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公开(公告)号：US20220202990A1
公开(公告)日：2022-06-30
申请号：US17136077
申请日：2020-12-29
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor： Hsin-Hsin Shen , Pei-I Tsai , Chih-Chieh Huang , Chien-Cheng Tai , Yi-Hung Wen , Jeng-Liang Kuo , Chun-Hsien Ma , Lih-Tao Hsu , Shin-I Huang , Kuo-Yi Yang , Tsung-Hsien Wu
Abstract: A tissue scaffold for use in a tendon and/or ligament is provided, which includes a weave formed by interlacing warp yarns and weft yarns, wherein the warp yarns include a plurality of fibers with an alternative shaped cross section structure, and the weave includes: a main body area with a bioactive component formed on the fiber surface, and a fixed area comprises the weft yarn having a bioceramic material. The tissue scaffold prepared in the present disclosure has the characteristics of stimulating the growth of tissues and inducing tissue repair, effectively improving the ability of tissue regeneration and bone healing, and is beneficial to the reconstruction of the tendon and/or ligament.
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Patent Agency Ranking
公开(公告)号：US12194192B2
公开(公告)日：2025-01-14
申请号：US17136077
申请日：2020-12-29
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor： Hsin-Hsin Shen , Pei-I Tsai , Chih-Chieh Huang , Chien-Cheng Tai , Yi-Hung Wen , Jeng-Liang Kuo , Chun-Hsien Ma , Lih-Tao Hsu , Shin-I Huang , Kuo-Yi Yang , Tsung-Hsien Wu
Abstract: A tissue scaffold for use in a tendon and/or ligament is provided, which includes a weave formed by interlacing warp yarns and weft yarns, wherein the warp yarns include a plurality of fibers with an alternative shaped cross section structure, and the weave includes: a main body area with a bioactive component formed on the fiber surface, and a fixed area comprises the weft yarn having a bioceramic material. The tissue scaffold prepared in the present disclosure has the characteristics of stimulating the growth of tissues and inducing tissue repair, effectively improving the ability of tissue regeneration and bone healing, and is beneficial to the reconstruction of the tendon and/or ligament.
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公开(公告)号：US11850143B2
公开(公告)日：2023-12-26
申请号：US17243858
申请日：2021-04-29
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor： Chih-Chieh Huang , Jeng-Liang Kuo , Hui-Ting Huang , Shiun-Yin Chang , Meng-Hsueh Lin , Cheng-Yi Wu , Lih-Tao Hsu , Pei-I Tsai , Hsin-Hsin Shen , Chih-Yu Chen , Kuo-Yi Yang , Chun-Hsien Ma
IPC: A61F2/08
CPC classification number: A61F2/0811 , A61F2210/0076 , A61F2220/0075 , A61F2230/0069 , A61F2230/0091 , A61F2250/0017 , A61F2250/0056
Abstract: A tissue repair device and a method for using the same are provided. The tissue repair device includes a body portion and at least one wire. The body portion includes an inner layer and an outer layer. The inner layer is close to a tissue, wherein the inner layer includes a hydrophilic structure, and the outer layer includes a hydrophobic structure. The wire is connected to the body portion to fix the body portion to the tissue.
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4.发明申请METHOD FOR PREPARING HEPATOCYTE AND METHOD FOR EVALUATING DRUG HEPATOTOXICITY OF INTEREST 审中-公开制备肝素的方法和评价药物毒性毒性的方法公开(公告)号：US20160266096A1
公开(公告)日：2016-09-15
申请号：US15162627
申请日：2016-05-24
Applicant: Industrial Technology Research Institute
Inventor： Chen-Ming Chen , Wannhsin Chen , Lih-Tao Hsu
CPC classification number: G01N33/5067 , C12N5/067 , C12N5/0672 , C12N2500/05 , C12N2500/30 , C12N2500/62 , C12N2501/11 , C12N2501/113 , C12N2501/12 , C12N2501/237 , C12N2501/33 , C12N2501/998 , C12N2506/02 , C12N2506/45 , G01N33/5014
Abstract: A method for preparing a hepatocyte includes the following steps: providing a liver progenitor cell, proliferating the liver progenitor cell in a medium supplemented with nicotinamide, insulin-transferrin-selenium (ITS) and EGF, and inducing the liver progenitor cell into the hepatocyte having a hepatic cord-like structure morphology. In one embodiment, the method further includes providing a pluripotent stem cell and differentiating the pluripotent stem cell into the liver progenitor cell.
Abstract translation: 一种制备肝细胞的方法包括以下步骤：提供肝祖细胞，在补充有烟酰胺，胰岛素转铁蛋白 - 硒（ITS）和EGF的培养基中增殖肝祖细胞，并诱导肝祖细胞进入具有 肝脏线状结构形态。 在一个实施方案中，该方法还包括提供多能干细胞并将多能干细胞分化为肝祖细胞。
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公开(公告)号：US20220379311A1
公开(公告)日：2022-12-01
申请号：US17824929
申请日：2022-05-26
Applicant: Industrial Technology Research Institute
Inventor： Lih-Tao Hsu , Shen-Hua Peng , Cheng-Yi Wu , Jeng-Liang Kuo , Meng-Hsueh Lin , Chih-Chieh Huang , Wei-Lin Yu , Hui-Ting Huang
IPC: B01L3/00
Abstract: A cell purification module, configured to purify multiple cells from a fluid sample is provided. The cell purification module includes a hollow column, multiple hollow fiber membranes, at least one first magnetic component, a fluid sample inlet end, and a fluid sample outlet end. The hollow column has a first opening, a second opening, and an accommodating space connecting the first opening and the second opening. The hollow fiber membranes are disposed in the accommodating space and each hollow fiber membrane has multiple pores. The first magnetic component is disposed at a periphery of the hollow column. The fluid sample inlet end and the fluid sample outlet end are respectively disposed at two ends of the hollow column. The hollow fiber membranes extend in an axial direction of the hollow column, and are arranged in a radial direction of the hollow column. A cell purification system is also provided.
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公开(公告)号：US20150166952A1
公开(公告)日：2015-06-18
申请号：US14106874
申请日：2013-12-16
Applicant: Industrial Technology Research Institute
Inventor： Chen-Ming Chen , Wannhsin Chen , Lih-Tao Hsu
CPC classification number: G01N33/5067 , C12N5/067 , C12N5/0672 , C12N2500/05 , C12N2500/30 , C12N2500/62 , C12N2501/11 , C12N2501/113 , C12N2501/12 , C12N2501/237 , C12N2501/33 , C12N2501/998 , C12N2506/02 , C12N2506/45 , G01N33/5014
Abstract: Cultured hepatocytes with hepatic-cord structure and the applications were disclosed. Also the disclosure performed the method for obtaining the cultured hepatocytes with hepatic-cord structure from pluripotent stem cells and progenitor cells.
Abstract translation: 公开了具有肝绳结构的肝细胞培养和应用。 本发明还公开了从多能干细胞和祖细胞获得具有肝 - 绳结构的培养肝细胞的方法。
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