metal conjugated nanoparticles include a stabilizer component and a binding ligand, the stabilizer component coats a portion of the noble metal nanoparticle keeping it stable in biological buffers and cell cytoplasm. The binding ligand specifically binds to targeted cells designated for imaging. The method and kit permit multicolor imaging of cells, with the multiple colors being derived from localized surface plasmon resonance of the nanoparticles, each color the result of different amounts of one or more noble metals in the nanoparticle.

公开(公告)号：US20140017416A1

公开(公告)日：2014-01-16

申请号：US14025418

申请日：2013-09-12

申请人： IMRA AMERICA, INC.

发明人： Bing LIU ,  Zhendong Hu ,  Yong Che ,  Yuzuru Uehara

IPC分类号： C23C14/22

CPC分类号： C23C14/22 ,  C23C14/083 ,  C23C14/28

摘要： A p-type semiconductor zinc oxide (ZnO) film and a process for preparing the film are disclosed. The film is co-doped with phosphorous (P) and lithium (Li). A pulsed laser deposition scheme is described for use in growing the film. Further described is a process of pulsed laser deposition using transparent substrates which includes a pulsed laser source, a substrate that is transparent at the wavelength of the pulsed laser, and a multi-target system. The optical path of the pulsed laser is arranged in such a way that the pulsed laser is incident from the back of the substrate, passes through the substrate, and then focuses on the target. By translating the substrate towards the target, this geometric arrangement enables deposition of small features utilizing the root of the ablation plume, which can exist in a one-dimensional transition stage along the target surface normal, before the angular width of the plume is broadened by three-dimensional adiabatic expansion. This can provide small deposition feature sizes, which can be similar in size to the laser focal spot, and provides a novel method for direct deposition of patterned materials.

摘要翻译： 公开了一种p型半导体氧化锌（ZnO）膜及其制备方法。 该膜与磷（P）和锂（Li）共掺杂。 描述脉冲激光沉积方案用于生长膜。 进一步描述的是使用透明衬底的脉冲激光沉积过程，其包括脉冲激光源，在脉冲激光的波长处是透明的衬底和多目标系统。 脉冲激光器的光路布置成使得脉冲激光从衬底的背面入射，穿过衬底，然后聚焦在靶上。 通过将基板朝向目标平移，这种几何布置可以在羽流的角宽度扩大之前利用消融羽流的根部沉积小特征，其可以沿着目标表面法线存在于一维过渡阶段中 三维绝热膨胀。 这可以提供小的沉积特征尺寸，其尺寸可以与激光焦点类似，并且提供用于直接沉积图案化材料的新颖方法。