COMPOSITION FOR STABILIZING CELL-FREE NUCLEIC ACID AND/OR EXOSOMAL NUCLEIC ACID IN BLOOD, AND AGENT AND KIT CONTAINING THE SAME

    公开(公告)号:US20240327895A1

    公开(公告)日:2024-10-03

    申请号:US18400228

    申请日:2023-12-29

    CPC classification number: C12Q1/6806

    Abstract: A composition for stabilizing cell-free nucleic acid and/or exosomal nucleic acid in blood is provided. The composition for stabilizing cell-free nucleic acid and/or exosomal nucleic acid in blood is (a) a first composition or (b) a second composition. The first composition includes (i) an antiseptic component including an allantoin-formaldehyde condensation product; (ii) an enzyme inhibitory component including a first metal chelator and (iii) a metabolic inhibitory component including NaF or sodium azide. The second composition includes (i) an antiseptic component including an allantoin-formaldehyde condensate; (ii) an enzyme inhibiting component including a first metal chelator; (iii) a metabolic an inhibitory component including NaF or sodium azide; and (iv) an anticoagulant component including a second metal chelator.

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